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Molecules, Volume 5, Issue 1 (January 2000) – 16 articles , Pages 1-98, Articles M127-M133

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Open AccessReview
Recent Developments in the Area of Asymmetric Transfer Hydrogenation
Molecules 2000, 5(1), 4-18; https://doi.org/10.3390/50100004 - 21 Jan 2001
Cited by 28 | Viewed by 8682
Abstract
The use of an enantiomerically pure amino alcohol, coupled to a transfer hydrogenation process, in the asymmetric catalysis of the reduction of ketones to alcohols, is described. The process works well for unfunctionalised ketones, affording e.e.s of up to 98%, and excellent conversions. [...] Read more.
The use of an enantiomerically pure amino alcohol, coupled to a transfer hydrogenation process, in the asymmetric catalysis of the reduction of ketones to alcohols, is described. The process works well for unfunctionalised ketones, affording e.e.s of up to 98%, and excellent conversions. We have recently extended, for the first time in this application, the scope of the methodology to the reductions of a-heteroatom substituted substrates, through the use of the appropriate protecting groups on each atom. Full article
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Open AccessEditorial
Molecules, MolBank and ECSOC-4
Molecules 2000, 5(1), 1-3; https://doi.org/10.3390/50100001 - 31 Jan 2000
Cited by 5 | Viewed by 2511
Abstract
It is one of the great ironies of our information age that at the same time that we have the technical capability to make information freely available world-wide, budget problems are seriously endangering the free access to scientific information.[...] Full article
Open AccessArticle
JChemPaint - Using the Collaborative Forces of the Internet to Develop a Free Editor for 2D Chemical Structures
Molecules 2000, 5(1), 93-98; https://doi.org/10.3390/50100093 - 28 Jan 2000
Cited by 61 | Viewed by 8227
Abstract
The open source program for drawing 2D chemical structures JChemPaint, its current features, its envisioned further development and the principles enabling researchers and students at places all over the world to collaboratively develop such a program are described. Full article
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Open AccessArticle
Substituted Pyrroles
Molecules 2000, 5(1), 89-92; https://doi.org/10.3390/50100089 - 26 Jan 2000
Cited by 3 | Viewed by 4117
Abstract
A stepwise synthesis of a-unsubstituted pyrroles with desired substituents in the b-positions of the ring has been devised. Full article
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Open AccessShort Note
Copper 1,14:7,8-Diethenotetrapyrido-[2,1,6-de:2',1',6'-gh:2'',1'',6'''-na][1,3,5,8,10,12]hexaazacyclotetradecine Trifluoroacetate
Molecules 2000, 5(1), M133; https://doi.org/10.3390/M133 - 24 Jan 2000
Viewed by 2598
Abstract
1,14:7,8-Diethenotetrapyrido-[2,1,6-de:2,1,6-gh:2,1,6-na][1,3,5,8,10,12] hexaazacyclotetradecine (H2HAPP) was synthesized according to Ogawas method[1].[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note
4-Hydroxy-6-methyl-3-nitroso-1-phenethyl-2(1H)-pyridinone
Molecules 2000, 5(1), M132; https://doi.org/10.3390/M132 - 24 Jan 2000
Viewed by 1603
Abstract
The starting 4-hydroxy-6-methyl-1-phenethyl-2(1H)-pyridinone (1) was prepared according to the known procedure [1,2].[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note
Methane-diphosphonic Acid Tetraethyl Ester
Molecules 2000, 5(1), M131; https://doi.org/10.3390/M131 - 24 Jan 2000
Cited by 2 | Viewed by 1969
Abstract
Methanediphosphonic acid tetraethyl ester is a useful intermedaite for the synthesis of phosphonoalkenes [1] or diphosphonoalkenes [2].[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note
1-(6-Amino-9H-purin-9-yl)-3-diazoacetone
Molecules 2000, 5(1), M130; https://doi.org/10.3390/M130 - 24 Jan 2000
Cited by 1 | Viewed by 1875
Abstract
Adenine (1, 0.676 g, 5.0 mmol) was suspended in anhydrous DMF (20 mL) and sodium hydride (55-60 % suspension in mineral oil, 0.262 g, 6.0 mmol) was added at room temperature.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note
N-(3-Trifluoromethylphenyl)-4-nitroaniline
Molecules 2000, 5(1), M129; https://doi.org/10.3390/M129 - 24 Jan 2000
Viewed by 1683
Abstract
The general part of the experimental section and the purposes of this synthesis have been present elsewhere [1].[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note
4-Furyl-6-hydroxy-6-methyl-1,2,4,5,6,7-hexahydro-3H-indazole-3-one
Molecules 2000, 5(1), M128; https://doi.org/10.3390/M128 - 24 Jan 2000
Viewed by 2431
Abstract
It is known that indazoles have varied biological activity [1,2].[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note
2-Ethoxycarbonyl-3-(2-furyl)-5-hydroxy-5-methylcyclohexanone
Molecules 2000, 5(1), M127; https://doi.org/10.3390/M127 - 24 Jan 2000
Viewed by 2175
Abstract
Furylcyclohexanones can be prepared by the reaction of acetoacetic ester (AAE) with b-furyl-a,b-unsaturated ketones [1,2].[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessReview
A Short Review on Cardiotonic Steroids and Their Aminoguanidine Analogues
Molecules 2000, 5(1), 51-81; https://doi.org/10.3390/50100051 - 21 Jan 2000
Cited by 75 | Viewed by 9193
Abstract
A short review on cardiotonic steroids and their analogues is presented. The natural, semisynthetic and synthetic derivatives, as well as their mechanism of action and structure-activity relationships are shown, with a special reference to aminoguanidine derivatives. Full article
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Open AccessArticle
Acid-Base Initiated Cyclization and Retrocyclization Reactions of Ethyl 2-(3-Acylselenoureido)benzoates, -thiophene-3-carboxylates and the Corresponding 2-(3-Acylisoselenoureido) Derivatives
Molecules 2000, 5(1), 37-50; https://doi.org/10.3390/50100037 - 21 Jan 2000
Cited by 5 | Viewed by 6418
Abstract
Acid and base initiated cyclization and retrocyclization reactions of the selenoureas 1-6 and isoselenoureas 7-12 to fused 4H-1,3-selenazine and 1,2,3,4-tetrahydropyrimidine-4-one skeletons are reported. Fused 2-acylamino-4H-1,3-selenazine-4-ones 13-18 were formed by the action of concentrated sulfuric acid on acylselenoureas 1-6 or on 2,2-dimethylpropanoylisoselenoureas 10-12 at [...] Read more.
