Optimization Design for Receiving Coil with Novel Structure Based on Mutual Coupling Model in Wireless Power Transmission for Capsule Endoscope

: Wireless capsule endoscope (WCE) is a promising technology for noninvasive and painless imaging detection on gastrointestinal (GI) diseases. On the other hand, conventional endoscopes with wires could discomfort patients and cause them to vomit and aerosolize coronavirus if the patients are infected with COVID-19. However, there stands a technical bottleneck on power supply for the WCE. With the help of wireless power transmission technology, a hollow receiving coil (RC) is proposed to supply su ﬃ cient power and also minimize the size of WCE. A model on mutual inductance between transmitting and receiving coils is proposed to evaluate receiving power when the RC is in a di ﬀ erent position and direction of patient’s GI tract. Based on the model, an optimal RC is built to obtain su ﬃ cient and stable power. Measurement of mutual inductance with the optimal RC validates high accuracy of the proposed model. The standard deviation of receiving power is very low. WCE with optimum RC gets su ﬃ cient power and captures images stably in live pig’s intestine tract. Additionally, the model is little a ﬀ ected by biological tissues. It ensures reliable performance of WCE and makes popular clinical application of WCE possible, which is also a relief to reduce epidemics like COVID-19. can be applied to electromagnetic calculation when directional misalignment exists. The mutual inductance model provides a fast and accurate approach to study coupling related parameters, such as coupling coe ﬃ cient and receiving power. With su ﬃ cient power supply by the novel RC, more advanced functions like drug release are able to be equipped into WCE soon. It makes the reliable clinical application of WCE possible, which would also help reduce epidemics like COVID-19.


Introduction
A wireless capsule endoscope (WCE) for detection and treatment on the gastrointestinal (GI) tract is painless, noninvasive, and portable compared to conventional endoscopes equipped with wires [1]. What's more, the conventional endoscope could discomfort patients and cause them to vomit and aerosolize corona virus like SARS-COV-2 if infected with COVID-19 [2]. WCE does not discomfort patients and is effective for reducing epidemics like COVID-19. It primarily consists of imaging, powering, communicating, and controlling circuits, and some other modules [3]. To ensure that it is swallowable and passes through the whole GI tract smoothly and safely, the diameter and length should be less than 15 and 17.5 mm, respectively [4]. To sustain normal work of WCE, it demands at least a power of 380 mW during the whole digestion period for more than 24 h [5]. It is not spatially beneficial to utilize a battery, since its power capacity per unit volume is not qualified [6]. If a battery is applied to provide sufficient power, the size of the WCE would be too large to swallow. Wireless power transmission (WPT) technology makes a sufficient power supply for micro WCEs possible [7].
WPT mainly concludes a transmitting coil (TC), a receiving coil (RC), and related circuits. A TC is worn rightly around human body, while the RC is encapsulated in WCE and works in the GI tract [8].
The main challenge for WPT on WCE lies in that RC is micro, and separated from TC with a large distance, as it is dozens of times of the size of RC [9]. They are weakly coupled with quite low power transmission efficiency [10]. Additionally, the structure and size of RC are strictly constrained within the capsule [11]. After being ingested by the patient, WCE passes through the whole GI tract, capturing images in high resolution of 400 × 400 and sending them out wirelessly [12]. Its detection scope covers the whole GI tract. By contrast, there exist some blind locations, hard to reach in the intestine for conventional endoscopes [13]. On the other hand, WCE could be in any possible position and direction in the GI tract during the detection, causing misalignment between RC and TC [14]. Thus, the receiving power varies correspondingly [15]. Solid cubic RC takes much of the space in the tiny WCE, and in some particular positions and directions, its receiving power is insufficient [16]. Solid cylindrical RC reaches a power transmission efficiency of 1% at most [17]. Meanwhile, novel functions such as auto-fluorescence imaging or drug release are promoted to increase the medical detection performance of WCE [18][19][20], and the power demand rises further. Above all, the geometry and configuration of RC should be specially designed to supply sufficient power for WCE.
It is too time-consuming to utilize the popular finite element method (FEM) to study receiving power of the WPT [21]. As long as misalignment alters, the FEM should be remodeled with quite high computational repetition and redundancy [22]. Its computational efficiency is low, and vital information about position and direction of WCE is not used properly. To make full use of intrinsic information about misalignments, there should be some shortcut to analyze receiving power.
In this paper, a hollow RC with novel structure is proposed so that other modules of WCE can be put inside it to save much space for WCE. Then, a model of mutual inductance between TC and RC is built to study the power issue for various misalignments of RC. It makes full use of information and characteristics of position and direction of WCE. Accuracy of the model is validated with measurement. Optimization on design parameters of the RC is implemented to ensure sufficient power even when RC is badly misaligned. Then it is put into pork tissues to infer the effect of biological tissues on the power supply of the RC. Finally, the power performance of optimal RC is verified with imaging with WCE in GI tract of live pig.

