Towards Anion Recognition and Precipitation with Water-Soluble 1,2,4-Selenodiazolium Salts: Combined Structural and Theoretical Study

The synthesis and structural characterization of a series of supramolecular complexes of bicyclic cationic pyridine-fused 1,2,4-selenodiazoles with various anions is reported. The binding of trifluoroacetate, tetrachloroaurate, tetraphenylborate, perrhenate, and pertechnetate anions in the solid state is regarded. All the anions interact with selenodiazolium cations exclusively via a pair of “chelating” Se⋯O and H⋯O non-covalent interactions, which make them an attractive, novel, non-classical supramolecular recognition unit or a synthon. Trifluoroacetate salts were conveniently generated via novel oxidation reaction of 2,2′-dipyridyl diselenide with bis(trifluoroacetoxy)iodo)benzene in the presence of corresponding nitriles. Isolation and structural characterization of transient 2-pyridylselenyl trifluoroacetate was achieved. X-ray analysis has demonstrated that the latter forms dimers in the solid state featuring very short and strong Se⋯O and Se⋯N ChB contacts. 1,2,4-Selenodiazolium trifluoroacetates or halides show good solubility in water. In contrast, (AuCl4)−, (ReO4)−, or (TcO4)− derivatives immediately precipitate from aqueous solutions. Structural features of these supramolecular complexes in the solid state are discussed. The nature and energies of the non-covalent interactions in novel assembles were studied by the theoretical methods. To the best of our knowledge, this is the first study that regards perrhenate and pertechnetate as acceptors in ChB interactions. The results presented here will be useful for further developments in anion recognition and precipitation involving cationic 1,2,4-selenodiazoles.


Introduction
The search for new anion receptors and exploration of novel modes of anion binding is a topic of considerable interest in supramolecular chemistry. Design and synthesis Electrophilic reagents 2 and 3 could be easily generated via oxidation of diselenide 1 by Br2 or SO2Cl2 (Scheme 1). Within this work, we show that the treatment of 1 with bis(trifluoroacetoxy)iodo)benzene (PIFA) in Et2O results in the Se-Se bond cleavage and formation of 2-pyridylselenyl trifluoroacetate 4 (Scheme 1). When the reaction was performed in acetonitrile, trichloroacetonitrile, or hexanenitrile, the corresponding adduct 5-7 gradually precipitated from the reaction mixtures (Scheme 1), which suggested that in situ generated 4 rapidly reacts with nitriles and its isolation is not necessary. This simple methodology allowed the preparation of selenodiazolium salts 4-7, which contained trifluoroacetate anion. Compounds 4-7 precipitate from the reaction mixtures, as well-shaped crystals suitable for the X-ray structural analysis ( Figure 1). Compounds 4-7 precipitate from the reaction mixtures, as well-shaped crystals suitable for the X-ray structural analysis ( Figure 1).
Electrophilic reagents 2 and 3 could be easily generated via oxidation of diselenide 1 by Br2 or SO2Cl2 (Scheme 1). Within this work, we show that the treatment of 1 with bis(trifluoroacetoxy)iodo)benzene (PIFA) in Et2O results in the Se-Se bond cleavage and formation of 2-pyridylselenyl trifluoroacetate 4 (Scheme 1). When the reaction was performed in acetonitrile, trichloroacetonitrile, or hexanenitrile, the corresponding adduct 5-7 gradually precipitated from the reaction mixtures (Scheme 1), which suggested that in situ generated 4 rapidly reacts with nitriles and its isolation is not necessary. This simple methodology allowed the preparation of selenodiazolium salts 4-7, which contained trifluoroacetate anion. Compounds 4-7 precipitate from the reaction mixtures, as well-shaped crystals suitable for the X-ray structural analysis ( Figure 1).  Ball-and-stick representations of the crystal structures of 4-7 demonstrating supramolecular dimerization via Se· · · N ChB. Grey and light-grey spheres represent carbon and hydrogen, respectively.
