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Review

The Role of Ionic Liquids in the Pharmaceutical Field: An Overview of Relevant Applications

Department of Chemistry, CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal
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Int. J. Mol. Sci. 2020, 21(21), 8298; https://doi.org/10.3390/ijms21218298
Received: 25 September 2020 / Revised: 31 October 2020 / Accepted: 2 November 2020 / Published: 5 November 2020
(This article belongs to the Special Issue Ionic Liquids in Drug Development, Formulation, and Delivery)
Solubility, bioavailability, permeation, polymorphism, and stability concerns associated to solid-state pharmaceuticals demand for effective solutions. To overcome some of these drawbacks, ionic liquids (ILs) have been investigated as solvents, reagents, and anti-solvents in the synthesis and crystallization of active pharmaceutical ingredients (APIs), as solvents, co-solvents and emulsifiers in drug formulations, as pharmaceuticals (API-ILs) aiming liquid therapeutics, and in the development and/or improvement of drug-delivery-based systems. The present review focuses on the use of ILs in the pharmaceutical field, covering their multiple applications from pharmaceutical synthesis to drug delivery. The most relevant research conducted up to date is presented and discussed, together with a critical analysis of the most significant IL-based strategies in order to improve the performance of therapeutics and drug delivery systems. View Full-Text
Keywords: active pharmaceutical ingredients; drug delivery systems; formulations; ionic liquids; solubility; permeability active pharmaceutical ingredients; drug delivery systems; formulations; ionic liquids; solubility; permeability
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MDPI and ACS Style

Pedro, S.N.; R. Freire, C.S.; Silvestre, A.J.D.; Freire, M.G. The Role of Ionic Liquids in the Pharmaceutical Field: An Overview of Relevant Applications. Int. J. Mol. Sci. 2020, 21, 8298. https://doi.org/10.3390/ijms21218298

AMA Style

Pedro SN, R. Freire CS, Silvestre AJD, Freire MG. The Role of Ionic Liquids in the Pharmaceutical Field: An Overview of Relevant Applications. International Journal of Molecular Sciences. 2020; 21(21):8298. https://doi.org/10.3390/ijms21218298

Chicago/Turabian Style

Pedro, Sónia N., Carmen S. R. Freire, Armando J.D. Silvestre, and Mara G. Freire 2020. "The Role of Ionic Liquids in the Pharmaceutical Field: An Overview of Relevant Applications" International Journal of Molecular Sciences 21, no. 21: 8298. https://doi.org/10.3390/ijms21218298

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