Correction: Complex Epigenetic Regulation of Chemotherapy Resistance and Biology in Esophageal Squamous Cell Carcinoma via MicroRNAs. Int. J. Mol. Sci. 2018, 19, 499

We would like to submit a correction to the published paper [...].

We would like to submit a correction to the published paper [1]. The reason for the correction lies in the fact that we performed and analyzed a number of experimental studies at the same time, and the current paper was the first publication from this work. However, when analyzing the other studies in detail, we found some inconsistencies; therefore we present the entire analysis of the current manuscript based on the raw data.
In summary, we finally identified a number of minor errors, mostly with regard to the presentation of our data in the original manuscript: (1) Statistical re-analysis of the experiments shown in Figure 2 revealed an incorrect p-value for the miR-148a-3p/miR-130a-3p co-transfection. After correction, the p-value changed from p ≤ 0.005 to p ≤ 0.016 (mentioned in the Abstract, and on page 4). This change does not affect the significance or discussion of results.
In the Abstract we change "Simultaneous manipulation of two microRNAs exhibited additive sensitizing effects towards cisplatin in 50% (miR-125a-5p/miR-148a-3p), and 75% (miR-148a-3p/miR-130a-3p) of cell lines (p ≤ 0.006)." to "Simultaneous manipulation of two microRNAs exhibited additive sensitizing effects towards cisplatin in 50% (miR-125a-5p/miR-148a-3p), and 75% (miR-148a-3p/miR-130a-3p) of cell lines (p ≤ 0.016)." In page 4 we change "Co-transfection of miR-148a-3p/miR-130a-3p resulted in significantly increased sensitivity towards cisplatin in all cell lines (+15% to +39%; p ≤ 0.005) compared to scrambled controls, and led in 75% of our experiments to an additive effect of co-transfection when compared to transfections with either miRNA alone ( Figure 2B)." to "Co-transfection of miR-148a-3p/miR-130a-3p resulted in significantly increased sensitivity towards cisplatin in all cell lines (+15% to +39%; p ≤ 0.016) compared to scrambled controls, and led in 75% of our experiments to an additive effect of co-transfection when compared to transfections with either miRNA alone ( Figure 2B)." 2) Apoptosis data were found to be partly incorrect due to confusion with data from a second study. Re-analysis, however, confirmed in general most of the results their significance values. In our new analysis we found that early apoptosis after miR-130a inhibition significantly increased, and early apoptosis after miR-148a mimic transfection still increased but failed to reach significance. We adjusted Figure 4 and the corresponding text accordingly. In summary, these changes did not affect the overall significance or discussion of results. In page 4 we change "Altered expression of all four miRNAs significantly increased (especially late-) apoptosis rates with a maximum increase in apoptosis of up to 332% after miR-125a-5p upregulation ( Figure 4)." to "Altered expression of all four miRNAs significantly increased (especially late-) apoptosis rates with a maximum increase in apoptosis of up to 463% after miR-125a-5p upregulation ( Figure 4)." Figure 4 should be replaced with: (2) Apoptosis data were found to be partly incorrect due to confusion with data from a second study. Re-analysis, however, confirmed in general most of the results their significance values. In our new analysis we found that early apoptosis after miR-130a inhibition significantly increased, and early apoptosis after miR-148a mimic transfection still increased but failed to reach significance. We adjusted Figure 4 and the corresponding text accordingly. In summary, these changes did not affect the overall significance or discussion of results.
In page 4 we change "Altered expression of all four miRNAs significantly increased (especially late-) apoptosis rates with a maximum increase in apoptosis of up to 332% after miR-125a-5p upregulation (Figure 4)." to "Altered expression of all four miRNAs significantly increased (especially late-) apoptosis rates with a maximum increase in apoptosis of up to 463% after miR-125a-5p upregulation (Figure 4)." Figure 4 should be replaced with: 3) Protein expression data on XIAP expression after miR-130a downregulation had to be corrected. We found that miR-130a downregulation in fact led, in all experiments, to the upregulation of its putative target. We adjusted Figures 6 and 7 and the corresponding section in the manuscript accordingly. In page 5 we change "Similarly, PPARγ, Bcl-2, XIAP, and RUNX3 showed decreased protein levels after upregulation of miR-130a-3p." to "Similarly, PPARγ, Bcl-2, XIAP, and RUNX3 showed increased protein levels after downregulation of miR-130a-3p" Figures 6 and 7 should be replaced with: (3) Protein expression data on XIAP expression after miR-130a downregulation had to be corrected. We found that miR-130a downregulation in fact led, in all experiments, to the upregulation of its putative target. We adjusted Figures 6 and 7 and the corresponding section in the manuscript accordingly.
Figures 6 and 7 should be replaced with:    In summary, these changes did not impact in any way the significance of the overall results or the conclusions of our paper. We updated the manuscript, and the original version will remain online. We apologize for any inconvenience we may have caused to our readers.

Conflicts of Interest:
The authors declare no conflict of interest.