Transition Metal Oxodiperoxo Complex Modified Metal-Organic Frameworks as Catalysts for the Selective Oxidation of Cyclohexane

In this work, a series of modified metal-organic frameworks (MOFs) have been prepared by pre- and post-treatment with transition metal oxodiperoxo complexes (MoO(O2)2, WO(O2)2, and KVO(O2)2). The obtained materials are characterized by XRD, FTIR, SEM, TEM, inductively coupled plasma atomic emission spectrometry (ICP-AES), and X-ray photoelectron spectroscopy (XPS), as well as by N2 adsorption/desorption measurement. The characterization results show that transition metal oxodiperoxo complexes are uniformly incorporated into the MOF materials without changing the basic structures. The performance of cyclohexane oxidation on metal oxodiperoxo complex modified MOFs are evaluated. UiO-67-KVO(O2)2 shows the best performance for cyclohexane oxidation, with 78% selectivity to KA oil (KA oil refers to a cyclohexanol and cyclohexanone mixture) at 9.4% conversion. The KA selectivity is found to depend on reaction time, while hot-filtration experiments indicates that the catalytic process is heterogeneous with no leaching of metal species.


Introduction
Selective C-H oxidation is of crucial importance in activating raw materials to produce oxygenates in many industrial processes [1,2]. The oxidation of cyclohexane is the main industrial process to obtain a mixture of cyclohexanone (Cyone) and cyclohexanol (CyOH) (referred to as KA oil of ketone and alcohol mixture), which are important intermediates in the production of Nylon-6 and Nylon-66 [3][4][5], and are also raw materials for the production of caprolactam and adipic acid [6]. In the oxidation process, the deep oxidation often results in the formation of undesired by-products [7]. In the industrial process, reasonable selectivity to the desired intermediate KA oil is achieved at a lower conversion [8,9]. Therefore, the selective oxidation of cyclohexane at mild condition with high energy efficiency is one of the major needs and biggest challenges for sustainable industry [10,11]. To tackle this issue, there is an urgent need for efficient, high selectivity, environmentally benign catalysts towards the sustainable development of such an important oxidation process [12]. Primarily, there are two commercial processes in cyclohexane oxidation: The non-catalytic autoxidation process and the catalyzed process [13]. In both processes, radical chemistry plays a major role. Many transition Scheme 1. Illustration of modified UiO-67 as a catalyst for the selective oxidation of cyclohexane.
The powder X-ray diffraction (XRD) patterns were recorded on a Rigaku D-Max-2400 diffractometer using Cu Kα radiation at 40 kV and 100 mA. The metal content in the samples was determined by inductively coupled plasma atomic emission spectrometry (ICP-AES) (Optima 2000DV). Fourier transform infrared spectra (FTIR) was recorded on an FT-IR-800 spectrometer in KBr disks at room temperature. The specific surface area of the catalyst was determined by N2 adsorption/desorption isotherm using a Tristar II 3020 adsorption analyzer (The data are treated according to the Brunauer, Emmett and Teller (BET) adsorption isotherm equation). Before the measurement, the sample was degassed at 120 °C under vacuum overnight. The morphology and structures of the catalysts were characterized using scanning electron microscopy (SEM) (NOVA nanoSEM 450). X-ray photoelectron spectroscopy (XPS) measurements were recorded on a Multilab 2000 X-ray photoelectron spectrometer using an Al Kα source. The binding energies of all the observed peaks were calibrated towards a value for the C 1 s peak of adventitious carbon at 284.6 eV.

