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Molecules
Volume 28
Issue 9
10.3390/molecules28093827
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Article
Peer-Review Record

Lipid Mediators Metabolic Chaos of Asthmatic Mice Reversed by Rosmarinic Acid

Molecules 2023, 28(9), 3827; https://doi.org/10.3390/molecules28093827
by Tuo Qin 1,2, Xiaojuan Rong 3,*, Xiaohui Zhang 4, Lingfei Kong 1,2, Yutong Kang 3, Xuanlin Liu 3, Mengying Hu 3, Handong Liang 1 and Cai Tie 1,2,*
Reviewer 1:
Małgorzata Kozyra
Reviewer 2: Anonymous
Molecules 2023, 28(9), 3827; https://doi.org/10.3390/molecules28093827
Submission received: 27 February 2023 / Revised: 17 April 2023 / Accepted: 26 April 2023 / Published: 30 April 2023
(This article belongs to the Special Issue Mass Spectrometry for Biomedical and Food Analysis)

Round 1

Reviewer 1 Report

Rosemary acid is found not only in Hyssopus cuspidatus, the acid is popular in the Labiatae family. if this species is mentioned, the research was conducted on extracts from this plant? , on which ?. Hyssop also contains other active ingredients. Were the studies conducted on the rosemary acid standard? There are many studies on the anti-asthmatic activity of rosemary acid.

 

  • DOI: 10.1017/S1466252317000081

doi.org/10.3389/fphar.2023.1066643 

 

Author Response

Please see the attachment

Author Response File: Author Response.pdf

Reviewer 2 Report

The authors state that both SXCF and RosA had the effect of asthma control and inflammation reduction by regulation of LMs associated with cytokine production and leukocyte chemotaxis, in addition, that some constituents in SXCF could neutralize a side effect associated with RosA-induced LMs overregulation. The paper may contain some results of interest, but it has several points that require further attention.

#1 Not showing a significant difference in change of the ethological score and lung histology after OVA sensitizing in SXCF and RosA groups compared with that in Mod group, the therapeutic effect on phenotypes in an animal model of asthma is unclear in this study.

#2 The authors should discuss the implications of the difference between the effect of SXCF and RosA on IgE and IL-4 levels, including the relationship to lipid mediators such as TXA2. Some explanation is required.

Author Response

Please see the attachment

Author Response File: Author Response.pdf

Round 2

Reviewer 2 Report

Requests have been fulfilled in present form.

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