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Mitochondrial Dysfunction and Heart Disease: Critical Appraisal of an Overlooked Association

1
MIUR Department of Excellence, Department of Neuroscience, Imaging and Clinical Sciences, University “G.d’Annunzio” of Chieti-Pescara, Via Luigi Polacchi, 11-66100 Chieti, Italy
2
Department of Clinical Sciences, Lund University, E-205 02 Malmö, Sweden
3
Casa di Cura Villa Serena, Città Sant’Angelo, 65013 Pescara, Italy
4
Department of Medicine and Aging Sciences, University “G.d’Annunzio” of Chieti-Pescara, 66100 Chieti, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(2), 614; https://doi.org/10.3390/ijms22020614
Received: 14 December 2020 / Revised: 3 January 2021 / Accepted: 7 January 2021 / Published: 9 January 2021
(This article belongs to the Special Issue Bioenergetics, Mitochondrial Dynamics and Cardiac Disease)
The myocardium is among the most energy-consuming tissues in the body, burning from 6 to 30 kg of ATP per day within the mitochondria, the so-called powerhouse of the cardiomyocyte. Although mitochondrial genetic disorders account for a small portion of cardiomyopathies, mitochondrial dysfunction is commonly involved in a broad spectrum of heart diseases, and it has been implicated in the development of heart failure via maladaptive circuits producing and perpetuating mitochondrial stress and energy starvation. In this bench-to-bedside review, we aimed to (i) describe the key functions of the mitochondria within the myocardium, including their role in ischemia/reperfusion injury and intracellular calcium homeostasis; (ii) examine the contribution of mitochondrial dysfunction to multiple cardiac disease phenotypes and their transition to heart failure; and (iii) discuss the rationale and current evidence for targeting mitochondrial function for the treatment of heart failure, including via sodium-glucose cotransporter 2 inhibitors. View Full-Text
Keywords: mitochondria; heart failure; mitochondrial dynamics; cardiomyopathy; cardiac energetics mitochondria; heart failure; mitochondrial dynamics; cardiomyopathy; cardiac energetics
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MDPI and ACS Style

Bisaccia, G.; Ricci, F.; Gallina, S.; Di Baldassarre, A.; Ghinassi, B. Mitochondrial Dysfunction and Heart Disease: Critical Appraisal of an Overlooked Association. Int. J. Mol. Sci. 2021, 22, 614. https://doi.org/10.3390/ijms22020614

AMA Style

Bisaccia G, Ricci F, Gallina S, Di Baldassarre A, Ghinassi B. Mitochondrial Dysfunction and Heart Disease: Critical Appraisal of an Overlooked Association. International Journal of Molecular Sciences. 2021; 22(2):614. https://doi.org/10.3390/ijms22020614

Chicago/Turabian Style

Bisaccia, Giandomenico, Fabrizio Ricci, Sabina Gallina, Angela Di Baldassarre, and Barbara Ghinassi. 2021. "Mitochondrial Dysfunction and Heart Disease: Critical Appraisal of an Overlooked Association" International Journal of Molecular Sciences 22, no. 2: 614. https://doi.org/10.3390/ijms22020614

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