Synthesis of UiO-67-bpydc
UiO-67-bpydc (1) was synthesized according to a reported procedure with slight modification [31]. A mixture of ZrCl4 (0.245 g, 1.05 mmol), H2bpydc (0.256 g, 1.05 mmol), acetic acid (HOAc) (1.8 mL), and DMF (50 mL) was added in a Schlenk flask and sonicated for 20 min, then sealed and held at 120 °C for 24 h under stirring. After cooling down to room temperature, the precipitate was isolated by centrifugation. The powder product was suspended in DMF (50 mL) at 80 °C for 3 h under stirring and isolated by centrifugation. The obtained white powder was washed by ethanol twice and dried at 100 °C overnight (yield: 89% based on Zr).
The powder X-ray diffraction (XRD) patterns were recorded on a Rigaku D-Max-2400 diffractometer using Cu Kα radiation at 40 kV and 100 mA. The metal content in the samples was determined by inductively coupled plasma atomic emission spectrometry (ICP-AES) (Optima 2000DV). Fourier transform infrared spectra (FTIR) was recorded on an FT-IR-800 spectrometer in KBr disks at room temperature. The specific surface area of the catalyst was determined by N 2 adsorption/desorption isotherm using a Tristar II 3020 adsorption analyzer (The data are treated according to the Brunauer, Emmett and Teller (BET) adsorption isotherm equation). Before the measurement, the sample was degassed at 120 • C under vacuum overnight. The morphology and structures of the catalysts were characterized using scanning electron microscopy (SEM) (NOVA nanoSEM 450). X-ray photoelectron spectroscopy (XPS) measurements were recorded on a Multilab 2000 X-ray photoelectron spectrometer using an Al Kα source. The binding energies of all the observed peaks were calibrated towards a value for the C 1 s peak of adventitious carbon at 284.6 eV.

Synthesis of UiO-67-bpydc
UiO-67-bpydc (1) was synthesized according to a reported procedure with slight modification [31]. A mixture of ZrCl 4 (0.245 g, 1.05 mmol), H 2 bpydc (0.256 g, 1.05 mmol), acetic acid (HOAc) (1.8 mL), and DMF (50 mL) was added in a Schlenk flask and sonicated for 20 min, then sealed and held at 120 • C for 24 h under stirring. After cooling down to room temperature, the precipitate was isolated by centrifugation. The powder product was suspended in DMF (50 mL) at 80 • C for 3 h under stirring and isolated by centrifugation. The obtained white powder was washed by ethanol twice and dried at 100 • C overnight (yield: 89% based on Zr).

Synthesis of UiO-67-MoO(O 2 ) 2
UiO-67-MoO(O 2 ) 2 (2) was prepared by post-synthetic modification following a reported procedure [40]. Typically, MoO(O 2 ) 2 ·2DMF (0.36 g, 1.12 mmol) was fully dissolved in ethanol (80 mL) under vigorous stirring, and 1 (0.4 g, 0.187 mmol) was added into the solution and stirred vigorously at 80 • C for 24 h. The solution was cooled to room temperature and the precipitate was isolated by centrifugation. The solid product was washed by ethanol twice and dried at 100 • C overnight (yield: 85% based on UiO-67).

Synthesis of UiO-67-WO(O 2 ) 2
UiO-67-WO(O 2 ) 2 (3) was synthesized by preparing the partially metalated ligand and then building the MOF structure. Peroxotungstate solution was prepared following a reported procedure with modification [41]. A mixture of H 2 WO 4 (4.5 g, 18 mmol) and H 2 O 2 (40 mL, 30% by weight solution) was stirred at 45 • C for 24 h. Then the solution was centrifuged and the supernatant liquid was placed in the refrigerator (2 • C-4 • C) prior to use. H 2 bpydc (1 g, 4.1 mmol) was added into the supernatant (20 mL) and then stirred at room temperature for 24 h. The solution was centrifuged, and the solid was washed by ethanol twice. After drying at 100 • C overnight, H 2 bpydc-WO(O 2 ) 2 precursor was obtained with a yield of 0.98 g.
A mixture of ZrCl 4 (0.245 g, 1.05 mmol), H 2 bpydc-WO(O 2 ) 2 (0.534 g), HOAc (1.8 mL), and DMF (50 mL) was added in a Schlenk flask and sonicated for 20 min, then sealed and stirred at 120 • C for 24 h. The solution was cooled to room temperature, and the precipitate was isolated by centrifugation. The solid product was washed by DMF once, followed by ethanol twice and finally dried at 100 • C overnight. (yield: 82% based on Zr).