Novel Structure of Receiving Coil
Modules of WCE are concisely and compactly capsulate, as illustrated in Figure 1. The size of WCE is strictly tiny to get through the GI tract safely. The RC in the patient's GI tract receives power wirelessly from RC outside the body through WPT technology. Based on our early work, TC is designed as following: Current at 1A in frequency of 108 kHz, solenoid pair in diameter of 0.4 m and height of 0.2 m, and 40 turns of litz wire (180 stranded AWG38) [4,13]. It provides adequate and stable magnetic flux inside the TC, and ensures human tissues' safety at the same time. Otherwise, higher electromagnetic field or work frequency may threaten the safety of human tissues exposed to it. In certain structures and sizes, it is comfortable to wear for the patient.
Energies 2020, 13, x FOR PEER REVIEW 2 of 14 [8]. The main challenge for WPT on WCE lies in that RC is micro, and separated from TC with a large distance, as it is dozens of times of the size of RC [9]. They are weakly coupled with quite low power transmission efficiency [10]. Additionally, the structure and size of RC are strictly constrained within the capsule [11]. After being ingested by the patient, WCE passes through the whole GI tract, capturing images in high resolution of 400*400 and sending them out wirelessly [12]. Its detection scope covers the whole GI tract. By contrast, there exist some blind locations, hard to reach in the intestine for conventional endoscopes [13]. On the other hand, WCE could be in any possible position and direction in the GI tract during the detection, causing misalignment between RC and TC [14]. Thus, the receiving power varies correspondingly [15]. Solid cubic RC takes much of the space in the tiny WCE, and in some particular positions and directions, its receiving power is insufficient [16]. Solid cylindrical RC reaches a power transmission efficiency of 1% at most [17]. Meanwhile, novel functions such as auto-fluorescence imaging or drug release are promoted to increase the medical detection performance of WCE [18][19][20], and the power demand rises further. Above all, the geometry and configuration of RC should be specially designed to supply sufficient power for WCE. It is too time-consuming to utilize the popular finite element method (FEM) to study receiving power of the WPT [21]. As long as misalignment alters, the FEM should be remodeled with quite high computational repetition and redundancy [22]. Its computational efficiency is low, and vital information about position and direction of WCE is not used properly. To make full use of intrinsic information about misalignments, there should be some shortcut to analyze receiving power.
In this paper, a hollow RC with novel structure is proposed so that other modules of WCE can be put inside it to save much space for WCE. Then, a model of mutual inductance between TC and RC is built to study the power issue for various misalignments of RC. It makes full use of information and characteristics of position and direction of WCE. Accuracy of the model is validated with measurement. Optimization on design parameters of the RC is implemented to ensure sufficient power even when RC is badly misaligned. Then it is put into pork tissues to infer the effect of biological tissues on the power supply of the RC. Finally, the power performance of optimal RC is verified with imaging with WCE in GI tract of live pig.

Novel Structure of Receiving Coil
Modules of WCE are concisely and compactly capsulate, as illustrated in Figure 1. The size of WCE is strictly tiny to get through the GI tract safely. The RC in the patient's GI tract receives power wirelessly from RC outside the body through WPT technology. Based on our early work, TC is designed as following: Current at 1A in frequency of 108 kHz, solenoid pair in diameter of 0.4 m and height of 0.2 m, and 40 turns of litz wire (180 stranded AWG38) [4,13]. It provides adequate and stable magnetic flux inside the TC, and ensures human tissues' safety at the same time. Otherwise, higher electromagnetic field or work frequency may threaten the safety of human tissues exposed to it. In certain structures and sizes, it is comfortable to wear for the patient. Meanwhile, to fit in the topology of WCE, a hollow cylinder is preferred for RC [5]. Other modules of WCE can be put inside RC to minimize the size of capsule. As illustrated in Figure 2a, the Meanwhile, to fit in the topology of WCE, a hollow cylinder is preferred for RC [5]. Other modules of WCE can be put inside RC to minimize the size of capsule. As illustrated in Figure 2a, the top round of the cylinder is equally divided into three groups in series. For Group 1, a litz wire comes from A 1 down to the corresponding diagonally symmetric point B 1 on the bottom round, then up back to A 2 , the point right next to A 1. The single turn is in a shape of an ellipse, approximately. The second turn is wound from A 2 down to B 2 , and then back up to A 3 , forming another ellipse next to the first one. Other turns are implemented with the same winding. The top round of the cylinder is evenly divided into 3 N 0 points of A 1 , A 2 , . . . , A 3N0 by densely wound litz wire. That is, each group contains N 0 turns of coils per layer. N 0 is a decisive design parameter, which will be optimized in detail in the following section. The novel structure enables RC to receive power from three dimensions (3D). The design parameters of RC remain to be optimized to improve power performance of WCE, especially for cases of terrible misalignment between TC and RC. So, receiving power is analyzed first, and then the parameters of RC are optimized.
Energies 2020, 13, x FOR PEER REVIEW 3 of 14 top round of the cylinder is equally divided into three groups in series. For Group 1, a litz wire comes from A1 down to the corresponding diagonally symmetric point B1 on the bottom round, then up back to A2, the point right next to A1. The single turn is in a shape of an ellipse, approximately. The second turn is wound from A2 down to B2, and then back up to A3, forming another ellipse next to the first one. Other turns are implemented with the same winding. The top round of the cylinder is evenly divided into 3 N0 points of A1, A2, …, A3N0 by densely wound litz wire. That is, each group contains N0 turns of coils per layer. N0 is a decisive design parameter, which will be optimized in detail in the following section. The novel structure enables RC to receive power from three dimensions (3D). The design parameters of RC remain to be optimized to improve power performance of WCE, especially for cases of terrible misalignment between TC and RC. So, receiving power is analyzed first, and then the parameters of RC are optimized.

