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Open AccessArticle

Towards Tuning the Mechanical Properties of Three-Dimensional Collagen Scaffolds Using a Coupled Fiber-Matrix Model

1
Department of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588-0656, USA
2
Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA
3
Nebraska Center for Materials and Nanoscience, Lincoln, NE 68588-0656, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Juergen Stampfl
Materials 2015, 8(8), 5376-5384; https://doi.org/10.3390/ma8085254
Received: 24 June 2015 / Revised: 12 August 2015 / Accepted: 14 August 2015 / Published: 20 August 2015
(This article belongs to the Section Biomaterials)
Scaffold mechanical properties are essential in regulating the microenvironment of three-dimensional cell culture. A coupled fiber-matrix numerical model was developed in this work for predicting the mechanical response of collagen scaffolds subjected to various levels of non-enzymatic glycation and collagen concentrations. The scaffold was simulated by a Voronoi network embedded in a matrix. The computational model was validated using published experimental data. Results indicate that both non-enzymatic glycation-induced matrix stiffening and fiber network density, as regulated by collagen concentration, influence scaffold behavior. The heterogeneous stress patterns of the scaffold were induced by the interfacial mechanics between the collagen fiber network and the matrix. The knowledge obtained in this work could help to fine-tune the mechanical properties of collagen scaffolds for improved tissue regeneration applications. View Full-Text
Keywords: collagen scaffold; fiber-matrix interaction; glycation; collagen concentration; computational biomechanics collagen scaffold; fiber-matrix interaction; glycation; collagen concentration; computational biomechanics
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Lin, S.; Hapach, L.A.; Reinhart-King, C.; Gu, L. Towards Tuning the Mechanical Properties of Three-Dimensional Collagen Scaffolds Using a Coupled Fiber-Matrix Model. Materials 2015, 8, 5376-5384.

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