Acid and base initiated cyclization and retrocyclization reactions of the selenoureas 1-6 and isoselenoureas 7-12 to fused 4H-1,3-selenazine and 1,2,3,4-tetrahydropyrimidine-4-one skeletons are reported. Fused 2-acylamino-4H-1,3-selenazine-4-ones 13-18 were formed by the action of concentrated sulfuric acid on acylselenoureas 1-6 or on 2,2-dimethylpropanoylisoselenoureas 10-12 at room temperature. On the other hand, benzoylisoselenoureas 7-9 were not obtained in this cyclocondensation under the same conditions. The reaction of potassium ethoxide on selenazines 13-18 in the ethanol solution evoked retrocyclization to the starting acylselenoureas 1-6. Both types of the title compounds, i.e. selenoureas 1-6 and isoselenoureas 7-12, were deprotonated in a methanol solution of potassium hydroxide used in an equimolar amount, giving rise to potassium salts 19-24, which were isolated only for the thiophene series. By heating the separated potassium salts 20, 21, 23 and 24 in the methanol solution provided, deacylation and isoselenoureas 26, 27 were formed. The in situ prepared salts 19, 22 cyclized under the same conditions with deacylation to 4-selanyl-3,4-dihydroquinazoline-4-one 28. The title compounds 1-6, 7-12 and products of their deacylation 26, 27 on boiling in methanolic potassium hydroxide cyclized to the corresponding fused 2-selenoxo-1,2,3,4-tetrahydropyrimidine-4-one potassium salts. These compounds provided pyrimidine-4-ones 28-30 on acidification. Acid initiated retrocyclization 28-30 to the corresponding 2-amino-4H-1,3-selenazine-4-ones was unsuccessful. C, H, N, Se elemental analyses, FTIR, 1H-NMR, and 13C-NMR spectroscopies supported the structure of synthesized compounds.A short review on cardiotonic steroids and their analogues is presented. The natural, semisynthetic and synthetic derivatives, as well as their mechanism of action and structure-activity relationships are shown, with a special reference to aminoguanidine derivatives. Full article
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Open AccessArticle
On the Need for Multiple Lists of Chemical Information
Molecules 2000, 5(1), 33-36; https://doi.org/10.3390/50100033 - 21 Jan 2000
Cited by 2 | Viewed by 4263
Abstract
Cambridge University Department of Chemistry has a list of University Chemistry Departments and Chemistry-related journals around the world: ChemSites (http://www.ch.cam.ac.uk/ChemSitesIndex.html). This article describes what makes it distinct from other lists, and justifies the existence of more than one such list. Full article
Open AccessArticle
General Method for the Preparation of Substituted 2-Amino-4H,5H-pyrano[4,3-b]pyran-5-ones and 2-Amino-4H-pyrano[3,2-c]pyridine-5-ones
Molecules 2000, 5(1), 19-32; https://doi.org/10.3390/50100019 - 21 Jan 2000
Cited by 60 | Viewed by 5672
Abstract
Reaction of 4-hydroxy-6-methyl-2-pyrone (1a) as well as 4-hydroxy-6-methyl-2(1H)-pyridones (1b-d) with arylmethylene malononitriles or arylmethylene methyl cyanoacetates (2a-h) leads to the formation of the very stable 5,6-fused bicyclic 2-amino-4Hpyran derivatives 3a-3af. Full article
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Open AccessArticle
A High-Yielding Synthesis of the Naturally Occurring Antitumour Agent Irisquinone
Molecules 2000, 5(1), 82-88; https://doi.org/10.3390/50100082 - 18 Jan 2000
Cited by 8 | Viewed by 5461
Abstract
A short, high-yielding synthesis of the antitumour agent irisquinone (1) is described. The key steps are the palladium catalysed coupling reaction of dec-9-yn-1-ol with iodide (2) to form alkyne (3) and the Fremy’s salt oxidation of phenol (7). Full article
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