Oral–Gut Microbiota, Periodontal Diseases, and Arthritis: Literature Overview on the Role of Probiotics

Periodontal diseases are oral inflammatory diseases affecting the tissues supporting and surrounding the teeth and include gingivitis and periodontitis. Oral pathogens may lead to microbial products spreading into the systemic circulation and reaching distant organs, while periodontal diseases have been related to low-grade systemic inflammation. Gut and oral microbiota alterations might play a role in the pathogenesis of several autoimmune and inflammatory diseases including arthritis, considering the role of the gut–joint axis in the regulation of molecular pathways involved in the pathogenesis of these conditions. In this scenario, it is hypothesized that probiotics might contribute to the oral and intestinal micro-ecological balance and could reduce low-grade inflammation typical of periodontal diseases and arthritis. This literature overview aims to summarize state-of-the-art ideas about linkages among oral–gut microbiota, periodontal diseases, and arthritis, while investigating the role of probiotics as a potential therapeutic intervention for the management of both oral diseases and musculoskeletal disorders.


Introduction
Periodontal diseases are oral inflammatory diseases affecting the tissues supporting and surrounding the teeth and include gingivitis and periodontitis [1,2]. Furthermore, gingivitis is associated with bleeding, swollen gums, and pain, whereas periodontitis is related to the loss of periodontal attachment and supporting bone [3]. The latter is often considered a "silent disease" due to the absence of symptoms that characterize the clinical presentation. However, if untreated, the inflammatory condition of periodontitis can lead to tooth loss, with a consequent impairment in mastication function, esthetics, self-confidence, and quality of life [4,5]. The prevalence of periodontal diseases is estimated to range from 20% to 50% worldwide, emerging as the 11th most prevalent condition in the world as reported by the Global Burden of Disease Study of 2016 [6]. Therefore, this detrimental condition is currently considered as a global health problem [7,8].
In this scenario, the first step is understanding the mechanisms underpinning the etiopathogenesis of periodontal diseases, considering that the local inflammatory response might be perpetuated by several oral pathogens (e.g., A. actinomycetemcomitans, P. intermedia, P. gingivalis, T. denticola, F. nucleatum, and T. forsyth) [9][10][11].
High levels of bacteria present in the dysbiotic biofilm in periodontitis might also play a role in the pathogenesis of autoimmune diseases [18][19][20]. In this context, recent studies reported a link between periodontitis and rheumatoid arthritis (RA), considering the higher prevalence of RA in these patients and the correlation between the severity of arthritis and periodontitis [19]. Indeed, it was reported that P. gingivalis has been implicated in the generation of anticyclic citrullinated peptide antibodies (ACPAs), which are recognized as diagnostic and prognostic biomarkers for RA patients [20]. Moreover, Zhou et al. [19] suggested that the downregulation of IL-10 could represent the key mechanism by which periodontitis may promote RA.
Several scientific studies showed that gut and oral microbiota alterations might play a role in the pathogenesis of several autoimmune and inflammatory diseases [21][22][23][24].
Although the pathophysiological mechanisms underpinning the interactions among oral-gut microbiota have still not been characterized in detail, it has been hypothesized that dietary supplements including probiotics could contribute to the oral and intestinal microecological balance [26,[32][33][34]. However, to date, there is still a large gap of knowledge about the optimal management of oral and gut dysbiosis. Therefore, the present literature overview aims to summarize the current scientific evidence on correlations among oral-gut microbiota, periodontal diseases, and arthritis, exploring the role that probiotics might play as a therapeutic intervention for oral diseases and musculoskeletal disorders. Although the pathophysiological mechanisms underpinning the interactions among oral-gut microbiota have still not been characterized in detail, it has been hypothesized that dietary supplements including probiotics could contribute to the oral and intestinal micro-ecological balance [26,[32][33][34]. However, to date, there is still a large gap of knowledge about the optimal management of oral and gut dysbiosis.
Therefore, the present literature overview aims to summarize the current scientific evidence on correlations among oral-gut microbiota, periodontal diseases, and arthritis, exploring the role that probiotics might play as a therapeutic intervention for oral diseases and musculoskeletal disorders.