Model of Mutual Inductance and Receiving Power
Electrical parameters are analyzed to investigate receiving power of WCE in the lumped parameter circuit as shown in Figure 2b. R1 and R2, L1 and L2, C1 and C2, and Z1 and Z2 represent the winding resistance, self-inductance, tuning capacitor to get resonant, and equivalent impedance of TC and RC circuits correspondingly. So, impedance of TC and RC turns out to be , respectively. As for RL, the load of the RC circuit in Figure 2b, turns out to be 29.72 Ω according to our previous study [18]. M is the mutual inductance between TC and RC. The angular frequency is 2 f ω π = , where f is the resonant frequency of TC and RC. Based on our previous study, for WCE, f is set as 220kHz to implement stable and sufficient WPT. There is no source voltage in the RC circuit. Its voltage is induced by TC based on an electromagnetic induction principle. Name the current in the TC circuit as I1(t), and the induced current in the RC circuit as I2(t). Magnetic hysteresis is not taken into consideration, since all related frequencies for WCE are below 10 MHz [23]. The loop equation of the WPT is: Based on Faraday's law, the induced electromotive force r ε is:

Model of Mutual Inductance and Receiving Power
Electrical parameters are analyzed to investigate receiving power of WCE in the lumped parameter circuit as shown in Figure 2b. R 1 and R 2 , L 1 and L 2 , C 1 and C 2 , and Z 1 and Z 2 represent the winding resistance, self-inductance, tuning capacitor to get resonant, and equivalent impedance of TC and RC circuits correspondingly. So, impedance of TC and RC turns out to be Z 1 = R 1 + jωL 1 + 1/( jωC 1 ) and Z 2 = R 2 + jωL 2 + 1/( jωC 2 ), respectively. As for R L , the load of the RC circuit in Figure 2b, turns out to be 29.72 Ω according to our previous study [18]. M is the mutual inductance between TC and RC. The angular frequency is ω = 2π f , where f is the resonant frequency of TC and RC. Based on our previous study, for WCE, f is set as 220kHz to implement stable and sufficient WPT. There is no source voltage in the RC circuit. Its voltage is induced by TC based on an electromagnetic induction principle. Name the current in the TC circuit as I 1 (t), and the induced current in the RC circuit as I 2 (t). Magnetic hysteresis is not taken into consideration, since all related frequencies for WCE are below 10 MHz [23]. The loop equation of the WPT is: Based on Faraday's law, the induced electromotive force ε r is: And M is: where µ r is the relative magnetic permeability, B is the magnetic flux density generated by TC, S is the projection area of RC in the direction of the magnetic field of TC. When TC and RC are modulated to resonance to 220 kHz, there goes ωL 1 = 1/(ωC 1 ) and ωL 2 = 1/(ωC 2 ), and Equation (2) is transformed into: The load power is [18]: where R 1 and R 2 are calculated according to the definition of resistance. So R 1 turns out to be 1.6527Ω. Note that for different design parameters of RC, the electrical parameters L 2 , C 2 , and R 2 vary correspondingly. Power transmission efficiency is the ratio of the load power on RC to the motivated power from source voltage of TC, as below: Based on our previous study in [4,5,13], the transmitting voltage V 1 is strictly constrained below the safety threshold to ensure electromagnetic and thermal safety issues of human tissues exposed in the electromagnetic field. According to Equations (3)-(5), in resonant state, the mutual inductance M is intrinsically decisive for receiving power. Practically, M varies all the time, since the position and direction of RC changes all the time in the patient's GI tract. The model of mutual inductance between TC and RC of WCE is proposed as follows. Considering the huge difference on magnitude between TC and RC, the magnetic flux density generated by TC can be treated as uniform inside the tiny cylinder of RC. Generally, name the magnetic flux density on the central point C of RC as B c . The mutual inductance between TC and each single turn of RC is studied firstly. Litz wire is selected as the winding material of RC to eliminate the electromagnetic