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Open AccessCommunication
Mar. Drugs 2017, 15(12), 387; https://doi.org/10.3390/md15120387

Collismycin C from the Micronesian Marine Bacterium Streptomyces sp. MC025 Inhibits Staphylococcus aureus Biofilm Formation

1,†
,
2,†
,
2,* and 1,*
1
School of Chemical Engineering, Yeungnam University, Gyeongsan-si 38541, Gyeongsangbukdo, Korea
2
College of Pharmacy, Yeungnam University, Gyeongsan-si 38541, Gyeongsangbukdo, Korea
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 22 November 2017 / Revised: 3 December 2017 / Accepted: 7 December 2017 / Published: 12 December 2017
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Abstract

Biofilm formation plays a critical role in antimicrobial resistance in Staphylococcus aureus. Here, we investigated the potential of crude extracts of 79 Micronesian marine microorganisms to inhibit S. aureus biofilm formation. An extract of Streptomyces sp. MC025 inhibited S. aureus biofilm formation. Bioactivity-guided isolation led to the isolation of a series of 2,2′-bipyridines: collismycin B (1), collismycin C (2), SF2738 D (3), SF2738 F (4), pyrisulfoxin A (5), and pyrisulfoxin B (6). Among these bipyridines, collismycin C (2) was found to be the most effective inhibitor of biofilm formation by methicillin-sensitive S. aureus and methicillin-resistant S. aureus (MRSA), and this compound inhibited MRSA biofilm formation by more than 90% at a concentration of 50 μg/mL. The antibiofilm activity of collismycin C was speculated to be related to iron acquisition and the presence and position of the hydroxyl group of 2,2′-bipyridines. View Full-Text
Keywords: collismycin C; antibiofilm activity; methicillin-resistant Staphylococcus aureus; iron chelation collismycin C; antibiofilm activity; methicillin-resistant Staphylococcus aureus; iron chelation
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Lee, J.-H.; Kim, E.; Choi, H.; Lee, J. Collismycin C from the Micronesian Marine Bacterium Streptomyces sp. MC025 Inhibits Staphylococcus aureus Biofilm Formation. Mar. Drugs 2017, 15, 387.

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