Oral-Gut Microbiome and Periodontal Diseases
Microbiota includes microbial communities colonizing the mucosae (such as the intestinal tract, reproductive organs, and the respiratory tract) and the skin, for a total of more than 100 trillion microbial cells that encode 100-fold more unique genes than the human genome [35][36][37]. Microbiota colonization appears in the early years of life and

Oral-Gut Microbiome and Periodontal Diseases
Microbiota includes microbial communities colonizing the mucosae (such as the intestinal tract, reproductive organs, and the respiratory tract) and the skin, for a total of more than 100 trillion microbial cells that encode 100-fold more unique genes than the human genome [35][36][37]. Microbiota colonization appears in the early years of life and changes rapidly, until it becomes unique for each person, then remains relatively stable in adulthood [38]. The oral cavity is one of the most complex ecosystems in the body due to its repeated interaction with the external environment, as well as containing several different microbial habitats, both hard tissues (i.e., the teeth) and soft tissues (i.e., the buccal mucosa, the tongue, the soft and hard palates, and the gingiva) and their respective interfaces (i.e., the supragingival and subgingival margins) [39].
The oral microbiome is estimated to be the second most divergent and abundant after the gut microbiota, considering that it is mainly composed of bacteria, viruses, fungi, protozoa, and archaea; indeed, in the oral cavity of humans, 700 bacterial species, belonging to 185 genera and 12 phyla, have been identified [39]. The oral microbiome includes different phyla consisting of Firmicutes (including Streptococcus), Bacteroidetes (strongly represented by Prevotella), Proteobacteria, Fusobacteria, and Actinobacteria [40]. These bacteria commonly coexist and thrive by forming a biofilm and living in a symbiotic state of co-aggregation, thus maintaining the homeostasis of the oral ecosystem; furthermore, it should be noted that the plaque biofilm can create an adequate balance among the pathogens and commensals and is highly resistant to the environmental stimuli [41][42][43].
Furthermore, fungi are an integral part of a healthy oral microbiota, where commensal fungi entertain a multitude of synergic or antagonistic interactions with bacteria. It is estimated that more than 100 species of fungi colonize the oral cavity (e.g., Candida species, Cladosporium, Aureobasidium, Saccharomyces, Aspergillus, Fusarium, and Cryptococcus), and only in immunocompromised subjects or specific conditions (especially drug abuse) can they become opportunistic pathogens [44,45].
Interestingly, the oral microbiome might be affected not only by the overall health condition of the host but also by environmental and behavioral factors including oral hygiene, nutrition, smoking, and mechanical stress [46]. In particular, the regular consumption of beverages and food with elevated levels of polyphenols (e.g., tea, cranberry, and almond) have been shown to inhibit some oral pathogenic bacteria [47,48]. Meanwhile, Esberg et al. reported that some species, including Actinomyces, Bifidobacterium, Veillonella, and Streptococcus (e.g., S. wiggsiae, S. mutans, and S. sobrinus) were frequently associated with high sucrose intake [49].
The gut microbiota shows several differences compared to the oral one, including pH and O 2 tension, host secretions, substrate availability, and digest flow rates [50]. It should be noted that the gastric tract (median pH 1.4) is mainly colonized by Actinobacteria, Bacteroidetes, Firmicutes (including Streptococcus), and Proteobacteria (which include Helicobacter pylori) in healthy subjects [51]. The large intestine hosts the most abundant microbial community, probably because of the slow flow rates and the neutral-to-mildlyacidic pH [52], while the main gut bacterial phyla are the Firmicutes (including Clostridium, Enterococcus, Lactobacillus, and Ruminococcus genera), Bacteroidetes (including Prevotella genera), Actinobacteria, Proteobacteria, and Fusobacteria [37]. However, several pathological conditions might occur in response to the loss of the balance within a human-associated gut microbiota; such gut dysbiosis might be closely related to inflammatory bowel disorders (e.g., Crohn's disease), esophagitis, Barrett's esophagus, vaginitis, type 2 diabetes, arthritis, autism, neurodegenerative diseases, and cancer [24,35,[53][54][55]. Furthermore, gut microorganisms may stimulate regulatory cells of the immune system to inhibit inflammation and provide a natural defense against pathogenic species through competition [56,57].
Poor oral hygiene is strictly related to oral microbiota modifications, especially in subgingival communities. In this context, Gram-negative species (e.g., Prevotella, Selenomonas, and F. nucleatum) can significantly increase after 2-3 weeks of plaque accumulation, and clinical inflammation of the gingiva is a common clinical presentation of this condition [58]. On the other hand, the depletion of Gram-positive species (e.g., R. dentocariosa, Propionibacterium, and S. maltophila) has negative implications for oral health [58].
