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Article

Low-Energy Laser-Driven Ultrashort Pulsed Electron Beam Irradiation-Induced Immune Response in Rats

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Institute of Molecular Biology NAS RA, Yerevan 0014, Armenia
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CANDLE Synchrotron Research Institute, Yerevan 0040, Armenia
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Department of Genetics and Cytology, Faculty of Biology, Yerevan State University, Yerevan 0025, Armenia
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Experimental Laboratory, Yerevan State Medical University after Mkhitar Heratsi, Yerevan 0025, Armenia
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Group for Radiation Biochemistry of Nucleic Acids, N.N. Semenov Federal Research for Chemical Physics, Russian Academy of Sciences, 119991 Moscow, Russia
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Laboratory for the Development of Innovative Drugs and Agricultural Biotechnology, Moscow Institute of Physics and Technology, 141701 Moscow, Russia
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Experimental Radiobiology and Radiation Medicine Department, State Research Center—Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, 123098 Moscow, Russia
*
Author to whom correspondence should be addressed.
Academic Editor: Michael Hausmann
Int. J. Mol. Sci. 2021, 22(21), 11525; https://doi.org/10.3390/ijms222111525
Received: 26 August 2021 / Revised: 18 October 2021 / Accepted: 20 October 2021 / Published: 26 October 2021
(This article belongs to the Special Issue Advances and Challenges in Biomolecular Radiation Research 2.0)
The development of new laser-driven electron linear accelerators, providing unique ultrashort pulsed electron beams (UPEBs) with low repetition rates, opens new opportunities for radiotherapy and new fronts for radiobiological research in general. Considering the growing interest in the application of UPEBs in radiation biology and medicine, the aim of this study was to reveal the changes in immune system in response to low-energy laser-driven UPEB whole-body irradiation in rodents. Forty male albino Wistar rats were exposed to laser-driven UPEB irradiation, after which different immunological parameters were studied on the 1st, 3rd, 7th, 14th, and 28th day after irradiation. According to the results, this type of irradiation induces alterations in the rat immune system, particularly by increasing the production of pro- and anti-inflammatory cytokines and elevating the DNA damage rate. Moreover, such an immune response reaches its maximal levels on the third day after laser-driven UPEB whole-body irradiation, showing partial recovery on subsequent days with a total recovery on the 28th day. The results of this study provide valuable insight into the effect of laser-driven UPEB whole-body irradiation on the immune system of the animals and support further animal experiments on the role of this novel type of irradiation. View Full-Text
Keywords: laser-driven ultrashort pulsed electron beam; Wistar rats; whole-body irradiation; peripheral blood profiling; bone marrow profiling; lymph node profiling; proinflammatory cytokines; DNA damage and repair; spleen; thymus laser-driven ultrashort pulsed electron beam; Wistar rats; whole-body irradiation; peripheral blood profiling; bone marrow profiling; lymph node profiling; proinflammatory cytokines; DNA damage and repair; spleen; thymus
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MDPI and ACS Style

Tsakanova, G.; Babayan, N.; Karalova, E.; Hakobyan, L.; Abroyan, L.; Avetisyan, A.; Avagyan, H.; Hakobyan, S.; Poghosyan, A.; Baghdasaryan, B.; Arakelova, E.; Ayvazyan, V.; Matevosyan, L.; Navasardyan, A.; Davtyan, H.; Apresyan, L.; Yeremyan, A.; Aroutiounian, R.; Osipov, A.N.; Grigoryan, B.; Karalyan, Z. Low-Energy Laser-Driven Ultrashort Pulsed Electron Beam Irradiation-Induced Immune Response in Rats. Int. J. Mol. Sci. 2021, 22, 11525. https://doi.org/10.3390/ijms222111525

AMA Style

Tsakanova G, Babayan N, Karalova E, Hakobyan L, Abroyan L, Avetisyan A, Avagyan H, Hakobyan S, Poghosyan A, Baghdasaryan B, Arakelova E, Ayvazyan V, Matevosyan L, Navasardyan A, Davtyan H, Apresyan L, Yeremyan A, Aroutiounian R, Osipov AN, Grigoryan B, Karalyan Z. Low-Energy Laser-Driven Ultrashort Pulsed Electron Beam Irradiation-Induced Immune Response in Rats. International Journal of Molecular Sciences. 2021; 22(21):11525. https://doi.org/10.3390/ijms222111525

Chicago/Turabian Style

Tsakanova, Gohar, Nelly Babayan, Elena Karalova, Lina Hakobyan, Liana Abroyan, Aida Avetisyan, Hranush Avagyan, Sona Hakobyan, Arpine Poghosyan, Bagrat Baghdasaryan, Elina Arakelova, Violetta Ayvazyan, Lusine Matevosyan, Arpine Navasardyan, Hakob Davtyan, Lilit Apresyan, Arsham Yeremyan, Rouben Aroutiounian, Andreyan N. Osipov, Bagrat Grigoryan, and Zaven Karalyan. 2021. "Low-Energy Laser-Driven Ultrashort Pulsed Electron Beam Irradiation-Induced Immune Response in Rats" International Journal of Molecular Sciences 22, no. 21: 11525. https://doi.org/10.3390/ijms222111525

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