X-H Bond Insertion Promoted by Heterogeneous Dirhodium Metal–Organic Cage with Alkynes as Safe Carbene Precursors

A facile and efficient methodology for the generation of the C-X (X = Si, B) bond through a carbene insertion process was demonstrated using a dirhodium metal–organic cage, MOC-Rh-1, as a heterogeneous catalyst. A series of functionalized alkynes were utilized as safe carbene precursors to furnish Si-H and B-H insertion products in moderate to excellent yields. These reactions featured a high atom-economy, a broad substrate scope, and mild reaction conditions. Moreover, the as-prepared MOC-Rh-1 catalyst was recovered easily from the reaction system by simple centrifugation and reused for ten runs without a significant loss in activity, which made good use of the valuable precious metal rhodium.


Introduction
Dinuclear rhodium(II) tetracarboxylates have attracted great interest for many years, which were proven to be exceptionally active and highly versatile catalysts for carbene and nitrene transfer reactions [1][2][3][4][5]. Rhodium(II) complexes, especially the chiral rhodium(II) carboxylic acids, are indispensable catalysts in many processes for the production of pharmaceuticals and fine chemicals, including cyclopropanations, X-H insertions, ylide transformations, and so on [6][7][8]. Recently, dirhodium(II) complexes even found use in photocatalysis for hydrogen evolution and carbon dioxide reduction [9][10][11]. Despite high activity and selectivity, the unavoidable high cost, the difficulty in recovering and recycling, and the metal contamination of pharmaceuticals became the main factors that limited the application of dirhodium catalysts in the chemical industry.
Organosilicon and organoboron compounds are extensively used in the fields of organic synthesis, materials science, and organometallic chemistry. Much effort has been devoted to developing efficient synthetic methodologies to gain structurally diverse organosilicon and organoboron compounds. The construction of Si-C bonds can be realized by alkyne hydrosilylation [23,24], a sila-Heck type process [25], or silyl conjugated addition [26]. As for organoboron compounds, several protocols, including the hydroborations of olefins and C-H bond borylations, offer straightforward access to establish B-C bond [27][28][29].
Molecules 2023, 28, 608 2 of 12 In addition to the above-mentioned methods, the insertion of carbene species into the X-H (X = Si, B) bond stands for another highly efficient route to construct Si-C and B-C bonds [30,31]. The past few decades have witnessed the tremendous development of X-H insertions. Among various carbene precursors, diazo compounds are one of the most traditional and popular kinds, which featured mild reaction conditions, high reactivity and selectivity. However, the danger of explosion and dimerization tendency limited the wide application of diazo compounds.
Alkynes, as emerging non-diazo carbene precursors, have been gaining much attention recently [32,33]. Increasing numbers of carbene transfer reactions are being reported, starting from functionalized alkynes under the catalysis of transition metals. Dirhodium complexes have shown high reactivity and selectivity in reactions with alkynes as carbene precursors, especially asymmetric processes [34][35][36][37]. However, to the best of our knowledge there is no report on the heterogeneous version. Herein, we demonstrated the insertions of alkyne-derived carbene into Si-H and B-H bonds in the presence of a dirhodium-based metal-organic cage (MOC-Rh-1) as a heterogeneous catalyst ( Figure 1). The reactions feature a mild reaction condition, high efficiency with up to 97% isolated yield, and a broad substrate scope. The catalyst showed excellent recyclability and could be reused for ten runs. Moreover, size selectivity was observed in the MOC-Rh-1-promoted B-H insertion.
organic synthesis, materials science, and organometallic chemistry. Much effort has been devoted to developing efficient synthetic methodologies to gain structurally diverse organosilicon and organoboron compounds. The construction of Si-C bonds can be realized by alkyne hydrosilylation [23,24], a sila-Heck type process [25], or silyl conjugated addition [26]. As for organoboron compounds, several protocols, including the hydroborations of olefins and C-H bond borylations, offer straightforward access to establish B-C bond [27][28][29]. In addition to the above-mentioned methods, the insertion of carbene species into the X-H (X = Si, B) bond stands for another highly efficient route to construct Si-C and B-C bonds [30,31]. The past few decades have witnessed the tremendous development of X-H insertions. Among various carbene precursors, diazo compounds are one of the most traditional and popular kinds, which featured mild reaction conditions, high reactivity and selectivity. However, the danger of explosion and dimerization tendency limited the wide application of diazo compounds.
Alkynes, as emerging non-diazo carbene precursors, have been gaining much attention recently [32,33]. Increasing numbers of carbene transfer reactions are being reported, starting from functionalized alkynes under the catalysis of transition metals. Dirhodium complexes have shown high reactivity and selectivity in reactions with alkynes as carbene precursors, especially asymmetric processes [34][35][36][37]. However, to the best of our knowledge there is no report on the heterogeneous version. Herein, we demonstrated the insertions of alkyne-derived carbene into Si-H and B-H bonds in the presence of a dirhodium-based metal-organic cage (MOC-Rh-1) as a heterogeneous catalyst ( Figure 1). The reactions feature a mild reaction condition, high efficiency with up to 97% isolated yield, and a broad substrate scope. The catalyst showed excellent recyclability and could be reused for ten runs. Moreover, size selectivity was observed in the MOC-Rh-1-promoted B-H insertion.

