4-(7-Bromobenzo[d][1,2,3]thiadiazol-4-yl)morpholine

Dibromoderivatives of benzofused chalcogen-nitrogen heterocycles are important precursors in the synthesis of various photovoltaic materials. 4,7-Dibromobenzo[d][1,2,3]thiadiazole is a practically unexplored compound in this series. In this communication, it was shown that the nucleophilic substitution of 4,7-dibromobenzo[d][1,2,3]thiadiazole with morpholine gave selectively 4-substituted product—4-(7-bromobenzo[d][1,2,3]thiadiazol-4-yl)morpholine. The structure of the newly synthesized compound was established by means of elemental analysis, high resolution mass-spectrometry, 1H, 13C NMR, and IR spectroscopy, mass-spectrometry, and X-ray analysis.


Results and Discussion
A promising precursor of various photovoltaic materials-4,7-dibromobenzo[d] [1,2,3] thiadiazole 1-was easily prepared by a two-step synthesis from commercially available 2-aminobenzenethiol [8,9]. In this communication, its nucleophilic substitution with morpholine was investigated. In this reaction, three products could be formed: two monosubstituted derivatives 2 and 3, and disubstituted compound 4. The literature describes two examples of nucleophilic substitution for its isomer 4,7-dibromobenzo[c] [1,2,5]thiadiazole; it was shown that refluxing in morpholine and piperidine leads to 4-monosubstituted derivatives [10,11].Therefore, the study of the reaction of compound 1 with morpholine began with boiling it in an excess of nucleophile.
Refluxing 4,7-dibromobenzo[d] [1,2,3] thiadiazole 1 in pure morpholine for 18 h (Entry 1, Table 1) led to a single product with a low yield of 35% (Scheme 1). In this case, complete conversion of the starting dibromide was observed, and other products were not isolated. To increase the yield of the product, as well as to reduce the excess of the used nucleophile, we carried out reactions in various solvents (Entries 2-4). We showed that among the investigated solvents, the highest yield was obtained when the reaction was carried out in dimethylsulfoxide (DMSO) (Entry 4). To reduce the excess of morpholine, we added an additional base into the reaction, to intercept the released hydrogen bromide (Entries 5-7). However, it turned out that DABCO (1,4-diazabicyclo[2.2.2]octane) and DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) reduce the overall product yield, while the reaction with Et 3 N yielded 4-(7-bromobenzo[d] [1,2,3]thiadiazol-4-yl) morpholine 2 in a high yield of 83% (Entry 5). The high selectivity of this process should be especially noted-even when the reaction is carried out in pure morpholine, the replacement of the bromine atom located next to the sulfur atom does not occur. Obviously, the reason for the absence of products 3 and 4, in the reaction mixture is the significantly lower reactivity of bromine atoms in position 7 of the heterocycle, compared to the bromine atom in position 4. This is probably due to the greater stabilization of the σ-complex formed upon attack by the nucleophilic agent of the bromine atom in position 4, as compared to the σ-complex, which would lead to the formation of product 3. This is owing to the immediate proximity of the nitrogen atom, which has a higher electronegativity than the sulfur atom and, as a consequence, an enhanced ability to stabilize the negatively charged σ-complex.  Table 1) led to a single product with a low yield of 35% (Scheme 1). In this case, complete conversion of the starting dibromide was observed, and other products were not isolated. To increase the yield of the product, as well as to reduce the excess of the used nucleophile, we carried out reactions in various solvents (Entries 2-4). We showed that among the investigated solvents, the highest yield was obtained when the reaction was carried out in dimethylsulfoxide (DMSO) (Entry 4). To reduce the excess of morpholine, we added an additional base into the reaction, to intercept the released hydrogen bromide (Entries 5-7). However, it turned out that DABCO (1,4-diazabicyclo[2.2.2]octane) and DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) reduce the overall product yield, while the reaction with Et3N yielded 4-(7-bromobenzo[d] [1,2,3]thiadiazol-4-yl) morpholine 2 in a high yield of 83% (Entry 5). The high selectivity of this process should be especially notedeven when the reaction is carried out in pure morpholine, the replacement of the bromine atom located next to the sulfur atom does not occur. Obviously, the reason for the absence of products 3 and 4, in the reaction mixture is the significantly lower reactivity of bromine atoms in position 7 of the heterocycle, compared to the bromine atom in position 4. This is probably due to the greater stabilization of the σ-complex formed upon attack by the nucleophilic agent of the bromine atom in position 4, as compared to the σ-complex, which would lead to the formation of product 3. This is owing to the immediate proximity of the nitrogen atom, which has a higher electronegativity than the sulfur atom and, as a consequence, an enhanced ability to stabilize the negatively charged σ-complex.  The structure of 4-(7-bromobenzo[d][1,2,3]thiadiazol-4-yl)morpholine 2 was confirmed by means of high resolution mass-spectrometry, 1 H, 13 C NMR, IR, and UV spectroscopy, mass-spectrometry, and X-ray analysis (Figure 1) (see Supplementary Materials).
