Predictors of Postoperative Complications in Metabolic and Bariatric Surgery: A Retrospective Analysis Using Multivariable Logistic Regression
Abstract
1. Introduction
2. Materials and Methods
2.1. Patients
2.2. Statistical Analysis
3. Results
3.1. Cohort
3.2. Univariate Analysis of Complications
3.3. Multivariable Analysis
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
| OSA | Obstructive sleep apnea |
| OR | Odds Ratio |
Appendix A
| Article Title, Author Name, Year of Publication | Number of Participants | Type of Study | Type of Bariatric Surgeries | Complication Rate | Overall Mortality Rate | Risk Factors Identified |
|---|---|---|---|---|---|---|
| Liang et al. [30] 2025 | 323,066 | Database analysis | SG, RYGB | 3.79% | Not specified |
|
| Hon et al. [20] 2025 | Not specified | Systematic review | Various primary bariatric surgeries | Not specified | Reported for older age groups: 2.62 × risk |
|
| Sebastian et al. 2024 [35] | 1,002,505 | Database analysis (MBSAQIP registry) | SG, RYGB | 0.2–0.6% bleeding | Not specified |
|
| Iranmanesh et al. [32] 2023 | 1276 | Multicenter retrospective cohort study | RYGB | 12.5% | 0.1% |
|
| Zengin et al. [33] 2022 | 67 | Prospective cohort study | SG, GB | 32.8% | Not reported |
|
| Nijland et al. [36] 2020 | 1669 | Retrospective cohort study | RYGB, SG | 8.3% complications | 0% |
|
| Chang et al. [22] 2018 | 107,874 | Systematic review and meta-analysis | GB, LAGB, SG | Anastemitic Leak 1.15%, MI 0.37%, PE 1.17%, | 0.12–0.37% |
|
| Lynn et al. [37] 2018 | 485 | Prospective chorot study | RYGB, SG | 4.7% | 0% (inpatient) | None significantly different between groups |
| Chen et al. [34] 2015 | 113,898 | Database analysis (NSQIP registry) | GB, LAGB, SG | 3.2% | 0.11% (30 days) |
|
| Stenberg et al. [23] 2014 | 26,173 | Database analysis (Scandinavian obesity surgery registry) | RYGB | 3.4% | 0.04% (90 days) |
|
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| Feature | Total (n = 927) | No Complication (n = 843) | Complication (n = 84) | p-Value |
|---|---|---|---|---|
| Gender | 96 (10%) | 90 (11%) | 6 (7%) | 0.409 |
| Age at time of surgery | 41.7 +/- 13.2 | 41.4 +/- 13.3 | 45.3 +/- 12.2 | 0.01 |
| BMI on the day of hospitalization | 41.5 +/- 9.3 | 41.6 +/- 9.4 | 39.7 +/- 7.6 | 0.063 |
| Current Smoker | 224 (24%) | 200 (24%) | 24 (29%) | 0.392 |
| Cigarettes per day | 14.0 +/- 5.2 | 14.0 +/- 5.0 | 14.2 +/- 6.5 | 0.688 |
| Years of smoking | 17.4 +/- 6.4 | 17.3 +/- 5.9 | 18.3 +/- 10.1 | 0.181 |
| Hypertension | 302 (33%) | 269 (32%) | 33 (39%) | 0.21 |
| DM | 241 (26%) | 213 (25%) | 28 (33%) | 0.14 |
| DM treated with medication | 165 (18%) | 143 (17%) | 22 (26%) | 0.05 |
| Dyslipidemia | 286 (31%) | 259 (31%) | 27 (32%) | 0.885 |
| Stress urinary incontinence | 196 (21%) | 178 (21%) | 18 (21%) | 0.942 |
| OSA treated with medication | 61 (7%) | 54 (6%) | 7 (8%) | 0.654 |
| Dyslipidemia treated with medication | 147 (16%) | 132 (16%) | 15 (18%) | 0.712 |
| Asthma | 77 (8%) | 67 (8%) | 10 (12%) | 0.296 |
| Asthma treated with medication | 61 (7%) | 54 (6%) | 7 (8%) | 0.654 |
| Hypertension treated with medication | 260 (28%) | 231 (27%) | 29 (35%) | 0.208 |
| GERD | 200 (22%) | 177 (21%) | 23 (27%) | 0.223 |