2-Pyridylselenyl trifluoroacetate 4 forms supramolecular dimers in the solid state via a pair of equivalent Se· · · N ChB interactions ( Figure 1). The Se centers adopt T-shaped geometry (∠N· · · Se· · · O 170.55 • ). Overall, the bonding situation in 4 is similar to what we observed earlier for PySeCl 2. In both compounds, the anion occupies a trans position against the N atom of the pyridyl in the solid state. A remarkable distinctive feature of 4 is short Se· · · O and Se· · · N distances (2.11 and 2.10 Å), which indicates the significant covalent character of these bonds. To shed light onto this matter, the QTAIM analysis of the dimer has been performed and the degree of covalency has been evaluated by the analysis of the total energy densities and Laplacian of the electron density. That is, in typical closed shell noncovalent interaction, the Laplacian (∇ 2 ρ) of the electron density at the bond critical point (CP) that characterizes the contact is positive, whilst it is negative in covalent bonds (∇ 2 ρ < 0) [22]. In bonds with partial covalent character (for instance coordination bonds between ligands and metal centers), the Laplacian is positive (∇ 2 ρ > 0) and the total energy density (H r ) at the bond CP is negative (|V r | > G r ), whilst in most weaker noncovalent contacts, such as hydrogen bonds, halogen bonds, chalcogen bonds, etc., both the ∇ 2 ρ and H r values are positive. Therefore, the QTAIM parameters are very useful to differentiate covalent, noncovalent, and "partial" covalent bonds. Furthermore, the strength of chalcogen and hydrogen bonds can be derived from the potential energy density (V r ) using the equations proposed in the literature [23,24] (E ≈ 0.5 × V r for HBs and E ≈ 0.37 × V r − 0.9 for ChBs, V r in kcal/mol).
The QTAIM analysis of the dimer of compound 4 is shown in Figure 2, where the strength of each ChB is indicated in red next to the bond CPs (represented as red spheres) and the H r values are indicated in blue. In all cases studied herein, the Laplacian values are positive, indicative of closed shell interactions. The ChBs in 4 are characterized by the corresponding bond CPs and bond paths (represented as orange lines) connecting the Se atom to both the O and N atoms of trifluoroacetate and pyridine, respectively. Both ChB contacts are very strong, the latter being slightly stronger than the former. The H r values are in both cases negative, disclosing a partial covalent character, in line with the short distances and strong interaction energies.
acter of these bonds. To shed light onto this matter, the QTAIM analysis of the dimer has been performed and the degree of covalency has been evaluated by the analysis of the total energy densities and Laplacian of the electron density. That is, in typical closed shell noncovalent interaction, the Laplacian (∇ 2 ρ) of the electron density at the bond critical point (CP) that characterizes the contact is positive, whilst it is negative in covalent bonds (∇ 2 ρ < 0) [22]. In bonds with partial covalent character (for instance coordination bonds between ligands and metal centers), the Laplacian is positive (∇ 2 ρ > 0) and the total energy density (Hr) at the bond CP is negative (|Vr| > Gr), whilst in most weaker noncovalent contacts, such as hydrogen bonds, halogen bonds, chalcogen bonds, etc., both the ∇ 2 ρ and Hr values are positive. Therefore, the QTAIM parameters are very useful to differentiate covalent, noncovalent, and "partial" covalent bonds. Furthermore, the strength of chalcogen and hydrogen bonds can be derived from the potential energy density (Vr) using the equations proposed in the literature [23,24] (E ≈ 0.5 × Vr for HBs and E ≈ 0.37 × Vr − 0.9 for ChBs, Vr in kcal/mol).
