Methods of Definitive Correction of Mandibular Deformity in Hemimandibular Hyperplasia Based on Radiological, Anatomical, and Topographical Measurements—Proposition of Author’s Own Protocol

In order to fully evaluate and establish the degree of bone overgrowth, various radiological studies are essential in the careful planning of the amount of surgical excision. In the presented paper, the authors use self-designed anatomo-topographical reference points for planning the surgeries. Routine panoramic radiographs and low-dose computed tomography based on anatomical landmarks help in measuring the proportions of mandibular bone overgrowth with the following preoperative anatomical landmarks: (Go-Go), (Go(Right)-Gn), (Go(Left)-Gn), and (Me–Gn). Measurements taken at selected points and landmarks (gonion-gnathion/gnathion-menton) are easy to conduct. In the authors’ proposal, the main key factor is total chin correction, which is necessary in cases of severe overgrowth; when F0 > C and Go-Gn>, there is >7 mm of vertical bone overgrowth, and the mandibular canal is positioned <5 mm from the inferior mandibular border—MIB. Larger overgrowths (>7 mm) have a greater outcome on the final symmetry than smaller overgrowths. As no guidelines are known, the authors present their own proposal.


Introduction
Surgery is required for mandibular abnormalities, which result in facial asymmetry, a lack of balance, inappropriate mandibular proportions, and/or decreased jaw, speech, or masticatory functions. Most cases are treated with various orthognathic procedures. Presented herein, condylar hyperplasia (HH/CH2)-related cases at first require the removal of part of the affected condyle, causing an abnormal one-sided mandibular overgrowth. Secondly, the degree of undesirable mandibular overgrowth can be treated in one of various ways and modifications [1][2][3]. Achieving proper symmetry, or at least near-normal symmetrical dimensions of the inferior mandibular border (MIB), is considered to be an excellent surgical outcome. In the presented paper, the authors' experience and proposal on a definitive mandibular symmetry correction in mandibular hyperplasia are presented and discussed.
The authors believe that as no adequate guidelines and indications for total mandibular symmetry correction have been established, it is necessary to create a protocol to increase the surgical point of knowledge on the following topic. The presented and used anatomical landmarks in the following prospective study will perhaps improve surgeons' planning and overall concept. This study aims to present a radiological protocol that defines a set of approaches for mandibular asymmetry correction in a prospective study.

Materials and Methods
After careful data selection from 2012 to 2022 of all patients from the author's dataset treated because of various forms of skeletal asymmetry, just a small group of them required some advanced surgical interventions for a total mandibular body correction. In detailed preclinical planning based on LDCT or panoramic radiographs, a total of 12 people (10 females and 2 males; p > 0.05; min = 19; max = 33; p > 0.05) had skeletal asymmetry and unilateral mandibular bone overgrowth of active or inactive hemimandibular hyperplasia and/or condylar hyperplasia type 2 etiology (HH/CH2), which required additional surgical steps. There was a notable 5:1 ratio of females to males, but no significant statistical correlations between gender, age, or the type of additional surgery were found. Likewise, there were no correlations regarding etiological factors causing the HH/CH2 other than those possibly known [1,2,15,16]. A proposal of a surgical protocol and its usage in various approaches, along with an attempt to describe the usage of the given methods, is presented and discussed based on the preclinical radiological data collected (Table 1; Figure 1). Perhaps the presented prospective study based on anatomic reference points will highlight a new surgical proposal. Table 1. Proposed usage of anatomical reference points in surgery planning.

