COVID-19 Lessons for Climate Change and Sustainable Health

The drivers underpinning the emergence of SARS-CoV-2 and climate change attest to the fact that we are now living in the Anthropocene Epoch, with human activities significantly impacting and altering the global ecosystem. Here, we explore the historical context of zoonoses, the effect of anthropogenic climate change and interrelated drivers on the emergence of, and response to emerging infectious diseases. We call attention to an urgent need for inculcating a One Health research agenda that acknowledges the primary interconnection between animals, humans, pathogens, and their collective milieus to foster long term resilience across all systems within our shared planetary environment.


Introduction
In late 2019, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causal agent of the Coronavirus disease 2019 (COVID-19) emerged from a wildlife wet market in the city of Wuhan in the Hubei province of China [1,2]. The virus spread across the world reaching a pandemic status with an estimated global case count of 197 million and at least 4 million deaths as of July 2021 [3]. An estimated 7.8 billion people on Earth today are witnessing a pandemic unlike any other since the 1918-1919 Spanish Flu that had infected one-third of the world's population (500 million people) [4] at the time. Against the backdrop of ever-widening social inequities [4,5], globalization [4, 6,7], resource overexploitation [8,9] and biodiversity loss [10,11], the COVID-19 pandemic has highlighted a global gap in governance and pandemic preparedness [12]. After more than a year since the onset of COVID-19, and despite sustained travel restrictions, social distancing, lockdown measures and vaccine development, there is still no stage for a discussion on when or how the pandemic will end. While many have claimed that a pandemic of this scale was impossible to predict, let alone prevent, public health experts, conservationists and disease ecologists alike had been issuing warnings of a coronavirus pandemic since 2003 [13]. First with the identification of SARS-CoV-1 in China in 2004 [14] and then with the Middle Eastern Respiratory Syndrome (MERS-CoV) in Saudi Arabia, 2012 [15]. COVID-19 s origin at the human-environment-animal interface, its accelerated expansion and the collateral damage from a trillion-dollar economic fallout [16], warrants an urgent and renewed examination into the mechanistic causes responsible for such events.
Here, we explore the historical context of zoonoses, the effect of anthropogenic climate change and interrelated drivers on the emergence of, and response to Emerging Infectious Diseases (EIDs). We call attention to an urgent need for inculcating a One Health research agenda to mobilise multisectoral stakeholder groups and foster long term resilience across all systems within our shared planetary environment. between variables denote a change in the same direction, i.e., direct proportionality between variables. Negative causal links (-) denote a change in opposite directions, i.e., inverse proportionality between variables. Reinforcing causal loops (denoted by an R with a clockwise arrow) are associated with exponential increases/decreases between variables.

Land Use Change
EIDs are primarily driven by changes in land use and the increased rate of land conversion. Worldwide land usage changes from 1960 to 2019 now extend to the tune of 43 million km 2 (roughly a third of the global land surface) with an average annual change of 720,000 km 2 of land area every year, since 1960 [27]. With rising urbanisation, farmland area, and intensive livestock production, humans and farmland animals increasingly encroach on once natural ecosystems, forcing wildlife to recuperate near human settlements and vice versa. This reenforcing loop increases the frequency of contact between humans and wildlife species, effectively increasing the chances for zoonoses to occur. The Nipah virus outbreak in Malaysia (1998Malaysia ( -1999 and in Bangladesh (2000) are exemplary of the mechanistic linkage between changing land-use patterns and viral spill over to humans from domestic pigs [28] and bats [29], respectively. Both outbreak scenarios were facilitated by human resource supplementation in modified landscapes [30]. In Malaysia it was due to the proximity of fruit tree plantations to piggeries [28] and in Bangladesh, it was an increased proliferation of the bat population near date palms [29]. More recently, it has also been demonstrated that human-livestock-wildlife interactions in China can create zoonotic hotspots, increasing the likelihood of SARS-related coronavirus transmission from animals to humans [31].

