Short-Term Effects of Fine Particulate Matter and Temperature on Lung Function among Healthy College Students in Wuhan, China

Ambient fine particulate matter (PM) has been associated with impaired lung function, but the effect of temperature on lung function and the potential interaction effect between PM and temperature remain uncertain. To estimate the short-term effects of PM_2.5 combined with temperature on lung function, we measured the daily peak expiratory flow (PEF) in a panel of 37 healthy college students in four different seasons. Meanwhile, we also monitored daily concentrations of indoor and outdoor PM_2.5 (particulate matter with an aerodynamic diameter ≤2.5 μm), ambient temperature and relative humidity of the study area, where the study participants lived and attended school. Associations of air pollutants and temperature with lung function were assessed by generalized estimating equations (GEEs). A 10 μg/m³ increase of indoor PM_2.5 was associated with a change of −2.09 L/min in evening PEF (95%CI: −3.73 L/min–−0.51 L/min) after adjusting for season, height, gender, temperature and relative humidity. The changes of −2.17 L/min (95%CI: −3.81 L/min– −0.52 L/min) and −2.18 L/min (95%CI: −3.96 L/min–−0.41 L/min) in evening PEF were also observed after adjusting for outdoor SO₂ and NO₂ measured by Environmental Monitoring Center 3 kilometers away, respectively. An increase in ambient temperature was found to be associated with a decrease in lung function and our results revealed a small but significant antagonistic interactive effect between PM_2.5 and temperature. Our findings suggest that ambient PM_2.5 has an acute adverse effect on lung function in young healthy adults, and that temperature also plays an important role. View Full-Text