Anatomical reference points
See reference point distances between: (1) mandibular teeth and roots/apex: MIB; (2) roots and superior part of mandibular canal; (3) MIB and inferior mandibular part of the canal; (4) F0 (left-blue/right-red) and C (mandibular midline-yellow) measured between vertical and horizontal dimensions. wise, there were no correlations regarding etiological factors causing the HH/CH2 other than those possibly known [1,2,15,16]. A proposal of a surgical protocol and its usage in various approaches, along with an attempt to describe the usage of the given methods, is presented and discussed based on the preclinical radiological data collected (Table 1; Figure 1). Perhaps the presented prospective study based on anatomic reference points will highlight a new surgical proposal. This study followed the Declaration of Helsinki on medical protocol and ethics and the Regional Ethical Review Board of the local Medical University approved the study.
According to the available knowledge [1][2][3][4][5][6][7][8][9][10] and the authors' own proposal, the following points were adopted as the criteria for qualifying the patient for the mandibular asymmetry correction surgery procedure: (1) Patients with active growth or growth cessation in the pathological (hyperplastic) condyle, confirmed by at least two scintigraphic measurements taken at least six months apart; (2) Patients who required condylectomy as the sole procedure and/or performed in various modalities and/or just observation without joint surgery; (3) Multiple degrees (low, mild, or severe) of mandibular asymmetry and overgrowths caused by the hyperplastic condyle (active or previous growth); (4) Patients treated, diagnosed, and/or operated on only by the authors; (5) Full clinical and radiological data standardized and performed with the same technique, the same person, and following the authors' protocol; (6) Patient cases with mandibular asymmetrical overgrowth caused by present or past growth in the affected condyle; (7) Other mandible asymmetries caused by HH/CH2, or other factors related to recent growth.
It was assumed that the contraindications based on the gathered data and the authors' own modification [2,3] to perform the mandibular asymmetry correction surgery procedure were: (1) Patients with an asymmetrical mandible without any growth in the affected condyle in the past or at the time of the study; (2) Laterognathia without any symptoms of condylar hyperplasia (CH) or in the past according to the Wolford and Obwegeser classifications (HH/CH2); (3) Clinical records from outside the authors' data that could have resulted in a lack of standardization or access to full clinical patient records from other institutions; (4) Mandibular asymmetry related to pathology outside of the joint, for example, tumors and pseudotumors.
Study limitations included: (1) a low number of participants in full mandible overgrowth correction related to the rarity of the disease; (2) a low number of patients qualified for additional surgery based on the scope of overgrowth that had been not sufficiently treated with standard condylectomy and orthognathic surgery; (3) patient unwillingness for any additional surgery for a definitive symmetry correction; (4) no evaluation of lateral patients profile, because of its great individuality and soft tissue changes, which is a topic for authors' further studies; (5) a great variety of bone overgrowths and dentoalveolar discrepancies in each individual case.
A preoperative radiologically necessary measurement evaluation of the patient may be performed with RadiAnt Freeware Dicom Viewer (Medixant, Poland-Privat License). An extended radiological assessment should be delivered in patients with visible asymmetry symptoms of hyperplasia/elongation in both radiological and preclinical data using the Department of Radiology Software-GE-Discovery 750HD scanner (General Electric Healthcare, Milwaukee, USA with a dedicated workstation (Advantage Windows 4.6, General Electric Healthcare, Milwaukee, WI, USA)). The extent of the surgical approach in all cases was strictly measured on preclinical routine facial photographs and radiological studies (CT/LDCT, lateral-cephalogram, and panoramic X-ray). A detailed comparison between the excess of asymmetrical bone overgrowth and the patients' expectations from treatment is essential.
At the first planning step, the authors proposed the investigation and measurement of the degree of bone overgrowth, using anatomical-topographical features consisting of known index measurements (IMs): the preoperative anatomical landmarks (Go-Go), (Go(Right)-Gn), (Go(Left)-Gn), and (Me-Gn) shown in Table 1. The used anatomical landmarks are commonly known [18][19][20][29][30][31][32][33]. Anthropometric points in this paper refer to ARP and consist of the following: gonion = Go refers to the most posteroinferior part of the mandibular angle; gnathion = Gn is located perpendicular on the mandibular symphysis midway between the pogonion and menton; menton = Me is the lowest point on the mandibular symphysis [20][21][22].
Likewise, anatomical reference points (ARP) measuring the degree of asymmetrical bone overgrowth should be evaluated in vertical/horizontal distances and measured based on four index values: (1) Mandibular teeth-roots/apex: MIB; (2) The distance between the roots and the superior part of the mandibular canal; (3) MIB-inferior mandibular part of the canal; (4) The distance between F0 (left: blue; right: red) and C (mandibular midline: yellow), measured between vertical and horizontal dimensions proposed by study authors.
Lines were drawn between the IM and ARP, in either the LDCT-3D, RTG/panoramic and lateral cephalogram, or others, and the orientation marks and anatomical sites with bone overgrowth and asymmetry were set. Each reference point can be easily identified, modified, and used in the presented proposal.
Secondly, the lower border of the mandible was outlined, and a vertical line from the tip of the canine, premolars, and molars was drawn perpendicular to the outlined marginal baseline. The collected radiological (panoramic) and tomographic (CT/LDCT) data were converted and archived. The horizontal volume of the bone from the tip of the roots toward the mandibular base was measured ( Figure 1). Additional landmarks were set on the course of the mandibular canal to determine the distances between the roots, the mandibular base, and the mandibular canal itself.