The QTAIM analysis of the dimer of compound 4 is shown in Figure 2, where the strength of each ChB is indicated in red next to the bond CPs (represented as red spheres) and the Hr values are indicated in blue. In all cases studied herein, the Laplacian values are positive, indicative of closed shell interactions. The ChBs in 4 are characterized by the corresponding bond CPs and bond paths (represented as orange lines) connecting the Se atom to both the O and N atoms of trifluoroacetate and pyridine, respectively. Both ChB contacts are very strong, the latter being slightly stronger than the former. The Hr values are in both cases negative, disclosing a partial covalent character, in line with the short distances and strong interaction energies. The C=N bond lengths (1.27-1.30 Å for 5-7) are typical for C=N double bonds [10,11,13,14,[25][26][27][28][29][30][31][32][33][34]. Other covalent bonds in 5-7 are unremarkable. The adducts 5-7 form supramolecular dimers in the solid state via a pair of equivalent Se···N chalcogen bonds ( Figure 1). The formation of similar 2Se-2N squares was observed earlier for the adducts of PySeCl 2 with acetonitrile and trichloroacetonitrile. In contrast, the adduct of 2 with hexanenitrile formed supramolecular polymers via Se⋯Cl and H⋯Cl interactions [18]. Thus, the replacement of chloride by TFA in pentyl-substituted 1,2,4-selenodiazolium salt had a dramatic impact on the self-organization of the compound in the solid state.
Importantly, the TFA anion in 5-7 is involved in bifurcated non-covalent interactions (viz. Se⋯O and H⋯O, Figure 1), which form a robust chalcogen-bonded supramolecular synthon. So far, we have not observed the anion occupying any other position; it was always found to be involved in "chelating" Se⋯A and H⋯A interactions.
Importantly, the TFA anion in 5-7 is involved in bifurcated non-covalent interactions (viz. Se· · · O and H· · · O, Figure 1), which form a robust chalcogen-bonded supramolecular synthon. So far, we have not observed the anion occupying any other position; it was always found to be involved in "chelating" Se· · · A and H· · · A interactions.
It should be noted that the Se· · · O ChB interactions found for 5-7 (2.68, 2.56, and 2.68 Å) are unusually short and among the shortest Se· · · O non-covalent interactions involving organoselenium species [35], which is likely due to the cation···anion nature of the interaction. Figure 3 shows the QTAIM analyses of 5 and 6 as representative complexes. In both compounds, the TFA is connected to the 1,2,4-selenodiazolium via two bond CPs and bond paths that characterize the chalcogen and hydrogen bonds. The ChBs are significantly stronger than the HBs (around 2 kcal/mol). Moreover, the strength of the ChB is higher in 6 (−6.48 kcal/mol) than in compound 5 (−4.89 kcal/mol), likely due to the presence of the electron withdrawing the CCl 3 group in compound 6 instead of the electron donating methyl group in 5. The dimerization energies are also indicated in Figure 3, which are very large (−92.0 and −98.7 kcal/mol for 5 and 6, respectively) due to the ion-pair nature and dominance of the Coulombic attraction between counterions. and bond paths that characterize the chalcogen and hydrogen bonds. The ChBs are significantly stronger than the HBs (around 2 kcal/mol). Moreover, the strength of the ChB is higher in 6 (−6.48 kcal/mol) than in compound 5 (−4.89 kcal/mol), likely due to the presence of the electron withdrawing the CCl3 group in compound 6 instead of the electron donating methyl group in 5. The dimerization energies are also indicated in Figure 3, which are very large (−92.0 and −98.7 kcal/mol for 5 and 6, respectively) due to the ionpair nature and dominance of the Coulombic attraction between counterions. Further, we were interested how other anions would bind 1,2,4-selenodiazolium cations. For this purpose, 1,2,4-selenodiazolium chloride 6′, derived from the coupling between trichloroacetonitrile and 2-pyridylselenyl chloride, was chosen for further anion variations. In addition, compound 6′ is very soluble in water, which makes it attractive for anion precipitation purposes. The addition of NaNO3 or HBF4 to 6′ in water does not result in any precipitation. However, the addition of aqueous NaAuCl4, perrhenic, or pertechnetic acids to the aqueous solution of 6′ resulted in the immediate formation of the corresponding salts 8-10. Interestingly, while compounds 8-10 are insoluble in water, the TFA salt 6 or analogous chloride 6′ are highly soluble. These facts make our novel 1,2,4selenodiazolium salts promising for selective anion precipitation purposes.
