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Article

Proteome and Peptidome of Human Acquired Enamel Pellicle on Deciduous Teeth

Schulich School of Medicine & Dentistry, The University Western University, London, ON N5A6C1, Canada
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Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2013, 14(1), 920-934; https://doi.org/10.3390/ijms14010920
Received: 13 October 2012 / Revised: 18 December 2012 / Accepted: 4 January 2013 / Published: 7 January 2013
(This article belongs to the Collection Advances in Proteomic Research)
Understanding the composition and structure of the acquired enamel pellicle (AEP) has been a major goal in oral biology. Our lab has conducted studies on the composition of AEP formed on permanent enamel. The exhaustive exploration has provided a comprehensive identification of more than 100 proteins from AEP formed on permanent enamel. The AEP formed on deciduous enamel has not been subjected to the same biochemical characterization scrutiny as that of permanent enamel, despite the fact that deciduous enamel is structurally different from permanent enamel. We hypothesized that the AEP proteome and peptidome formed on deciduous enamel may also be composed of unique proteins, some of which may not be common with AEP of permanent enamel explored previously. Pellicle material was collected from 10 children (aged 18–54 months) and subjected to mass spectrometry analysis. A total of 76 pellicle proteins were identified from the deciduous pellicle proteome. In addition, 38 natural occurring AEP peptides were identified from 10 proteins, suggesting that primary AEP proteome/peptidome presents a unique proteome composition. This is the first study to provide a comprehensive investigation of in vivo AEP formed on deciduous enamel. View Full-Text
Keywords: acquired enamel pellicle; saliva; proteomics; primary teeth; proteins; oral; LC-MS/MS acquired enamel pellicle; saliva; proteomics; primary teeth; proteins; oral; LC-MS/MS
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MDPI and ACS Style

Zimmerman, J.N.; Custodio, W.; Hatibovic-Kofman, S.; Lee, Y.H.; Xiao, Y.; Siqueira, W.L. Proteome and Peptidome of Human Acquired Enamel Pellicle on Deciduous Teeth. Int. J. Mol. Sci. 2013, 14, 920-934. https://doi.org/10.3390/ijms14010920

AMA Style

Zimmerman JN, Custodio W, Hatibovic-Kofman S, Lee YH, Xiao Y, Siqueira WL. Proteome and Peptidome of Human Acquired Enamel Pellicle on Deciduous Teeth. International Journal of Molecular Sciences. 2013; 14(1):920-934. https://doi.org/10.3390/ijms14010920

Chicago/Turabian Style

Zimmerman, Jason N.; Custodio, William; Hatibovic-Kofman, Sahza; Lee, Young H.; Xiao, Yizhi; Siqueira, Walter L. 2013. "Proteome and Peptidome of Human Acquired Enamel Pellicle on Deciduous Teeth" Int. J. Mol. Sci. 14, no. 1: 920-934. https://doi.org/10.3390/ijms14010920

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