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Viruses 2018, 10(12), 712; https://doi.org/10.3390/v10120712

Suppression of Type I Interferon Signaling by Flavivirus NS5

1
Department of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA
2
Graduate Program in Cell, Molecular and Developmental Biology, University of California, Riverside, Riverside, CA 92521, USA
3
Department of Biochemistry, University of California, Riverside, Riverside, CA 92521, USA
*
Authors to whom correspondence should be addressed.
Received: 21 November 2018 / Revised: 8 December 2018 / Accepted: 9 December 2018 / Published: 14 December 2018
(This article belongs to the Special Issue New Advances on Zika Virus Research)
Full-Text   |   PDF [263 KB, uploaded 14 December 2018]

Abstract

Type I interferon (IFN-I) is the first line of mammalian host defense against viral infection. To counteract this, the flaviviruses, like other viruses, have encoded a variety of antagonists, and use a multi-layered molecular defense strategy to establish their infections. Among the most potent antagonists is non-structural protein 5 (NS5), which has been shown for all disease-causing flaviviruses to target different steps and players of the type I IFN signaling pathway. Here, we summarize the type I IFN antagonist mechanisms used by flaviviruses with a focus on the role of NS5 in regulating one key regulator of type I IFN, signal transducer and activator of transcription 2 (STAT2). View Full-Text
Keywords: flavivirus; ZIKV; NS5; type I IFN antagonist flavivirus; ZIKV; NS5; type I IFN antagonist
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Thurmond, S.; Wang, B.; Song, J.; Hai, R. Suppression of Type I Interferon Signaling by Flavivirus NS5. Viruses 2018, 10, 712.

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