Development of a PrGO-Modified Electrode for Uric Acid Determination in the Presence of Ascorbic Acid by an Electrochemical Technique
1
Department of Chemistry, Faculty of Science, Universiti Putra Malaysia (UPM), Serdang 43400, Selangor, Malaysia
2
Institute of Advanced Technology (ITMA), Universiti Putra Malaysia (UPM), Serdang 43400, Selangor, Malaysia
*
Author to whom correspondence should be addressed.
Academic Editor: Yogeswaran Umasankar
Sensors 2017, 17(7), 1539; https://doi.org/10.3390/s17071539
Received: 27 April 2017
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Revised: 30 May 2017
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Accepted: 1 June 2017
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Published: 1 July 2017
(This article belongs to the Special Issue Sensors for Health Monitoring and Disease Diagnosis)
An attractive electrochemical sensor of poly(3,4-ethylenedioxythiophene)/reduced graphene oxide electrode (PrGO) was developed for an electrochemical technique for uric acid (UA) detection in the presence of ascorbic acid (AA). PrGO composite film showed an improved electrocatalytic activity towards UA oxidation in pH 6.0 (0.1 M PBS). The PrGO composite exhibited a high current signal and low charge transfer resistance (Rct) compared to a reduced graphene oxide (rGO) electrode or a bare glassy carbon electrode (GCE). The limit of detection and sensitivity of PrGO for the detection of UA are 0.19 μM (S/N = 3) and 0.01 μA/μM, respectively, in the range of 1–300 μM of UA.
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Keywords:
analytical sensor; uric acid; poly(3,4-ethylenedioxythiophene); reduced graphene oxide; differential pulse voltammetry; electrochemistry
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MDPI and ACS Style
Tukimin, N.; Abdullah, J.; Sulaiman, Y. Development of a PrGO-Modified Electrode for Uric Acid Determination in the Presence of Ascorbic Acid by an Electrochemical Technique. Sensors 2017, 17, 1539. https://doi.org/10.3390/s17071539
AMA Style
Tukimin N, Abdullah J, Sulaiman Y. Development of a PrGO-Modified Electrode for Uric Acid Determination in the Presence of Ascorbic Acid by an Electrochemical Technique. Sensors. 2017; 17(7):1539. https://doi.org/10.3390/s17071539
Chicago/Turabian StyleTukimin, Nurulkhalilah, Jaafar Abdullah, and Yusran Sulaiman. 2017. "Development of a PrGO-Modified Electrode for Uric Acid Determination in the Presence of Ascorbic Acid by an Electrochemical Technique" Sensors 17, no. 7: 1539. https://doi.org/10.3390/s17071539
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