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Article

Utilizing Edible Agar as a Carrier for Dual Functional Doxorubicin-Fe3O4 Nanotherapy Drugs

1
Department of Nursing, Kaohsiung Armed Forces General Hospital, 2 Zhongzheng 1st Rd., Kaohsiung 80284, Taiwan
2
Department of Chemistry, National Sun Yat-sen University, 70 Lien-Hai Rd., Kaohsiung 80424, Taiwan
3
Department of Seafood Science, National Kaohsiung University of Science and Technology, 142 Haijhuan Rd., Kaohsiung 81157, Taiwan
4
College of Hydrosphere Science, National Kaohsiung University of Science and Technology, 142 Haijhuan Rd., Kaohsiung 81157, Taiwan
5
Division of Cardiology, Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, 2 Zhongzheng 1st Rd., Kaohsiung 80284, Taiwan
6
School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, 100 Shih-Chuan 1st Rd., Kaohsiung 80708, Taiwan
7
Regenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, 100 Shih-Chuan 1st Rd., Kaohsiung 80708, Taiwan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Diana Ciolacu
Materials 2021, 14(8), 1824; https://doi.org/10.3390/ma14081824
Received: 18 February 2021 / Revised: 31 March 2021 / Accepted: 1 April 2021 / Published: 7 April 2021
(This article belongs to the Special Issue Research Advances in Natural Polymer-Based Hydrogels)
The purpose of this study was to use agar as a multifunctional encapsulating material to allow drug and ferromagnetism to be jointly delivered in one nanoparticle. We successfully encapsulated both Fe3O4 and doxorubicin (DOX) with agar as the drug carrier to obtain DOX-Fe3O4@agar. The iron oxide nanoparticles encapsulated in the carrier maintained good saturation of magnetization (41.9 emu/g) and had superparamagnetism. The heating capacity test showed that the specific absorption rate (SAR) value was 18.9 ± 0.5 W/g, indicating that the ferromagnetic nanoparticles encapsulated in the gel still maintained good heating capacity. Moreover, the magnetocaloric temperature could reach 43 °C in a short period of five minutes. In addition, DOX-Fe3O4@agar reached a maximum release rate of 85% ± 3% in 56 min under a neutral pH 7.0 to simulate the intestinal environment. We found using fluorescent microscopy that DOX entered HT-29 human colon cancer cells and reduced cell viability by 66%. When hyperthermia was induced with an auxiliary external magnetic field, cancer cells could be further killed, with a viability of only 15.4%. These results show that agar is an efficient multiple-drug carrier, and allows controlled drug release. Thus, this synergic treatment has potential application value for biopharmaceutical carrier materials. View Full-Text
Keywords: iron oxide; doxorubicin; ferromagnetic nanoparticles; drug delivery; synergic cytotoxic effects iron oxide; doxorubicin; ferromagnetic nanoparticles; drug delivery; synergic cytotoxic effects
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MDPI and ACS Style

Wang, Y.-J.; Lin, P.-Y.; Hsieh, S.-L.; Kirankumar, R.; Lin, H.-Y.; Li, J.-H.; Chen, Y.-T.; Wu, H.-M.; Hsieh, S. Utilizing Edible Agar as a Carrier for Dual Functional Doxorubicin-Fe3O4 Nanotherapy Drugs. Materials 2021, 14, 1824. https://doi.org/10.3390/ma14081824

AMA Style

Wang Y-J, Lin P-Y, Hsieh S-L, Kirankumar R, Lin H-Y, Li J-H, Chen Y-T, Wu H-M, Hsieh S. Utilizing Edible Agar as a Carrier for Dual Functional Doxorubicin-Fe3O4 Nanotherapy Drugs. Materials. 2021; 14(8):1824. https://doi.org/10.3390/ma14081824

Chicago/Turabian Style

Wang, Yu-Jyuan, Pei-Ying Lin, Shu-Ling Hsieh, Rajendranath Kirankumar, Hsin-Yi Lin, Jia-Huei Li, Ya-Ting Chen, Hao-Ming Wu, and Shuchen Hsieh. 2021. "Utilizing Edible Agar as a Carrier for Dual Functional Doxorubicin-Fe3O4 Nanotherapy Drugs" Materials 14, no. 8: 1824. https://doi.org/10.3390/ma14081824

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