Results
The degree of asymmetry and bone overgrowth varies in each case individually ( Figure 2). A classic panoramic radiograph is sufficient to plan the scope of surgery, but because of the natural object enlargement in size by about 15-25%, any detailed measure-ments are troublesome. Despite this magnification, panoramic visualization enables good estimation of the degree of oversized mandibular bone, which can later be accurately measured on CT/LDCT radiographs. The authors present their proposal for approaches, the usage of which depends significantly on the anatomical-radiological distances (ARD) and proportions. All are based on the six most commonly found situations in CT/CBCT-RTG. Based on the following anatomical-topographical measurements, a protocol for surgical intervention was prepared. Perhaps the presented method of bone measurements will be a valuable study for future surgeries as condylar hyperplasia-related treatment remains without any particular guidelines and remains exceedingly individual. The detailed proposition of approaches based on the author's proposal and own used anatomical indexes are presented in Table 2. After a detailed radiological data analysis on the RTG/panoramic and lateral cephalogram or LDCT/CT, the following anatomical-radiological proportions should be included for surgical planning:  will be a valuable study for future surgeries as condylar hyperplasia-related treatment remains without any particular guidelines and remains exceedingly individual. The detailed proposition of approaches based on the author's proposal and own used anatomical indexes are presented in Table 2. After a detailed radiological data analysis on the RTG/panoramic and lateral cephalogram or LDCT/CT, the following anatomical-radiological proportions should be included for surgical planning:

Mandibular Canal
The distance between the mandibular canal and the inferior mandibular border-at least 5 mm of vertical bone overgrowth (Table 2)-could indicate the usage of marginectomy. The MIB cut (approx. 5-10 mm) is performed just under the inferior border of the mandibular canal. The degree of bone excised is measured by IM and ARP ( Figure 1). When the vertical bone height is limited (<5 mm) due to a low-set mandibular canal, approach three should be used. On the other hand, marginectomy or marginectomy-swing could be performed if there is ≥7 mm of vertical bone overgrowth, and the mandibular canal is positioned ≥5 mm from the MIB. While a single cut might damage the mandibular canal, altering it with two, three, or more cuts can reduce this damage due to the curved cut line. An indication for this approach is a low-set mandibular canal with irregular placement along with the MIB, according to index measurements of teeth apices F0-F5 ( Figure 1; Tables 1 and 2). The suggested measurements in preoperative radiographs on the degree of bone overgrowth influence the used surgical approaches in the authors' proposed perspective.

Gonial Angle
The length between Go-Gn/Go-Gn and the vertical bone volume relation decreases the bone height on the opposite healthy side-the critical point of this technique is the distance between the Go-Go/Go-Gn position and the value of the F0-C bone index. In this case, approach 1C can be used with or without corrective angulotomy/anguloplasty, which reduces the angled volume on the affected side in vertical and horizontal dimensions. If both Go (Right) and Go (Left) are situated on the same horizontal line, no major surgery should be planned, unless performing a condylectomy might relocate the Go point on the affected side to a higher position afterward. Therefore, careful planning in the horizontal plane and the F5: Go measurement can help estimate whether any additional mandibular angle surgery should be planned (Figures 1 and 2; Table 1). This was used in some of the authors' cases where there was no maxillary bite-plane deviation, and no chin bone asymmetry was present.