Synthesis of UiO-67-KVO(O 2 ) 2
UiO-67-KVO(O 2 ) 2 (4) was synthesized by preparing the partially metalated ligand and then building the MOF structure. Peroxovanadate precursor solution was prepared following the reported procedure with modification [42]. H 2 bpydc (0.2442 g, 1 mmol) was added into ethanol (20 mL) and suspended using ultrasound for 30 min to form a suspension (a). KVO 3 (0.138 g, 1 mmol) was dissolved into H 2 O 2 (10 mL) in a beaker to give a solution (b) by stirring in an ice water bath. All steps described subsequently in this paragraph were operated in an ice water bath. Solution a was added drop wise into solution b, with constant stirring. After the addition was completed, the yellow mixture was stirred for 5 min, then 10 mL of cold ethanol was added. After 10 min, the mixture was allowed to stand for 15 min for stratification. Then, another 10 mL of cold ethanol was added, and the mixture was stirred for 10 min and then left to stand for another 10 min. The solid product was isolated by centrifugation and washed by ethanol twice and finally dried at room temperature in vacuum. We then obtained the light yellow H 2 bpydc-KVO(O 2 ) 2 precursor with a yield of 0.25 g.
A mixture of the obtained solid (H 2 bpydc-KVO(O 2 ) 2 , 0.171 g), ZrCl 4 (0.082 g, 0.35 mmol), HOAc (0.6 mL), and DMF (17 mL) was added in a sealed glass flask and sonicated for 20 min; it was then stirred at 120 • C for 24 h. The solution was cooled to room temperature and the precipitate was isolated by centrifugation. The solid product was washed by DMF once and by ethanol twice and finally dried at 80 • C overnight. (yield: 88% based on Zr).

Catalytic Oxidation of Cyclohexane
The oxidation of cyclohexane was performed in a 35 mL Pyrex tube under stirring. In a typical reaction, the cyclohexane (8 mmol), tert-butyl hydroperoxide (TBHP, 8 mmol, 70 wt% in water), and 1,2,4-trichlorobenzene (2.78 mmol) (the internal standard) were added into 8 mL acetonitrile. UiO-67-MO(O 2 ) 2 (M = Mo, W, V) was added as a catalyst with a molar ratio of the second metal to cyclohexane of 1:266. After the reaction, the spent catalyst was separated by centrifugation and washed with acetone, dried at room temperature, and subsequently reused.

Product Analysis
The oxidation products include the target products CyOH and Cyone, a radical product, CHHP, and by-products such as organic acids and esters. In our catalytic reaction system, only organic acid was detected, and no ester product was found in the titration. (1) CyOH and Cyone Cyclohexane, CyOH, and Cyone were analyzed by gas chromatography (GC) with HP-5 capillary column (30 m × 0.32 mm). Quantitative analysis of cyclohexane, CyOH, and Cyone was performed by the internal standard curve method.
(2) Peroxide The peroxides in the reaction solution included the oxidant TBHP and the intermediate product CHHP, which were quantified by an indirect iodometric method. The peroxide concentration was calculated as follows: where C is the peroxide concentration, mol/L; V is the consumption sodium thiosulfate (Na 2 S 2 O 3 ) standard solution volume, mL; V 0 is the blank experiment consumption Na 2 S 2 O 3 standard solution volume, mL; C 0 is the Na 2 S 2 O 3 standard solution concentration, and mol/L; V sample is the sample volume, mL.
(3) CHHP The radical product, CHHP, is thermally unstable and will be partially decomposed into CyOH and Cyone in GC, which affects the analysis results. An excess of triphenylphosphine (PPh 3 ) was added to the sample to completely reduce CHHP to CyOH, and the CHHP content was calculated by chromatography before and after PPh 3 addition. The simplified formula is: where [A] PPh3 is the result of chromatographic analysis of CyOH after the addition of PPh 3 ; [A] is the result of chromatographic analysis of CyOH before the addition of PPh 3 ; and [CHHP] is CHHP content.

Synthesis
UiO-67-MoO(O 2 ) 2 is prepared by treating a suspension of the pristine UiO-67 in ethanol with MoO(O 2 ) 2 ·2DMF. This post-synthetic approach was commonly used to provide MOFs with new functionalities by a solid-liquid reaction [43]. However, the attempt to prepare UiO  [41,42]. Please note that the anchoring procedure of the organic ligand is incomplete; only part of the ligand was successfully functionalized. ICP and elemental analysis showed that the metalated linker has a doping molar ratio of 0.31 for W and 0.35 for V (Table S1, Supplementary Material), FTIR spectra of H 2 bpydc after metalation showed a band at 1684 cm −1 , which was assigned to the -COOH stretching vibration ( Figure S1, Supplementary Material). The characterization demonstrated that the free carboxylic acid group is still available for further coordination with Zr salt to build the MOF framework. However, such a mixed-ligand was sufficient enough to build the MOF framework containing certain amounts of oxodiperoxo complexes.