Furthermore, the development of periodontitis has been associated with the accumulation of different Gram-negative species compared to gingivitis. In 1998, Socransky et al. [59] identified "the red complex" including three different bacteria species (Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola) closely related to the arousal of clinical signs and symptoms of periodontitis, and strictly associated with the severity of the disease. In recent years, periodontitis has been correlated with several pathogens, such as F. alocis, Porphyromonas, Synergistetes, Peptostreptococcaceae, and A. actinomycetemcomitans, associated with aggressive periodontitis [60][61][62][63].
Moreover, a strict relationship has been hypothesized among members of the oral microbiome, which shows both antagonistic and synergistic interactions. For instance, Fusobacterium nucleatum was shown to increase the survivability of the periodontal pathogen, P. gingivalis [64], while T. denticola seems to benefit from the succinate produced by P. gingivalis [65]. Furthermore, T. denticola and P. gingivalis concentrations increase significantly in co-culture; indeed, alterations to glycine and glutamate catabolism by T. denticola, as well as changes to thiamine pyrophosphate and fatty acid synthesis by P. gingivalis, have been observed [63,66].

Gut-Microbiota and Musculoskeletal Health: "Gut-Joint Axis"
Recent evidence has focused on the impact of gut microbiota on musculoskeletal health, highlighting the role of the "gut-joint axis" in the regulation of the pathogenic pathways of musculoskeletal conditions [25,26,73,74]. However, to date, the longevity has been negatively correlated with increased alpha diversity in gut microbiota, with recent research focusing on "leaky gut syndrome", an aged-related condition characterized by increased gut permeability, resulting in microbial products spreading in the bloodstream and an increase in inflammatory states [74][75][76].
Although several questions are still open about the role of the leaky gut syndrome in the development and progression of osteoarthritis (OA), serum levels of bacterial metabolites might be correlated with joint degeneration in OA patients [23]. Inflammation serum markers in patients with OA are positively associated with bacterially produced lipopolysaccharides (LPS), supporting the hypothesis of a role of microbiota-induced systemic inflammation in several pathways underpinning the development of OA [77,78]. Therefore, these findings suggested that gut dysbiosis, especially in the elderly, might be strictly linked to OA pathogenesis, and the gut-joint axis might be a potentially modifiable cofactor to be targeted by a comprehensive therapeutic intervention [21][22][23]79]. In line with these findings, the expert consensus of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) has recently supported the hypothesis that gut microbiota alterations might be considered as hidden risk factors for the development and progression of OA [79]. In this context, it has been proposed that gut microbiota modulation might have positive effects on OA [25]. Furthermore, a recent study on mice underlined that probiotic administration might significantly reduce proinflammatory cytokine production in knee cartilage [80]. Similarly, a probiotic diet might be effective in modulating prostaglandin-endoperoxide synthase 2 (PTGS2) and transforming growth factor-beta (TGF-β), with intriguing implications for targeting low-grade systemic inflammation promoted by dysbiosis in patients with OA [80]. In accordance with these findings, gut microbiota might be crucially affected by dietary supplements, with several studies underlining the positive effects of nutraceuticals in promoting health status in older adults, particularly in the case of early diagnoses [23,81].
The main linking factor between gut microbiota and OA seems to be represented by low-grade chronic inflammation, supporting a new OA phenotype called "metabolic OA", where several pro-inflammatory stimuli are associated with drastic changes in the composition of the intestinal microbiota [22]. Thus, aging might play a key role in intestinal microbiota composition, inducing reduced phyla diversity, a greater proportion of Bacteroides spp., and a distinct abundance of Clostridium groups [82].
In the last decade, a growing literature showed that the alteration of gut and oral cavity microbiota could have a detrimental impact on the pathogenesis of autoimmune and inflammatory joint diseases, such as OA and rheumatoid arthritis (RA) [21][22][23]. Increased inflammation is a relevant pathophysiological mechanism in RA and the potential correlation between serum levels of bacterial metabolites and joint degeneration is a crucial issue for future investigation [83,84].
Furthermore, several components of intestinal microbiota might affect host immunity, particularly in patients with autoimmune diseases such as RA [85][86][87]. The correlation between intestinal immune cell activation and arthritis is based on the potential migration of gut-derived immune cells to the joints, provoking an impairment in terms of differentiation of T cell types (i.e., Treg cells) involved in the pathogenesis of RA [86][87][88][89].