Results and Discussion
To investigate the catalytic activity of MOC-Rh-1 in the carbene transfer reaction via the non-diazo approach, conjugated enynones were employed as carbene precursors. In our initial study, enynone 1a and trisubstituted silane 2a were chosen as model substrates in the presence of 1 mol% of MOC-Rh-1. The reaction was conducted in toluene at room temperature under ambient atmosphere. Delightfully, the desired Si-H insertion product 3a was obtained in 84% yield after 1 h ( Table 1, entry 1). To improve the reaction efficiency, several other solvents were then explored. CH2Cl2 and CHCl3 led to comparable yields with that of toluene (entries 2 and 3). 1,4-Dioxane, acetone, and tetrahydrofuran (THF) were proved to be inferior solvent with reduced yields (entries 4-6). The reaction in THF

Results and Discussion
To investigate the catalytic activity of MOC-Rh-1 in the carbene transfer reaction via the non-diazo approach, conjugated enynones were employed as carbene precursors. In our initial study, enynone 1a and trisubstituted silane 2a were chosen as model substrates in the presence of 1 mol% of MOC-Rh-1. The reaction was conducted in toluene at room temperature under ambient atmosphere. Delightfully, the desired Si-H insertion product 3a was obtained in 84% yield after 1 h ( Table 1, entry 1). To improve the reaction efficiency, several other solvents were then explored. CH 2 Cl 2 and CHCl 3 led to comparable yields with that of toluene (entries 2 and 3). 1,4-Dioxane, acetone, and tetrahydrofuran (THF) were proved to be inferior solvent with reduced yields (entries 4-6). The reaction in THF only gave rise to 3a in 38% yield, which might be ascribed to the existence of the active C-H bond disturbing the Si-H insertion process. When it came to 1,2-dichloroethane (DCE) as the solvent, the isolated yield of the expected product could be enhanced to 89% (entry 7). Frustratingly, when we tried to lower the catalyst loading to 0.5 mol%, the yield decreased to 82% (entry 8). The homogeneous mode of this reaction was also carried out with Rh 2 (CH 3 COO) 4 , Rh 2 (OPiv) 4, and Rh 2 (CF 3 COO) 4 as catalysts (entries 9-11). The reaction functioned well and was completed within 5 min, with the highest yield being 91% for Rh 2 (OPiv) 4 . The homogeneous Rh 2 (CH 3 COO) 4 was quite efficient, even when the catalyst loading was lowered to 0.05 mol%, giving 85% yield in 30 min (entry 12). As for MOC-Rh-1, only 35% yield was obtained under the same reaction conditions (entry 13).
These results indicated that the heterogeneous MOC-Rh-1 catalyst was not as effective as the homogeneous analogues, which is a common phenomenon in a heterogeneous catalysis system. Control experiments indicated that the reaction did not occur in the absence of catalysts (entry 14). Table 1. Optimization of the reaction conditions a . 7). Frustratingly, when we tried to lower the catalyst loading to 0.5 mol%, the yield decreased to 82% (entry 8). The homogeneous mode of this reaction was also carried out with Rh2(CH3COO)4, Rh2(OPiv)4, and Rh2(CF3COO)4 as catalysts (entries 9-11). The reaction functioned well and was completed within 5 min, with the highest yield being 91% for Rh2(OPiv)4. The homogeneous Rh2(CH3COO)4 was quite efficient, even when the catalyst loading was lowered to 0.05 mol%, giving 85% yield in 30 min (entry 12). As for MOC-Rh-1, only 35% yield was obtained under the same reaction conditions (entry 13). These results indicated that the heterogeneous MOC-Rh-1 catalyst was not as effective as the homogeneous analogues, which is a common phenomenon in a heterogeneous catalysis system. Control experiments indicated that the reaction did not occur in the absence of catalysts (entry 14). With the optimized reaction conditions in hand, we set out to explore the substrate scope of this Si-H insertion. The heterogeneous MOC-Rh-1 catalytic system proved to be effective with a variety of trisubstituted silanes. As illustrated in Scheme 1, the combination of standard substrates 1a and 2a (PhSiMe2H) could give rise to 3a in 89% yield. It is noteworthy that the bulky silanes Ph2SiMeH and Ph3SiH also functioned well to generate products 3b and 3c in excellent yields, thus demonstrating that the catalytic efficiency was not limited by the pore size of MOC-Rh-1. Silane 2d tethered with benzyl group could successfully give 3d in 92% yield. When the rhodium carbenoid was trapped by less sterically hindered trialkylsilanes Et3SiH and n Bu3SiH, the desired products 3e and 3f were obtained in 84% and 83% yields, respectively. However, the silane bearing With the optimized reaction conditions in hand, we set out to explore the substrate scope of this Si-H insertion. The heterogeneous MOC-Rh-1 catalytic system proved to be effective with a variety of trisubstituted silanes. As illustrated in Scheme 1, the combination of standard substrates 1a and 2a (PhSiMe 2 H) could give rise to 3a in 89% yield. It is noteworthy that the bulky silanes Ph 2 SiMeH and Ph 3 SiH also functioned well