XRD Characterization
In Figure 1, the simulated XRD pattern of UiO-67 derived from single-crystal x-ray diffraction data and the experimentally synthesized UiO-67 before and after modification are compared. The crystal structure of the experimentally synthesized MOF material was consistent with the simulated XRD pattern, indicating that the structural integrity was well preserved after modification. After anchoring MoO(O 2 ) 2 , WO(O 2 ) 2 , and KVO(O 2 ) 2 , the position of the diffraction peak was unchanged, but the intensity was decreased, especially for UiO-67-KVO(O 2 ) 2 . However, no additional diffraction peak appeared. It indicates that the MOF material had a decreased crystallinity after metal peroxide modification, but the framework structure was intact. The supported transition metal peroxide was highly dispersed on the MOF framework, and there was no characteristic diffraction of the transition metal oxide or metal complexes.
Materials 2020, 13, x FOR PEER REVIEW 6 of 15 In Figure 1, the simulated XRD pattern of UiO-67 derived from single-crystal x-ray diffraction data and the experimentally synthesized UiO-67 before and after modification are compared. The crystal structure of the experimentally synthesized MOF material was consistent with the simulated XRD pattern, indicating that the structural integrity was well preserved after modification. After anchoring MoO(O2)2, WO(O2)2, and KVO(O2)2, the position of the diffraction peak was unchanged, but the intensity was decreased, especially for UiO-67-KVO(O2)2. However, no additional diffraction peak appeared. It indicates that the MOF material had a decreased crystallinity after metal peroxide modification, but the framework structure was intact. The supported transition metal peroxide was highly dispersed on the MOF framework, and there was no characteristic diffraction of the transition metal oxide or metal complexes.

Nitrogen Physical Adsorption, ICP-AES, and FTIR Studies
The metal loading of the modified MOF materials and BET specific surface areas are listed in Table 1. The loadings of Mo, W, and V were determined by ICP analysis and were 14.1 wt%, 6.3 wt%, and 2.7 wt%, respectively. It should be noted that, although the MoO(O2)2 was tethered on the framework by post-synthetic modification, the loading of the Mo complex was very high. There were 4.2 MoO(O2)2 molecules in one UiO-67 structural unit ( Table 1). The WO(O2)2 and KVO(O2)2 complexes were anchored on the MOF frameworks by coordinating first with the organic ligand and then by building the MOF structure. There were certain losses of metal oxodiperoxo complexes during the formation of MOFs, as evidenced by ICP and elemental analysis. Metalated ligand has a metal to ligand molar ratio of 0.35 for V (Table S1, Supplementary Material), while UiO-67-KVO(O2)2 has a metal to MOF molar ratio of 1.2, which indicates that there is 57% of KVO(O2)2 remaining on the MOF framework. Similarly, 43% of WO(O2)2 was anchored onto the MOF framework compared to the partially metalated linker. The BET specific surface area of UiO-67 was 1562 m 2 /g, and after pre-and post-modification, the surface areas of UiO-67-MoO(O2)2, UiO-67-WO(O2)2, and UiO-67-KVO(O2)2 significantly reduced to 583 m 2 /g, 656 m 2 /g, and 305 m 2 /g, respectively, which may be due to the fact that the metal complexes can occupy and/or block the cavities of the UiO-67, and the MOF structure partially collapsed during the modification process. As shown in Figure S2

Nitrogen Physical Adsorption, ICP-AES, and FTIR Studies
The metal loading of the modified MOF materials and BET specific surface areas are listed in Table 1. The loadings of Mo, W, and V were determined by ICP analysis and were 14.1 wt%, 6.3 wt%, and 2.7 wt%, respectively. It should be noted that, although the MoO(O 2 ) 2 was tethered on the framework by post-synthetic modification, the loading of the Mo complex was very high. There were 4.2 MoO(O 2 ) 2 molecules in one UiO-67 structural unit ( Table 1). The WO(O 2 ) 2 and KVO(O 2 ) 2 complexes were anchored on the MOF frameworks by coordinating first with the organic ligand and then by building the MOF structure. There were certain losses of metal oxodiperoxo complexes during the formation of MOFs, as evidenced by ICP and elemental analysis. Metalated ligand has a metal to ligand molar ratio of 0.35 for V (Table S1, Supplementary Material), while UiO-67-KVO(O 2 ) 2 has a metal to MOF molar ratio of 1.2, which indicates that there is 57% of KVO(O 2 ) 2 remaining on the MOF framework. Similarly, 43% of WO(O 2 ) 2 was anchored onto the MOF framework compared to the partially metalated linker. The BET specific surface area of UiO-67 was 1562 m 2 /g, and after pre-and post-modification, the surface areas of UiO-67-MoO(O 2 ) 2 , UiO-67-WO(O 2 ) 2 , and UiO-67-KVO(O 2 ) 2 significantly reduced to 583 m 2 /g, 656 m 2 /g, and 305 m 2 /g, respectively, which may be due to the fact that the metal complexes can occupy and/or block the cavities of the UiO-67, and the MOF structure partially collapsed during the modification process. As shown in Figure S2