Compounds 8-10 were recrystallized from MeOH, and their structures were confirmed by the X-ray structural analysis ( Figure 4). Further, we were interested how other anions would bind 1,2,4-selenodiazolium cations. For this purpose, 1,2,4-selenodiazolium chloride 6 , derived from the coupling between trichloroacetonitrile and 2-pyridylselenyl chloride, was chosen for further anion variations. In addition, compound 6 is very soluble in water, which makes it attractive for anion precipitation purposes. The addition of NaNO 3 or HBF 4 to 6 in water does not result in any precipitation. However, the addition of aqueous NaAuCl 4 , perrhenic, or pertechnetic acids to the aqueous solution of 6 resulted in the immediate formation of the corresponding salts 8-10. Interestingly, while compounds 8-10 are insoluble in water, the TFA salt 6 or analogous chloride 6 are highly soluble. These facts make our novel 1,2,4-selenodiazolium salts promising for selective anion precipitation purposes.
Compounds 8-10 were recrystallized from MeOH, and their structures were confirmed by the X-ray structural analysis ( Figure 4).  The salts 8-10 formed exclusively 2Se-2N squares in the solid state ( Figure 4). Switching from the chloride to AuCl4 − , ReO4 − , or TcO4 − did not result in the rupture of supramolecular dimers with two antiparallel Se⋯N ChB interactions. Moreover, 1,2,4-selenodiazolium cations in the dimers of 9 and 10 were interconnected by the XB between the XB The salts 8-10 formed exclusively 2Se-2N squares in the solid state ( Figure 4). Switching from the chloride to AuCl 4 − , ReO 4 − , or TcO 4 − did not result in the rupture of supramolecular dimers with two antiparallel Se· · · N ChB interactions. Moreover, 1,2,4-selenodiazolium cations in the dimers of 9 and 10 were interconnected by the XB between the XB donating chlorine atom of the heterocycle and AuCl 4 − , ReO 4 − , or TcO 4 − anion ( Figure 4). For compound 8, we have analyzed the possible co-existence of Cl···Cl and Cl···Au contacts in addition to the ChB and HBs. The QTAIM analysis of the tetrameric assembly is represented in Figure 5. It demonstrates the presence of an intricate combination of interactions, including two symmetrically equivalent Se···N ChBs that are the strongest ones, connecting the five membered rings. The analysis also discloses three Se···Cl contacts, two involving the tetrachloroaurate anion and one the trichloromethyl group. The energies of these ChBs are similar, ranging from −1.25 to −1.44 kcal/mol. Two additional C-H···Cl contacts connect the AuCl 4 − anion to the cation. It is interesting to highlight the presence of three bond CPs and bond paths connecting one Cl atom of the trichloromethyl group to the AuCl 4 − , confirming the existence of Cl···Cl and Cl···Au contacts. To further analyze these contacts, we have computed the molecular electrostatic potential (MEP) surface of compound 8, which is represented in Figure 5b. It reveals the typical σ-holes at the Se-atoms with MEP values of +68 and +51 kcal/mol. Moreover, a σ-hole is also present at the extension of the C-Cl bonds of the trichloromethyl group (+29 kcal/mol). The MEP minimum value is located at the AuCl 4 -(chlorine belt), thus explaining the formation of the Cl···Cl contacts between the counterions. Moreover, the MEP value is also negative at the Au-atoms, thus revealing that the Cl···Au contact observed in 8 is also electrostatically favored. Moreover, for compounds 9 and 10, we have compared the strength of the Se···O contacts. It can be observed ( Figure 6) that they are weaker (−4.47 and −4.74 kcal/mol for 9 and 10, respectively) than those of compounds 5 and 6, due to the lower nucleophilicity of ReO4 − or TcO4 − anions compared to TFA. The energetic results gathered in Figure 6 show that the metal (Re or Tc) has little influence on the ChB and HB energies. The ionpair interactions are large and negative (−82.3 and −83.4 kcal/mol for 9 