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Viroporins: Structures and functions beyond cell membrane permeabilization
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Viruses 2015, 7(10), 5375-5387;

Emerging Roles of Viroporins Encoded by DNA Viruses: Novel Targets for Antivirals?

School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK
Author to whom correspondence should be addressed.
Academic Editors: José Luis Nieva and Luis Carrasco
Received: 20 August 2015 / Revised: 2 October 2015 / Accepted: 12 October 2015 / Published: 16 October 2015
(This article belongs to the Special Issue Viroporins)
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Studies have highlighted the essential nature of a group of small, highly hydrophobic, membrane embedded, channel-forming proteins in the life cycles of a growing number of RNA viruses. These viroporins mediate the flow of ions and a range of solutes across cellular membranes and are necessary for manipulating a myriad of host processes. As such they contribute to all stages of the virus life cycle. Recent discoveries have identified proteins encoded by the small DNA tumor viruses that display a number of viroporin like properties. This review article summarizes the recent developments in our understanding of these novel viroporins; describes their roles in the virus life cycles and in pathogenesis and speculates on their potential as targets for anti-viral therapeutic intervention. View Full-Text
Keywords: DNA virus; viroporin; papillomavirus; polyomavirus DNA virus; viroporin; papillomavirus; polyomavirus

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Royle, J.; Dobson, S.J.; Müller, M.; Macdonald, A. Emerging Roles of Viroporins Encoded by DNA Viruses: Novel Targets for Antivirals? Viruses 2015, 7, 5375-5387.

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