Statistical Study of the Method of Radius-Change Sphericity Measurements

At the Kielce University of Technology, a concept of the accurate measurement of sphericity deviations of machine parts has been developed. The concept is based upon the measurement of roundness profiles in many clearly defined cross-sections of the workpiece. Measurements are performed with the use of a typical radius change measuring instrument equipped with a device for accurate positioning of the ball. This paper focuses on the statistical analysis of the differences between measurement results of spherical parts obtained by the new and traditional method. The differences were analyzed by applying preselected statistical parameters and diagrams. Results of the analysis revealed that that the new method may contribute to a much more reliable measurement of form deviations of spherical parts.


Introduction
Spherical elements constitute a significant group of machine parts. In particular, they are common in the bearing industry, where they have to meet high quality requirements. One of the most important factors regarding the quality of spherical parts are form deviations.
In contemporary industrial practice, the form deviations of spherical parts are determined through the measurement of the roundness deviation in a random cross-section of the sphere. The dominant method used in the industry to measure roundness deviation is the so-called radius-change method, in which a sensor detects variations in the radius of the measured part [1].
It is obvious that such a measurement technique does not enable obtaining reliable information about the whole investigated surface, because a large fragment of the surface is not sampled. Therefore, the authors undertook research aimed at developing a new method of measuring spherical elements, which would enable a more reliable assessment of form deviations of such parts. These studies were conducted in close cooperation with the Rolling Bearings Factory in Kraśnik (Poland). The research activities resulted in the development of a system that could measure the sphericity deviation of bearing balls using a highly accurate radius-change system. The authors' aim was to develop a method to be practically useful in industry. Therefore, a comparative study of the new method with the traditional method were carried out under conditions closest to real industrial conditions. The aim of this research was to determine to what extent the results obtained with the new method differed from the results obtained with the traditional method, and an additional goal was to investigate the nature of these differences. In Section 2 of this paper, the state of the art of the measurement and evaluation of form deviations of spherical elements is presented. Section 3 describes the developed measurement concept. Section 4 presents the experiment. Sections 5 and 6 describe the results of the experiments and their statistical analysis. The last section of this paper contains conclusions and directions for further research.