effect of any two single turns [18]. So, for two arbitrary single turns of RC, their mutual inductance is negligible. The Cartesian coordinate system of RC is built as shown in Figure 2c. Let the unitized normal vector for each single turn of RC be n 1 , n 2 , . . . , n 3N 0 , respectively. The coordinate of n k turns out to be cos α · (cos kθ 0 , sin kθ 0 , tan α), where α is the angle between the diagonal and central axis of the cylinder as illustrated in Figure 2a. Additionally, α is determinative for receiving power, which will be optimized in the following section. Note the radial of the cylinder as r, and the height as h, then tan α = 2r/h. For each single turn k (k = 1, 2, ..., 3N 0 ), the major and minor axis is 2r/ sin α and 2r, respectively. The area of the arbitrary k-th turn is the same as S 0 = 4πr 2 / sin α.
The position of the center of RC is nominated as r c = (x c , y c , z c ), which tells its positional displacement. The coordinates of B c is |B c | · cos ϕ · (cos θ, sin θ, tan ϕ), where θ ∈ [0 • , 90 • ] and ϕ ∈ [0 • , 90 • ] stands for radially and axially directional misalignment of RC, respectively, and According to the symmetry of RC, both ϕ and θ from 0 • to 90 • together cover all possible cases of directional misalignment. The mutual inductance between TC and the k-th turn of RC in the certain positional (r c ) and directional (ϕ and θ) misalignment is: where the directional factor is: It is determinative for the mutual inductance between TC and RC with directional misalignment. For RC with L 0 layers, the total mutual inductance between TC and the Group 1 of RC is: For Group 2 and 3, M 2 and M 3 are obtained in the same way. In total, the mutual inductance between TC and RC is: Thanks to the rotational symmetry characteristic of magnetic flux density generated by TC, any axial cross section of TC equivalently covers all possible positional misalignments of RC. The cross section forms a rectangle P. To infer the actual mutual inductance of RC on all positions, let C traverse the whole P. For each position, traversal of θ and ϕ from 0 • to 90 • includes all possible directional misalignments of RC.

Optimization Design for Receiving Coil
The parameters of proposed RC are optimized to sustain normal work of WCE as follows. The primary purpose is to induce sufficient power for WCE. Receiving power P L should be above the typical demanding power P D . Based on our previous study, for the proposed WCE, P D is 0.38 W, as illustrated in Table 1 [24]. Then, P L ≥ 0.38. Unstable or jumping power causes abnormalities such as low signal noise ratio of images or damage on components. So, the other aim is uniform and stable power performance in as many misalignment cases as possible. The standard deviation of M is introduced as M d to depict the stability of receiving power: where M avg is the average of M for all possible positional and directional misalignments. Lower M d indicates higher stability for receiving power. The objective function is: To ensure the safety of intestinal tissues near WCE, temperature rise τ of WCE caused by its heat dissipation should be under 5.5 • C [23].
According to Pennes' Equation, temperature rise τ is related to power as following: The WCE is swallowable when the outer diameter of RC is below 0.0125 m. Meanwhile, other circuits can be put inside the hollow RC on the condition that inner diameter is larger than 0.0065 m. So, where d 0 is the diameter of litz wire, d 0 ( √ 3(L 0 − 1)/2 + 1) represents the thickness of L 0 layers of wires [23].
Based on objective function of Equation (14) and constraints of Equations (5), (12) and (15)-(17), the optimization problem is built with respect to optimizing variables of N 0 (number of turns per layer for each group), L 0 (layers of RC), d 0 (wire diameter), and α (angle between diagonal and central axis of cylinder). Additionally, the optimal M d is obtained as 1.0938 µH with genetic algorithm, where optimal design parameters of RC are N 0 = 14, L 0 = 3, d 0 = 0.00128 m, and α = 34.8713 • , respectively. Then, the diameter and height of RC are 0.0120 m and 0.0173 m, respectively.

