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Article

Anti HSV-1 Activity of Halistanol Sulfate and Halistanol Sulfate C Isolated from Brazilian Marine Sponge Petromica citrina (Demospongiae)

1
Laboratory of Natural Products, Department of Pharmaceutical Sciences, Universidade Federal de Santa Catarina, Florianópolis 88040-900, SC, Brazil
2
Laboratory of Applied Virology, Department of Microbiology, Immunology and Parasitology, Universidade Federal de Santa Catarina, Florianópolis 88040-900, SC, Brazil
3
Laboratory of Porifera, National Museum, Universidade Federal do Rio de Janeiro, Rio de Janeiro 20940-040, RJ, Brazil
4
UMYMFOR—Department of Organic Chemistry, FCEN—University of Buenos Aires, Buenos Aires C1428EGA, Argentina
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Mar. Drugs 2013, 11(11), 4176-4192; https://doi.org/10.3390/md11114176
Received: 2 September 2013 / Revised: 18 September 2013 / Accepted: 30 September 2013 / Published: 29 October 2013
The n-butanol fraction (BF) obtained from the crude extract of the marine sponge Petromica citrina, the halistanol-enriched fraction (TSH fraction), and the isolated compounds halistanol sulfate (1) and halistanol sulfate C (2), were evaluated for their inhibitory effects on the replication of the Herpes Simplex Virus type 1 (HSV-1, KOS strain) by the viral plaque number reduction assay. The TSH fraction was the most effective against HSV-1 replication (SI = 15.33), whereas compounds 1 (SI = 2.46) and 2 (SI = 1.95) were less active. The most active fraction and these compounds were also assayed to determine the viral multiplication step(s) upon which they act as well as their potential synergistic effects. The anti-HSV-1 activity detected was mediated by the inhibition of virus attachment and by the penetration into Vero cells, the virucidal effect on virus particles, and by the impairment in levels of ICP27 and gD proteins of HSV-1. In summary, these results suggest that the anti-HSV-1 activity of TSH fraction detected is possibly related to the synergic effects of compounds 1 and 2. View Full-Text
Keywords: antiviral activity; HSV-1; marine sponge; Petromica citrina; sulfate sterols antiviral activity; HSV-1; marine sponge; Petromica citrina; sulfate sterols
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MDPI and ACS Style

Da Rosa Guimarães, T.; Quiroz, C.G.; Rigotto, C.; De Oliveira, S.Q.; De Almeida, M.T.R.; Bianco, É.M.; Moritz, M.I.G.; Carraro, J.L.; Palermo, J.A.; Cabrera, G.; Schenkel, E.P.; Reginatto, F.H.; Simões, C.M.O. Anti HSV-1 Activity of Halistanol Sulfate and Halistanol Sulfate C Isolated from Brazilian Marine Sponge Petromica citrina (Demospongiae). Mar. Drugs 2013, 11, 4176-4192. https://doi.org/10.3390/md11114176

AMA Style

Da Rosa Guimarães T, Quiroz CG, Rigotto C, De Oliveira SQ, De Almeida MTR, Bianco ÉM, Moritz MIG, Carraro JL, Palermo JA, Cabrera G, Schenkel EP, Reginatto FH, Simões CMO. Anti HSV-1 Activity of Halistanol Sulfate and Halistanol Sulfate C Isolated from Brazilian Marine Sponge Petromica citrina (Demospongiae). Marine Drugs. 2013; 11(11):4176-4192. https://doi.org/10.3390/md11114176

Chicago/Turabian Style

Da Rosa Guimarães, Tatiana, Carlos G. Quiroz, Caroline Rigotto, Simone Q. De Oliveira, Maria T.R. De Almeida, Éverson M. Bianco, Maria I.G. Moritz, João L. Carraro, Jorge A. Palermo, Gabriela Cabrera, Eloir P. Schenkel, Flávio H. Reginatto, and Cláudia M.O. Simões 2013. "Anti HSV-1 Activity of Halistanol Sulfate and Halistanol Sulfate C Isolated from Brazilian Marine Sponge Petromica citrina (Demospongiae)" Marine Drugs 11, no. 11: 4176-4192. https://doi.org/10.3390/md11114176

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