and 10, respectively) and smaller than those observed for 5 and 6, in line with the ChB and HB energies. contacts. It can be observed ( Figure 6) that they are weaker (−4.47 and −4.74 kcal/mo 9 and 10, respectively) than those of compounds 5 and 6, due to the lower nucleophili of ReO4 − or TcO4 − anions compared to TFA. The energetic results gathered in Figu show that the metal (Re or Tc) has little influence on the ChB and HB energies. The pair interactions are large and negative (−82.3 and −83.4 kcal/mol for 9 and 10, res tively) and smaller than those observed for 5 and 6, in line with the ChB and HB energ  Interestingly, introduction of BPh4 -anion resulted in the rupture of 2Se-2N squ The two σ-holes of selenodiazolium cation were involved in ChB-π interactions wit phenyls of BPh4 − anion. It should be noted that chalcogen-π interactions are a bon motif found in biological systems, such as proteins [36]. Both ChB-π interactions h lighted in Figure 7 were analyzed theoretically. The QTAIM results (see Figure 8) co orate the presence of the ChB-π interactions that are characterized by bond CPs and b paths connecting the Se-atoms to C-atoms of the six membered rings. The formatio such assemblies was further assisted by π-π and C-H···Cl interactions, as revealed b QTAIM analysis. The dimerization energies are −78.8 and −78.3 kcal/mol for both bin modes, which are similar to the ion-pair energies obtained for compounds 9 and 10, suggesting that the ChB-π and π-π combined are almost equivalent to the ChB and formed by the tetrahedral ReO4 − and TcO4 − anions. Interestingly, introduction of BPh 4 anion resulted in the rupture of 2Se-2N squares. The two σ-holes of selenodiazolium cation were involved in ChB-π interactions with the phenyls of BPh 4 − anion. It should be noted that chalcogen-π interactions are a bonding motif found in biological systems, such as proteins [36]. Both ChB-π interactions highlighted in Figure 7 were analyzed theoretically. The QTAIM results (see Figure 8) corroborate the presence of the ChB-π interactions that are characterized by bond CPs and bond paths connecting the Se-atoms to C-atoms of the six membered rings. The formation of such assemblies was further assisted by π-π and C-H···Cl interactions, as revealed by the QTAIM analysis. The dimerization energies are −78.8 and −78.3 kcal/mol for both binding modes, which are similar to the ion-pair energies obtained for compounds 9 and 10, thus suggesting that the ChB-π and π-π combined are almost equivalent to the ChB and HBs formed by the tetrahedral ReO 4 − and TcO 4 − anions. Further, we were interested in how the substituent by the selenodiazolium core (which derives from a nitrile) would affect the self-assembly of salts, which contain ReO 4 − or TcO 4 − anions. The compounds 12 and 13, which were derived from chloroacetonitrile, were simply prepared in the same way as 9 and 10. Surprisingly, switching from the CCl 3 to CH 2 Cl group had a noticeable impact on the self-assembly of the compound in the solid state ( Figure 9). orate the presence of the ChB-π interactions that are characterized by bond CPs and bond paths connecting the Se-atoms to C-atoms of the six membered rings. The formation of such assemblies was further assisted by π-π and C-H···Cl interactions, as revealed by the QTAIM analysis. The dimerization energies are −78.8 and −78.3 kcal/mol for both binding modes, which are similar to the ion-pair energies obtained for compounds 9 and 10, thus suggesting that the ChB-π and π-π combined are almost equivalent to the ChB and HBs formed by the tetrahedral ReO4 − and TcO4 − anions.  