SEM
As shown in Figure 3, the SEM micrograph of UiO-67-KVO(O2)2 shows that the particle size was uniform at around 60 nm, but no obvious regular octahedron shape of UiO-67 material was observed. The reason for this might be due to the stirring during the synthesis, which has a negative effect on the growth of regular crystals.   Figure 3, the SEM micrograph of UiO-67-KVO(O 2 ) 2 shows that the particle size was uniform at around 60 nm, but no obvious regular octahedron shape of UiO-67 material was observed. The reason for this might be due to the stirring during the synthesis, which has a negative effect on the growth of regular crystals.

SEM
As shown in Figure 3, the SEM micrograph of UiO-67-KVO(O2)2 shows that the particle size was uniform at around 60 nm, but no obvious regular octahedron shape of UiO-67 material was observed. The reason for this might be due to the stirring during the synthesis, which has a negative effect on the growth of regular crystals.

X-ray Photoelectron Spectroscopy
X-ray photoelectron spectroscopy (XPS) is an advanced analytical technique in microscopic analysis of electronic materials and components and is used for investigating the electronic characteristics of the species created on the surface, including the environment of electron, state of oxidation, and the binding energy of the core electron of the metal [45]. An XPS elemental survey scan of the surface of the UiO-67-KVO(O 2 ) 2 is shown in Figure 4. The peaks related to O 1 s, C 1 s, and N 1 s were observed in this spectrum (Figure 4a). In Figure 4b, UiO-67-KVO(O 2 ) 2 shows peaks at 523.7 eV and 516.3 eV, which correspond to V 2p 1/2 and V 2p 3/2 of V 5+ [46]. Materials 2020, 13, x FOR PEER REVIEW 9 of 15 3.1.5. X-ray Photoelectron Spectroscopy X-ray photoelectron spectroscopy (XPS) is an advanced analytical technique in microscopic analysis of electronic materials and components and is used for investigating the electronic characteristics of the species created on the surface, including the environment of electron, state of oxidation, and the binding energy of the core electron of the metal [45]. An XPS elemental survey scan of the surface of the UiO-67-KVO(O2)2 is shown in Figure 4. The peaks related to O 1 s, C 1 s, and N 1 s were observed in this spectrum (Figure 4a). In Figure 4b, UiO-67-KVO(O2)2 shows peaks at 523.7 eV and 516.3 eV, which correspond to V 2p1/2 and V 2p3/2 of V 5+ [46].

Catalytic Performance
The catalytic activity of metal oxodiperoxo complex modified UiO-67 materials was investigated in the liquid phase oxidation of cyclohexane at 343 K with TBHP as the oxidant. The XRD patterns of the three metal oxodiperoxo complex modified UiO-67s before and after catalysis are shown in Figure  5. It is shown that the diffraction peaks were basically unchanged, indicating that the structural robustness of the material was fully retained during the reaction. The catalytic conversion and