Deforestation and Biodiversity Loss
With increasing deforestation, biodiversity has reduced substantially, with an estimated species loss of 68% in less than 50 years. This has also altered disease transmission dynamics and resulted in more human contact with vectors or reservoirs [32]. Over the years, converting land for agriculture has simultaneously caused a 70% global biodiversity loss and halved all tree cover [32]. Disruption of species diversity in such systems has increased chances of pathogen exposure among susceptible hosts in addition to increasing overall risk of zoonotic EIDs (by vector and non-vector species) such as, Lassa fever, lyme

Land Use Change
EIDs are primarily driven by changes in land use and the increased rate of land conversion. Worldwide land usage changes from 1960 to 2019 now extend to the tune of 43 million km 2 (roughly a third of the global land surface) with an average annual change of 720,000 km 2 of land area every year, since 1960 [27]. With rising urbanisation, farmland area, and intensive livestock production, humans and farmland animals increasingly encroach on once natural ecosystems, forcing wildlife to recuperate near human settlements and vice versa. This reenforcing loop increases the frequency of contact between humans and wildlife species, effectively increasing the chances for zoonoses to occur. The Nipah virus outbreak in Malaysia (1998Malaysia ( -1999 and in Bangladesh (2000) are exemplary of the mechanistic linkage between changing land-use patterns and viral spill over to humans from domestic pigs [28] and bats [29], respectively. Both outbreak scenarios were facilitated by human resource supplementation in modified landscapes [30]. In Malaysia it was due to the proximity of fruit tree plantations to piggeries [28] and in Bangladesh, it was an increased proliferation of the bat population near date palms [29]. More recently, it has also been demonstrated that human-livestock-wildlife interactions in China can create zoonotic hotspots, increasing the likelihood of SARS-related coronavirus transmission from animals to humans [31].

Deforestation and Biodiversity Loss
With increasing deforestation, biodiversity has reduced substantially, with an estimated species loss of 68% in less than 50 years. This has also altered disease transmission dynamics and resulted in more human contact with vectors or reservoirs [32]. Over the years, converting land for agriculture has simultaneously caused a 70% global biodiversity loss and halved all tree cover [32]. Disruption of species diversity in such systems has increased chances of pathogen exposure among susceptible hosts in addition to increasing overall risk of zoonotic EIDs (by vector and non-vector species) such as, Lassa fever, lyme disease and multiple vector borne diseases. Lassa fever, for instance, an acute viral disease endemic to several West African countries has been aggravated by deforestation, biodiversity, and habitat loss of the Mastomys natalensis rodents [33]. consequently, these rodents seek refuge in neighbouring structures that have, in many cases, proliferated due to population increase, industrialization and agricultural purposes. Mastomys rodents breed frequently and produce large numbers of offspring and readily colonize human homes and areas where food is stored, and all these factors contribute to the spread of Lassa virus from infected rodents [34].

Travel Connectivity Ramifications
The introduction, dissemination, and exportation of pathogens to new environments and populations has always been associated with cross-border and cross-continental travel. As population mobility increases, the speed with which these emerging and newly identified pathogens with epidemic and pandemic potential spread has increased [35]. As we saw with the pandemic history, the sluggish march of the second cholera epidemic could be seen in the 1800s, following commercial and military campaign lines out of India through Central Asia, the Middle East, Europe, and eventually North America [36]. Whereas now, with advancements in the availability of and access to various modes of transportation and the reductions in travel time, infectious diseases can travel throughout the world in less than a day. We are currently witnessing this phenomenon with the ongoing pandemic [6].

Energy Exploitation
Our indiscriminate exploitation of natural environments has also been a direct result of increased social and economic dependence on non-renewable resources. Effective management of environmental health risks such as air and water pollution, road traffic accidents and food security issues can significantly reduce the incidence, morbidity and mortality associated with non-communicable diseases (NCDs) [37]. Another major contributor to the increasing burden of NCDs in LMICs is the heavy reliance on burning biomass, which are heavy emitters of particulate matter, as a source of energy [38]. Diverting investments into alternative renewable sources of energy, robust urban and housing planning and the development of public transport infrastructure can significantly reduce emissions of harmful greenhouse gases and carcinogens, and directly reduce the burden of cardiovascular diseases, chronic lung disorders and cancers worldwide [39].
As populations grow, there is also an increased demand for provision services to ensure food security. This has led to the indiscriminate exploitation of natural environments which are cleared out en masse for agricultural and animal husbandry purposes [40]. The lost biodiversity as a result translates into reduced ecosystem services. Any zoonoses that originate from farms will have undergone selection within their susceptible animal hosts prior to entering the human transmission chain and are thus likely to be more efficient at causing severe disease [41,42].