Specifically, it has been hypothesized that gut dysbiosis might be a mediator for inflammation in the temporomandibular joint (TMJ) by regulating the microglial activation in the trigeminal nociceptive system [90,91]. Moreover, it should be noted that TMJ inflammation commonly leads to temporomandibular disorders (TMDs), which are considered a sub-classification of musculoskeletal disorders commonly treated with conservative approaches [91][92][93]. Furthermore, RA might affect TMJ by causing disease-related symptoms, with a correlation between laboratory values of various inflammatory biomarkers causing rheumatic diseases and the progression of TMD [94][95][96][97][98][99].
Scher et al. [100] compared the composition of subgingival microbiota in patients with RA against controls and revealed that Prevotella and Leptotrichia species might characterize patients with RA. Meanwhile, distinct subgingival microbiota was found in RA patients without periodontal diseases, suggesting that changes in oral microbiota might be RAspecific [101][102][103][104]. Furthermore, it has been demonstrated that serum antibodies against P. gingivalis could increase during the preclinical phase, becoming stable after the diagnosis of RA [105,106]. Thus, an association between periodontal bacteria exposure and RA autoantibody development might represent an emerging research topic in the future [106].
A growing literature now seems to support the role of oral-gut microbiota in inflammatory conditions (i.e., OA, RA, and TMJ arthritis); however, several questions are still open in this field and future studies are needed to better characterize this concept.

Impact of Probiotics on Oral Microbiota and Periodontal Diseases
Probiotics are defined as living microorganisms that can have beneficial effects on the host when taken in sufficient doses [107]. They are available in several food products, such as yogurts, milk-based foods, powders, capsules, and oral solutions [108].
Moreover, the scientific literature is focused on the use of probiotic strains (e.g., Lactobacillus, Bifidobacterium, Escherichia, Enterococcus, and B. subtilis) and yeasts (e.g., Saccharomyces) in the maintenance of gastrointestinal microbiota balance. Figure 2 summarizes the effects of probiotics in oral and gut dysbiosis management, including restoration of the epithelial membrane resulting in a reduction of systemic inflammation. Probiotic supplements with a concentration of 10 7 -10 8 cells per gram could play a role in the treatment of inflammatory chronic diseases [107][108][109]. Indeed, recent evidence showed that probiotics might reinforce the epithelial barrier, thus allowing fibroblastic activity and epithelial cell migration [109,110]. Probiotic supplements with a concentration of 10 7 -10 8 cells per gram could play a role in the treatment of inflammatory chronic diseases [107][108][109]. Indeed, recent evidence showed that probiotics might reinforce the epithelial barrier, thus allowing fibroblastic activity and epithelial cell migration [109,110].
Interestingly, probiotics that have a role in oral health are concentrated in the genera Streptococcus, Lactobacillus, Bifidobacterium, Weissella, B. subtilis, and S. cerevisiae, with their therapeutic use in dentistry growing significantly in recent years [111].
Several microorganisms isolated from the oral cavity are commercially produced as oral health-promoting probiotics, including L. reuteri, L. brevis, and S. salivarius, and their effectiveness is shown in the management of dental caries, oral candida infection, halitosis, and periodontal diseases [107,[112][113][114][115].
Recently, Liu et al. [116] performed a systematic review and meta-analysis of randomized controlled trials (RCTs) on the effects of probiotics on gingival inflammation and oral microbiota composition in patients suffering from plaque-induced gingivitis. The authors included 11 RCTs with a total of 554 patients, reporting that the oral probiotics had no significant improvement in the Gingival Index (GI), Plaque Index (PI), and bleeding on probing (BOP) in patients affected by plaque-induced gingivitis. Moreover, no significant differences were found in the amount of P. gingivalis, A. actinomycetemcomitans, P. intermedia, and F. nucleatum between the probiotic group and the placebo group. Their findings were in line with another systematic review and meta-analysis by Hardan et al. [117] on the use of probiotics as an adjuvant therapy within clinical periodontal parameters. The authors showed that the use of probiotics did not improve the PI (p = 0.16). However, the systematic review also assessed the efficacy of probiotics as an adjuvant therapy in the treatment of periodontitis, and showed significant improvement in terms of PPD, CAL, and BOP (p < 0.001).
In line with these results, the effects of probiotics on the management of periodontal diseases were reported by several other studies [118][119][120]. Tekce et al. [119] evaluated the effectiveness of L. reuteri as an adjuvant treatment for chronic periodontitis patients, evaluating the clinical effects on periodontal tissues. The authors reported that plaque index, gingival index, bleeding on probing, and probing depth were significantly lower (p < 0.05) in the study group compared with controls at all time points [119].
