Fetal Brain Infection Is Not a Unique Characteristic of Brazilian Zika Viruses
AbstractThe recent emergence of Zika virus (ZIKV) in Brazil was associated with an increased number of fetal brain infections that resulted in a spectrum of congenital neurological complications known as congenital Zika syndrome (CZS). Herein, we generated de novo from sequence data an early Asian lineage ZIKV isolate (ZIKV-MY; Malaysia, 1966) not associated with microcephaly and compared the in vitro replication kinetics and fetal brain infection in interferon α/β receptor 1 knockout (IFNAR1−/−) dams of this isolate and of a Brazilian isolate (ZIKV-Natal; Natal, 2015) unequivocally associated with microcephaly. The replication efficiencies of ZIKV-MY and ZIKV-Natal in A549 and Vero cells were similar, while ZIKV-MY replicated more efficiently in wild-type (WT) and IFNAR−/− mouse embryonic fibroblasts. Viremias in IFNAR1−/− dams were similar after infection with ZIKV-MY or ZIKV-Natal, and importantly, infection of fetal brains was also not significantly different. Thus, fetal brain infection does not appear to be a unique feature of Brazilian ZIKV isolates. View Full-Text
- Supplementary File 1:
Supplementary (PDF, 161 KB)
Share & Cite This Article
Setoh, Y.X.; Peng, N.Y.; Nakayama, E.; Amarilla, A.A.; Prow, N.A.; Suhrbier, A.; Khromykh, A.A. Fetal Brain Infection Is Not a Unique Characteristic of Brazilian Zika Viruses. Viruses 2018, 10, 541.
Setoh YX, Peng NY, Nakayama E, Amarilla AA, Prow NA, Suhrbier A, Khromykh AA. Fetal Brain Infection Is Not a Unique Characteristic of Brazilian Zika Viruses. Viruses. 2018; 10(10):541.Chicago/Turabian Style
Setoh, Yin X.; Peng, Nias Y.; Nakayama, Eri; Amarilla, Alberto A.; Prow, Natalie A.; Suhrbier, Andreas; Khromykh, Alexander A. 2018. "Fetal Brain Infection Is Not a Unique Characteristic of Brazilian Zika Viruses." Viruses 10, no. 10: 541.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.