Measurement for Mutual Inductancew with Positional or Directional Misalignment
The accuracy of the mutual inductance model when there is positional and directional misalignment on RC is verified with a measurement platform as below. The TC of the WPT system is built as referred, as shown in Figure 3. The RC with optimal design parameters is wound and put in the TC. Lumped parameters in Equation (1) are measured by HIOKI 3532-50 LCR HITESTER. L 1 , L 2 are measured as 1066.0237 µH and 202.21 µH, respectively. C 1 , C 2 are 0.4909 nF and 2.5882 nF, respectively. In resonant state, Z 1 , Z 2 are reduced to R 1 , R 2 , of which the measurements are 1.7194 Ω and 27.5014 Ω, respectively. The position of the center point of RC is set to (0, 0.005i, 0.005j) orderly by the device in Figure 3, where radial i = 0, 1, . . . , 40, and axial j = 0, 1, . . . , 30. Additionally, RC is parallel with TC, without directional misalignment. The induced electromotive force is measured by digital multimeter Agilent 34410A. Based on Equation (2), the measurement of mutual inductance is inferred and obtained as in Figure 4b as a contrast to the calculation with the proposed model in Figure 4a. It indicates that the maximum of calculation from the proposed model (of 5.7862 µH) is a little bit less than that of the measurement (of 5.8223 µH), while the minimum of calculation (of 2.5263 µH) is more than that of the measurement (of 2.2738 µH). The proposed model slightly smooths the actual mutual inductance due to the assumption that electromagnetic interaction between any two single turns of RC is ignorable, which could be improved in future research. The root mean square error between measurement and calculation of Equation (11) in the proposed model for various positional misalignments of RC is 0.2238 µH, which indicates the high accuracy of the proposed model overall. Additionally, the error caused by the assumption is minor. When there is no directional misalignment, the standard deviation of measured mutual inductance for all positional misalignments is 1.3194 µH. It is bit higher than the calculated outcome of optimization problem (of 1.1283 µH), which is reasonable and tolerable due to discretization error from measurement. So, the receiving power for different positional misalignments of RC is stable and basically sufficient.  At the position of (0, 0.10, 0.06 m), the RC in different directional misalignments of ( , ) θ ϕ is accomplished by a directionally rotational device as illustrated in Figure 5. The calculated and measured mutual inductance when RC is in a different direction is shown in Figure 6a,b, respectively. It indicates that the maximum of calculation with the proposed model (of 5.7862 μH) is slightly lower than that of the measurement (of 5.8221 μH), while the minimum of the model (of 1.2493 μH) is higher than that of the measurement (of 0.9628 μH). It attributes to the same assumption as referred to in the last section. The root mean square error between measurement and the proposed model is 0.2475 μH, indicating good agreement between them. The standard deviation of measured mutual inductance for all directional misalignments is 1.1747 μH. It is a little bit higher than the calculated result of the proposed model (of 1.0893 μH). It tells us that receiving power is relatively smooth and stable without an intolerably high gradient for various directional misalignments. These all benefit from the special structure and geometry of the optimal and novel RC. The 3D structure of RC ensures that at least one dimension (1D) of it is well coupled with TC, no matter how badly misaligned the RC is.  At the position of (0, 0.10, 0.06 m), the RC in different directional misalignments of ( , ) θ ϕ is accomplished by a directionally rotational device as illustrated in Figure 5. The calculated and measured mutual inductance when RC is in a different direction is shown in Figure 6a,b, respectively. It indicates that the maximum of calculation with the proposed model (of 5.7862 μH) is slightly lower than that of the measurement (of 5.8221 μH), while the minimum of the model (of 1.2493 μH) is higher than that of the measurement (of 0.9628 μH). It attributes to the same assumption as referred to in the last section. The root mean square error between measurement and the proposed model is 0.2475 μH, indicating good agreement between them. The standard deviation of measured mutual inductance for all directional misalignments is 1.1747 μH. It is a little bit higher than the calculated result of the proposed model (of 1.0893 μH). It tells us that receiving power is relatively smooth and stable without an intolerably high gradient for various directional misalignments. These all benefit from the special structure and geometry of the optimal and novel RC. The 3D structure of RC ensures that at least one dimension (1D) of it is well coupled with TC, no matter how badly misaligned the RC is. At the position of (0, 0.10, 0.06 m), the RC in different directional misalignments of (θ, ϕ) is accomplished by a directionally rotational device as illustrated in Figure 5. The calculated and measured mutual inductance when RC is in a different direction is shown in Figure 6a,b, respectively. It indicates that the maximum of calculation with the proposed model (of 5.7862 µH) is slightly lower than that of the measurement (of 5.8221 µH), while the minimum of the model (of 1.2493 µH) is higher than that of the measurement (of 0.9628 µH). It attributes to the same assumption as referred to in the last section. The root mean square error between measurement and the proposed model is 0.2475 µH, indicating good agreement between them. The standard deviation of measured mutual inductance for all directional misalignments is 1.1747 µH. It is a little bit higher than the calculated result of the proposed model (of 1.0893 µH). It tells us that receiving power is relatively smooth and stable without an intolerably high gradient for various directional misalignments. These all benefit from the special structure and geometry of the optimal and novel RC. The 3D structure of RC ensures that at least one dimension (1D) of it is well coupled with TC, no matter how badly misaligned the RC is.

