Next Article in Journal
Reply to Comment on Małgorzata Krówczyńska and Ewa Wilk. Environmental and Occupational Exposure to Asbestos as a Result of Consumption and Use in Poland. Int. J. Environ. Res. Public Health 2019, 16, 2611
Previous Article in Journal
Passion or Perseverance? The Effect of Perceived Autonomy Support and Grit on Academic Performance in College Students
Open AccessArticle

Glomerular Filtration Rate in Former Extreme Low Birth Weight Infants over the Full Pediatric Age Range: A Pooled Analysis

1
Department of Development and Regeneration, KU Leuven, Herestraat 49, 3000 Leuven, Belgium
2
Department of Pediatric Nephrology and Organ Transplantation, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
3
Department of Pharmacy and Pharmaceutical Sciences, KU Leuven, Herestraat 49, 3000 Leuven, Belgium
4
Department of Clinical Pharmacy, Wytemaweg Hospital Pharmacy Postbus 2040, Erasmus MC, Rotterdam, The Netherlands
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(6), 2144; https://doi.org/10.3390/ijerph17062144
Received: 8 March 2020 / Accepted: 20 March 2020 / Published: 24 March 2020
(This article belongs to the Section Global Health)
Various cohort studies document a lower glomerular filtration rate (GFR) in former extremely low birth weight (ELBW, <1000 g) neonates throughout childhood when compared to term controls. The current aim is to pool these studies to describe the GFR pattern over the pediatric age range. To do so, we conducted a systematic review on studies reporting on GFR measurements in former ELBW cases while GFR data of healthy age-matched controls included in these studies were co-collected. Based on 248 hits, 6 case-control and 3 cohort studies were identified, with 444 GFR measurements in 380 former ELBW cases (median age 5.3–20.7 years). The majority were small (17–78 cases) single center studies, with heterogeneity in GFR measurement (inulin, cystatin C or creatinine estimated GFR formulae) tools. Despite this, the median GFR (mL/min/1.73 m2) within case-control studies was consistently lower (−13%, range −8% to −25%) in cases, so that a relevant minority (15–30%) has a eGFR<90 mL/min/1.73 m2). Consequently, this pooled analysis describes a consistent pattern of reduced eGFR in former ELBW cases throughout childhood. Research should focus on perinatal risk factors for impaired GFR and long-term outcome, but is hampered by single center cohorts, study size and heterogeneity of GFR assessment tools. View Full-Text
Keywords: glomerular filtration rate; Brenner hypothesis; extreme low birth weight infants; renal outcome glomerular filtration rate; Brenner hypothesis; extreme low birth weight infants; renal outcome
Show Figures

Figure 1

MDPI and ACS Style

Goetschalckx, E.; Mekahli, D.; Levtchenko, E.; Allegaert, K. Glomerular Filtration Rate in Former Extreme Low Birth Weight Infants over the Full Pediatric Age Range: A Pooled Analysis. Int. J. Environ. Res. Public Health 2020, 17, 2144.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop