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Article

Protective Effects of Zerumbone on Colonic Tumorigenesis in Enterotoxigenic Bacteroides fragilis (ETBF)-Colonized AOM/DSS BALB/c Mice

1
Department of Biomedical Laboratory Science, College of Health Sciences, MIRAE Campus, Yonsei University, Wonju, Gangwon-do 26493, Korea
2
Cell Therapy and Tissue Engineering Center, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do 26426, Korea
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(3), 857; https://doi.org/10.3390/ijms21030857
Received: 6 January 2020 / Accepted: 27 January 2020 / Published: 29 January 2020
(This article belongs to the Special Issue The Effect of Dietary Factors on Cancer 2.0)
Chronic inflammation has been linked to colitis-associated colorectal cancer in humans. The human symbiont enterotoxigenic Bacteroides fragilis (ETBF), a pro-carcinogenic bacterium, has the potential to initiate and/or promote colorectal cancer. Antibiotic treatment of ETBF has shown promise in decreasing colonic polyp formation in murine models of colon cancer. However, there are no reported natural products that have shown efficacy in decreasing polyp burden. In this study, we investigated the chemopreventive effects of oral administration of zerumbone in ETBF-colonized mice with azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced tumorigenesis. Zerumbone significantly reduced the severity of disease activity index (DAI) scores as well as several parameters of colonic inflammation (i.e., colon weight, colon length, cecum weight and spleen weight). In addition, inflammation of the colon and cecum as well as hyperplasia was reduced. Zerumbone treatment significantly inhibited colonic polyp numbers and prevented macroadenoma progression. Taken together, these findings suggest that oral treatment with zerumbone inhibited ETBF-promoted colon carcinogenesis in mice indicating that zerumbone could be employed as a promising protective agent against ETBF-mediated colorectal cancer. View Full-Text
Keywords: zerumbone; enterotoxigenic Bacteroides fragilis; colorectal cancer; colitis; polyps zerumbone; enterotoxigenic Bacteroides fragilis; colorectal cancer; colitis; polyps
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MDPI and ACS Style

Hwang, S.; Jo, M.; Hong, J.E.; Park, C.O.; Lee, C.G.; Rhee, K.-J. Protective Effects of Zerumbone on Colonic Tumorigenesis in Enterotoxigenic Bacteroides fragilis (ETBF)-Colonized AOM/DSS BALB/c Mice. Int. J. Mol. Sci. 2020, 21, 857. https://doi.org/10.3390/ijms21030857

AMA Style

Hwang S, Jo M, Hong JE, Park CO, Lee CG, Rhee K-J. Protective Effects of Zerumbone on Colonic Tumorigenesis in Enterotoxigenic Bacteroides fragilis (ETBF)-Colonized AOM/DSS BALB/c Mice. International Journal of Molecular Sciences. 2020; 21(3):857. https://doi.org/10.3390/ijms21030857

Chicago/Turabian Style

Hwang, Soonjae, Minjeong Jo, Ju E. Hong, Chan O. Park, Chang G. Lee, and Ki-Jong Rhee. 2020. "Protective Effects of Zerumbone on Colonic Tumorigenesis in Enterotoxigenic Bacteroides fragilis (ETBF)-Colonized AOM/DSS BALB/c Mice" International Journal of Molecular Sciences 21, no. 3: 857. https://doi.org/10.3390/ijms21030857

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