Chin Symmetry
The chin area position in IM and ARP ( Figure 1)-severe chin area asymmetry-could be treated with the surgical approach suggested by Ferguson, while smaller ones could be successfully treated conservatively by drilling and bone reshaping or with other proposed methods of marginectomy. IM is used when the distance between C and F0 is equal (1:1); when C < F0 in both the vertical and horizontal dimensions, then a leveling and/or corrective genioplasty is used by the authors (Figure 1; Table 2). After the inferior dental neurovascular bundle is wholly free and retracted, bone correction and reshaping of the new inferior alveolar nerve canal is performed. Instead of a leveling genioplasty, the remnants of the overgrowth are smoothed with surgical drills. In the authors' system, the primary key factor is total chin correction, which is necessary in cases of severe overgrowth; when F0 > C and Go-Gn>, there is >7 mm of vertical bone overgrowth, and the mandibular canal is positioned <5 mm from the MIB. The presented measurements are novel and not used in any previous reports and should be considered an additional tool for surgery planning.

Low-Dose Computer Tomography
Both panoramic radiographs and LDCT evaluations are important for any surgery planning. There is a possibility to estimate the shape and position of the mandibular canal while tracing its course on 3D evaluation and then estimating the degree of surgery in MIB (Figures 3 and 4). Secondly, based on the studied patients' data, the authors also include that the position of the mental foramina, chin deviation, and Go reference points described herein are valuable reference points for future surgical planning. Another important feature possible to estimate on 3D-LDCT is the scope of mandibular basis overgrowth in three dimensions. used in some of the authors' cases where there was no maxillary bite-plane deviation, an no chin bone asymmetry was present.

Chin Symmetry
The chin area position in IM and ARP (Figure 1)-severe chin area asymmetrycould be treated with the surgical approach suggested by Ferguson, while smaller one could be successfully treated conservatively by drilling and bone reshaping or with othe proposed methods of marginectomy. IM is used when the distance between C and F0 equal (1:1); when C < F0 in both the vertical and horizontal dimensions, then a levelin and/or corrective genioplasty is used by the authors (Figure 1; Table 2). After the inferio dental neurovascular bundle is wholly free and retracted, bone correction and reshapin of the new inferior alveolar nerve canal is performed. Instead of a leveling genioplast the remnants of the overgrowth are smoothed with surgical drills. In the authors' system the primary key factor is total chin correction, which is necessary in cases of severe ove growth; when F0 > C and Go-Gn>, there is >7 mm of vertical bone overgrowth, and th mandibular canal is positioned <5 mm from the MIB. The presented measurements ar novel and not used in any previous reports and should be considered an additional too for surgery planning.

Low-Dose Computer Tomography
Both panoramic radiographs and LDCT evaluations are important for any surger planning. There is a possibility to estimate the shape and position of the mandibular can while tracing its course on 3D evaluation and then estimating the degree of surgery i MIB (Figures 3 and 4). Secondly, based on the studied patients' data, the authors als include that the position of the mental foramina, chin deviation, and Go reference poin described herein are valuable reference points for future surgical planning. Anothe important feature possible to estimate on 3D-LDCT is the scope of mandibular bas overgrowth in three dimensions.

Maxillary Secondary Deformities
Maxillary bite-plane deviation-if this is present, in the authors' system, it should be treated with orthognathic surgery and a full osteotomy protocol. Special exclusion from the following could include: a patient's unwillingness to undergo total osteotomy or small bite-plane deviations when masticating are not decreased, which may serve as contraindications for the procedures presented herein. In most reviewed cases, a surgical camouflage was used after the removal of the pathological growth in the condyle. All of the above-mentioned points underline that major bone discrepancies require additional procedures as perfect symmetry is difficult to achieve and major all-in-one osteotomies with swelling that progresses over time decrease the overall perception of the surgery, which the authors tried to explain in their own material and outcomes.

Post-Surgical Key Points
As occlusion in each patient with CH2/HH is greatly individual, an early orthodontic treatment soon after a surgical procedure is essential (preferably within 24-48 h post-surgery). In cases of a condylectomy, some premature contacts must be corrected. Camouflage treatment focuses on teeth position correction in the dental arch, along with facial/dental midline and proper occlusal cant restoration. In cases of full osteotomy protocols, all patients require strict and well-established orthodontic and surgical planning. In cases of asymmetric mandible correction, the orthodontic treatment is essential to maintain not only teeth symmetry but also jawline shape and to increase teeth and bite stability in decreasing the potential relapse related to possible muscle dysfunction.