Climate Change
Drastic changes in the land use patterns, loss of biodiversity and an indiscriminate consumption of animal food sources exert influence on and are themselves influenced by the broader context of climate change which, with its many elements, is already altering how humans relate and interact with other species on Earth. The spatial heterogeneity of climate change and its impacts have been widely studied and over the past decade, there is unequivocal evidence that the planet is warming [43]. The combined land and ocean temperature have in conjunction, increased at an average rate of 0.13 • F (0.08 • C) per decade since 1880; with more than a double (0.18 • C/0.32 • F) increase observed onwards of 1981 [44]. The temperature increase is very likely due to anthropogenic influence of indiscriminate fossil fuel use, deforestation, intensive agricultural practices, greenhouse gas emissions, etc. Changes in abiotic factors such as increasing sea temperatures have caused host range shifts, displacing and dispersing organisms into new areas [45]. Such changes implicate an increased viral transmission from one host to another and prolong a pathogen's survival outside of its usual host. Indirectly, such changes impact potential pathogens by changing its host/vector behaviour, distribution, and cross-species interactions. Not only could such changes foster novel human to non-human interfaces increasing the chances of spill over events, but they also cause latitudinal and altitudinal expansion of existing zoonotic pathogens in regions that are hotspots for climate change i.e., the arctics, drylands, and mountains [46].
Vector borne zoonotic diseases are particularly susceptible to climate driven pathogen range expansion due to global increases in temperature. Increased temperature creates conditions conducive for the spread of tropical parasites, along with their vectors towards higher latitudes that present conditions more favourable for transmission. Increased incidence of diseases like malaria, Zika, and dengue, caused by pathogens, spread by mosquito vectors between animals and humans is already occurring in Europe [47] and Latin America [48]. Progressively adverse changes in our climate and weather conditions have not only catalysed shifts in both the range and mobility of all living organisms within the zoonotic EID pathway but have also compounded our responses to them. In the near term, climate change potentiates the destabilization of co-evolved host-pathogen interactions by not only altering the seasonality of parasite transmission, but also by increasing their rate of development. The nematode parasitism of the red grouse in Scotland [49] is exemplary of this trend. Certain range shifts are poised to result in novel and evolutionarily untested host-pathogen interactions, which could cause host shifts and catalyse new zoonotic EIDs.
The effects of climate change, however, are not limited to incremental changes. In many regions across the globe, its effects are being reflected in local trends of average temperature and precipitation patterns. Increased surface temperatures, monsoons, etc. can also exert influence in the emergence of non-zoonotic EIDs, such as cholera [50]. Over and above its influence on future EIDs, climate change is speculated to intensify climate variability and weather extremes, including increased intensity of tropical cyclones with higher wind speeds, wetter monsoons, and, possibly, more intense mid-latitude storms and wildfires [51]. Climate change has and will continue to raise the level of uncertainty surrounding known natural hazard risks. Renewable energies can address the challenges of air pollution and climate change, reducing greenhouse gas emissions and thereby global warming [52,53]. With an increased focus on cleaner energy sources, majority of the adverse impacts related to atmospheric and ocean temperature increases can be reduced [54]. Consequently, adverse drivers of zoonosis can also be mitigated. A strong global engagement is required to develop strategies and technologies that limit and eliminate risks, such as those posed by climate change, by supporting the obligation to drastically reduce emissions, strengthen societal equality, improve community resilience, and achieve the UN's sustainable development goals.