State of the Art of Sphericity Measurements
As mentioned in the previous section, an evaluation of form deviations of spherical parts in industry is usually performed by so-called radius-change measuring instruments equipped with a contact sensor [1].
Apart from radius change methods with a contact sensor, intensive research has been conducted in the field of optical measurements. It is noteworthy that the first automated system dedicated to the optical measurement of spherical parts was produced in Czechoslovakia in the 1960s for the bearing industry. The operation of the system was based on an analysis of the changes in the intensity of the light beam reflected from the spherical surface [2].
Currently, methods based on using laser interferometers for accurate measurements of the surface topography of spherical parts are intensively studied, which are described elsewhere [3].
The authors of the abovementioned study present a system that measures small regions of a sphere with the use of a Fizeau interferometer. The measured regions are then numerically joined (this operation is called stitching) together to assess the topography of the whole surface of the sphere. In this method, it is essential to accurately determine the position of the sphere. Therefore, the fundamental parts of the system are the units that control the change of the position of the sphere during measurement.
A similar system is described in [4]. This system uses an appropriately modified Fizeau interferometer, and small fragments of the sphere are measured in the subsequent stages of the measurement. The method described in [4] requires, similarly to the method proposed in [3], numerical stitching of small fragments of the sphere, and the topography of the sphere is reconstructed from small fragments.
The authors of [5] dealt with the form deviation measurements of the spherical part of electrodes used in the electro-discharge machining process. The measurements were performed with the use of an appropriately calibrated camera that captures images of the spherical tip of the electrode. The system saves the image of the electrode, and the relevant software computes the coordinates of the points lying on the edge of the image of the electrode. Then, the electrode is rotated to the next position and the procedure of computing coordinates of the points lying on the edge of the image is repeated. This way, a matrix containing coordinates of the points of the tip of the electrode is obtained. On the basis of these coordinates, the form deviations of the spherical part of the electrode are then determined.
Interesting solutions of the problem of sphericity measurements by optical method have been presented. The authors of [6] proposed the application of digital image processing methods to obtain a 3D view of a surface which is reconstructed from 2D images. It is obvious that, on the basis of a singular 2D image, only a half-sphere can be reconstructed. In this method, firstly, a 2D image of the surface is captured with the use of a pre-calibrated camera. The distances of individual points of the surface from the camera correspond to changes in the intensity of the grey scale of the captured image. The analysis of the changes in the intensity contributes to the generation of a 3D view of the studied surfaces.
It is noteworthy that various research centers and universities have investigated the problem of applying coordinate measuring machines to accurately measure form deviations of spherical parts. Taking into account the dynamic development of coordinate metrology, it can be assumed that, in the near future, measurements of spheres with the use of CMMs will be one of the leading methods in industry. However, currently, coordinate measuring machines do not offer measurement accuracy that fulfils all the requirements of manufacturers of very precise machine parts (for example, manufacturers of rolling bearings, eyeglasses, etc.).
Apart from investigating the methods of measuring form deviations of spherical parts, research activities aiming to develop new methods of sphericity evaluation have also been carried out. Usually, in the evaluation of sphericity deviations, the methodology is used that is analogical to that applied in the case of evaluating roundness deviation. The main difference is that for the evaluation of roundness deviation, 2D features and parameters are used, whereas for the evaluation of sphericity deviation, analogical 3D features and parameters are applied. For example, minimum zone circles for roundness evaluations correspond to minimum zone spheres for the sphericity evaluation.
Studies of the evaluation of sphericity deviations include, for example, computing various types of reference features from measurement data. Various methods can be applied for this purpose, for example, the numerical processing of coordinate measurement data [7][8][9].
Another way to calculate parameters of reference features are computational geometric techniques. Usually, such techniques use so-called Voronoi diagrams, which have been described in detail elsewhere [10,11].
Other methods of evaluating sphericity deviations that are noteworthy are a method applying the theory of minimum potential energy [12] and a method based on the analysis of statistical parameters [13].
It is worth noting that spherical specimens are also used in the so-called random ball test. The random ball test (RBT) is a technique for calibrating spherical wavefronts. In this test, a high-quality ball is measured against the reference surface at its confocal position. Measurements of the sphere are conducted in a number of random orientations. Such an approach averages out errors due to the surface irregularity of the ball [14,15].
However, it should be noted that spherical parts used in bearing industry have much larger surface irregularities than balls used in RBT.