Imaging in Live Pig's Gastro-Intestine by Capsule Endoscope
WCE should be clinically applied into patients' intestine. So, the effect of biological tissues on the receiving power of the optimized RC is studied as below. WCE with the optimal RC is swallowed by a live pig, before which it gets fasted for 12 h to empty its GI tract for better imaging. It gets anesthetic and sleeps quietly inside TC, as illustrated in Figure 7. No hurt or damage happens to it during the whole experiment. All procedures complied with the Institutional Animal Use and Care Committee of Shanghai Jiao Tong University. The WCE could be in any position and direction in the pig's tract. If power is insufficient, the WCE will malfunction, and image quality will go down rapidly or even no image will display. Actually, during the whole detection process, imaging by WCE is clear and fluent, from which two

Imaging in Live Pig's Gastro-Intestine by Capsule Endoscope
WCE should be clinically applied into patients' intestine. So, the effect of biological tissues on the receiving power of the optimized RC is studied as below. WCE with the optimal RC is swallowed by a live pig, before which it gets fasted for 12 h to empty its GI tract for better imaging. It gets anesthetic and sleeps quietly inside TC, as illustrated in Figure 7. No hurt or damage happens to it during the whole experiment. All procedures complied with the Institutional Animal Use and Care Committee of Shanghai Jiao Tong University. The WCE could be in any position and direction in the pig's tract. If power is insufficient, the WCE will malfunction, and image quality will go down rapidly or even no image will display. Actually, during the whole detection process, imaging by WCE is clear and fluent, from which two

Imaging in Live Pig's Gastro-Intestine by Capsule Endoscope
WCE should be clinically applied into patients' intestine. So, the effect of biological tissues on the receiving power of the optimized RC is studied as below. WCE with the optimal RC is swallowed by a live pig, before which it gets fasted for 12 h to empty its GI tract for better imaging. It gets anesthetic and sleeps quietly inside TC, as illustrated in Figure 7. No hurt or damage happens to it during the whole experiment. All procedures complied with the Institutional Animal Use and Care Committee of Shanghai Jiao Tong University.

Imaging in Live Pig's Gastro-Intestine by Capsule Endoscope
WCE should be clinically applied into patients' intestine. So, the effect of biological tissues on the receiving power of the optimized RC is studied as below. WCE with the optimal RC is swallowed by a live pig, before which it gets fasted for 12 h to empty its GI tract for better imaging. It gets anesthetic and sleeps quietly inside TC, as illustrated in Figure 7. No hurt or damage happens to it during the whole experiment. All procedures complied with the Institutional Animal Use and Care Committee of Shanghai Jiao Tong University. The WCE could be in any position and direction in the pig's tract. If power is insufficient, the WCE will malfunction, and image quality will go down rapidly or even no image will display. Actually, during the whole detection process, imaging by WCE is clear and fluent, from which two The WCE could be in any position and direction in the pig's tract. If power is insufficient, the WCE will malfunction, and image quality will go down rapidly or even no image will display. Actually, during the whole detection process, imaging by WCE is clear and fluent, from which two frames are stochastically sampled as illustrated in Figure 8. It indicates that WCE works normally and receiving power of the optimal RC is sufficient and stable.
Energies 2020, 13, x FOR PEER REVIEW 9 of 14 frames are stochastically sampled as illustrated in Figure 8. It indicates that WCE works normally and receiving power of the optimal RC is sufficient and stable.

