Insights into Adenovirus Uncoating from Interactions with Integrins and Mediators of Host Immunity
Abstract
:1. Introduction
2. Uncoating (Disassembly) Is a Key Element of the Adenovirus Infection Cycle
3. Initial Interactions with Cell Receptors Trigger Capsid Disassembly
4. Adenovirus–Integrin Interactions May Destabilize the Capsid Vertex
5. Mechanochemical Properties of the Adenovirus Capsid Provide Clues to Capsid Disassembly
6. Role of Endosome Acidification in Capsid Disassembly
7. Role of the Viral Cysteine Protease (AVP) in Capsid Disassembly
8. Human α-Defensins Inhibit Adenovirus Infection by Blocking Uncoating
9. Evasion of Antibody Neutralization
10. Transit of HAdV to the Nuclear Pore Complex and the Final Steps of Uncoating
11. Summary and Future Studies
Acknowledgments
Conflicts of Interest
References
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Nemerow, G.R.; Stewart, P.L. Insights into Adenovirus Uncoating from Interactions with Integrins and Mediators of Host Immunity. Viruses 2016, 8, 337. https://doi.org/10.3390/v8120337
Nemerow GR, Stewart PL. Insights into Adenovirus Uncoating from Interactions with Integrins and Mediators of Host Immunity. Viruses. 2016; 8(12):337. https://doi.org/10.3390/v8120337
Chicago/Turabian StyleNemerow, Glen R., and Phoebe L. Stewart. 2016. "Insights into Adenovirus Uncoating from Interactions with Integrins and Mediators of Host Immunity" Viruses 8, no. 12: 337. https://doi.org/10.3390/v8120337
APA StyleNemerow, G. R., & Stewart, P. L. (2016). Insights into Adenovirus Uncoating from Interactions with Integrins and Mediators of Host Immunity. Viruses, 8(12), 337. https://doi.org/10.3390/v8120337