2D versus 3D Surgical Planning
The usage of a 2D-panoramic radiograph is helpful. More important measurements nowadays are made on 3D-virtual planning models ( Figure 5). 3D planning might improve surgeons' insight and the scope of bone evaluation. Because of great improvements in surgical planning, not only 3D-CT/LDCT evaluation is helpful. The usage of 3D stereolithographic models is an alternative method, where surgical cuts and plate bending might be quite easily made before surgery to ensure that the selected surgical approach is

Maxillary Secondary Deformities
Maxillary bite-plane deviation-if this is present, in the authors' system, it should be treated with orthognathic surgery and a full osteotomy protocol. Special exclusion from the following could include: a patient's unwillingness to undergo total osteotomy or small bite-plane deviations when masticating are not decreased, which may serve as contraindications for the procedures presented herein. In most reviewed cases, a surgical camouflage was used after the removal of the pathological growth in the condyle. All of the above-mentioned points underline that major bone discrepancies require additional procedures as perfect symmetry is difficult to achieve and major all-in-one osteotomies with swelling that progresses over time decrease the overall perception of the surgery, which the authors tried to explain in their own material and outcomes.

Post-Surgical Key Points
As occlusion in each patient with CH2/HH is greatly individual, an early orthodontic treatment soon after a surgical procedure is essential (preferably within 24-48 h postsurgery). In cases of a condylectomy, some premature contacts must be corrected. Camouflage treatment focuses on teeth position correction in the dental arch, along with facial/dental midline and proper occlusal cant restoration. In cases of full osteotomy protocols, all patients require strict and well-established orthodontic and surgical planning. In cases of asymmetric mandible correction, the orthodontic treatment is essential to maintain not only teeth symmetry but also jawline shape and to increase teeth and bite stability in decreasing the potential relapse related to possible muscle dysfunction.

2D versus 3D Surgical Planning
The usage of a 2D-panoramic radiograph is helpful. More important measurements nowadays are made on 3D-virtual planning models ( Figure 5). 3D planning might improve surgeons' insight and the scope of bone evaluation. Because of great improvements in surgical planning, not only 3D-CT/LDCT evaluation is helpful. The usage of 3D stereolithographic models is an alternative method, where surgical cuts and plate bending might be quite easily made before surgery to ensure that the selected surgical approach is the most adequate of all. In cases of asymmetry visualized in patients in face view after orthognathic, surgical, and orthodontic treatment, some detailed total mandibular symmetry correction protocols are needed. Direct 3D-LDCT planning based on the used anatomical reference points presented herein is helpful in restoring facial balance and mandibular symmetry (Figures 6 and 7). The authors' future studies will focus on the 3D evaluation of facial skeleton, soft tissue changes in CT/MR, and lateral profile alterations; because of that, any other data are excluded from this study. the most adequate of all. In cases of asymmetry visualized in patients in face view after orthognathic, surgical, and orthodontic treatment, some detailed total mandibular symmetry correction protocols are needed. Direct 3D-LDCT planning based on the used anatomical reference points presented herein is helpful in restoring facial balance and mandibular symmetry (Figures 6 and 7). The authors' future studies will focus on the 3D evaluation of facial skeleton, soft tissue changes in CT/MR, and lateral profile alterations; because of that, any other data are excluded from this study.

Discussion
The authors hypothesize that surgical planning in each case of condylar hyperplasia depends on the severity of factors. The total correction of mandibular asymmetrical deformities remains difficult. Each surgery focuses on the restoration of facial balance, proper bite, and occlusion, and it can be achieved in various methods [29][30][31][32]. The scope of secondary mandibular body deformities related to their overgrowths can be treated in a variety of methods. The used landmarks and anatomical proportions presented herein may also be useful. The authors' proposal for a treatment protocol and indications for the surgical approach was based on individual bone measurements. Because most asymmetry cases are determined by different factors, including the patients' willingness to undergo extensive surgeries at a certain age or perhaps only surgical camouflage instead of more invasive approaches, the authors tried to set some basis, indications, and contraindications for the procedures used to achieve a definitive mandibular asymmetry correction in preclinical radiological planning.
Other proposed methods suggested by Blair and Schneider [4] and Jensen [5] were milestones in correcting excess mandibular bone. The position of the inferior mandibular

