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Viruses 2010, 2(1), 244-261;

Virus Infection Recognition and Early Innate Responses to Non-Enveloped Viral Vectors

Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195-7720, USA
Received: 20 October 2009 / Revised: 13 January 2010 / Accepted: 14 January 2010 / Published: 19 January 2010
(This article belongs to the Special Issue Novel Viral Vector Systems for Gene Therapy)
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Numerous human genetic and acquired diseases could be corrected or ameliorated if viruses are harnessed to safely and effectively deliver therapeutic genes to diseased cells and tissues in vivo. Innate immune and inflammatory response represents one of the key stumbling blocks during the development of viral-based therapies. In this review, current data on the early innate immune responses to viruses and to the most commonly used gene therapy vectors (using adenovirus and adeno-associated virus) will be discussed. Recent findings in the field may help develop new approaches to moderate these innate immune anti-viral responses and thus improve the safety of viral vectors for human gene therapy applications. View Full-Text
Keywords: virus vectors; innate immunity; inflammation virus vectors; innate immunity; inflammation

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Shayakhmetov, D.M. Virus Infection Recognition and Early Innate Responses to Non-Enveloped Viral Vectors. Viruses 2010, 2, 244-261.

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