Interrelationship between Climate Change, COVID-19, and AMR
The co-occurrence of the pandemic in the context of climate change and vice versa has showcased the overlapping vulnerability of communities that have contributed to the already high morbidity and mortality burden. A minimum of 92 of the estimated 132 unique extreme weather events that occurred in 2020, have overlapped with the pandemic [55]. While the specific nature of threats changed over seasons and regions, these hazards jeopardized sensitive public health work pertaining to pandemic response. In Zimbabwe, millions were left without access to clean water and at risk of acute food insecurity due to drought. Several southern African countries, heavily dependent on hydropower, experienced large scale power cuts. This led to a hampered coordination of response to the pandemic. In 2020, an estimated 437.1 million people in vulnerable groups were exposed to extreme heat [55], the impacts of which were glaringly apparent in Australia [56], where adverse health impacts because of air pollution due to an extreme bushfire season likely worsened COVID-19 morbidity [57]. On a broader scale, a combination of geopolitical stressors and climate catalysed large scale forced migrations [58][59][60]. Displaced populations, such as the ones Energies 2021, 14, 5938 6 of 13 residing in refugee camps in Yemen and Rohingya, developed an increased risk of contracting COVID-19 due to living conditions incompatible with social distancing, improper access to testing facilities and an acute lack of healthcare facilities. Cases of other infectious diseases such as diphtheria also skyrocketed in these camps [61,62]. EIDs with the potential to become pandemics and climate change along with their underlying drivers occur on distinct temporal scales. They are, in many ways, like the complex disease interaction(s), shared pathways and underlying social forces serving as interrelated impressions shaping their collective exhibition (Figure 1).
Both EIDs and climate risks are systemic, i.e., their direct manifestations and knock-on effects proliferate rapidly in an interconnected world. Both are nonstationary, i.e., their past probabilities and distribution of occurrence changes rapidly and is usually inadequate to base future projections. Both are nonlinear, with disproportionate socioeconomic impacts once certain thresholds are breached (surface temperature thresholds in case of climate change and hospital capacities in case of COVID 19). They both constitute risk multipliers, i.e., they underscore and aggravate previously untested susceptibilities intrinsic to human society and systems. Both are regressive, i.e., the most vulnerable communities across the world are disproportionately affected and neither can be considered a 'black swan' event that experts have been consistently warning against for many years. Addressing both requires a fundamental shift, from optimizing largely for the shorter-term performance of systems to building correspondingly in their longer-term resiliency [63]. The ongoing pandemic has demonstrated, healthcare systems, agricultural practices, supply chains, and cities because of their design, are struggling to function within operational conditions. The measures being implemented to respond to the pandemic, including vaccine development, research, genotyping, personal protective equipment, tracking, pop-up hospitals, mass vaccination and changes to fiscal policies (government stimulus packages approaching several trillion dollars) are illustrative of how expensive the failure to build systemic resiliency can ultimately prove to be [63]. For both climate change and pandemics, the cost of controlling a global crisis inevitably exceeds investments toward their prevention.
Over the next few decades, climate change and antimicrobial resistance (AMR) will rise in prominence as two imminent threats to global public health, accelerated by globalisation. AMR is widely acknowledged as the next big pandemic, and in the US alone, drug-resistant infections are the third leading cause of mortality-estimated to account for 162,000 deaths annually [64]. The complex transmission dynamics of AMR combined with large interregional inequalities in surveillance systems and reporting frameworks pose grave challenges in estimating the true burden of AMR infections worldwide [65]. However, as an evolutionary feature, it is inevitable that microbes develop resistance traits that will be maintained and propagated so long as the selection pressure induced by antimicrobials persists.
Warmer temperatures can broaden the endemicity of pathogens that host resistance determinants by increasing their growth rates, hence widening their scope, and expanding their pool of susceptible hosts. In the absence of alternatives to replace the existing repertoire of antimicrobials, the increased incidence of resistant infections can place a burden on health systems to prescribe more antimicrobials, propagating resistance further [66]. As AMR becomes more pervasive, healthcare infrastructure inadequacies highlighted during the COVID-19 pandemic will be compounded, as existing treatments against a multitude of infections become obsolete. Langford et al. conducted a meta-analysis into the current extent of irrational prescription practices, finding that 74.6% of 30,623 patients presenting with COVID-19 were incorrectly prescribed antibiotics in the first instance [67,68]. These figures warrant the development of rapid AMR diagnostics and stringent prescription guidelines to mitigate the risk of increasing the morbidity and mortality associated with resistant pathogens that are already selected for.
Several studies have also discussed the positive correlation between the incidence of bacterial infections with rising temperatures, humidity, and monthly precipitation [69]. A study of three clinically relevant pathogens (E. coli, K. pneumoniae and S. aureus) across  41 states in the US confirmed that warmer temperatures can drive bacterial growth and also potentially drive resistance acquisition through horizontal gene transfer. The study revealed that minimum temperatures rising by 10 • C can increase resistance acquisition rates between 2.2 and 4.2% (p < 0.05) [70]. This would provide a further explanation for the higher prevalence of extended-spectrum beta-lactamase-producing Enterobacteriaceae in Southern Europe, previously solely attributed to irrational prescription practices in the region. A study by Arias-Andres et al. also unearthed the role of microplastics in freshwater ecosystems in facilitating HGT between phylogenetically distant bacterial taxa, which can have health implications for communities that rely on these water sources [71].
As biomedical research begins to appreciate the complex involvement of the human microbiome and its varied roles in maintaining homeostatic function, the effects of antimicrobial-induced disruptions to the gut microbiota become increasingly clear [72]. Researchers have discovered relationships between dysbiosis of the gut microbiota and pathogenesis of non-communicable diseases such as heart disease, obesity, diabetes and even some cancers, although direct causality is yet to be established. Newer studies have also substantiated the complex dynamics between the gut microbiome and mental health disorders through the gut-brain axis [73]. Dysregulation of this bidirectional signalling pathway via antimicrobial use promotes the pathogenesis of psychiatric disorders such as anxiety and depression, with an opposite prophylactic effect observed in patients taking probiotic supplements to replenish the microbiota.
The climate has a profound effect on the incidence and transmission of communicable diseases. At a population level, warming temperatures can have an impact on climatesensitive infectious diseases. Extreme weather events and pollution can also affect clean water sources, hygiene, and sanitation infrastructure, which can act as reservoirs for resistance genes, inadvertently driving AMR at the genomic and molecular level within the microbiota [74]. These effects take time to accumulate and are likely to go unnoticed, gradually increasing our propensity to develop non-communicable diseases at the individual level. This demonstrates the potential direct and indirect impacts of climate change on global public health through varying degrees of granularity and should create an incentive to increase public healthcare expenditure-associated with lower levels of aggregate resistance overall.