Effect of Biological Tissues on Mutual Coupling and Wireless Power Transmission
Detailed effects of biological tissues on mutual inductance are studied quantitatively below. As for the imaging experiment on a live pig in the previous section, the mutual inductance corresponding to certain misalignment of RC is difficult to measure in real time in the pig's GI tract. An ex vivo experiment is carried out to quantitatively study the effect of biological tissues on mutual inductance, where RC is tightly surrounded by pork tissues, as in Figure 9. There is no routine for magnetic flux between TC and RC other than penetrating through pork tissues. Mutual inductance is measured when RC is set in the positional displacement of (0, 0.01i, 0) orderly, where i = 0, 1, …, 8, without directional misalignment. It is compared with calculations of the proposed model and measurement without biological tissues in the previous section, as illustrated in Figure 10. Errors between calculation of the proposed model and measurement with biological tissues in this section are higher than those between calculation of the model and measurement without biological tissues in the previous section. It indicates that biological tissues do weaken the mutual inductance to some degree. However, errors between measurement with and without tissues (curve b and c) are tolerable, significantly smaller than errors between calculation of the proposed model (curve a) and measurement either with (curve b) or without (curve c) tissues. So, the accuracy of the proposed model is still quite high when RC is blocked within biological tissues. In future work, the effect of biological tissues on mutual inductance should be taken into consideration.

Effect of Biological Tissues on Mutual Coupling and Wireless Power Transmission
Detailed effects of biological tissues on mutual inductance are studied quantitatively below. As for the imaging experiment on a live pig in the previous section, the mutual inductance corresponding to certain misalignment of RC is difficult to measure in real time in the pig's GI tract. An ex vivo experiment is carried out to quantitatively study the effect of biological tissues on mutual inductance, where RC is tightly surrounded by pork tissues, as in Figure 9. There is no routine for magnetic flux between TC and RC other than penetrating through pork tissues. Mutual inductance is measured when RC is set in the positional displacement of (0, 0.01i, 0) orderly, where i = 0, 1, . . . , 8, without directional misalignment. It is compared with calculations of the proposed model and measurement without biological tissues in the previous section, as illustrated in Figure 10. Errors between calculation of the proposed model and measurement with biological tissues in this section are higher than those between calculation of the model and measurement without biological tissues in the previous section. It indicates that biological tissues do weaken the mutual inductance to some degree. However, errors between measurement with and without tissues (curve b and c) are tolerable, significantly smaller than errors between calculation of the proposed model (curve a) and measurement either with (curve b) or without (curve c) tissues. So, the accuracy of the proposed model is still quite high when RC is blocked within biological tissues. In future work, the effect of biological tissues on mutual inductance should be taken into consideration.
Energies 2020, 13, x FOR PEER REVIEW 9 of 14 frames are stochastically sampled as illustrated in Figure 8. It indicates that WCE works normally and receiving power of the optimal RC is sufficient and stable.

Effect of Biological Tissues on Mutual Coupling and Wireless Power Transmission
Detailed effects of biological tissues on mutual inductance are studied quantitatively below. As for the imaging experiment on a live pig in the previous section, the mutual inductance corresponding to certain misalignment of RC is difficult to measure in real time in the pig's GI tract. An ex vivo experiment is carried out to quantitatively study the effect of biological tissues on mutual inductance, where RC is tightly surrounded by pork tissues, as in Figure 9. There is no routine for magnetic flux between TC and RC other than penetrating through pork tissues. Mutual inductance is measured when RC is set in the positional displacement of (0, 0.01i, 0) orderly, where i = 0, 1, …, 8, without directional misalignment. It is compared with calculations of the proposed model and measurement without biological tissues in the previous section, as illustrated in Figure 10. Errors between calculation of the proposed model and measurement with biological tissues in this section are higher than those between calculation of the model and measurement without biological tissues in the previous section. It indicates that biological tissues do weaken the mutual inductance to some degree. However, errors between measurement with and without tissues (curve b and c) are tolerable, significantly smaller than errors between calculation of the proposed model (curve a) and measurement either with (curve b) or without (curve c) tissues. So, the accuracy of the proposed model is still quite high when RC is blocked within biological tissues. In future work, the effect of biological tissues on mutual inductance should be taken into consideration.

Comparison of the Proposed Mutual Inductance Model with Existing Methods
Common analytic methods can only work out the mutual inductance when directional misalignment is in some particular situations: Such as 45°, 90°, and 135° [25]. The proposed model is applicable for any possible positional and directional misalignment. So only results for positional misalignment can get compared between them. As for directional misalignment, the proposed model is compared with the finite element method (FEM).
FEM is able to obtain mutual inductance in all positional and directional misalignments as long as the mesh of finite elements is tiny enough [26]. However, it is too time-consuming and complicated. The comparison on accuracy and computation time among analytic method, FEM, and proposed mutual inductance model is illustrated in Table 2. In each cell, the first row given is the accuracy, and the second row given is the computation time. The accuracy of the proposed model is higher than the analytic method. Both the accuracy of the proposed model and FEM decreases slightly when directional misalignment happens. The accuracy of FEM is higher than the proposed model to some degree; on the other hand, its computation time is thousands of times larger than the latter. As long as the positional or directional misalignment varies, the FEM should get reworked, which means an infeasible and unacceptable time cost. Considering both the accuracy and computation time, the proposed model reaches a good tradeoff.