Further, we were interested in how the substituent by the selenodiazolium core (which derives from a nitrile) would affect the self-assembly of salts, which contain ReO4 − or TcO4 − anions. The compounds 12 and 13, which were derived from chloroacetonitrile, were simply prepared in the same way as 9 and 10. Surprisingly, switching from the CCl3 to CH2Cl group had a noticeable impact on the self-assembly of the compound in the solid state ( Figure 9). Compound 12 formed Se2N2 squares in the solid state in the same fashion as 9 and 10. However, it had several distinctive features. The ReO4 − anion was involved in a bifurcated ChB interaction with the Se center via two O atoms (Figure 9). In contrast, structurally similar compounds 9 and 10 featured a terminal coordination of the ReO4 − and TcO4 − anions ( Figure 4). Another interesting structural peculiarity of 12 was the presence of H···O HB interactions between the ReO4 − anion and α-H atom of the substituent by the selenodiazolium core (Figure 9) in the solid state. H···O HB was preferential here over a potential Cl···O XB interaction. It should be noted that selenodiazolium salts, which contained the same cation but the Cl or Br anions, formed similar dimers, which exhibited (N.B.) Cl···Cl or Cl···Br XB interactions [16], but not H···Cl or H···Br HB.
Compound 13 exhibited even a more distinctive pattern in the crystal (Figure 9). In contrast to 9, 10, or 12, it did not exhibit Se2N2 squares but formed dimers via four Se···O ChB interactions with two bridging TcO4 − anions (Figure 9).
Cation-anion interactions in 12 and 13 were further studied theoretically. Figure 10 shows the QTAIM analyses of the ion-pair interactions of compounds 12 and 13, evidencing the bifurcated nature of the ChB in 12, which is stronger (−4.47 kcal/mol, sum of both CPs) than the Se···O ChB in 13. This is mostly compensated by the HB that is stronger in compound 12. The ChBs in 12 and 13 are weaker than those of compounds 9 and 10, due to the stronger electron withdrawing effect of the CCl3 group. Regarding the ion-pair dimerization energies, it is larger in compound 13 (−79.7 kcal/mol) than 12 (−76.1 kcal/mol),  (Figure 4). Another interesting structural peculiarity of 12 was the presence of H···O HB interactions between the ReO 4 − anion and α-H atom of the substituent by the selenodiazolium core (Figure 9) in the solid state. H···O HB was preferential here over a potential Cl···O XB interaction. It should be noted that selenodiazolium salts, which contained the same cation but the Cl or Br anions, formed similar dimers, which exhibited (N.B.) Cl···Cl or Cl···Br XB interactions [16], but not H···Cl or H···Br HB.
Compound 13 exhibited even a more distinctive pattern in the crystal (Figure 9). In contrast to 9, 10, or 12, it did not exhibit Se 2 N 2 squares but formed dimers via four Se···O ChB interactions with two bridging TcO 4 − anions (Figure 9). Cation-anion interactions in 12 and 13 were further studied theoretically. Figure 10 shows the QTAIM analyses of the ion-pair interactions of compounds 12 and 13, evidencing the bifurcated nature of the ChB in 12, which is stronger (−4.47 kcal/mol, sum of both CPs) than the Se···O ChB in 13. This is mostly compensated by the HB that is stronger in compound 12. The ChBs in 12 and 13 are weaker than those of compounds 9 and 10, due to the stronger electron withdrawing effect of the CCl 3 group. Regarding the ion-pair dimerization energies, it is larger in compound 13 (−79.7 kcal/mol) than 12 (−76.1 kcal/mol), and both are similar to the ChB-π dimers represented in Figure 8. Finally, we compared the impact of switching from the Cl to the F in haloacetonitrile on the self-assembly of corresponding selenodiazolium salts. For this reason, 2-pyridylselenylchloride was coupled with fluoroacetonitrile to give novel adduct 14 ( Figure 11). Xray analysis showed that 14 also formed Se2N2 dimers in the solid state in a similar fashion to what we observed for several other selenodiazolium salts [15,16]. The F-decorated selenodiazolium cation also formed water-insoluble salts 15 and 16 with perrhenate or pertechnetate, correspondingly. Both 15 and 16 formed dimers via four Se···O ChB interactions with two bridging ReO4 − or TcO4 − anions ( Figure 11).