Discussion
The authors hypothesize that surgical planning in each case of condylar hyperplasia depends on the severity of factors. The total correction of mandibular asymmetrical deformities remains difficult. Each surgery focuses on the restoration of facial balance, proper bite, and occlusion, and it can be achieved in various methods [29][30][31][32]. The scope of secondary mandibular body deformities related to their overgrowths can be treated in a variety of methods. The used landmarks and anatomical proportions presented herein may also be useful. The authors' proposal for a treatment protocol and indications for the surgical approach was based on individual bone measurements. Because most asymmetry cases are determined by different factors, including the patients' willingness to undergo extensive surgeries at a certain age or perhaps only surgical camouflage instead of more invasive approaches, the authors tried to set some basis, indications, and contraindications for the procedures used to achieve a definitive mandibular asymmetry correction in preclinical radiological planning.
Other proposed methods suggested by Blair and Schneider [4] and Jensen [5] were milestones in correcting excess mandibular bone. The position of the inferior mandibular neurovascular bundle was a limitation for surgery because of the risk of injury or even complete damage resulting in a lack of function. Nowadays, surgeons are not limited to only using hand saws. Still, more gentle and precise instruments and techniques can be used, such as piezosurgery, which can quickly and safely cut bone in the desired places with a very low likelihood of inferior alveolar nerve damage [12][13][14][15]. Bone chisels and special retractors can be useful as all of these procedures are carried out intra-orally and require both precision and attention to the safety of vital structures, such as nerves and arteries [5,14].
All of the points, as mentioned above, underline that significant bone discrepancies require additional procedures for achieving better symmetry. Perfect symmetry is difficult to achieve [1][2][3]. When measurements have been estimated based on horizontal and vertical lines and anatomical landmarks, it is quite easy to determine the surgical margin. Ongkosuwito et al.'s study on 2D radiographs indicate that they are also quite useful [20]. As most asymmetry is found at the chin area and/or its mandibular basis with or without mandibular angle involvement, one of the approaches presented below can be used. A low-positioned mandibular canal determined whether the marginectomy should be one cut or two to three cuts to minimize damage of the inferior alveolar bundle. According to Walters et al.'s study, the degree of mandibular downward rotation also affects the scope of asymmetry [33]. It is quite obvious while planning for a marginectomy when there is a great disproportion between the height levels of both mandibular bases, comparing the health and contralateral overgrowth side.
On the other hand, if the condylectomy is to be performed at the same time as a marginectomy, the degree of open bite on the contra-lateral side influences the degree of affected/hyperplastic condyle excision. Due to the degree of resection and the formation of a new bony stump, mandibular auto-rotation is noted. In addition, the degree of bone excised from the lower mandibular base could be minimal, or none, or perhaps a marginectomy swing-approach can be used [3,7,21,[24][25][26][27][28].
In the authors' proposed protocol, based on the relationships of the above-mentioned anatomical and topographical reference points and the excess of overgrowth/asymmetry, a series of six different techniques can be used: a corrective marginectomy, a marginectomy swing approach, a three-cut marginectomy, the Modified Ferguson approach without leveling genioplasty, the Ferguson approach for total asymmetry correction with leveling genioplasty, and bone drilling and chiseling. The authors would like to highlight the usage of the anatomical and topographic reference points used herein.
We measured the values of bone disproportions on standard panoramic radiographs and low-dose computed tomography (LDCT-3D) and evaluated the amount of excess. Others focused on strict CT-3D and CT measurements for a total symmetry correction, describing that simultaneously performed condylectomy and/or orthognathic surgery does not use such anatomical reference points [25][26][27][28][29][30][31][32]. It seems that no other similar way of using anatomical-radiological proportions and landmarks has been described in the literature. The technique presented here might perhaps establish a new background for surgical planning. Combining anatomical and cephalometric landmarks help in measuring the differences and the most important relationships between structures in the study, namely, the MIB, the mandibular canal, teeth apices, the gonion, the gnathion, and the mental foramen. This diagnostic protocol helps in evaluating the degree of bone overgrowth and mandibular angulation, which sets the basis for using several of the presented surgical techniques [21,22]. Most cases of mandibular asymmetry require individual considerations [3,6,14,[18][19][20]. The surgical approaches mentioned herein were used according to the accompanying radiological anatomical-topographical protocol, which is fast and straightforward. The new reference points used turned out to be very reasonable and effective in setting the basis for this classification and the surgical proposal for total mandibular asymmetry correction. A condylectomy is mandatory in all cases of condyle head pathological growth, except with a lack of growth [1][2][3][4][5][6]. The usage of any known modification of condylectomy (low, medium, high, reshaping, total, or proportional) is mostly related to either the scope of condyle overgrowth, growth factor/vector, surgeons' preference, the scope of coexisting dentoalveolar discrepancies, or vertical/horizontal mandible ramus diameters [1,2,10,11,14,27,30,32].