A One Health Paradigm for Policy
The current pandemic is merely a microcosmic, short-term reflection of the dynamics underpinning a global, long-term interrelated sustainability crisis-biodiversity loss, indiscriminate consumption patterns and climate change-that humanity is slated to face during the twenty-first century. However, it provides us with a window of opportunity to address future crises in a proactive manner and re-examine our current over-consumptive trajectory with nature. A collaborative, multisectoral and transdisciplinary One Health approach that recognizes the interconnectedness between, animals, microorganisms, humans, and their shared planetary environment is essential. It must work across the local, regional, national, and global levels with a singular goal of accomplishing optimal health. A One Health paradigm underscores the importance of interdisciplinary and transdisciplinary approaches that go beyond conventional boundaries of environmental sustainability and public health [75] (Figure 2). A One Health approach to both pandemics and climate change, is doubly advantageous as it potentiates significant contributions to the multiple contexts and issues including (but not restricted to) food security [76], animal food sources [76], livestock systems [77], environmental sanitation [78], and in establishing global integrated syndromic surveillance and response systems [79]. Research based on this understanding must assimilate evidence to inform a framework within which interpreting and applying evidence from a One Health approach for preventing further adverse global catastrophes would be key. on this understanding must assimilate evidence to inform a framework within which interpreting and applying evidence from a One Health approach for preventing further adverse global catastrophes would be key. The United Nations Framework Convention on Climate Change (UNFCCC) is a formal multilateral agreement which was first established in 1992 and falls under the United Nations Environment Programme (UNEP). The UNEP has attempted to act as the leading global authority for environmental governance, with a focus on sustainability. The UN-FCCC takes into consideration the heterogeneity of populations and geographies and sets out a framework to help participating states anticipate or mitigate climate effects by helping tailor strategic action plans to specific states depending on their vulnerability to environmental catastrophes, accounting for limitations posed by varying socio-economic contexts [80]. As the effects of globalisation were deemed to accelerate the rate of climate change, the original UNFCCC has since been updated with amendments to reflect shifting priorities based on evidence, recognised in the Kyoto protocol of 1997 and the Paris Agreement in 2015, which was adopted by 196 signatory states, with the United States joining in January 2021.
A key stakeholder and collaborator, specifically in contextualising the effects of these interventions within the public health landscape has been the World Health Organisation (WHO). The support of the WHO has been documented in the 'COP24 Special Report', written up following the 23rd Conference of the Parties (COP23) for the UNFCCC [81]. The report emphasises the complex and delicate interplay between climate change and worsening health outcomes, in the context of both communicable and non-communicable diseases. The report also highlights the economic and political co-benefits to various social sectors if management plans for climate change are established in advance to promote intersectional compliance and long-term investments for climate-adaptive infrastructure. The UNFCCC provides a solid foundation to base this action. The United Nations Framework Convention on Climate Change (UNFCCC) is a formal multilateral agreement which was first established in 1992 and falls under the United Nations Environment Programme (UNEP). The UNEP has attempted to act as the leading global authority for environmental governance, with a focus on sustainability. The UNFCCC takes into consideration the heterogeneity of populations and geographies and sets out a framework to help participating states anticipate or mitigate climate effects by helping tailor strategic action plans to specific states depending on their vulnerability to environmental catastrophes, accounting for limitations posed by varying socio-economic contexts [80]. As the effects of globalisation were deemed to accelerate the rate of climate change, the original UNFCCC has since been updated with amendments to reflect shifting priorities based on evidence, recognised in the Kyoto protocol of 1997 and the Paris Agreement in 2015, which was adopted by 196 signatory states, with the United States joining in January 2021.
