Prevention Is Better Than the Cure: Risk Management of COVID-19

A novel coronavirus was reported to the World Health Organization (WHO) in China on 31 December 2019. The WHO named the disease COVID-19 on 11 February 2020. As of 26 February 2020, the disease has been detected on all continents, except for Antarctica. Daily updates on COVID-19 since early February 2020 have made headline news worldwide for much of 2020. This editorial evaluates risk management based on the Global Health Security (GHS) Index of global health security capabilities in 195 countries. The GHS Index lists the countries best prepared for an epidemic or pandemic. COVID-19 is compared with two related coronavirus epidemics, SARS and MERS, in terms of the number of reported human infections, deaths, countries, major country clusters, timelines, and the likelihood of discovering a safe, effective, and approved vaccine.


Introduction
An unknown form of pneumonia was first detected in Wuhan, the capital city of Hubei Province, China, and reported to the World Health Organization (WHO) office in Wuhan on 31 December 2019. The WHO declared a "Public Health Emergency of International Concern" on 30 January 2020, and gave the name COVID-19 to the novel coronavirus disease on 11 February 2020.
As of 26 February 2020, the disease has been detected in all continents, except for Antarctica. Updates on the disease have made the news headlines worldwide every day for much of 2020.
Daily updates have appeared since early February 2020. As of 2 March 2020, the latest information (which can quickly become outdated) for worldwide and the leading 20 major country clusters are Coronavirus COVID-19 Outbreak: Latest News, Information and Updates (2020) (2020)).
The figure of 271 for Japan excludes 705 passengers who were diagnosed with the disease on the Diamond Princess cruise ship in the port of Yokohama.
It is informative to compare the numbers of reported cases and deaths since 19 February 2020 (see (Wang et al. 2020)); the total number of reported cases was 73,451 and the total number of deaths was 1875. In the short space of 12 days, the number of reported cases has increased by 15,621 (that is, 21.27%) from 73,451 to 89,072, while the number of deaths has increased by 1173 (that is, 62.56%) from 1875 to 3048.
Given a number of problematic issues surrounding the incubation period, as well as collecting and collating the reported data based on different sources, different methodologies, and at different times, it is premature to suggest that the number of deaths is increasing at a much faster rate than the number of reported cases. However, it does seem to be a disturbing development to have a three-fold higher rate for worldwide deaths than for reported cases.

Terminology
"What's in a name?"

William Shakespeare
As the names of the disease and the virus that causes it have evolved quickly since it was first detected, it is worth summarizing the following:
Before it was given a formal name by the World Health Organization (WHO), COVID-19 was discussed (presciently, though possibly prematurely) on the ResearchGate Q&A thread: "Does quality [of] life depend on money or principle?", posted 31 January 2020, as: "The Wuhan novel coronavirus is already a pandemic" (Does Quality [of] Life Depend on Money or Principle?-ResearchGate 2018).
On 27 February 2020, the World Health Organization (WHO) reported that, for the first time since its inception, the number of new cases confirmed outside China exceeded the number of new cases inside China. After the first case in Latin America was reported in Brazil on 26 February 2020, the only continent where COVID-19 has not (yet) been reported is Antarctica.
As it would now seem appropriate to refer to COVID-19 as a pandemic, regardless of the unwillingness of the WHO to do so, it is crucial to question whether the international community is prepared and capable of managing the risks associated with COVID-19. An appropriate risk index is discussed briefly in the following section.

Risk Management: Global Health Security (GHS) Index
The GHS Index is a comprehensive assessment, developed as a collaboration of the Nuclear Threat Initiative, Johns Hopkins Center for Health Security, and the Economist Intelligence Unit, covering global health security capabilities in 195 countries. The GHS Index lists the countries that are best prepared for an epidemic or pandemic (Global Health Security Index 2019).
The average overall GHS Index score is 40.2 out of a possible 100. While high-income countries report an average score of 51.9, the Index shows that collectively, international preparedness for epidemics and pandemics remains very weak.
Overall, the GHS Index finds severe weaknesses in country abilities to prevent, detect, and respond to health emergencies; severe gaps in health systems; vulnerabilities to political, socioeconomic, and environmental risks that can confound outbreak preparedness and response; and a lack of adherence to international norms." It is worth mentioning that, as part of China, Hong Kong was not included in the GHS Index as a country, while Taiwan was not included for reasons best known to the WHO.

GHS Overall Scores
(1) USA (2) UK (3) Netherlands (4) Australia (5) Canada (6) Thailand (7) Sweden (8) Denmark (9) South Korea (10) Finland (11) France (12) Slovenia (13) Switzerland (14) Germany It is worth noting that, while South Korea is ranked 9 in global security, North Korea is ranked 193. To date, North Korea claims to have no cases of Covid-19, which is scarcely believable. A similar comment applies to a number of other countries on the list with large populations.

When Will a Safe and Effective Vaccine Be Developed for COVID-19?
The severe acute respiratory syndrome (SARS) coronavirus caused 8,098 reported human infections and 774 deaths in 32 countries during [2002][2003], which at the time was a new coronavirus.
The Middle East respiratory syndrome (MERS) was caused by the Middle East respiratory syndrome coronavirus (MERS-CoV), which has led to 2492 reported human infections and 858 deaths in 27 countries since it was identified in Saudi Arabia in 2012. Like SARS, MERS-CoV was a new coronavirus at the time.
The reliable evidence based on many experimental clinical trials studies suggests that there is currently no safe and reliable vaccine, or combination of vaccines, to protect against SARS and MERS-CoV. One reason for this is the SARS epidemic disappeared in 2003, so there does not seem to be any urgency in that respect. Another reason is that clinical trials are costly, especially for commercial purposes, so the few clinical trials on humans have not yet led to any safe and effective vaccines, as approved by national and international regulators, against SARS and MERS-CoV.
Although animal clinical trials to discover a vaccine are reported to have begun in several countries, COVID-19 differs from SARS and MERS-CoV in a number of respects, including the speed of contagion, possible mutations, unknown percentages of false positive and false negative diagnoses, unknown rate of reinfections, and as a pandemic rather than an epidemic. For further discussion see, for example, Wu and McCoogan (2020).
An important issue regarding risk management through clinical trials is whether COVID-19 is a disease that will behave more like SARS and eventually disappear, will remain ongoing like MERS, or will continue unabated and indefinitely.
The world awaits expectantly for further updates, especially encouraging news regarding the development of safe, effective and timely vaccines.