to generate products 3b and 3c in excellent yields, thus demonstrating that the catalytic efficiency was not limited by the pore size of MOC-Rh-1. Silane 2d tethered with benzyl group could successfully give 3d in 92% yield. When the rhodium carbenoid was trapped by less sterically hindered trialkylsilanes Et 3 SiH and n Bu 3 SiH, the desired products 3e and 3f were obtained in 84% and 83% yields, respectively. However, the silane bearing electrondonating ethoxyl moiety led to a complex system with no desired product detected (3g). Except for the above trisubstituted silanes, the disubstituted substrate was examined as well. Similar to the catalytic results in the homogeneous reactions reported by zhu and co-workers [34] , Ph 2 SiH 2 showed passable activity to give 3h in 29% yield. As for monosubstituted silane PhSiH 3 , no reaction took place in 24 h, and a messy mixture was observed in further prolonged time.
electron-donating ethoxyl moiety led to a complex system with no desired product detected (3g). Except for the above trisubstituted silanes, the disubstituted substrate was examined as well. Similar to the catalytic results in the homogeneous reactions reported by zhu and co-workers [34], Ph2SiH2 showed passable activity to give 3h in 29% yield. As for mono-substituted silane PhSiH3, no reaction took place in 24 h, and a messy mixture was observed in further prolonged time. To further demonstrate the practicality and scalability of the present heterogeneous protocol, we moved on to investigate the reactions of various enynones 1 with the standard silane 2a (Scheme 2). In the presence of 1 mol% MOC-Rh-1, enynones containing the halogen group smoothly participated in the reaction with 2a, furnishing the organosilicon products in excellent yields (4a and 4b). This process was also compatible with the strong electron-withdrawing -CF3 group (4c, 89%). The steric effect was studied by comparing the reactivities of enynones with the methyl group substituted on different positions. It was illustrated that the less hindered para-and meta-substituted substrates could smoothly afford the expected products in high yields in 0.5 h (97% for 4d and 94% for 4e). As for the ortho-substituted one, the reaction took much longer time to give To further demonstrate the practicality and scalability of the present heterogeneous protocol, we moved on to investigate the reactions of various enynones 1 with the standard silane 2a (Scheme 2). In the presence of 1 mol% MOC-Rh-1, enynones containing the halogen group smoothly participated in the reaction with 2a, furnishing the organosilicon products in excellent yields (4a and 4b). This process was also compatible with the strong electron-withdrawing -CF 3 group (4c, 89%). The steric effect was studied by comparing the reactivities of enynones with the methyl group substituted on different positions. It was illustrated that the less hindered paraand meta-substituted substrates could smoothly afford the expected products in high yields in 0.5 h (97% for 4d and 94% for 4e). As for the ortho-substituted one, the reaction took much longer time to give product 4f in a decreased yield (87%). When the electron-donating methoxyl group was introduced, the reaction also went well to furnish the products. However, the activity was slighted effected, as illustrated by the longer reaction time for 4g (2 h) and relatively lower yield for 4h (82%). Enynone substituted with phenyl or n Bu group served as an effective substrate as well, producing the Si-H insertion products 4i and 4j in 95% and 91% yields, respectively. Except for the phenyl group, the thiofuran ring was also well-tolerated to give 4k in 93% yield. When it came to the alkyl group, the yield declined to 76% (4l). Furthermore, the propionyl-and benzoyl-substituted enynones could be utilized as active substrates, which all successfully transformed into the corresponding products in excellent yields (4m-4o). However, enynones with alkyl moiety only led to a 67% yield (4p). The results of 4l and 4p indicated that substrates with the alkyl group on alkyne moiety might be inferior candidates for this reaction.
introduced, the reaction also went well to furnish the products. However, the activity was slighted effected, as illustrated by the longer reaction time for 4g (2 h) and relatively lower yield for 4h (82%). Enynone substituted with phenyl or n Bu group served as an effective substrate as well, producing the Si-H insertion products 4i and 4j in 95% and 91% yields, respectively. Except for the phenyl group, the thiofuran ring was also well-tolerated to give 4k in 93% yield. When it came to the alkyl group, the yield declined to 76% (4l). Furthermore, the propionyl-and benzoyl-substituted enynones could be utilized as active substrates, which all successfully transformed into the corresponding products in excellent yields (4m-4o). However, enynones with alkyl moiety only led to a 67% yield (4p). The results of 4l and 4p indicated that substrates with the alkyl group on alkyne moiety might be inferior candidates for this reaction. The recyclability of precious metal is of great importance in the heterogeneous catalysis system. Ten successive Si-H insertion reactions of functionalized alkyne 1a with silane 2a were carried out to evaluate the reusability of MOC-Rh-1. Due to the heterogeneous nature and high catalytic activity of this dirhodium catalyst, the regeneration operation is quite simple and feasible. After each reaction cycle, MOC-Rh-1 was separated from the solution by centrifugation and air-dried for further use without activation under vacuum. Remarkably, the MOC-Rh-1 catalyst could be recycled for at least ten runs without significant loss of activity, showing 83-89% yields (Figure 2a).
The recyclability of precious metal is of great importance in the heterogeneous catalysis system. Ten successive Si-H insertion reactions of functionalized alkyne 1a with silane 2a were carried out to evaluate the reusability of MOC-Rh-1. Due to the heterogeneous nature and high catalytic activity of this dirhodium catalyst, the regeneration operation is quite simple and feasible. After each reaction cycle, MOC-Rh-1 was separated from the solution by centrifugation and air-dried for further use without activation under vacuum. Remarkably, the MOC-Rh-1 catalyst could be recycled for at least ten runs without significant loss of activity, showing 83-89% yields (Figure 2a).  To evaluate the heterogeneity of the catalyst, a hot filtration experiment was carried out by removing the MOC-Rh-1 catalyst after 15 min of the reaction, and 53% conversion was observed. Then, the filtrate was allowed to stand at room temperature for another 45 min, giving 65% conversion with a 12% increase. The inductively coupled plasma optical emission spectrometer (ICP-OES) measurement of the reaction filtrate indicated that 1.0% of the total Rh content in the catalyst was leached into the solution, thus leading to the 12% increased conversion. It is reasonable to conclude that MOC-Rh-1 was basically heterogeneous in this process. The valence state and morphology of MOC-Rh-1 after catalysis were also investigated to figure out the form of existence of the catalyst. X-ray photoelectron spectroscopy (XPS) indicated Rh in MOC-Rh-1 after catalysis remained +2 valence by displaying Rh 3d 3/2 and 3d 5/2 peaks at 312.5 and 307.8 eV, respectively (Figure 2b). Transmission electron microscopy (TEM) showed that the catalyst was uniformly arranged without observation of Rh(0) nanopaticles (Figure 2c,d). Therefore, it should be the Rh(II) in MOC-Rh-1 that mainly acted as a catalytic active site.
Based on literature reports and the above investigation results, a possible reaction mechanism for the MOC-Rh-1-promoted Si-H insertion was proposed with standard sub strates 1a and 2a as examples (Scheme 3). Firstly, the alkyne group of 1a was activated by the Rh(II) sites in MOC-Rh-1, which was then attacked by the carbonyl group to undergo a 5-exo-dig cyclization. Furanium vinyl-metal intermediate A was generated through the above process, which was resonant with 2-furanyl metal-carbene B. Then, the carbene intermediate B was trapped by silane 2a to give intermediate C, followed by protodemetallation to furnish the final Si-H insertion product 3a with regeneration of the catalyst. was observed. Then, the filtrate was allowed to stand at room temperature for another 45 min, giving 65% conversion with a 12% increase. The inductively coupled plasma optical emission spectrometer (ICP-OES) measurement of the reaction filtrate indicated that 1.0% of the total Rh content in the catalyst was leached into the solution, thus leading to the 12% increased conversion. It is reasonable to conclude that MOC-Rh-1 was basically heterogeneous in this process. The valence state and morphology of MOC-Rh-1 after catalysis were also investigated to figure out the form of existence of the catalyst. X-ray photo-electron spectroscopy (XPS) indicated Rh in MOC-Rh-1 after catalysis remained +2 valence by displaying Rh 3d3/2 and 3d5/2 peaks at 312.5 and 307.8 eV, respectively ( Figure  2b). Transmission electron microscopy (TEM) showed that the catalyst was uniformly arranged without observation of Rh(0) nanopaticles (Figure 2c,d). Therefore, it should be the Rh(II) in MOC-Rh-1 that mainly acted as a catalytic active site.
Based on literature reports and the above investigation results, a possible reaction mechanism for the MOC-Rh-1-promoted Si-H insertion was proposed with standard substrates 1a and 2a as examples (Scheme 3). Firstly, the alkyne group of 1a was activated by the Rh(II) sites in MOC-Rh-1, which was then attacked by the carbonyl group to undergo a 5-exo-dig cyclization. Furanium vinyl-metal intermediate A was generated through the above process, which was resonant with 2-furanyl metal-carbene B. Then, the carbene intermediate B was trapped by silane 2a to give intermediate C, followed by protodemetallation to furnish the final Si-H insertion product 3a with regeneration of the catalyst.

