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Int. J. Environ. Res. Public Health 2017, 14(11), 1344; https://doi.org/10.3390/ijerph14111344

Effects of 1.8 GHz Radiofrequency Fields on the Emotional Behavior and Spatial Memory of Adolescent Mice

1
Department of Radiation Biology, Faculty of Preventive Medicine, Fourth Military Medical University, 169# Chang Le West Road, Xi’an 710032, China
2
Department of Radiation Medicine, Faculty of Preventive Medicine, Fourth Military Medical University, 169# Chang Le West Road, Xi’an 710032, China
These authors contributed equally to the work.
*
Author to whom correspondence should be addressed.
Received: 8 September 2017 / Revised: 31 October 2017 / Accepted: 2 November 2017 / Published: 5 November 2017
(This article belongs to the Special Issue Electromagnetic Fields and Health—Effects on the Nervous System)
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Abstract

The increasing use of mobile phones by teenagers has raised concern about the cognitive effects of radiofrequency (RF) fields. In this study, we investigated the effects of 4-week exposure to a 1.8 GHz RF field on the emotional behavior and spatial memory of adolescent male mice. Anxiety-like behavior was evaluated by open field test (OFT) and elevated plus maze (EPM) test, while depression-like behavior was evaluated by sucrose preference test (SPT), tail suspension test (TST) and forced swim test (FST). The spatial learning and memory ability were evaluated by Morris water maze (MWM) experiments. The levels of amino acid neurotransmitters were determined by liquid chromatography-mass spectrometry (LC-MS). The histology of the brain was examined by hematoxylin-eosin (HE) staining. It was found that the depression-like behavior, spatial memory ability and histology of the brain did not change obviously after RF exposure. However, the anxiety-like behavior increased in mice, while, the levels of γ-aminobutyric acid (GABA) and aspartic acid (Asp) in cortex and hippocampus significantly decreased after RF exposure. These data suggested that RF exposure under these conditions do not affect the depression-like behavior, spatial memory and brain histology in adolescent male mice, but it may however increase the level of anxiety, and GABA and Asp were probably involved in this effect. View Full-Text
Keywords: RF field; anxiety-like behavior; depression-like behavior; spatial memory; amino acid neurotransmitters RF field; anxiety-like behavior; depression-like behavior; spatial memory; amino acid neurotransmitters
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Zhang, J.-P.; Zhang, K.-Y.; Guo, L.; Chen, Q.-L.; Gao, P.; Wang, T.; Li, J.; Guo, G.-Z.; Ding, G.-R. Effects of 1.8 GHz Radiofrequency Fields on the Emotional Behavior and Spatial Memory of Adolescent Mice. Int. J. Environ. Res. Public Health 2017, 14, 1344.

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