A key stakeholder and collaborator, specifically in contextualising the effects of these interventions within the public health landscape has been the World Health Organisation (WHO). The support of the WHO has been documented in the 'COP24 Special Report', written up following the 23rd Conference of the Parties (COP23) for the UNFCCC [81]. The report emphasises the complex and delicate interplay between climate change and worsening health outcomes, in the context of both communicable and non-communicable diseases. The report also highlights the economic and political co-benefits to various social sectors if management plans for climate change are established in advance to promote intersectional compliance and long-term investments for climate-adaptive infrastructure. The UNFCCC provides a solid foundation to base this action.
Recently, a growing chorus of calls for establishing inclusive and transparent One Health research coalitions to strengthen linkages with the evolving climate change between planetary health research communities, medical professionals, veterinarians, anthropologists, ecologists, politicians, laboratory-based scientists, economists, and others have gathered traction [82][83][84]. Mediation and sustenance of such partnerships will be critical in informing our collective and sustainable approach to tackling future challenges. Beyond research, multisectoral collaborations mediated under the One Health lens can act as an enabler for the health in all policies (HiAP) approach and engage key stakeholders that have chronically been underrepresented in the discourse surrounding research uptake in policy. Working off the foundations of the Alma Ata Declaration (1978) and the Ottawa Charter (1968), the one health paradigm could facilitate the HiAP approach that seeks synergies in taking into consideration the implications of intersectoral policy on the social determinants of health and health systems, encouraging health equity and promotion [85]. Such an approach would encompass a pragmatic and versatile set of policies employed systematically across different fora to achieve the same underlying goal of healthy living and wellbeing. Complemented by the One Health lens, HiAP could support the development of cross-sectoral partnerships by highlighting the co-benefits of factoring in health as a priority in the process of societal development to all parties involved-emphasising on the cost-effectiveness of these measures, the creation of jobs and the greater economic stability offered as a result of long-term investments [86]. Moreover, focussed evidence generation through the one health coalitions helps facilitate the political cooperation required between health, economic and environment actors to mobilize resources to address the effects of anthropogenic activity on the environment and ensures sustainable development for future generations.
By fostering an increased collaboration between the environmental and public health research community and by sharing cross sectoral expertise, especially in the sphere of policy, ownership of actions at various levels could be expedited. This could go a long way in bridging the gap in evidence informed policy making, which, incidentally, is often contested despite being central to health and environmental litigation [87].

Conclusions
While global pandemic preparedness has marginally improved overall by learning from past experiences, response to pandemics has always been reactionary. Going forward, adoption of a focused, preventative approach is required instead. However, to achieving this, there remain barriers to cooperation and collaboration required to address the root causes and underlying drivers of EIDs. Traditional, siloed approaches alone can neither be relied upon to predict spill over events leading to epidemics and pandemics nor they can inform strategies for addressing systemic and endemic problems. While the complex and dynamic nature of climate change makes direct cause-effect relationships difficult to establish, most currently available evidence points to a fast-evolving climate crisis and warrants urgent action. Therefore, a precautionary approach towards addressing climate change, acknowledging the long-term outcomes of exploiting existing ecosystem on human health and wellbeing, is worth the investment despite the risks involved. Governments need to start conducting proactive cost-benefit analyses and develop appropriately guided policy frameworks. A One Health approach could, with sufficient goodwill, conviction, political provision, and financial support, substantially reduce the dual threat of a climate crisis and future pandemics. An essential element of global pandemic preparedness would be to recognise and act upon the timely recognized interests of the scientific and political agendas, in a hope to eventually harmonise our shared existence with nature.