Role of the Serotonin Receptor 7 in Brain Plasticity: From Development to Disease
1
Department of Biology, University of Naples Federico II, 80126 Naples, Italy
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Department of Pharmacy, University of Naples Federico II, 80131 Naples, Italy
3
Institute of Genetics and Biophysics “Adriano Buzzati Traverso”, National Research Council, (CNR), 80131 Naples, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(2), 505; https://doi.org/10.3390/ijms21020505
Received: 6 December 2019
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Revised: 8 January 2020
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Accepted: 10 January 2020
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Published: 13 January 2020
(This article belongs to the Special Issue Molecular Mechanisms of Synaptic Plasticity: Dynamic Changes in Neurons Functions)
Our knowledge on the plastic functions of the serotonin (5-HT) receptor subtype 7 (5-HT7R) in the brain physiology and pathology have advanced considerably in recent years. A wealth of data show that 5-HT7R is a key player in the establishment and remodeling of neuronal cytoarchitecture during development and in the mature brain, and its dysfunction is linked to neuropsychiatric and neurodevelopmental diseases. The involvement of this receptor in synaptic plasticity is further demonstrated by data showing that its activation allows the rescue of long-term potentiation (LTP) and long-term depression (LTD) deficits in various animal models of neurodevelopmental diseases. In addition, it is becoming clear that the 5-HT7R is involved in inflammatory intestinal diseases, modulates the function of immune cells, and is likely to play a role in the gut-brain axis. In this review, we will mainly focus on recent findings on this receptor’s role in the structural and synaptic plasticity of the mammalian brain, although we will also illustrate novel aspects highlighted in gastrointestinal (GI) tract and immune system.
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Keywords:
brain connectivity; brain development; gut-brain axis; neurodevelopmental diseases; neuronal cytoarchitecture; neuroplasticity; regulatory T cells; serotonin (5-HT)
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MDPI and ACS Style
Crispino, M.; Volpicelli, F.; Perrone-Capano, C. Role of the Serotonin Receptor 7 in Brain Plasticity: From Development to Disease. Int. J. Mol. Sci. 2020, 21, 505. https://doi.org/10.3390/ijms21020505
AMA Style
Crispino M, Volpicelli F, Perrone-Capano C. Role of the Serotonin Receptor 7 in Brain Plasticity: From Development to Disease. International Journal of Molecular Sciences. 2020; 21(2):505. https://doi.org/10.3390/ijms21020505
Chicago/Turabian StyleCrispino, Marianna, Floriana Volpicelli, and Carla Perrone-Capano. 2020. "Role of the Serotonin Receptor 7 in Brain Plasticity: From Development to Disease" International Journal of Molecular Sciences 21, no. 2: 505. https://doi.org/10.3390/ijms21020505
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