Concept of Radius Change Measurement of Sphericity
The concept of using a typical radius-change instrument to measure sphericity deviations of machine parts was as follows: A typical radius-change measuring instruments commonly applied in the bearing industry, for example, Talyrond 73, was used. Additionally, we equipped the measuring instrument with the unit allowing precise controlled rotation of the sphere. With this unit, we could perform roundness measurements in clearly defined cross-sections of the measured parts. After a series of measurements, we sent the measurement data to the software that combined the measured 2D profiles into a 3D model of the part. The concept is presented in Figure 1.
The concept requires solving a number of various computational problems, such as profile matching and filtering or computing of the reference sphere.
The main reason for computational difficulties is that the sphericity deviation is a 3D problem. The area of measurement and evaluation of roundness deviations, which is a 2D problem, is quite well recognized. Roundness deviations can be conveniently written using polar coordinates R and ϕ, where R is the radius at a given point of the roundness profile, the position of which is described by the angular coordinate ϕ.
Assuming that the radius of a measured circle is much larger than coordinates of the origin of the circle e x and e y , one can write the equation of the reference circle as follows: where R 0 is the mean value of R(ϕ), and e x , e y , and e z are the coordinates of the origin of the circle. Considering Equation (1), a distance of any given point of the roundness profile R (ϕ) from the reference circle can be written as follows:  The concept requires solving a number of various computational problems, such as profile matching and filtering or computing of the reference sphere.
The main reason for computational difficulties is that the sphericity deviation is a 3D problem. The area of measurement and evaluation of roundness deviations, which is a 2D problem, is quite well recognized. Roundness deviations can be conveniently written using polar coordinates R and φ, where R is the radius at a given point of the roundness profile, the position of which is described by the angular coordinate φ.
Assuming that the radius of a measured circle is much larger than coordinates of the origin of the circle ex and ey, one can write the equation of the reference circle as follows: where R0 is the mean value of R(φ), and ex, ey, and ez are the coordinates of the origin of the circle.
Considering Equation (1), a distance of any given point of the roundness profile R(φ) from the reference circle can be written as follows: Solving the problem of measuring sphericity deviations requires a transition from 2D to 3D. Therefore, it is most convenient to analyze this problem using the spherical coordinates S, ϕ, θ, where S is the radius of the sphere at a given point whose position is described by the two angular coordinates ϕ and θ.
Assuming that the radius of the measured sphere is much larger than coordinates of the origin of the sphere e x , e y , e z , the equation of the reference sphere can be written as follows: where S 0 is the mean value of S, and e x , e y , and e z are the coordinates of the origin of the sphere. Considering Equation (3), a distance of any given point of the spherical surface S(ϕ,θ) from the reference sphere can be written as follows: It should be emphasized that the method presented by the authors makes it impossible to easily generalize the equations related to the deviation of roundness into a 3D space. The primary reason for this is that the radius-change measurement is a relative assessment. The measuring instrument does not record the coordinates of the measurement points in the global system; therefore, the roundness profiles in various cross sections of the same part may have significantly different mean values. If we plot the raw measurement data on the diagram, we obtain distorted results, as shown in Figure 2a.
the same part may have significantly different mean values. If we plot the raw measurement data on the diagram, we obtain distorted results, as shown in Figure 2a.
Therefore, it is necessary to perform so-called profile matching. To match the profiles, the coordinates of the intersection of the profiles should be determined first. We know that the values of matched profiles in the points of the intersections should be equal. Using this fact and appropriate functions (e.g., the LinearSolve function of Wolfram Mathematica), we can correct the values of the profiles so that they match each other, as shown in Figure 2b. The solution of the problem of profiles matching is explained in detail in [16]. A full mathematical model of the method has been presented in [17], whereas an example of its practical application for singular spherical part has been published in [18]. In addition, practical verification of the method under industrial conditions has been given in [1]. Therefore, it is necessary to perform so-called profile matching. To match the profiles, the coordinates of the intersection of the profiles should be determined first. We know that the values of matched profiles in the points of the intersections should be equal. Using this fact and appropriate functions (e.g., the LinearSolve function of Wolfram Mathematica), we can correct the values of the profiles so that they match each other, as shown in Figure 2b.
The solution of the problem of profiles matching is explained in detail in [16]. A full mathematical model of the method has been presented in [17], whereas an example of its practical application for singular spherical part has been published in [18]. In addition, practical verification of the method under industrial conditions has been given in [1].
The practical part of the work included the design and construction of the unit for the controlled positioning of the measured sphere. Successful solving of the abovementioned theoretical and practical problems made it possible to evaluate the deviations of the spherical part on the basis of the set of roundness profiles measured in clearly defined cross-sections. There were various measuring strategies tested during the experiment, and finally, the "cage" strategy was selected to be applied for verification of the concept under industrial conditions.

Experiment
To verify a concept experimentally, a system for the accurate positioning of spherical parts was designed and constructed. The system has been described in detail in [18].
The fundamental part of the system is the unit for the controlled rotation of spherical parts. The unit was designed to be mounted on a measuring table of a Talyrond 73. The experiment had two stages: in each stage, a set of 23 spherical parts was measured by the traditional and by the new method, and the aim of the measurements was to determine form deviations of the parts. The traditional method was that commonly applied in industry, i.e., roundness deviation in a random cross-section of the sphere was measured. The diameter of the measured spheres was equal to 50.8 mm. Using the new method enabled the observation of sphericity deviations of the parts. Figure 3 shows the traditional and the new measurement strategies.
After each measurement, data were saved in the computer memory and then transferred to the software, enabling the accurate analysis of sphericity deviations. All procedures allowing the processing of measurement data were developed in Mathematica. Source codes of the selected functions are given in the Appendix A.
Measurements by the traditional method were performed with the use of the instrument MWA series C, by SKF. There were 1024 sampling points taken in one cross-section. The rotational speed of the sensor was equal to 9.837 rev./min. The reference was the least squares circle. The value of the roundness deviation was determined for the unfiltered profiles. For each part, a diagram of the measured profile was plotted as well as a bar chart of the harmonic components. The maximum number of harmonic components was 128.
parts. The unit was designed to be mounted on a measuring table of a Talyrond 73. experiment had two stages: in each stage, a set of 23 spherical parts was measured by traditional and by the new method, and the aim of the measurements was to determ form deviations of the parts. The traditional method was that commonly applied in dustry, i.e., roundness deviation in a random cross-section of the sphere was measu The diameter of the measured spheres was equal to 50.8 mm. Using the new method abled the observation of sphericity deviations of the parts. Figure 3 shows the traditi and the new measurement strategies. After each measurement, data were saved in the computer memory and then tr ferred to the software, enabling the accurate analysis of sphericity deviations. All pr dures allowing the processing of measurement data were developed in Mathema Source codes of the selected functions are given in the Appendix A.
Measurements by the traditional method were performed with the use of the ins ment MWA series C, by SKF. There were 1024 sampling points taken in one cross-sec The rotational speed of the sensor was equal to 9.837 rev./min. The reference was the l squares circle. The value of the roundness deviation was determined for the unfilt profiles. For each part, a diagram of the measured profile was plotted as well as a bar c of the harmonic components. The maximum number of harmonic components was 1