Scheme 3. A plausible reaction mechanism.
Except for the Si-H bond, the insertion of carbene species generated from alkyne precursors into the B-H bond was explored as well (Scheme 4). A variety of enynones were subjected to the reaction with trimethylamine borane 5 in the presence of MOC-Rh-Scheme 3. A plausible reaction mechanism.
Except for the Si-H bond, the insertion of carbene species generated from alkyne precursors into the B-H bond was explored as well (Scheme 4). A variety of enynones were subjected to the reaction with trimethylamine borane 5 in the presence of MOC-Rh-1. The reactions were conducted in DCE at 60 • C under an N 2 atmosphere. Furan-2-ylmethylborane product 6a was smoothly generated in 89% yield. 4-Methyl and 4methoxyl-substituted enynones were both successfully converted into the desired products in high yields (6b and 6c). Enynone with the electron-withdrawing chloro group on the para-position of the aryl ring served as an effective substrate to give 6d in 90% yield. When the methyl and methoxyl moiety were introduced onto the meta-position, the corresponding borane adducts 6e and 6f could be smoothly generated. It is noted that no desired product was detected when it came to ortho-substituted enynone, which might be due to the steric hindrance effect (6g). R 1 and R 2 could also be ethyl moiety, furnishing 6h in 93% yield. When bulky phenyl groups were tethered on the carbonyl moiety, the reaction efficiency dramatically decreased to give 6i in only 22% yield in 48 h. To shed light on the reason for the low activity, Rh 2 (OAc) 4 was employed in the B-H insertion process as a contrast to the heterogeneous porous MOC-Rh-1 catalyst. The homogeneous version displayed high efficiency with 96% yield, illustrating that the low yield was unlikely due to the substrate itself. Therefore, the porous catalyst MOC-Rh-1 displayed size selectivity in the B-H insertion reaction. Substrates with smaller sizes resulted in a higher yield (6a for example), whereas that with a larger size led to a lower yield (6i, 22% yield). It might be that the channels in MOC-Rh-1 limited the transportation of larger substrates, leading to less active sites being accessible and thus a loss of activity.
corresponding borane adducts 6e and 6f could be smoothly generated. It is noted that no desired product was detected when it came to ortho-substituted enynone, which might be due to the steric hindrance effect (6g). R 1 and R 2 could also be ethyl moiety, furnishing 6h in 93% yield. When bulky phenyl groups were tethered on the carbonyl moiety, the reaction efficiency dramatically decreased to give 6i in only 22% yield in 48 h. To shed light on the reason for the low activity, Rh2(OAc)4 was employed in the B-H insertion process as a contrast to the heterogeneous porous MOC-Rh-1 catalyst. The homogeneous version displayed high efficiency with 96% yield, illustrating that the low yield was unlikely due to the substrate itself. Therefore, the porous catalyst MOC-Rh-1 displayed size selectivity in the B-H insertion reaction. Substrates with smaller sizes resulted in a higher yield (6a for example), whereas that with a larger size led to a lower yield (6i, 22% yield). It might be that the channels in MOC-Rh-1 limited the transportation of larger substrates, leading to less active sites being accessible and thus a loss of activity.