Comparison of the Proposed Mutual Inductance Model with Existing Methods
Common analytic methods can only work out the mutual inductance when directional misalignment is in some particular situations: Such as 45 • , 90 • , and 135 • [25]. The proposed model is applicable for any possible positional and directional misalignment. So only results for positional misalignment can get compared between them. As for directional misalignment, the proposed model is compared with the finite element method (FEM).
FEM is able to obtain mutual inductance in all positional and directional misalignments as long as the mesh of finite elements is tiny enough [26]. However, it is too time-consuming and complicated. The comparison on accuracy and computation time among analytic method, FEM, and proposed mutual inductance model is illustrated in Table 2. In each cell, the first row given is the accuracy, and the second row given is the computation time. The accuracy of the proposed model is higher than the analytic method. Both the accuracy of the proposed model and FEM decreases slightly when directional misalignment happens. The accuracy of FEM is higher than the proposed model to some degree; on the other hand, its computation time is thousands of times larger than the latter. As long as the positional or directional misalignment varies, the FEM should get reworked, which means an infeasible and unacceptable time cost. Considering both the accuracy and computation time, the proposed model reaches a good tradeoff.

Comparison of the Novel Receiving Coil with Existing Coils
For coils with different configuration, their self-inductance varies. So, it is hard to make a distinctive and uniform contrast on mutual inductance between receiving coils in different WPT systems. The coupling coefficient is introduced as following: where L 1 and L 2 are the self-inductance of transmitting and receiving coil of the WPT system respectively, and M 12 is the mutual inductance between them. k 12 is a normalized parameter and can be utilized to compare coupling performance of different WPT systems. The performance of coupling and receiving power of the proposed RC with novel structure is compared with existing RCs in different WPT systems, as shown in Table 3. Although the receiving power of the proposed WPT is not the most, both the maximum and minimum of its coupling coefficient are the highest, inferring a most remarkable mutual coupling performance. Additionally, the coupling coefficient of the proposed WPT is stable, which ensures steady and fluent work of WCE. Other WPT systems in [24,27] with higher receiving power but lower coupling efficient indicate a low utilization ratio of energy and excessively high voltage in their TCs, which could do harm to human tissues. The receiving power and coupling coefficient in [28] are too low, even if its RC is the tiniest. The proposed WPT transmit power most efficiently attributes to the special RC. It seems that there is no advantage on size of RC for the proposed WPT, compared with other systems. Actually, RC should be capsuled into WCE to obtain sufficient power. So, it is more rational to compare the size of WCE to them instead of size of RC. Thanks to the hollow RC with novel structure allowing other modules of WCE to be put inside it, the proposed WCE has the tiniest size to get through intestines safely and smoothly. In conclusion, the proposed RC uses transmitting coil in the highest utilization ratio, receives sufficient and stable power, and minimizes the size of WCE.

Conclusions
For WPT, a hollow cylindrical RC is proposed to supply sufficient power and minimize the size of WCE at the same time. Thanks to its structure and geometry, it receives power from all three dimensions of the electromagnetic field. Neither mutual inductance nor receiving power will vary drastically, no matter how terribly misaligned the RC is. A fast and accurate model on mutual inductance is proposed to study the receiving power in lumped parameter circuits when various positional and directional misalignments happen to RC. The model is validated with a measurement bench. Additionally, measurement of mutual inductance when RC is inside pork tissues indicates that the model is affected slightly by biological tissues. The geometry parameters of RC are specially designed to obtain high mutual inductance for as many misalignments as possible. Standard deviation for mutual inductance of various positional and directional misalignment in the RC is 1.3194 and 1.1747 µH, respectively. It indicates relatively low and smooth variation on receiving power even when the RC is badly misaligned. The performance of the optimal RC is verified with imaging experiment in the GI tract of live pig. Imaging is clear and stable during the whole process. Receiving power is sufficient and stable, even when the position and direction of the RC changes rapidly.
As referred, the effect of biological tissues on mutual inductance should be taken into consideration to improve accuracy for the model in future work. The hollow geometry for coils can also be adopted in other WPT applications with severe constraints in size. The directional factor in Equation (9) can be applied to electromagnetic calculation when directional misalignment exists. The mutual inductance model provides a fast and accurate approach to study coupling related parameters, such as coupling coefficient and receiving power. With sufficient power supply by the novel RC, more advanced functions like drug release are able to be equipped into WCE soon. It makes the reliable clinical application of WCE possible, which would also help reduce epidemics like COVID-19.

Conflicts of Interest:
The authors state no conflict of interest.