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Current Oncology
Volume 23
Issue 1
10.3747/co.23.2839
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Article

Relationship between HLA-DRB1 Allele Polymorphisms and Familial Aggregations of Hepatocellular Carcinoma

by
S. Ma
,
J. Wu
*,
J. Wu
,
Y. Wei
,
L. Zhang
,
Q. Ning
and
D. Hu
Department of Infectious Diseases, First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, China
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2016, 23(1), 1-7; https://doi.org/10.3747/co.23.2839
Submission received: 4 November 2015 / Revised: 2 December 2015 / Accepted: 6 January 2016 / Published: 1 February 2016

Abstract

Objective: We explored the relationship between HLA-DRB1 allele polymorphisms and familial aggregation of hepatocellular carcinoma (fHCC). Methods: Polymerase chain reaction sequence-specific primers were used to determine HLA-DRB1 genotypes for 130 members of families with 2 or more liver cancer patients and for 130 members of families without any diagnosed cancers. The genotype profiles were then compared to explore the relationship between HLA-DRB1 gene polymorphism and fHCC. Result: Of 11 selected alleles, the frequencies of DRB1*11 and DRB1*12 were significantly lower in the fHCC group than in no-cancer group (p < 0.05; odds ratio: 0.286; 95% confidence interval: 0.091 to 0.901; and odds ratio: 0.493; 95% confidence interval: 0.292 to 0.893). Differences in the frequencies of the other 9 alleles were not statistically significant in the two groups (p > 0.05). Conclusions: Our research suggests that if genetic factors play a role in fHCC, the deficiency in the DRB1*11 and DRB1*12 alleles might be the risk factor at work in Guangxi Zhuang Autonomous Region, P.R.C.
Keywords: HLA-DRB1 alleles; polymorphisms; hepatocellular carcinoma; familial aggregation; pcr-ssp HLA-DRB1 alleles; polymorphisms; hepatocellular carcinoma; familial aggregation; pcr-ssp

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MDPI and ACS Style

Ma, S.; Wu, J.; Wu, J.; Wei, Y.; Zhang, L.; Ning, Q.; Hu, D. Relationship between HLA-DRB1 Allele Polymorphisms and Familial Aggregations of Hepatocellular Carcinoma. Curr. Oncol. 2016, 23, 1-7. https://doi.org/10.3747/co.23.2839

AMA Style

Ma S, Wu J, Wu J, Wei Y, Zhang L, Ning Q, Hu D. Relationship between HLA-DRB1 Allele Polymorphisms and Familial Aggregations of Hepatocellular Carcinoma. Current Oncology. 2016; 23(1):1-7. https://doi.org/10.3747/co.23.2839

Chicago/Turabian Style

Ma, S., J. Wu, J. Wu, Y. Wei, L. Zhang, Q. Ning, and D. Hu. 2016. "Relationship between HLA-DRB1 Allele Polymorphisms and Familial Aggregations of Hepatocellular Carcinoma" Current Oncology 23, no. 1: 1-7. https://doi.org/10.3747/co.23.2839

APA Style

Ma, S., Wu, J., Wu, J., Wei, Y., Zhang, L., Ning, Q., & Hu, D. (2016). Relationship between HLA-DRB1 Allele Polymorphisms and Familial Aggregations of Hepatocellular Carcinoma. Current Oncology, 23(1), 1-7. https://doi.org/10.3747/co.23.2839

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