Results
For the traditional method, the total roundness deviation RONt was determi whereas for the new method, the total sphericity deviation was determined. The res of the measurements are given in Tables 1 and 2.

Results
For the traditional method, the total roundness deviation RONt was determined, whereas for the new method, the total sphericity deviation was determined. The results of the measurements are given in Tables 1 and 2.  The results given in Tables 1 and 2       Diagrams shown in Figures 4 and 5 show that values of form deviations obtained by the traditional and the new method can differ significantly. To investigate this difference more precisely, statistical analysis was conducted; this is presented in the next section.

The Statistical Analysis of the Results and Discussion
The statistical analysis of the results was divided into two parts. The first part concerned the comparison of the results obtained with the traditional method and the new method. The second part focused on the study of the differences between the results of roundness measurements in various cross-sections of the same elements.

The Analysis of Differences between the Results Obtained by the New and Traditional Methods
The measurement results given in Tables 1 and 2 were investigated with the use of statistical parameters and tools [19]. For the measurement results given in Tables 1 and 2, the relative difference diff r between the results was calculated according to Equation (5): where Dt is the form deviation obtained by the traditional method, and Dn is the form deviation obtained by the new method. Figures 6 and 7 show the values of relative differences calculated according to Equation (5) for both sets of parts.
Then, the statistical parameters related to the values of the relative differences between the results for both sets of parts were calculated. In this study, the following statistical parameters were analyzed: mean value, maximum value, minimum value and the standard deviation. The values of the parameters mentioned above are given in Table 3.
The next stage of the study was to conduct a statistical comparison of mean values for the results of both measurement series. To conduct this test, the following formula was used: where x av1 is the mean value of relative difference for the first set of parts, x av2 is the mean value of relative difference for the second set of parts, s 1 is the standard deviation of the relative differences for the first set of parts, s 2 is the standard deviation of the relative differences for the second set of parts, and n is the number of parts in one set (n = 23).

ods
The measurement results given in Tables 1 and 2 were investigated with the use of statistical parameters and tools [19]. For the measurement results given in Tables 1 and 2, the relative difference diffr between the results was calculated according to Equation (5): where Dt is the form deviation obtained by the traditional method, and Dn is the form deviation obtained by the new method. Figures 6 and 7 show the values of relative differences calculated according to Equation (5) for both sets of parts.  Then, the statistical parameters related to the values of the relative differences between the results for both sets of parts were calculated. In this study, the following statistical parameters were analyzed: mean value, maximum value, minimum value and the standard deviation. The values of the parameters mentioned above are given in Table 3. Table 3. Statistical parameters of the relative difference between results obtained by new and traditional methods for the first set of parts.

