Biomaterials for Cleft Lip and Palate Regeneration
1
Facultad de Estomatología, Universidad Autónoma de San Luis Potosí, Av. Dr. Salvador Nava No. 2, Zona Universitaria, San Luis Potosí (S.L.P.) 78290, Mexico
2
Consejo Superior de Investigaciones Científicas, Instituto de Ciencia y Tecnología de Polímeros, Calle Juan de la Cierva, 3, 28006 Madrid, Spain
3
Laboratorio de Ingeniería Tisular y Medicina Traslacional, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de Mexico, Avenida de los Barrios N 1, Iztacala Tlalnepantla, Estado de Mexico 54090, Mexico
4
Consorcio Centro de Investigación Biomédica en Red CIBER-BBN, Calle Monforte de Lemos S/N, 28029 Madrid, Spain
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(9), 2176; https://doi.org/10.3390/ijms20092176
Received: 1 March 2019
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Revised: 2 April 2019
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Accepted: 30 April 2019
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Published: 2 May 2019
(This article belongs to the Special Issue Biomaterials for Musculoskeletal System)
Craniofacial bone defect anomalies affect both soft and hard tissues and can be caused by trauma, bone recessions from tumors and cysts, or even from congenital disorders. On this note, cleft/lip palate is the most prevalent congenital craniofacial defect caused by disturbed embryonic development of soft and hard tissues around the oral cavity and face area, resulting in most cases, of severe limitations with chewing, swallowing, and talking as well as problems of insufficient space for teeth, proper breathing, and self-esteem problems as a consequence of facial appearance. Spectacular advances in regenerative medicine have arrived, giving new hope to patients that can benefit from new tissue engineering therapies based on the supportive action of 3D biomaterials together with the synergic action of osteo-inductive molecules and recruited stem cells that can be driven to the process of bone regeneration. However, few studies have focused on the application of tissue engineering to the regeneration of the cleft/lip and only a few have reported significant advances to offer real clinical solutions. This review provides an updated and deep analysis of the studies that have reported on the use of advanced biomaterials and cell therapies for the regeneration of cleft lip and palate regeneration.
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Keywords:
cleft palate; cleft lip; regenerative medicine; bone; craniofacial defects; orofacial disorders; musculoskeletal tissue engineering
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Martín-del-Campo, M.; Rosales-Ibañez, R.; Rojo, L. Biomaterials for Cleft Lip and Palate Regeneration. Int. J. Mol. Sci. 2019, 20, 2176. https://doi.org/10.3390/ijms20092176
AMA Style
Martín-del-Campo M, Rosales-Ibañez R, Rojo L. Biomaterials for Cleft Lip and Palate Regeneration. International Journal of Molecular Sciences. 2019; 20(9):2176. https://doi.org/10.3390/ijms20092176
Chicago/Turabian StyleMartín-del-Campo, Marcela, Raúl Rosales-Ibañez, and Luis Rojo. 2019. "Biomaterials for Cleft Lip and Palate Regeneration" International Journal of Molecular Sciences 20, no. 9: 2176. https://doi.org/10.3390/ijms20092176
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