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Differential Expression Patterns of TDP-43 in Single Moderate versus Repetitive Mild Traumatic Brain Injury in Mice

1
Department of Basic and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Rijeka, 51 000 Rijeka, Croatia
2
Department of Psychiatry and Neuroscience, Faculty of Medicine, Université Laval, Quebec City, QC G1V 0A6, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Giuseppe Lazzarino
Int. J. Mol. Sci. 2021, 22(22), 12211; https://doi.org/10.3390/ijms222212211
Received: 1 October 2021 / Revised: 31 October 2021 / Accepted: 5 November 2021 / Published: 11 November 2021
(This article belongs to the Section Molecular Neurobiology)
Traumatic brain injury (TBI) is a disabling disorder and a major cause of death and disability in the world. Both single and repetitive traumas affect the brain acutely but can also lead to chronic neurodegenerative changes. Clinical studies have shown some dissimilarities in transactive response DNA binding protein 43 (TDP-43) expression patterns following single versus repetitive TBI. We explored the acute cortical post-traumatic changes of TDP-43 using the lateral fluid percussion injury (LFPI) model of single moderate TBI in adult male mice and investigated the association of TDP-43 with post-traumatic neuroinflammation and synaptic plasticity. In the ipsilateral cortices of animals following LFPI, we found changes in the cytoplasmic and nuclear levels of TDP-43 and the decreased expression of postsynaptic protein 95 within the first 3 d post-injury. Subacute pathological changes of TDP-43 in the hippocampi of animals following LFPI and in mice exposed to repetitive mild TBI (rmTBI) were studied. Changes in the hippocampal TDP-43 expression patterns at 14 d following different brain trauma procedures showed pathological alterations only after single moderate, but not following rmTBI. Hippocampal LFPI-induced TDP-43 pathology was not accompanied by the microglial reaction, contrary to the findings after rmTBI, suggesting that different types of brain trauma may cause diverse pathophysiological changes in the brain, specifically related to the TDP-43 protein as well as to the microglial reaction. Taken together, our findings may contribute to a better understanding of the pathophysiological events following brain trauma. View Full-Text
Keywords: mice; microglia; NF-κ B; postsynaptic density protein 95; traumatic brain injury; transactive response DNA-binding protein 43 mice; microglia; NF-κ B; postsynaptic density protein 95; traumatic brain injury; transactive response DNA-binding protein 43
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MDPI and ACS Style

Janković, T.; Dolenec, P.; Rajič Bumber, J.; Gržeta, N.; Kriz, J.; Župan, G.; Pilipović, K. Differential Expression Patterns of TDP-43 in Single Moderate versus Repetitive Mild Traumatic Brain Injury in Mice. Int. J. Mol. Sci. 2021, 22, 12211. https://doi.org/10.3390/ijms222212211

AMA Style

Janković T, Dolenec P, Rajič Bumber J, Gržeta N, Kriz J, Župan G, Pilipović K. Differential Expression Patterns of TDP-43 in Single Moderate versus Repetitive Mild Traumatic Brain Injury in Mice. International Journal of Molecular Sciences. 2021; 22(22):12211. https://doi.org/10.3390/ijms222212211

Chicago/Turabian Style

Janković, Tamara, Petra Dolenec, Jelena Rajič Bumber, Nika Gržeta, Jasna Kriz, Gordana Župan, and Kristina Pilipović. 2021. "Differential Expression Patterns of TDP-43 in Single Moderate versus Repetitive Mild Traumatic Brain Injury in Mice" International Journal of Molecular Sciences 22, no. 22: 12211. https://doi.org/10.3390/ijms222212211

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