In 2018, Invernici et al. [121] evaluated the effect of Bifidobacterium animalis subsp. lactis HN019 as an adjuvant to scaling and root planing (SRP) in patients with generalized chronic periodontitis (with 30% or more of the sites with probing pocket depth ≥ 4 mm and clinical attachment level ≥ 4 mm, and a minimum of five teeth with at least one site with CAL and PPD ≥ 5 mm). By collecting gingival crevicular fluid they determined the levels of IL-1β, IL-10, and IL-8. Furthermore, they evaluated the microbiota changes after probiotic therapy. The authors showed that subjects who underwent probiotic therapy reported higher levels of IL-10 than those at baseline at 30 days (p < 0.05) and showed greater amounts of Actinomyces naeslundii and Streptococcus mitis, and lower amounts of P. gingivalis, T. denticola, F. nucleatum, C. showae, and E. nodatum in deep periodontal pockets (p < 0.05) [121].
In 2020, the same research group evaluated the effects of Bifidobacterium animalis subsp. lactis HN019 in generalized chronic periodontitis patients [122]. They analyzed the immunocompetence of the gingival tissues by evaluating the expression of beta-defensin (BD)-3, toll-like receptor 4 (TLR4), and cluster of differentiation (CD)-57 and CD-4. Plaque accumulation, gingival bleeding, and the antimicrobial properties of HN019 were analyzed. Their results showed that subjects who underwent probiotic therapy presented with a lower PI at 30 days and had lower marginal gingival bleeding at 90 days (p < 0.05); in addition, increased BD-3, TLR4, and CD-4 expression in periodontal tissues were reported. Lastly, the findings showed a lower mean adhesion of P. gingivalis together with B. lactis HN019 to buccal epithelial cells (p < 0.05).
In this context, as depicted by Table 1, the oral microbiota could represent a potential target for probiotic supplementation to reduce the risk of periodontal diseases.
However, the role of probiotics in humans affected by inflammatory joint diseases is still debated in the scientific literature. In 2017, Mohammed et al. [124] performed a systematic review and meta-analysis of randomized or quasi-randomized clinical trials on the effect of probiotics on the treatment of RA. The authors included six randomized and controlled trials and three quasi-RCTs, with a total of 361 patients. Their results showed that oral probiotics lowered the pro-inflammatory cytokine IL-6 (SMD-0.708, 95% CI-1.370 to 0.047, p = 0.036), which is an indicator for joint destruction in RA, but no significant differences were found in disease activity score (DAS) and swollen joint count (SJC) between the probiotic and placebo groups.
Another recent systematic review with a meta-analysis performed by Zeng et al. [123] showed that the use of probiotics did not improve clinical variables such as DAS (p = 0.17) and swollen joint counts (p = 0.71) in patients. However, they assessed the efficacy of probiotics on inflammatory markers in RA and showed significantly lower levels of CRP (SMD −1.57 (−2.98, −0.15; p = 0.03)), highlighting the potential role of curcumin in CRP reduction [123]. Furthermore, Mandel et al. [127] demonstrated that the administration of B. coagulans to RA patients was effective in reducing the patient pain assessment score and the pain scale (p = 0.052 and 0.046, respectively). Moreover, a randomized, double-blind, placebo-controlled clinical trial showed the effects of L. casei on RA activity and inflammatory cytokines in women [128]. The authors demonstrated an improvement in the DAS (p < 0.01) associated with a reduction of serum levels, TNF-α, IL-6, and IL-12 (p < 0.05), and an increase of IL-10 (p < 0.05) in the group supplemented with probiotics [128]. Furthermore, Alipour et al. [129] treated patients with L. casei and found improvements in CRP levels, tender/swollen joint counts, and DAS28 compared to a placebo (p < 0.05). Zamani et al. [130] also demonstrated that patients who received a daily capsule containing three viable and freeze-dried strains (L. acidophilus, L. casei, and B. bifidum) showed an improvement in DAS28 (−0.3 ± 0.4 vs. −0.1 ± 0.4, p = 0.01) and serum high-sensitivity C-reactive protein (hs-CRP) concentrations (−6.66 ± 2.56 vs. +3.07 ± 5.53 mg/L, p < 0.001) compared with a placebo. Moreover, Cannarella et al. [131] demonstrated an exertive role of supplementing with a mixture of probiotics (L. acidophilus, L. casei, L. lactis, B. lactis, and B. bifidus) on TNF-α (p = 0.004) and IL-6 (p < 0.05), but no effect on DAS28 (p > 0.05). On other hand, a pilot study conducted by Hataka et al. [132] demonstrated that Lactobacillus rhamnosus administration did not show a statistically significant difference in the activity of RA in terms of both clinical variables and inflammatory markers. In accordance with this result, Pineda et al. [133] showed a non-significant decreasing trend in serum levels of IL-1α, IL-6, IL-10, IL-12, TNF-α, and Monocyte chemoattractant protein-1 (MCP-1) following L. rhamnosus combined with L. reuteri treatment in RA patients.
