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Convection Enhanced Delivery of Topotecan for Gliomas: A Single-Center Experience

1
Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA
2
Department of Cell Biology and Pathology, Columbia University Irving Medical Center, New York, NY 10032, USA
*
Author to whom correspondence should be addressed.
Pharmaceutics 2021, 13(1), 39; https://doi.org/10.3390/pharmaceutics13010039
Received: 4 December 2020 / Revised: 24 December 2020 / Accepted: 24 December 2020 / Published: 30 December 2020
(This article belongs to the Special Issue Drug Delivery to Brain Tumors)
A key limitation to glioma treatment involves the blood brain barrier (BBB). Convection enhanced delivery (CED) is a technique that uses a catheter placed directly into the brain parenchyma to infuse treatments using a pressure gradient. In this manuscript, we describe the physical principles behind CED along with the common pitfalls and methods for optimizing convection. Finally, we highlight our institutional experience using topotecan CED for the treatment of malignant glioma. View Full-Text
Keywords: convection enhanced delivery; glioma; glioblastoma; topotecan convection enhanced delivery; glioma; glioblastoma; topotecan
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MDPI and ACS Style

Upadhyayula, P.S.; Spinazzi, E.F.; Argenziano, M.G.; Canoll, P.; Bruce, J.N. Convection Enhanced Delivery of Topotecan for Gliomas: A Single-Center Experience. Pharmaceutics 2021, 13, 39. https://doi.org/10.3390/pharmaceutics13010039

AMA Style

Upadhyayula PS, Spinazzi EF, Argenziano MG, Canoll P, Bruce JN. Convection Enhanced Delivery of Topotecan for Gliomas: A Single-Center Experience. Pharmaceutics. 2021; 13(1):39. https://doi.org/10.3390/pharmaceutics13010039

Chicago/Turabian Style

Upadhyayula, Pavan S.; Spinazzi, Eleonora F.; Argenziano, Michael G.; Canoll, Peter; Bruce, Jeffrey N. 2021. "Convection Enhanced Delivery of Topotecan for Gliomas: A Single-Center Experience" Pharmaceutics 13, no. 1: 39. https://doi.org/10.3390/pharmaceutics13010039

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