Conclusions
We disclosed the transformations of the functionalized alkynes as carbene precursors under the catalysis of a metal-organic cage (MOC-Rh-1), which contains dirhodium clusters as both building blocks and active sites. The heterogeneous and porous MOC-Rh-1 demonstrated high efficiency in promoting the Si-H insertion of alkyne-derived carbene intermediate into silanes. Being compatible with various enynones and silanes, this protocol displayed a broad substrate scope as well as mild reaction conditions and high atomeconomy. What is more, MOC-Rh-1 could be reused for ten runs without a significant loss of activity. The basic heterogeneity of the catalyst was verified by a hot filtration experiment and an ICP test. The XPS and TEM results indicated that the Rh species in MOC-Rh-1 remained +2 valence after catalysis. Furthermore, MOC-Rh-1 was effective in terms of carbene insertion into B-H bonds as well, giving borane adducts in up to 93% yield. It is noted that due to the porosity of MOC-Rh-1, size selective catalysis was observed in the B-H insertion reactions. MOC-Rh-1 exhibited potential in the heterogeneous catalysis involving carbene species derived from various precursors.

General
All the reagents were obtained from commercial sources and used directly without further purification unless otherwise noted. The solvent dimethylacetamide used in the synthesis of MOC-Rh-1 is GC pure (99.8%). The ligand 3,3 -[1,3-phenylenebis(ethyne-2,1-diyl)] dibenzoic acid (H 2 pbeddb) was prepared according to the literature [38]. The enynone substrates were prepared following the reported procedures [39]. The 1 H NMR and 13 C NMR spectra were recorded on Bruker AVANCE III 400 MHz or 500 MHz. The 1 H NMR and 13 C NMR chemical shifts were determined relative to internal standard TMS at δ 0.0. Chemical shifts (δ) are reported in ppm, and coupling constants (J) are in Hertz (Hz). ICP spectroscopy was conducted on PE Avio ICP-OES spectrometer. TEM images were recorded on Talos F200S G2 spectrometer. XPS was performed on a ULVAC PHI Quantera microprobe. Binding energies (BE) were calibrated by setting the measured BE of C 1s to 284.65 eV.