Catalytic Performance
The catalytic activity of metal oxodiperoxo complex modified UiO-67 materials was investigated in the liquid phase oxidation of cyclohexane at 343 K with TBHP as the oxidant. The XRD patterns of the three metal oxodiperoxo complex modified UiO-67s before and after catalysis are shown in Figure 5. It is shown that the diffraction peaks were basically unchanged, indicating that the structural robustness of the material was fully retained during the reaction. The catalytic conversion and selectivity are shown in detail in Table 2. In the MOF modification process, the binding ability of different active metal components to the ligand is different, and it is difficult to ensure that the active metal M/MOF molar ratio is the same. Therefore, in the cyclohexane oxidation reaction, the amount of different catalysts was controlled based on the molar amount of the active metal. The molar ratio of cyclohexane to active metal (CH:M) was fixed to 266. Blank experiments were carried out to ensure the role of the active sites in the selective oxidation of cyclohexane. As summarized in Table 2, without adding any catalyst to the reaction mixture, negligible conversion of cyclohexane was observed; when UiO-67 was added to the reaction mixture, a low conversion of cyclohexane was observed, with CHHP as the major product. The formation of CHHP is mainly catalyzed by certain amounts of unsaturated zirconium sites on UiO-67. Compared to UiO-67-KVO(O 2 ) 2 , UiO-67-MoO(O 2 ) 2 and UiO-67-WO(O 2 ) 2 catalyzed the cyclohexane oxidation with a very low cyclohexane conversion, and, similarly, CHHP was the main product, indicating only a minor contribution from the catalyst. On the other hand, it is clearly noticed that UiO-67-KVO(O 2 ) 2 was more active in the oxidation of cyclohexane, with a relatively higher cyclohexane conversion of 9.4% in 12 h. This observation was in agreement with the earlier report, which confirmed that the vanadium (V) oxodiperoxo complexes had the ability to transfer oxygen to aromatic hydrocarbons, acting as powerful epoxidizing and hydroxylating reagents.  The trend in cyclohexane conversion and selectivity over time is shown in Figure 6a. The cyclohexane conversion increased to 6.3% in 6 h, slowly reached 9.4% conversion in 12 h, and remained almost constant afterward. However, the selectivities towards Cyone, CyOH, and CHHP were quite different over time. While increasing the reaction time, the selectivity toward Cyone had a constant increase from 46.2% at 6 h up to a maximum value of 86.9% at 24 h. The intermediate product, CHHP, decreased slowly, while the selectivity toward CyOH decreased over time as well, and no CyOH was observed after 24 h. While in a prolonged reaction timeframe, the selectivity to the by-product acids increased slowly. These results showed that a longer reaction time promoted the decomposition of the intermediate CHHP to afford the main product, CyOH and CyOne, whereas further prolongation of the reaction time led to an increased Cyone formation and decreased CyOH The trend in cyclohexane conversion and selectivity over time is shown in Figure 6a. The cyclohexane conversion increased to 6.3% in 6 h, slowly reached 9.4% conversion in 12 h, and remained almost constant afterward. However, the selectivities towards Cyone, CyOH, and CHHP were quite different over time. While increasing the reaction time, the selectivity toward Cyone had a constant increase from 46.2% at 6 h up to a maximum value of 86.9% at 24 h. The intermediate product, CHHP, decreased slowly, while the selectivity toward CyOH decreased over time as well, and no CyOH was observed after 24 h. While in a prolonged reaction timeframe, the selectivity to the by-product acids increased slowly. These results showed that a longer reaction time promoted the decomposition of the intermediate CHHP to afford the main product, CyOH and CyOne, whereas further prolongation of the reaction time led to an increased Cyone formation and decreased CyOH formation. The total selectivity toward the main product, KA oil, increased monotonically with time. Thus, the optimum reaction time was 24 h. To exclude the contribution of leached V species in the solution, a hot-filtration experiment was performed. After 6 h of reaction, the solid catalyst was removed from the reaction mixture by filtration, and the filtrate was recovered to continue the reaction under the same condition for an additional 6 h. Figure 6b indicates that the conversion of cyclohexane remained stable after the catalyst was filtered off, suggesting that the cyclohexane oxidation was terminated after removal of the solid catalyst (with the catalyst, the cyclohexane conversion reached 9.4% after 12 h).   Conversion/% based on cyclohexane = total moles of products after reaction/moles of cyclohexane before reaction × 100. c Selectivity/% of product = moles of product after reaction/total moles of products. d Others are mainly organic acid (quantified based on the titration result with NaOH); no ester product was found based on the titration result. e Hot filtration: The reaction stopped after 6 h, the catalyst was filtered off, and the filtrate was left to continue to react under the same condition for another 6 h. The XPS spectra of UiO-67-KVO(O2)2 before and after reaction are illustrated in Figure 7. The V 2p1/2 and V 2p3/2 peak binding energy shifted from 523.7 eV and 516.3 eV (Figure 7a) to 524.4 eV and 517.0 eV (Figure 7b), respectively, with an 0.7 eV offset of both peaks. This is the characteristic of V 5+ [47,48], confirming no obvious change in the valence state of V over the catalysis before and after reactions.
Among several metal oxodiperoxo complex modified UiO-67, UiO-67-KVO(O2)2 showed the best catalytic activity. In Table 3, a comparison between the reported vanadium-based silica, The XPS spectra of UiO-67-KVO(O 2 ) 2 before and after reaction are illustrated in Figure 7. The V 2p 1/2 and V 2p 3/2 peak binding energy shifted from 523.7 eV and 516.3 eV (Figure 7a) to 524.4 eV and 517.0 eV (Figure 7b), respectively, with an 0.7 eV offset of both peaks. This is the characteristic of V 5+ [47,48], confirming no obvious change in the valence state of V over the catalysis before and after reactions. and VPO-Co(0.10) (cobalt promoted VPO) catalysts showed similar selectivity toward KA oil, around 53%~55%, and the by-product for the VPO catalysts was mainly cyclohexene. However, cobalt doping significantly increased the overall activity for the oxidation of cyclohexane from 10% to 65%. Therefore, our future planning work includes the further tethering of Co 2+ ions into UiO-67-KVO(O2)2 to investigate the effect toward the liquid phase oxidation of cyclohexane.