The indications and selection of techniques is simply the authors' proposal. The measurements and proportions used are helpful, mainly because the extent of each overgrowth is unique, which also requires the surgeon to evaluate each patient's expectations.
A limitation of the paper is the variability in each case. Despite the individuality of each case, a critical position between anatomical points-such as the gonion, menton, gnathion, and pogonion-and their proportions indicate which corrective surgical protocol should be used. The measured distances between the MIB, the mandibular canal, and the teeth apexes set additional protocol reference points to determine the margin for surgical bone correction. The landmarks are used to describe the position, angulation, and proportions between several mandibular anthropometric points. All of the approaches presented herein selected based on these measurements could help restore full mandibular symmetry. Lippold et al.'s and Rodrigues et al.'s studies confirm that the growth component within the affected joint influences the scope of secondary mandibular overgrowth [1,8].
Some general considerations should be addressed. An increase in bone height between the inferior part of the mandibular canal and the MIB on the affected side allows for a swing toward the right side. The camouflage approach should include a variety of factors, e.g., patients may be unwilling to undergo any orthodontic treatment because of their age or socioeconomic status, or when bone asymmetry is the only problem, not bite or other factors [8,29,32]. During routine orthognathic surgery, chin area drilling and polishing are used instead of genioplasty. One indication of this procedure is a low or moderate degree of chin asymmetry. Total orthodontic preparation for surgery is mandatory. The degree of bone overgrowth is not essential, because when an entire orthognathic surgery protocol is used, the MIB is reduced and corrected during BSSO. Leveling genioplasty was first described and proposed by Ferguson [6]. The authors fully agree with this proposed approach, though it ought to be reserved for severe cases of overgrowth when a total surgical protocol of asymmetry correction is used. On the other hand, it should never be used for camouflage cases, but should always be related to MIB reduction and neuro-vascular bundle repositioning. Finally, bone modeling with the use of a hand saw, piezoelectric devices, and surgical burrs can also be used. It is a very conservative, but still surgical, approach that focuses on small overgrowths. This technique is very well-known and often used, so it is not necessary to describe it here [7][8][9][10][11][12][13][14][15].
Various degrees of mandibular and skeletal asymmetry caused by condylar hyperplasia and its overgrowth, treated with different surgical approaches for mandibular asymmetry correction, have been presented [3,6,14,[18][19][20][25][26][27][28]. A preoperative patient assessment is required, with detailed planning and a decision about the volume of bone to be reduced or corrected during mandibular surgery. Nowadays, a complete 3D-CT/LDCT evaluation with a comparison of standard radiograms is considered to be the gold standard [21,22,30]. Patients who required orthodontic preparation and treatment had not only increased malocclusion but also significant disproportion in the skeletal bones, which required full osteotomy protocols [23,25,29,31]. The authors conclude that orthodontic treatment is not mandatory to improve mandibular symmetry, though it nevertheless enables more stable and functional outcomes in terms of bite and tooth stability. Some authors advise orthodontic treatment in almost every case [3,9,11]. Secondly, at the beginning of treatment, each surgeon should ask the patient if a full orthodontic surgical approach or perhaps a camouflage protocol is desired.
The most reasonable surgical approach consisted of a two-stage surgery in dentofacial discrepancies: first, a condylectomy; then, BSSO with various modalities (marginectomy, swing, or Ferguson) when the patient is willing to undergo further procedures necessary after a detailed orthodontic and scheduled procedure [6,7,11,[13][14][15][16][17][18]. The authors conclude that in cases where the patient does not require or is unwilling to undergo any appropriate orthodontic treatment, a mandibular swing procedure with additional bone grafting (where necessary, from healthy mandibular bone overgrowth or other bone from the patient) on the contra-lateral side can be useful in restoring mandibular balance and improving bone coverage. On the other hand, a slow progressive growth on the condyle also resulting in the co-existing maxillary rotation should always be an indication for orthognathic surgery [1,2,[15][16][17].