General Procedure for the Catalytic Si-H Insertion Reactions
Enynone (0.2 mmol) and silane (0.4 mmol) were added to the suspension of MOC-Rh-1 (4.0 mg, 0.002 mmol, and 1 mol%) in 1,2-dichloroethane (2 mL) The whole mixture was stirred under air at room temperature until the full consumption of the enynone substrate (monitored by TLC) took place. The reaction mixture was filtrated through a pad of silica gel and purified by chromatography (petroleum ether/ethyl acetate) to yield the desired Si-H insertion product. The NMR data of the products are listed in the Supplementary Materials.

General Procedure for the Recycling Experiment
A mixture of 1a (424 mg, 2 mmol), PhSiMe 2 H (4 mmol), and activated MOC-Rh-1 (40.0 mg, 1 mol%) in 1,2-dichloroethane (20 mL) was stirred under air at room temperature for 1 h. The catalyst was separated by centrifugation, washed with ethyl acetate (5 mL × 3), dried under air, and reused in the consecutive run. The resulting residue was purified by chromatography to determine the isolated yield.

Procedure for Hot Filtration
Enynone (0.2 mmol) and silane (0.4 mmol) were added to the suspension of MOC-Rh-1 (4.0 mg, 0.002 mmol, and 1 mol%) in 1,2-dichloroethane (2 mL). The whole mixture was stirred under air at room temperature for 15 min. Then, the reaction mixture was filtrated with a filtration membrane (0.45 mm), and the filtrate was allowed to stir for another 45 min.

Procedure for ICP-OES Experiment
Enynone (0.6 mmol) and silane (1.2 mmol) were added to the suspension of MOC-Rh-1 (12.0 mg, 0.006 mmol, and 1 mol%, containing ca. 2.460 mg of Rh) in 1,2-dichloroethane (6 mL). The whole mixture was stirred under air at room temperature until full consumption of enynone. Then, the reaction mixture was filtrated with a filtration membrane (0.45 mm), and the filtrate was digested by acid before ICP-OES evaluation. The measured Rh content was 0.0242 mg, and the leached Rh content was 1.0%.

General Procedure for the Catalytic B-H Insertion Reactions
Enynone (0.2 mmol) and trimethylamine borane 5 (0.4 mmol) were added to the suspension of MOC-Rh-1 (4.0 mg, 0.002 mmol, and 1 mol%) in 1,2-dichloroethane (2 mL). The whole mixture was stirred under N 2 at 60 • C until the full consumption of the enynone substrate (monitored by TLC) was achieved. The reaction mixture was filtrated through a pad of silica gel and purified by chromatography to yield the desired B-H insertion product.The NMR data of the products are listed in the Supplementary Materials.

Supplementary Materials:
The following supporting information can be downloaded at https:// www.mdpi.com/article/10.3390/molecules28020608/s1, the NMR data and spectra of the catalytic products.