Conclusions
In the present study, characterization results confirmed that UiO-67-MoO(O2)2, UiO-67-WO(O2)2, and UiO-67-KVO(O2)2 was obtained, and the transition metal oxodiperoxo complexes (MoO(O2)2, WO(O2)2, and KVO(O2)2) were anchored on the framework by coordination. UiO-67-KVO(O2)2 showed the best catalytic performance in the liquid phase oxidation of cyclohexane with TBHP as the oxidant. The effect of reaction time in the reaction is critical. Cyclohexane conversion reached the highest value of 9.4% at 12 h, and further prolongation of reaction time led to an increased Cyone formation and a decreased CyOH formation. The selectivity towards the main product, KA oil, increased constantly over time. Hot-filtration experiment excluded the leaching of V species and its contribution to the catalytic reaction.   Among several metal oxodiperoxo complex modified UiO-67, UiO-67-KVO(O 2 ) 2 showed the best catalytic activity. In Table 3, a comparison between the reported vanadium-based silica, phosphorus, or mesoporous catalysts with UiO-67-KVO(O 2 ) 2 of the current study is summarized. All the catalytic reactions used TBHP as the oxidant, and UiO-67-KVO(O 2 ) 2 showed the second best selectivity toward KA oil (77%) with Cyone as the major product. V-Co-TUD-1, a cobalt promoted vanadium based mesoporous siliceous material, showed the best selectivity toward KA oil (87.9%) in a solvent free condition, and CyOH was the major product. The vanadium phosphorus oxide (VPO) and VPO-Co(0.10) (cobalt promoted VPO) catalysts showed similar selectivity toward KA oil, around 53%~55%, and the by-product for the VPO catalysts was mainly cyclohexene. However, cobalt doping significantly increased the overall activity for the oxidation of cyclohexane from 10% to 65%. Therefore, our future planning work includes the further tethering of Co 2+ ions into UiO-67-KVO(O 2 ) 2 to investigate the effect toward the liquid phase oxidation of cyclohexane.

Conclusions
In the present study, characterization results confirmed that UiO-67-MoO(O 2 ) 2 , UiO-67-WO(O 2 ) 2 , and UiO-67-KVO(O 2 ) 2 was obtained, and the transition metal oxodiperoxo complexes (MoO(O 2 ) 2 , WO(O 2 ) 2 , and KVO(O 2 ) 2 ) were anchored on the framework by coordination. UiO-67-KVO(O 2 ) 2 showed the best catalytic performance in the liquid phase oxidation of cyclohexane with TBHP as the oxidant. The effect of reaction time in the reaction is critical. Cyclohexane conversion reached the highest value of 9.4% at 12 h, and further prolongation of reaction time led to an increased Cyone formation and a decreased CyOH formation. The selectivity towards the main product, KA oil, increased constantly over time. Hot-filtration experiment excluded the leaching of V species and its contribution to the catalytic reaction.