The authors indicate that a modification of the classic, horizontally performed, onecut mandibular marginectomy-and changes consisting of two, three, or more cuts-can be used to reshape the overgrown mandibular base on its hyperplastic side. Distances measured with ARP: IM help to indicate the degree of bone resection (Table 2). It could also be used to reshape the mandibular angle on the hyperplastic side of the mandible or can be used with simultaneously performed anguloplasty and/or angulotomy-if the mandibular angle is enlarged and more square-shaped. Furthermore, this same approach can be used to avoid damage to the inferior alveolar nerve in its canal with the multiple horizontal cuts, while a single one could damage the nerve [3][4][5][6]. The tooth apices: MIB index values help in the possibility of lower border modeling estimation (Figure 1). Some authors conclude that when the chin slightly deviates, then bone drilling/smoothing after an extended sagittal osteotomy is enough to improve esthetics and to minimize surgery when the chin is not fully involved. This finding is related to the low post-op growth factor in the affected condyle. Standard titanium mini plates with or without bicortical screws (18-22 mm) should be used for additional stability of the bony fragments' position [15]. On the other hand, one bicortical screw placed in the middle of an extended osteotomy fragment is enough to stabilize the bone. Intramaxillary fixation (IMF) devices helped to secure the mandible after joint surgery.
The authors conclude that a very severe mandibular overgrowth with increased chin involvement should be a mandatory indication for the classic Ferguson approach with a surgical reduction in the mandibular angle on the affected side [7,13]. The main reason for this is the increased distance and height of the F0:F1 and F0:C:F0 values in this study ( Figure 1). The authors fully agree with Ferguson's approach, which is confirmed in the author's measurements based on the suggested ARP: IM values and the distances between reference points in the presented study radiographs. Two different cases of one-sided mandibular overgrowths in hemimandibular hyperplasia are drawn and explained in Figure 2.
In some cases, in addition to a standard osteotomy, an additional genioplasty can be used if necessary. In the modified approach for total mandibular correction suggested by Ferguson [6], a corrective leveling genioplasty was a crucial factor in achieving full symmetry. In contrast, in the authors' opinion, a few different approaches were used with a great overall outcome as well. Still, a leveling genioplasty should be considered mandatory in extensive bone overgrowth where the methods presented herein are insufficient, such as the proposed protocol in Table 1. CT/RTG and CBCT/3D studies [21,22,[33][34][35] should be carried out, especially in the estimation of the position, height, and length of the mandibular inferior margin [7,[13][14][15][16][17].
Before this paper, no attempt at describing possible vital points for a surgical protocol in total asymmetry correction had been presented or described.
In some cases, the surgeon's clinical judgment during surgery and a comparison with the patient's facial photographs should determine the amount of bone removed [14][15][16]21,22]. A calibrated ruler or surgical caliper is also essential for measuring the intra-operative dimensions between anatomical/cephalometric reference points. Virtual preoperative planning based on the patient's radiographs and facial photographs is also useful [15,17,21,22]. Therefore, the authors' perspective on the subject of restoring full mandibular symmetry is presented as clearly as possible. This study is perhaps the first attempt at describing a protocol based on specific anatomical-topographical references on preclinical radiographs.

Conclusions
A significant outcome from the protocol presented herein on the studied anatomicaltopographical reference points and their proportions is instrumental in planning the degree of surgical approach in all of the known and presented strategies. Furthermore, the study presents the authors' philosophy on total asymmetry correction planning based on the most commonly found radiological-anatomical situations in asymmetrical patients' radiographs. The author's idea of ARP and IM reference points could improve overall surgical planning. The Go-Gn diameter is essential for full symmetry from the angle to the chin midline. In severe chin overgrowth correction, when F0 > C and Go-Gn>, and there is >7 mm of vertical bone overgrowth, Ferguson's approach should be used. The surgical procedures presented herein can be used successfully in all cases of mandibular asymmetry, resulting most commonly from hemimandibular hyperplasia, and should improve patient's expectations. Informed Consent Statement: Informed consent was obtained from all subjects involved in the study.

Data Availability Statement:
The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Conflicts of Interest:
The authors declare no conflict of interest.