Parameter Name
Parameter Relative difference for the second set of the parts For the test, a confidence level α = 0.05 was assumed and the critical value was t α = 1.717. As shown, the experimental value of t calculated with the use of Equation (6) (t = 1.717) did not exceed the critical value t α = 1.717. Thus, the test indicates that the difference between mean values of the relative difference for both sets of the parts is not statistically significant.
To evaluate the distribution of the relative differences between results for both sets of the parts, histograms were generated. The histograms are shown in Figures 8 and 9.
Sensors 2021, 21, x FOR PEER REVIEW 11 of 20 As shown, the experimental value of t calculated with the use of Equation (6) ( = 1.717) did not exceed the critical value = 1.717. Thus, the test indicates that the difference between mean values of the relative difference for both sets of the parts is not statistically significant.
To evaluate the distribution of the relative differences between results for both sets of the parts, histograms were generated. The histograms are shown in Figures 8 and 9.  Additionally, the function FindDistribution of Wolfram Mathematica was used to find a statistical distribution that fitted the data shown in Figures 8 and 9. Results of the application of the function FindDistribution to measurement data are given in Table 4.  As shown, the experimental value of t calculated with the use of Equation (6) ( = 1.717) did not exceed the critical value = 1.717. Thus, the test indicates that the difference between mean values of the relative difference for both sets of the parts is not statistically significant.
To evaluate the distribution of the relative differences between results for both sets of the parts, histograms were generated. The histograms are shown in Figures 8 and 9.  Additionally, the function FindDistribution of Wolfram Mathematica was used to find a statistical distribution that fitted the data shown in Figures 8 and 9. Results of the application of the function FindDistribution to measurement data are given in Table 4.  Additionally, the function FindDistribution of Wolfram Mathematica was used to find a statistical distribution that fitted the data shown in Figures 8 and 9. Results of the application of the function FindDistribution to measurement data are given in Table 4. Information about the distribution of results can be used to evaluate the confidence intervals of the results for both sets of data.
For the first set of data, the confidence interval ∆ 1 is given by Equation (8): where a is the distribution range. For the measurement data of the first set, the distribution range was equal to a = 178.47%. For the second set of data, the confidence interval ∆ 2 is given by Equation (9): where k is the coverage factor attributed to the assumed distribution and the probability level. For normal distribution and for probability level P = 0.95, the value of the coverage factor k = 1.96. s is the standard deviation in a given set. For the measurement data of the second set, the standard deviation was equal to s = 25%. Table 5 provides the values of the confidence intervals for the measurement results of both sets of parts. Table 5. Confidence intervals for measurement results of both sets of parts.

The Number of the Measurement Dataset Confidence Interval
First set ∆ 1 = ± 178.47 Values given in Table 5 show that the confidence intervals for both measurements of both sets of parts are similar despite the fact that the assumed distributions are different.
Measurement data presented in Tables 1 and 2 and in Figures 4 and 5 show that, for some parts, in both sets, the differences between the measurement results obtained by the traditional way and by the new method are significant. It is noticeable that in most cases the relative difference did not exceed 50%; however, for some parts they were greater than 100%. Analysis of the values given in Table 3 shows that for the first set, the mean value, the maximum value, and the standard deviation were about 50% higher than the relevant values for the second set. The minimum values of diff r for both sets of data were very similar. Despite the differences of basic statistical parameters, the result of the test of mean values indicated that the difference between the mean values of diff r was not statistically significant. Results of the operation of the function FindDistribution (Wolfram Mathematica package) indicated that best fitting distributions for both sets of data were as follows: uniform distribution for the first set and normal distribution for the second set. Nevertheless, the confidence intervals evaluated for both sets were quite similar (51%, 56% for the first set, and 49% for the second set).

Analysis of Differences in Values of the Roundness Deviation in Various Cross-Sections of the Same Spherical Part
The presented method of sphericity measurements is based on the numerical joining of roundness profiles measured in a number of strictly defined cross-sections of a sphere (we call this operation profile matching). Such an approach made it possible to conduct a comparative analysis of the values of the roundness deviation in various cross-sections of the same part. Figure 10 shows the values of the roundness deviation in various crosssections of one of the measured parts (it was the third part in the first dataset). The diagram shown in Figure 10 shows that the values of roundness deviation obtained in various cross-sections of the measured part differed significantly. Therefore, statistical evaluations of the differences in the roundness deviation values in individual cross-sections for each of the measured spheres were performed. For this purpose, the following parameters were determined for each part: minimum value, maximum value, range, mean value and standard deviation. The results of the calculated parameters are presented in Tables 6 and 7. Table 6. Statistical parameters describing the differences between form deviations in subsequent cross-sections of each sphere from the first dataset (all values are given in micrometers).  Roundness deviation (micrometers)