| GERD treated with medication | 124 (13%) | 110 (13%) | 14 (17%) | 0.447 |
| Arthralgia | 426 (46%) | 388 (46%) | 38 (45%) | 0.981 |
| OSA | 174 (19%) | 150 (18%) | 24 (29%) | 0.023 |
| How many floors can climb in a row | 6.5 +/- 18.4 | 6.5 +/- 18.4 | 6.3 +/- 18.0 | 0.923 |
| Previous abdominal surgery | 335 (36%) | 301 (36%) | 34 (40%) | 0.454 |
| Previous bariatric surgery | 238 (26%) | 208 (25%) | 30 (36%) | 0.038 |
| Less than 5 years from previous bariatric surgery | 71 (8%) | 57 (7%) | 14 (17%) | 0.002 |
| Addition to surgery | 173 (19%) | 159 (19%) | 14 (17%) | 0.73 |
| Type of surgery: One Anastomosis Gastric Bypass (Omega loop, Mini) | 500 (54%) | 463 (55%) | 37 (44%) | 0.073 |
| Type of surgery: Sleeve gastrectomy | 282 (30%) | 256 (30%) | 26 (31%) | 0.989 |
| Type of surgery: Roux-en-Y gastric bypass | 139 (15%) | 118 (14%) | 21 (25%) | 0.011 |
| Type of surgery: One Anastomosis Duodenal switch (Omega loop) | 5 (1%) | 5 (1%) | 0 (0%) | 0.942 |
| Surgery Length | 106.0 +/- 51.5 | 104.9 +/- 48.8 | 117.4 +/- 72.9 | 0.034 |
| Length of stay | 3.9 +/- 2.9 | 3.4 +/- 1.4 | 9.4 +/- 6.4 | 0 |
| Feature | Complication (n = 84) |
|---|---|
| Clavien-Dindo Grade 1 | 51 (60%) |
| Clavien-Dindo Grade 2 | 9 (11%) |
| Clavien-Dindo Grade 3 | 15 (18%) |
| Clavien-Dindo Grade 4 | 9 (11%) |
| Leak/intra-abdominal abscess | 20 (24%) |
| Life-threatening Leak/intra-abdominal abscess | 5 (6%) |
| Surgical site infection | 6 (8%) |
| Life-threatening surgical site infection | 0 (0%) |
| Thromboembolic event | 4 (5%) |
| Life-threatening thromboembolic event | 1 (1%) |
| Cardio/Respiratory complication | 15 (18%) |
| Life-threatening cardio/respiratory complication | 3 (3%) |
| Sepsis | 0 (0%) |
| Life-threatening Sepsis | 0 (0%) |
| Bleeding | 39 (46%) |
| Invasive procedure during hospitalization | 32 (38%) |
| Mortality (Perioperative and 90-day) | 0 (0%) |
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Shoham, G.; Naveh, S.; Zoabi, T.; Gosher, N.; Messer, N.; Yuval, J.B.; Shnell, M.; Abu-Abeid, A. Predictors of Postoperative Complications in Metabolic and Bariatric Surgery: A Retrospective Analysis Using Multivariable Logistic Regression. Medicina 2026, 62, 881. https://doi.org/10.3390/medicina62050881
Shoham G, Naveh S, Zoabi T, Gosher N, Messer N, Yuval JB, Shnell M, Abu-Abeid A. Predictors of Postoperative Complications in Metabolic and Bariatric Surgery: A Retrospective Analysis Using Multivariable Logistic Regression. Medicina. 2026; 62(5):881. https://doi.org/10.3390/medicina62050881
Chicago/Turabian StyleShoham, Gon, Shira Naveh, Tariq Zoabi, Noa Gosher, Nir Messer, Jonathan B. Yuval, Mati Shnell, and Adam Abu-Abeid. 2026. "Predictors of Postoperative Complications in Metabolic and Bariatric Surgery: A Retrospective Analysis Using Multivariable Logistic Regression" Medicina 62, no. 5: 881. https://doi.org/10.3390/medicina62050881
APA StyleShoham, G., Naveh, S., Zoabi, T., Gosher, N., Messer, N., Yuval, J. B., Shnell, M., & Abu-Abeid, A. (2026). Predictors of Postoperative Complications in Metabolic and Bariatric Surgery: A Retrospective Analysis Using Multivariable Logistic Regression. Medicina, 62(5), 881. https://doi.org/10.3390/medicina62050881

