Prevention of Diabetes and Cardiovascular Disease in Obesity
1
Laboratory of Cardiovascular and Dysmetabolic Disease, IRCCS MultiMedica, 20138 Milan, Italy
2
Dipartimento di Scienze della Salute, Università degli Studi di Milano, 20142 Milan, Italy
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(21), 8178; https://doi.org/10.3390/ijms21218178
Received: 25 September 2020
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Revised: 29 October 2020
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Accepted: 30 October 2020
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Published: 31 October 2020
(This article belongs to the Special Issue Effects of Prediabetes on the Progression of Cardiovascular Diseases: When Should We Care?)
Obesity is one of the major risk factors for the development of both impaired glucose tolerance (IGT, or prediabetes) and type 2 diabetes (T2D), and its prevalence worldwide drives toward an increased rate of cardiovascular morbidity and mortality. Given the estimations of the World Health Organization (WHO) and the recommendation of the Diabetes Prevention Program (DPP), where IGT and diabetes are considered as risk factors for the development of cardiovascular complications and obesity, the development of diabetes should be treated because of its potential reversibility. In this view, several interventions such as diet, lifestyle changes, and pharmacological treatment are effective, including bariatric metabolic surgery (BMS), which is the most incisive way to efficiently lower body weight. In this review, we sought to summarize some of the major aspects linked to diabetes prevention in overweight/obesity, focusing on the use of surgery; we also attempted to elucidate molecular pathways involved in a variety of obesity-induced processes able to favor the progression of chronic diseases, such as diabetes and its complications.
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Keywords:
prevention; obesity; diabetes; T2D; CVD; atherosclerosis; inflammation; microRNA; metabolic syndrome; cardiovascular complications
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MDPI and ACS Style
La Sala, L.; Pontiroli, A.E. Prevention of Diabetes and Cardiovascular Disease in Obesity. Int. J. Mol. Sci. 2020, 21, 8178. https://doi.org/10.3390/ijms21218178
AMA Style
La Sala L, Pontiroli AE. Prevention of Diabetes and Cardiovascular Disease in Obesity. International Journal of Molecular Sciences. 2020; 21(21):8178. https://doi.org/10.3390/ijms21218178
Chicago/Turabian StyleLa Sala, Lucia, and Antonio E. Pontiroli. 2020. "Prevention of Diabetes and Cardiovascular Disease in Obesity" International Journal of Molecular Sciences 21, no. 21: 8178. https://doi.org/10.3390/ijms21218178
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