The QTAIM analyses of the ion-pair dimers of compounds 14-16 are represented in Figure 12. For compounds 15 and 16, where the anion is bridging the five membered selenodiazolium rings (Figure 11), we have analyzed both types of Se···O ChBs, where the O-atom is located opposite the Se-N or Se-C bond. Finally, we compared the impact of switching from the Cl to the F in haloacetonitrile on the self-assembly of corresponding selenodiazolium salts. For this reason, 2-pyridylselenylchloride was coupled with fluoroacetonitrile to give novel adduct 14 ( Figure 11). X-ray analysis showed that 14 also formed Se 2 N 2 dimers in the solid state in a similar fashion to what we observed for several other selenodiazolium salts [15,16]. Finally, we compared the impact of switching from the Cl to the F in haloacetonitrile on the self-assembly of corresponding selenodiazolium salts. For this reason, 2-pyridylselenylchloride was coupled with fluoroacetonitrile to give novel adduct 14 ( Figure 11). Xray analysis showed that 14 also formed Se2N2 dimers in the solid state in a similar fashion to what we observed for several other selenodiazolium salts [15,16]. The F-decorated selenodiazolium cation also formed water-insoluble salts 15 and 16 with perrhenate or pertechnetate, correspondingly. Both 15 and 16 formed dimers via four Se···O ChB interactions with two bridging ReO4 − or TcO4 − anions ( Figure 11).
The QTAIM analyses of the ion-pair dimers of compounds 14-16 are represented in Figure 12. For compounds 15 and 16, where the anion is bridging the five membered selenodiazolium rings (Figure 11), we have analyzed both types of Se···O ChBs, where the O-atom is located opposite the Se-N or Se-C bond.  show that the dimers, where the anion is opposite the C-N bond, are significantly more favored than those where it is opposite the Se-C bond. Finally, in compound 14, the ion-pair energy is significantly larger (−107.9 kcal/mol) due to the higher nucleophilicity of the Cl-atom (in the other anions, the negative charge is shared by all the O-atoms).

Materials and Methods
General remarks. All manipulations were carried out in air. All the reagents used in this study were obtained from the commercial sources (Aldrich, TCI-Europe, Strem, ABCR). Commercially available solvents were purified by conventional methods and distilled immediately prior to use. NMR spectra were recorded on a Bruker Avance Neo ( 1 H: 700 MHz); chemical shifts (δ) were given in ppm, coupling constants (J) in Hz. C, H, and N elemental analyses were carried out on a Euro EA 3028HT CHNS/O analyzer. Massspectra were obtained on a Bruker micrOTOF spectrometer equipped with an electrospray ionization (ESI) source; a MeOH, CH2Cl2, or MeOH/CH2Cl2 mixture was used as a solvent. 2-Pyridylselenylbromide and di(2-pyridyl)diselenide were prepared as reported earlier [37]. 2-Pyridylselenylchloride was obtained by the method reported earlier [38].
X-ray crystal structure determination. The single-crystal X-ray diffraction data for 6, 8, 11, and 14 were collected on the 'RSA' beamline of the National Research Center 'Kurchatov Institute' (Moscow, Russian Federation) using a Rayonix SX165 CCD detector. A total of 720 images for two different orientations in the case of each crystal were collected using an oscillation range of 1.0° and φ scan mode. The data were indexed and integrated using the utility iMOSFLM in the CCP4 program [39] and then scaled and corrected for show that the dimers, where the anion is opposite the C-N bond, are significantly more favored than those where it is opposite the Se-C bond. Finally, in compound 14, the ion-pair energy is significantly larger (−107.9 kcal/mol) due to the higher nucleophilicity of the Cl-atom (in the other anions, the negative charge is shared by all the O-atoms).

