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Extremely Low-Frequency Electromagnetic Fields Increase the Expression of Anagen-Related Molecules in Human Dermal Papilla Cells via GSK-3β/ERK/Akt Signaling Pathway

Department of Medical Biotechnology (BK21 Plus team), Dongguk University, Goyang-si 10326, Gyeonggi-do, Korea
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Int. J. Mol. Sci. 2020, 21(3), 784; https://doi.org/10.3390/ijms21030784
Received: 13 December 2019 / Revised: 20 January 2020 / Accepted: 22 January 2020 / Published: 25 January 2020
(This article belongs to the Section Molecular Biophysics)
Despite advances in medical treatments, the proportion of the population suffering from alopecia is increasing, thereby creating a need for new treatments to control hair loss and prevent balding. Human hair follicle dermal papilla cells (hDPCs), a type of specialized fibroblast in the hair bulb, play an essential role in controlling hair growth and in conditions like androgenic alopecia. This study aimed to evaluate the intensity-dependent effect of extremely low-frequency electromagnetic fields (ELF-EMFs) on the expression of anagen-related molecules in hDPCs in vitro. We examined the effect of ELF-EMF on hDPCs to determine whether activation of the GSK-3β/ERK/Akt signaling pathway improved hDPC activation and proliferation; hDPCs were exposed to ELF-EMFs at a frequency of 70 Hz and at intensities ranging from 5 to 100 G, over four days. Various PEMF intensities significantly increased the expression of anagen-related molecules, including collagen IV, laminin, ALP, and versican. In particular, an intensity of 10 G is most potent for promoting the proliferation of hDPC and expression of anagen-related molecules. Moreover, 10 G ELF-EMF significantly increased β-catenin and Wnt3α expression and GSK-3β/ERK/Akt phosphorylation. Our results confirmed that ELF-EMFs enhance hDPC activation and proliferation via the GSK-3β/ERK/Akt signaling pathway, suggesting a potential treatment strategy for alopecia. View Full-Text
Keywords: alopecia; hair follicle dermal papilla cell; electromagnetic field alopecia; hair follicle dermal papilla cell; electromagnetic field
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Ki, G.-E.; Kim, Y.-M.; Lim, H.-M.; Lee, E.-C.; Choi, Y.-K.; Seo, Y.-K. Extremely Low-Frequency Electromagnetic Fields Increase the Expression of Anagen-Related Molecules in Human Dermal Papilla Cells via GSK-3β/ERK/Akt Signaling Pathway. Int. J. Mol. Sci. 2020, 21, 784.

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