Minimum Value Maximum
The number of the cross-section The diagram shown in Figure 10 shows that the values of roundness deviation obtained in various cross-sections of the measured part differed significantly. Therefore, statistical evaluations of the differences in the roundness deviation values in individual cross-sections for each of the measured spheres were performed. For this purpose, the following parameters were determined for each part: minimum value, maximum value, range, mean value and standard deviation. The results of the calculated parameters are presented in Tables 6 and 7.     Accordingly, Figures 13 and 14 show the average values of the deviations along with their confidence intervals calculated as ±2 s, where s is the standard deviation. Figure 13. Average values of the roundness deviation and their confidence levels (calculated as ± 2 s) for each sphere from the first dataset.    The results presented in Tables 7 and 8 and the graphs presented in  show that there are very large differences in the values of roundness deviation in various sections of the same sphere.
It proves that the value of the roundness deviation for a given part may be very dependent on how the sphere is oriented initially. In the method of sphericity measurements proposed by the authors, the roundness profiles in many cross-sections of the sphere are analyzed and numerically joined. Therefore, in our opinion, this method is a more consistent way of evaluating of form deviations of spherical parts during the manufacturing process.

Conclusions
In previously published studies [16][17][18], researchers have presented the concept of measurements of form deviations of spherical parts with the use of the radius-change method. For the new method, a much larger area of the part is covered with sampling points than for the traditional method. In addition, the radius-change measuring instruments are highly accurate. Therefore, it is reasonable to assume that the new method gives more reliable results than the traditional technique. The aim of the study presented in this paper was to quantitatively assess to what extent the measurement with the new method is more accurate than the measurement with the traditional method. The analysis was performed with the use of statistical tools and parameters for the two sets of data. It is noticeable that for both sets, the results obtained by the traditional and by the new method differed significantly. In addition, the conducted research has shown that the results of measurements made using the traditional method may be strongly dependent on the initial position of the ball.
Thus, the new method can be recommended as a process that provides more reliable results of measurements of spherical parts.
Results of the experiments show that the proposed method is quite easy to apply. Additionally, it can be more user-friendly if the process of rotation of the spherical elements is automated. Considering the possibilities of practical application of the described method, one should note that the proposed measurement system is relatively simple. It requires accurate instruments for radial roundness measurements and a unit for the The results presented in Tables 6 and 7 and the graphs presented in  show that there are very large differences in the values of roundness deviation in various sections of the same sphere.
It proves that the value of the roundness deviation for a given part may be very dependent on how the sphere is oriented initially. In the method of sphericity measurements proposed by the authors, the roundness profiles in many cross-sections of the sphere are analyzed and numerically joined. Therefore, in our opinion, this method is a more consistent way of evaluating of form deviations of spherical parts during the manufacturing process.

Conclusions
In previously published studies [16][17][18], researchers have presented the concept of measurements of form deviations of spherical parts with the use of the radius-change method. For the new method, a much larger area of the part is covered with sampling points than for the traditional method. In addition, the radius-change measuring instruments are highly accurate. Therefore, it is reasonable to assume that the new method gives more reliable results than the traditional technique. The aim of the study presented in this paper was to quantitatively assess to what extent the measurement with the new method is more accurate than the measurement with the traditional method. The analysis was performed with the use of statistical tools and parameters for the two sets of data. It is noticeable that for both sets, the results obtained by the traditional and by the new method differed significantly. In addition, the conducted research has shown that the results of measurements made using the traditional method may be strongly dependent on the initial position of the ball.
Thus, the new method can be recommended as a process that provides more reliable results of measurements of spherical parts.
Results of the experiments show that the proposed method is quite easy to apply. Additionally, it can be more user-friendly if the process of rotation of the spherical elements is automated. Considering the possibilities of practical application of the described method, one should note that the proposed measurement system is relatively simple. It requires accurate instruments for radial roundness measurements and a unit for the controlled rotation of measured spheres. Radial roundness measurement instruments are widespread; therefore, the concept could be easily applied in industrial situations.
In further research on the new method, the authors will focus on determining the uncertainty of the measuring systems. This will be performed using a spherical standard. First, the authors will deal with the calculation of type A uncertainty. Next, the plan is to focus on type B uncertainty.
Author Contributions: Conceptualization, S.A.; methodology and software, D.J.; validation, investigation, writing-original draft preparation, K.S. All authors have read and agreed to the published version of the manuscript.
Funding: This research was funded by National Science Centre, Poland, grant number 317012.
Institutional Review Board Statement: Not applicable.

Informed Consent Statement: Not applicable.
Data Availability Statement: Data supporting the findings of this study are available from the corresponding author on request.

Conflicts of Interest:
The authors declare no conflict of interest.