The structure of 4-(7-bromobenzo[d] [1,2,3]thiadiazol-4-yl)morpholine 2 was confirmed by means of high resolution mass-spectrometry, 1 H, 13 C NMR, IR, and UV spectroscopy, mass-spectrometry, and X-ray analysis (Figure 1) (see Supplementary Materials). IR spectra were measured with a Bruker "Alpha-T" instrument in KBr pellet. Highresolution MS spectra were measured on a Bruker micrOTOF II instrument (Bruker Daltonik Gmbh, Bremen, Germany) using electrospray ionization (ESI). The measurement was performed in a positive ion mode (interface capillary voltage -4500 V) or in a negative ion mode (3200 V); mass range was from m/z 50 to m/z 3000 Da; external or internal calibration was performed with Electrospray Calibrant Solution (Fluka). Syringe injection was used for solutions in acetonitrile, methanol, or water (flow rate 3 L/min -1 ). Nitrogen was applied as a dry gas; the interface temperature was set at 180 °C. Solution UV-visible absorption spectra were recorded using a OKB Spektr SF-2000 UV/Vis/NIR spectrophotometer controlled with SF-2000 software. All samples were measured in a 1 cm quartz cell at room temperature with 1 × 10 −4 mol mL −1 concentration in CH2Cl2.
Crystal structure determination was performed in the Department of Structural Studies of Zelinsky Institute of Organic Chemistry, Moscow. X-ray diffraction data were collected at 100 K on a Bruker Quest D8 diffractometer equipped with a Photon-III area-detector (graphite monochromator, shutterless φ-and ω-scan technique), using Mo K-radiation (0.71073 Å). The intensity data were integrated by the SAINT program and were corrected for absorption and decay using SADABS. The structure was solved by direct methods using SHELXS-2013 and refined on F 2 using SHELXL-2018. All non-hydrogen atoms were refined with individual anisotropic displacement parameters. The positions of all hydrogen atoms were found from the electron density-difference map, these atoms were refined with individual isotropic displacement parameters. The Cambridge Crystallographic Data Centre contains the supplementary crystallographic data for this paper No. CCDC 2073153. These data can be obtained free of charge via In conclusion, it was shown that the nucleophilic substitution of 4,7-dibromobenzo[d]-[1,2,3]thiadiazole 1 is regioselective and led to 4-monosubstituted derivative. This reaction opens up possibilities to synthesize functional derivatives of benzo[d] [1,2,3]thiadiazoles, which may be of interest as compounds with useful physical properties. [1,2,3]thiadiazole 1 was prepared according to the published method [9].The solvents and reagents were purchased from commercial sources and used as received. Elemental analysis was performed on a 2400 Elemental Analyzer (Perkin Elmer Inc., Waltham, MA, USA). Melting point was determined on a Kofler hot-stage apparatus and is uncorrected. 1 H and 13 C NMR spectra were taken with a Bruker AM-300 machine (Bruker AXS Handheld Inc., Kennewick, WA, USA) (at frequencies of 300 and 75 MHz) in CDCl 3 solution, with TMS as the standard. J values are given in Hz. MS spectrum (EI, 70 eV) was obtained with a Finnigan MAT INCOS 50 instrument (Hazlet, NJ, USA). IR spectra were measured with a Bruker "Alpha-T" instrument in KBr pellet. High-resolution MS spectra were measured on a Bruker micrOTOF II instrument (Bruker Daltonik Gmbh, Bremen, Germany) using electrospray ionization (ESI). The measurement was performed in a positive ion mode (interface capillary voltage −4500 V) or in a negative ion mode (3200 V); mass range was from m/z 50 to m/z 3000 Da; external or internal calibration was performed with Electrospray Calibrant Solution (Fluka). Syringe injection was used for solutions in acetonitrile, methanol, or water (flow rate 3 L/min −1 ). Nitrogen was applied as a dry gas; the interface temperature was set at 180 • C. Solution UV-visible absorption spectra were recorded using a OKB Spektr SF-2000 UV/Vis/NIR spectrophotometer controlled with SF-2000 software. All samples were measured in a 1 cm quartz cell at room temperature with 1 × 10 −4 mol mL −1 concentration in CH 2 Cl 2 .

4,7-Dibromobenzo[d]
Crystal structure determination was performed in the Department of Structural Studies of Zelinsky Institute of Organic Chemistry, Moscow. X-ray diffraction data were collected at 100 K on a Bruker Quest D8 diffractometer equipped with a Photon-III areadetector (graphite monochromator, shutterless ϕand ω-scan technique), using Mo Kradiation (0.71073 Å). The intensity data were integrated by the SAINT program and were corrected for absorption and decay using SADABS. The structure was solved by direct methods using SHELXS-2013 and refined on F 2 using SHELXL-2018. All nonhydrogen atoms were refined with individual anisotropic displacement parameters. The positions of all hydrogen atoms were found from the electron density-difference map, these atoms were refined with individual isotropic displacement parameters. The Cambridge Crystallographic Data Centre contains the supplementary crystallographic data for this paper No. CCDC 2073153. These data can be obtained free of charge via http://www.ccdc.cam.ac.uk/conts/retrieving.html (or from the CCDC, 12 Union Road, Cambridge CB2 1EZ, UK; Fax: +44 1223 336033; E-mail: deposit@ccdc.cam.ac.uk).