Concerning the use of probiotics in patients affected by spondyloarthritis, two studies affirmed no significant decrease in any disease activity markers such as the Bath Ankylosing Spondylitis Functional Index (BASFI) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), ASAS-endorsed core domains, global health status, and CRP after probiotic intervention compared with a placebo (p > 0.05) [134,135]. As mentioned above, OA can be considered a persistent low-grade inflammation of the joints. Thus, over the past few years, there has been a growing interest in the role of the probiotics in OA therapy [136,137]. An important link between gut microbiota and patient' clinical features highlighted the possibility of positively interfering with disease progression and presentation with microbiota modulation [26]. To date, mouse model studies on the use of probiotics, such as C. butyricum, L. casei, L. acidophilus, L. fermentum, L. paracasei, S. thermophilus, B. longum, B. bifidum, B. breve, L. rhamnosus, L. plantarum, L. helveticus, and L. salivarius, have demonstrated a positive role in the preservation of knee cartilage, synovial membrane, and fibrous tissue. Moreover, this supplementation significantly lowered serum levels of inflammatory and bone metabolism markers (such as metalloproteinases, cyclooxygenase-2, leukotriene B4, and cartilage oligomeric matrix protein) and inflammatory cytokines (such as IL-1β, IL-2, IL-6, IL-12, IL-17, TNF-α, and IFN-γ), while increasing levels of anti-inflammatory cytokines (IL-4 and IL-10) and anti-IFN-γ and glycosaminoglycans [138][139][140][141][142][143]. Meanwhile, a large RCT considered the effects of L. casei Shirota in human patients with knee OA who were asked to ingest either skimmed milk containing the probiotic or the placebo daily for 6 months. The study demonstrated an improvement in The Western Ontario and McMaster Universities Arthritis Index (WOMAC) in the intervention group (p < 0.05) [137].
Taken together, gut microbiome dysbiosis might be considered important in the pathogenic mechanism of inflammatory joint diseases both in terms of onset and progression; moreover, probiotics might play a role in the complex management of such chronic inflammatory diseases.
Accordingly, in Table 2 we describe the evidence for the role of probiotics in patients affected by musculoskeletal disorders.

Conclusions
This literature overview aimed to summarize the evidence on potential correlation among oral-gut microbiota, periodontal diseases, and arthritis, with an interest on the impact of probiotics on low-grade inflammation.
The scientific literature showed that poor oral hygiene can be correlated to oral microbiota modifications (e.g., F. alocis, Porphyromonas, Synergistetes, Peptostreptococcaceae, and A. actinomycetemcomitans) with a linkage between the accumulation of different Gramnegative species and the onset of periodontal diseases. Moreover, considering the role of the gut-joint axis in regulating molecular pathways involved in the pathogenesis of several musculoskeletal conditions (e.g., OA, RA, and TMJ arthritis), the microbiome may influence the pathogenesis of musculoskeletal diseases.
Although the pathophysiological mechanisms underpinning these interactions have not been fully characterized, a growing literature has been supporting the hypothesis of therapeutic action with dietary supplements and probiotics (e.g., E. faecium, L. casei, L. plantarum, B. longum, Bifidobacteria, P. histicola, L. acidophilus, L. helveticus, B. adolescentis, and L. fermentum) for the treatment of chronic inflammatory diseases.
In conclusion, in this paper, we described state-of-the-art findings from the scientific literature on the role of probiotics in the prevention and management of dysbiosis-related disorders. We consider that the gut-oral microbiota could be a new target for patients affected by periodontal diseases and arthritis in future.
However, it should be noted that there is still a gap in the scientific knowledge, not only on the role of oral microbiota in the pathogenesis of inflammation, but also on interactions among microbiota and other systemic conditions. Thus, further observational studies are needed to define, firstly, the specific target and, secondly, the impact of probiotics on patients affected by inflammatory diseases.