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Viruses, Volume 17, Issue 10

October 2025 - 118 articles

Cover Story: This study presents data on the characterization of extracellular vesicles (EVs) released by human adenovirus type 4-infected lung epithelial cells at the pre-lytic stage of infection. CD9/CD63/CD81-positive EVs purified from infected cell supernatants displayed a distinct protein and small non-coding RNA profile compared to EVs from uninfected controls. Their unique cargo included viral genomic DNA, virus associated RNAs I and II and select viral proteins such as the non-structural DNA-binding protein DBP and L4-100K. Importantly, in the absence of any visible viral particles, these EV preparations were infectious, operating as vehicles for non-lytic viral spread. This interplay between adenovirus and host EV biogenesis highlights the potential role of EVs in intra-host dissemination. View this paper
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Articles (118)

  • Review
  • Open Access
1,253 Views
19 Pages

Oropouche Virus: An Overview of the Current Status of Diagnostics

  • Daniele Lapa,
  • Maria Anele Romeo,
  • Alessandra Spina,
  • Eliana Specchiarello and
  • Fabrizio Maggi

17 October 2025

The Orthobunyavirus Oropouche (OROV) has become an urgent public health threat in Central and South America, as well as in other countries worldwide. Since its initial identification, there have been over 30 outbreaks, with the largest reported in la...

  • Article
  • Open Access
792 Views
21 Pages

Acute HIV Infection and ART Response: Insights into T Cell Subsets, Activation, Exhaustion, and Blood and GALT HIV Reservoir

  • Soraia Santana de Moura,
  • Diogo Gama Caetano,
  • Monick Lindenmeyer Guimarães,
  • Rayana Katylin Mendes da Silva,
  • Natasha Cabral,
  • Simone da Costa Cruz Silva,
  • Marcelo Ribeiro-Alves,
  • Sylvia L. M. Teixeira,
  • Ingebourg Georg and
  • Desirée Vieira Gomes dos Santos
  • + 8 authors

16 October 2025

Investigating immunological and viral reservoir dynamics in blood and GALT during acute HIV phase advances understanding of HIV persistence. Dynamics of T cells and HIV reservoirs immediately after early ART require further investigation. We evaluate...

  • Article
  • Open Access
836 Views
12 Pages

Different Susceptibility of Mammalian Cell Lines to Severe Fever with Thrombocytopenia Syndrome Virus Infection

  • Marla Anggita,
  • Samuel Nyampong,
  • Weiyin Hu,
  • Hiroshi Shimoda and
  • Daisuke Hayasaka

16 October 2025

Severe Fever with Thrombocytopenia Syndrome (SFTS) is an emerging tick-borne infectious disease that poses a significant public health threat. SFTS virus (SFTSV) has a broad host range, including humans, cats, and natural reservoir species. Therefore...

  • Case Report
  • Open Access
783 Views
11 Pages

Refractory CMV Enteritis in Small Bowel Transplantation: A Case Highlighting the Challenges of Balancing Immunosuppression and Novel Antiviral Therapies

  • Abdulrahman A. Al-Saud,
  • Ehab H. Abufarhaneh,
  • Madain S. Alsanea,
  • Reem M. Alameer,
  • Amani H. Yamani,
  • Fatimah S. Alhamlan and
  • Reem S. Almaghrabi

15 October 2025

Background: Cytomegalovirus (CMV) remains a formidable complication in small bowel transplantation (SBT) due to the graft’s high immunogenicity and profound immunosuppression required, with refractory disease representing a particularly devasta...

  • Article
  • Open Access
627 Views
29 Pages

Quantifying the Inhibitory Efficacy of HIV-1 Therapeutic Interfering Particles at a Single CD4 T-Cell Resolution

  • Igor Sazonov,
  • Dmitry Grebennikov,
  • Rostislav Savinkov,
  • Andreas Meyerhans and
  • Gennady Bocharov

15 October 2025

Efficient control of HIV-1 infection relies on highly active antiretroviral therapy (HAART). However, this therapy is not curative and requires continuous drug administration. Application of HIV-1 defective interfering particles (DIPs), engineered wi...

  • Systematic Review
  • Open Access
5,199 Views
11 Pages

Impact of Vaccinating Adult Women Who Are HPV-Positive or with Confirmed Cervical SIL with the 9-Valent Vaccine—A Systematic Review

  • Dominik Pruski,
  • Sonja Millert-Kalińska,
  • Robert Jach,
  • Jakub Żurawski and
  • Marcin Przybylski

15 October 2025

Infection with oncogenic human papillomavirus (HPV) remains a leading cause of cervical cancer and other HPV-related diseases. This situation persists despite the availability of effective prophylactic vaccines. While global vaccination programs have...

  • Article
  • Open Access
940 Views
14 Pages

Genetic and Serological Analysis of H7N3 Avian Influenza Viruses in Mexico for Pandemic Risk Assessment

  • Guadalupe Ayora-Talavera,
  • Irma López-Martínez,
  • Gisela Barrera-Badillo,
  • Rodrigo Aparicio-Antonio,
  • Nidia Aréchiga-Ceballos,
  • Anita Aguirre-Barbosa,
  • Rosa Maria Wong-Chew,
  • Daniel Canul-Canul and
  • Mario Solís-Hernández

15 October 2025

Avian influenza A viruses pose ongoing threats to human and animal health, with H7 subtypes causing outbreaks globally. In Mexico, highly pathogenic H7N3 viruses have circulated in poultry since 2012, causing sporadic human infections. Here we analyz...

  • Article
  • Open Access
775 Views
16 Pages

14 October 2025

Adherence to antiretroviral therapy (ART) is critical for HIV management and sustained virological suppression. Differentiating intentional from unintentional nonadherence is essential for developing tailored interventions, yet evidence from Asian po...

  • Article
  • Open Access
816 Views
13 Pages

Epidemiology and Evolution of Bovine Viral Diarrhea Virus (BVDV) in Uruguay: A 10-Year Study

  • Leticia Maya,
  • Matias Castells,
  • Caroline Silveira,
  • Federico Giannitti,
  • Ingryd Merchioratto,
  • Maria Barrandeguy,
  • Alejo Menchaca and
  • Rodney Colina

14 October 2025

Bovine viral diarrhea virus (BVDV) is a pathogen of worldwide economic importance. In Uruguay, BVDV is endemic, with seroprevalence >80% at the farm level. This study analyzed 912 samples collected from January 2018 to October 2024 by reverse tran...

  • Article
  • Open Access
690 Views
21 Pages

An Intranasal Challenge Model in African Green Monkeys (Chlorocebus aethiops) for Mild-to-Moderate COVID-19 Disease Caused by Subvariant XBB.1.5

  • Nadia Storm,
  • Ming Lo,
  • Nicholas Crossland,
  • Margaux Seyler-Schmidt,
  • Hilary Staples,
  • Daniela Silva-Ayala,
  • Ambre M. Laprise,
  • Lauren St. Denis,
  • Kyle Grosz and
  • Aoife O’Connell
  • + 10 authors

14 October 2025

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily causes mild to moderate respiratory illness in humans, but infection can also lead to long-term complications, including chronic fatigue, respiratory and cardiac issues, or even d...

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Viruses - ISSN 1999-4915