Materials and Methods
General remarks. All manipulations were carried out in air. All the reagents used in this study were obtained from the commercial sources (Aldrich, TCI-Europe, Strem, ABCR). Commercially available solvents were purified by conventional methods and distilled immediately prior to use. NMR spectra were recorded on a Bruker Avance Neo ( 1 H: 700 MHz); chemical shifts (δ) were given in ppm, coupling constants (J) in Hz. C, H, and N elemental analyses were carried out on a Euro EA 3028HT CHNS/O analyzer. Massspectra were obtained on a Bruker micrOTOF spectrometer equipped with an electrospray ionization (ESI) source; a MeOH, CH 2 Cl 2 , or MeOH/CH 2 Cl 2 mixture was used as a solvent. 2-Pyridylselenylbromide and di(2-pyridyl)diselenide were prepared as reported earlier [37]. 2-Pyridylselenylchloride was obtained by the method reported earlier [38].
X-ray crystal structure determination. The single-crystal X-ray diffraction data for 6, 8, 11, and 14 were collected on the 'RSA' beamline of the National Research Center 'Kurchatov Institute' (Moscow, Russian Federation) using a Rayonix SX165 CCD detector. A total of 720 images for two different orientations in the case of each crystal were collected using an oscillation range of 1.0 • and ϕ scan mode. The data were indexed and integrated using the utility iMOSFLM in the CCP4 program [39] and then scaled and corrected for absorption using the Scala program [40]. The single-crystal X-ray diffraction data  13  Synthesis of 10. 2-Pyridylselenyl chloride (93 µmol, 25 mg) and trichloroacetonitrile (50 µL) were stirred in Et2O (4 mL) at room temperature for 12 h. After that, solvent was evaporated, the residue was redissolved in MeOH (3 mL), 10 µL of pertechnetic acid (5 M) was added, and the mixture was left for 3 h until colorless crystals formed. Yield: 44 mg (73%).

Conclusions
In conclusion, we prepared and structurally characterized a series of 1,2,4-selenodiazolium salts with various anions. Trifluoroacetate derivatives were obtained via novel Se-Se bond scission reaction of 2,2 -dipyridyl diselenide with bis(trifluoroacetoxy)iodo)benzene in the presence of corresponding nitriles. The reactive 2-pyridylselenyl trifluoroacetate was also isolated and structurally characterized with the help of the X-ray single crystal analysis, which revealed that 4 forms supramolecular dimers in the solid state via a pair of equivalent Se· · · N ChB interactions. The dimers of 4 featured short and strong ChB contacts Se· · · O (21.5 kcal/mol) and Se· · · N (24.9 kcal/mol) and terminal binding with trifluoroacetate anion. In contrast, selenodiazolium cations bind trifluoroacetate via a pair of "chelating" Se· · · O and H· · · O non-covalent interactions, which is geometrically allowed.
The binding of AuCl 4 − , ReO 4 − , and TcO 4 − with model pyridine-fused 1,2,4-selenodiazolium cations, carrying halogen substituents in the core, was further regarded. To the best of our knowledge, this is the first study to regard perrhenate and pertechnetate as acceptors in ChB interactions. In these supramolecular complexes, selenodiazolium cations act as polyfunctional ChB, HB, and XB donors, as well as ChB acceptors. Regardless of the nature of the anion, the combination of directional Se· · · O ChB and H· · · O HB dictates the position of the anion in the supramolecular complex. In 8, featuring the AuCl 4 − anion, the presence of intricate combination of Cl···Cl, H···Cl, Se···Cl, and Cl···Au interactions was observed, involving the tetrachloroaurate anion and the trichloromethyl group. A more detailed and systematic study of selenodiazolium complexes with AuCl 4 − is required and will be published soon by our group.