Next Article in Journal
Orientation-Dependent Deformation Behavior of 316L Steel Manufactured by Laser Metal Deposition and Casting under Local Scratch and Indentation Load
Next Article in Special Issue
Sirolimus-Eluting Electrospun-Produced Matrices as Coatings for Vascular Stents: Dependence of Drug Release on Matrix Structure and Composition of the External Environment
Previous Article in Journal
Polydopamine-Modified Al2O3/Polyurethane Composites with Largely Improved Thermal and Mechanical Properties
Previous Article in Special Issue
Hydrogels as Potential Nano-, Micro- and Macro-Scale Systems for Controlled Drug Delivery
Open AccessArticle

Prototype Gastro-Resistant Soft Gelatin Films and Capsules—Imaging and Performance In Vitro

1
Department of Pharmaceutical Technology, Medical University of Gdansk, 80-416 Gdansk, Poland
2
Department of Chemistry and Chemical Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden
*
Author to whom correspondence should be addressed.
Materials 2020, 13(7), 1771; https://doi.org/10.3390/ma13071771
Received: 18 March 2020 / Revised: 3 April 2020 / Accepted: 7 April 2020 / Published: 9 April 2020
(This article belongs to the Special Issue Advanced Materials in Drug Release and Drug Delivery Systems)
The following study is a continuation of the previous work on preparation of gastro-resistant films by incorporation of cellulose acetate phthalate (CAP) into the soft gelatin film. An extended investigation on the previously described binary Gelatin-CAP and ternary Gelatin-CAP-carrageenan polymer films was performed. The results suggest that the critical feature behind formation of the acid-resistant films is a spinodal decomposition in the film-forming mixture. In the obtained films, upon submersion in an acidic medium, gelatin swells and dissolves, exposing a CAP-based acid-insoluble skeleton, partially coated by a residue of other ingredients. The dissolution-hindering effect appears to be stronger when iota-carrageenan is added to the film-forming mixture. The drug release study performed in enhancer cells confirmed that diclofenac sodium is not released in the acidic medium, however, at pH 6.8 the drug release occurs. The capsules prepared with a simple lab-scale process appear to be resistant to disintegration of the shell structure in acid, although imperfections of the sealing have been noticed. View Full-Text
Keywords: gelatin; gastro-resistant; films; capsules; structure; drug release gelatin; gastro-resistant; films; capsules; structure; drug release
Show Figures

Graphical abstract

MDPI and ACS Style

Maciejewski, B.; Arumughan, V.; Larsson, A.; Sznitowska, M. Prototype Gastro-Resistant Soft Gelatin Films and Capsules—Imaging and Performance In Vitro. Materials 2020, 13, 1771. https://doi.org/10.3390/ma13071771

AMA Style

Maciejewski B, Arumughan V, Larsson A, Sznitowska M. Prototype Gastro-Resistant Soft Gelatin Films and Capsules—Imaging and Performance In Vitro. Materials. 2020; 13(7):1771. https://doi.org/10.3390/ma13071771

Chicago/Turabian Style

Maciejewski, Bartosz; Arumughan, Vishnu; Larsson, Anette; Sznitowska, Małgorzata. 2020. "Prototype Gastro-Resistant Soft Gelatin Films and Capsules—Imaging and Performance In Vitro" Materials 13, no. 7: 1771. https://doi.org/10.3390/ma13071771

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop