Palladium-Catalysed Coupling Reactions En Route to Molecular Machines: Sterically Hindered Indenyl and Ferrocenyl Anthracenes and Triptycenes, and Biindenyls.

Pd-catalysed Stille and Suzuki cross-couplings were used to prepare 9-(3-indenyl)-, 6, and 9-(2-indenyl)-anthracene, 7; addition of benzyne led to the 9-Indenyl-triptycenes, 8 and 9. In 6, [4 + 2] addition also occurred to the indenyl substituent. Reaction of 6 through 9 with Cr(CO)6 or Re2(CO)10 gave their M(CO)3 derivatives, where the Cr or Re was complexed to a six- or five-membered ring, respectively. In the 9-(2-indenyl)triptycene complexes, slowed rotation of the paddlewheel on the NMR time-scale was apparent in the η5-Re(CO)3 case and, when the η6-Cr(CO)3 was deprotonated, the resulting haptotropic shift of the metal tripod onto the five-membered ring also blocked paddlewheel rotation, thus functioning as an organometallic molecular brake. Suzuki coupling of ferrocenylboronic acid to mono- or dibromoanthracene yielded the ferrocenyl anthracenes en route to the corresponding triptycenes in which stepwise hindered rotations of the ferrocenyl groups behaved like molecular dials. CuCl2-mediated coupling of methyl- and phenyl-indenes yielded their rac and meso 2,2′-biindenyls; surprisingly, however, the apparently sterically crowded rac 2,2′-Bis(9-triptycyl)biindenyl functioned as a freely rotating set of molecular gears. The predicted high rotation barrier in 9-phenylanthracene was experimentally validated via the Pd-catalysed syntheses of di(3-fluorophenyl)anthracene and 9-(1-naphthyl)-10-phenylanthracene.


Introduction
In recent decades, the goal of creating artificial molecule-scale mechanical systems (e.g., molecular machines, shuttles, gears, rotors, turnstiles) has attracted enormous attention within the synthetic community [1,2]. Herein, we focus on one specifically selected approach-transition metal catalysed coupling [3], towards the synthesis of the "skeletal backbones" of molecular mechanical systems, their basic construction elements. Incorporation of these rigid fragments allows us to investigate the functional behaviour of a wide selection of individual and mechanically interlocked systems, such as those illustrated schematically in Figure 1. Even a brief perusal of the vast literature on the syntheses of molecular machines leads one to conclude that transition metal-catalysed (especially palladium-catalysed) coupling reactions play a prominent role in this area of modern synthetic chemistry, as exemplified below.
Following the pioneering work on corannulene by Siegel et al. [4], the study of an umbrella-type inversion process in the nitrogen-embedded buckybowl, 2, from its precursor, 1, was made possible via three sequential Pd-catalysed coupling reactions (shown in red, Scheme 1). The bowl-to-bowl inversion barrier was reported to be 98 kJ mol −1 [5]. Palladium-catalysed aryl-acetylene coupling reactions have been used by Stoddart's group to construct long rigid molecular spacers of the [2]rotaxane shuttle, 3, (Figure 2) whereby low shuttling energy barriers were reported unless a "speed bump" moiety was attached to the naphthalene ring [6]. In a similar vein, we preceded these results with our non-degenerate tripodal two-station rotaxane shuttle, 4 ( Figure 3), which was designed to be adsorbed in an oriented way on a titanium dioxide surface [7]. Unexpectedly, the synthesis of the rigid spacer, B, via Suzuki-type cross-coupling proved problematic, as no terphenyl product could be isolated for R = H, X = OH; however, when R = Me, X = OH, the terphenyl linker was isolable in 75% yield, and was fully characterised by X-ray crystallography [8]. Similarly, catalysed coupling reactions were recently used by Loeb and co-workers in the synthesis of oligo-p-phenylene components of their solid-state shuttle 5 [9].
In the present report, we collect together some of our own work and focus chiefly on molecular machines and rotors, whereby a defined pair of molecular fragments is connected by a rotatable single C-C bond (Figure 1, part iv) to attain restricted intramolecular rotation. Our goal was to prepare molecular gearing systems, incorporating a paddlewheel-shaped triptycene fragment attached to a molecular shuttle. The dynamic behaviour of the shuttle could, in principle, allow free rotation or function as a molecular brake, as in Figure 4. . Palladium-catalysed formation of C-C bonds in the tripodal rigid non-degenerate shuttle, 4 [7,8], and the rigid ring-in-ring shuttle, 5 [9]. The planned approach was to prepare 9-(3-indenyl)anthracene, 6, and 9-(2-indenyl)anthracene, 7. The synthesis of such molecules requires the attachment of the bicyclic unit to anthracene, with subsequent Diels-Alder addition of benzyne to form the corresponding indenyl triptycenes, 8 and 9, respectively. One could then envisage incorporation of a bulky organometallic fragment that could undergo a reversible η 6 Figure 3. Palladium-catalysed formation of C-C bonds in the tripodal rigid non-degenerate shuttle, 4 [7,8], and the rigid ring-in-ring shuttle, 5 [9].
In the present report, we collect together some of our own work and focus chiefly on molecular machines and rotors, whereby a defined pair of molecular fragments is connected by a rotatable single C-C bond (Figure 1, part iv) to attain restricted intramolecular rotation. Our goal was to prepare molecular gearing systems, incorporating a paddlewheel-shaped triptycene fragment attached to a molecular shuttle. The dynamic behaviour of the shuttle could, in principle, allow free rotation or function as a molecular brake, as in Figure 4. Figure 4. Schematic of a molecular gearing system in which free rotation of the paddlewheel P is controlled by sliding the "latch" Y of the shuttle S.
The planned approach was to prepare 9-(3-indenyl)anthracene, 6, and 9-(2-indenyl)anthracene, 7. The synthesis of such molecules requires the attachment of the bicyclic unit to anthracene, with subsequent Diels-Alder addition of benzyne to form the corresponding indenyl triptycenes, 8 and 9, respectively. One could then envisage incorporation of a bulky organometallic fragment that could undergo a reversible η 6 ⇿ η 5 haptotropic shift across the indenyl framework, whereby the pentahapto-complexed system would hinder paddlewheel rotation. An appropriate cross-coupling procedure appeared to offer the most propitious route to 6 and 7.

Synthetic Aspects
Our initial target, 9-(3-indenyl)anthracene, 6, was successfully obtained in 42% yield via the Stille coupling of 9-bromoanthracene and 1-(tributylstannyl)indene catalysed by Pd(PPh3)4 in DMF [10]. Interestingly, benzyne addition to 6 occurred not only at the C(9) and C(10) positions of the anthracene to give the desired triptycene, 8, but also to the indenyl substituent, thus furnishing the [4 + 2] cyclo-adduct, 10 (Scheme 2). These three structures were validated by X-ray crystallography [10,11], and are shown in Figures 5 and 6. These data revealed the extent of steric crowding between the indenyl and the peri-hydrogens at C(1), C(8) and C(13) of the triptycyl unit in 8 that engenders a η 5 haptotropic shift across the indenyl framework, whereby the pentahapto-complexed system would hinder paddlewheel rotation. An appropriate cross-coupling procedure appeared to offer the most propitious route to 6 and 7.

Synthetic Aspects
Our initial target, 9-(3-indenyl)anthracene, 6, was successfully obtained in 42% yield via the Stille coupling of 9-bromoanthracene and 1-(tributylstannyl)indene catalysed by Pd(PPh 3 ) 4 in DMF [10]. Interestingly, benzyne addition to 6 occurred not only at the C(9) and C(10) positions of the anthracene to give the desired triptycene, 8, but also to the indenyl substituent, thus furnishing the [4 + 2] cyclo-adduct, 10 (Scheme 2). These three structures were validated by X-ray crystallography [10,11], and are shown in Figures 5 and 6. These data revealed the extent of steric crowding between the indenyl and the peri-hydrogens at C(1), C(8) and C(13) of the triptycyl unit in 8 that engenders a 50 kJ mol −1 rotational barrier, as measured by variable-temperature NMR, even before incorporation of the organometallic moiety.   In light of these observations, it was decided to focus on the preparation of 9-(2-indenyl)anthracene, 7, the precursor to 9-(2-indenyl)triptycene. A previous report indicated that Heck-type palladium cross-couplings of indene with iodoarenes led primarily to formation of 2-arylindenes and, to a lesser extent, 3-arylindenes [12]. However, since their characterisations were based only on NMR data, we chose to perform the reaction of indene with 1-bromo-4-iodobenzene, using palladium acetate as the catalyst and triethylamine as the base [11]. Gratifyingly, the major product was identified unequivocally by X-ray crystallography as 2-(4-bromophenyl)indene, 11, whose structure appears as Figure 7. Molecules 2020, 25, 1950 5 of 22 As anticipated, the iodo substituent, rather than bromo, was replaced (Scheme 3, upper). Nevertheless, we found that bromobenzene and indene in the presence of dichloro-bis(tri-Otolylphosphine)palladium(II) in DMF at 100 • C delivered 2-phenylindene in 90% yield. Therefore, with some confidence (unjustified, as it turned out), we carried out the reaction of indene with 9-bromoanthracene under these same conditions in the expectation of forming the desired 9-(2-indenyl)anthracene, 7, as the major isomer. However, as depicted in Scheme 3 (lower), the already known 9-(3-indenyl)anthracene, 6, together with the indeno-dihydroaceanthrylene, 12, (Figure 8) were the only cross-coupled products [11].  These results may be rationalised in terms of the two different modes of insertion of indene into the palladium-aryl linkage of (9-anthracenyl)Pd(O-tolyl 3 P) 2 Br, thereby generating intermediates 13 and 14 (Scheme 4). In the former case, syn-elimination of HPd(O-tolyl 3 P) 2 Br occurs readily to yield 9-(1-indenyl)anthracene that subsequently rearranges to its 9-(3-indenyl)anthracene counterpart, 6. However, intermediate 14 lacks a suitably positioned hydrogen syn to palladium and so instead undergoes intramolecular palladation of the adjacent anthracene ring to form the aceanthrylene, 12. Such a mechanism should leave the two bridgehead hydrogens in a syn arrangement, as is indeed evident in the X-ray crystal structure shown in Figure 8, which emphasizes the folded nature of the molecule about the common bond linking the two five-membered rings.
With 9-(2-indenyl)anthracene in hand, Diels-Alder addition of benzyne to form 9-(2indenyl)triptycene, 9, proceeded in 81% yield. This much improved yield of 9 compared to that of 9-(3-indenyl)triptycene, 8 (42%) may be attributed to the trajectory of approach for a potential [4 + 2] cycloaddition of benzyne to the five-membered ring of either 6 or 7. As depicted in Schemes 2 and 7, in the former case, access to both the anthracene and the indene is available, whereas, in the 2-indenyl system, the latter process would be blocked by the proximity of the planar anthracenyl, thus leading to a single product in enhanced yield [11]. Scheme 7. Reaction of benzyne and 9-2(indenyl)anthracene yields only a single adduct, 9.

Cycloadditions of Benzyne to 2-Phenylindene
Intrigued by the unexpected cycloaddition of benzyne to the indenyl substituent of 9-(3-indenyl)anthracene to form the methano-dihydrophenanthrene, 10, we chose to investigate the reaction of benzyne with 2-phenylindene. Although the majority of the starting indene was recovered, two products were isolated and fully characterised as benzyne adducts [11]. The first was readily identified spectroscopically as the known indeno-phenanthrene, 20, resulting from the addition of a single benzyne to 2-phenylindene. Presumably, the initially formed dihydrophenanthrene, 21, was further oxidised in the presence of excess isoamyl nitrite (Scheme 9). Scheme 9. Cycloaddition reactions of benzyne to 2-phenylindene.
The formula of the second product corresponded to the addition of two benzyne units to 2-phenylindene; one can envisage the first step as the [4 + 2] cycloaddition to the indenyl moiety to form 22, entirely analogous to the reaction of benzyne with 9-(3-indenyl)anthracene to form 10. In the second step, [2 + 2] addition yields a cyclobutene, 23, that adopts the syn, rather than the anti, configuration because of the presence of the adjacent phenyl substituent. Subsequent thermolysis can open up the four-membered ring and bring about rearrangement to the observed product 24 that was unequivocally characterised by X-ray crystallography ( Figure 10). The thermodynamic driving force for such a process would be the relief of steric strain in the cyclobutene ring, and the recovery of aromatic character in the original six-membered ring of the indene [11].
The 2-phenylindene reacts with Cr(CO) 6 in 1,4-dioxane at 125 • C to form two isomeric complexes wherein the Cr(CO) 3 tripod is attached in an η 6 fashion either to the phenyl substituent, as in 25, or to the six-membered ring of the indene, as in 26 (Scheme 10). (η 5 -2-phenylindenyl)Re(CO) 3 , 27, was prepared either directly by heating the ligand with Re 2 (CO) 10 in decalin in a sealed tube at 160 • C or indirectly by transmetallation of 2-phenyl-1-trimethylstannylindene. The structures of 25 and 27 appear as Figure 11 and show that the indenyl and phenyl planes differ only slightly from coplanarity [20]. We note that complexes 25 and 27 can each adopt a mirror-symmetric (C s ) conformation; in the chromium case, the indenyl unit must be aligned orthogonal to the plane of the phenyl ring (dihedral angle of 90 • ), whereas, in the rhenium complex, 27, the molecular mirror plane only bisects both the indenyl and phenyl rings when they are coplanar (dihedral angle of 0 • ). In all these cases, the rotation barrier about the axis connecting the rings is very low; DFT calculations suggest values in the range of 20-30 kJ mol −1 [20]. As shown in Scheme 11, the syntheses of the chromium and rhenium tricarbonyl complexes of 9-(2-indenyl)anthracene, 28 and 29, respectively, parallel those of their 2-phenylindene counterparts. However, the considerably larger wingspan of the anthracenyl moiety brings about noticeable changes in their structures and dynamic behaviour; the interplanar indenyl anthracenyl angles in the chromium and rhenium complexes were found to be 62 • and 52 • , respectively ( Figure 12).
In the η 6 -bonded chromium system, 28, the rotational barrier for equilibration of the benzo rings of the anthracene was measured by V-T NMR as~63 kJ mol −1 , a value 15 kJ mol −1 higher than that found for the (η 5 -indenyl)rhenium complex, 29, despite the Cr(CO) 3 tripod being further away from the anthracene. However, one should recall that the NMR experiment yields a value for the energy separation between the ground state and the transition state for the dynamic process. In this case, rather than invoking a decrease in the energy of the transition state, it is more likely that the ground state has been raised by steric interactions with the methylene hydrogen atoms rather than with the metal carbonyl tripodal fragment, thus lowering the observed barrier. It is, therefore, particularly noteworthy that upon deprotonation of [η 6 -2-(9-anthracenyl)indene]tricarbonylchromium, 28, which brings about a haptotropic shift of the tripod to form the anion [η 5 -2-(9-anthracenyl)indenyl]tricarbonylchromium, 30, closely analogous to the rhenium complex, 29, this rotational barrier has once again decreased, an effect we designated as an "anti-braking" phenomenon.  As depicted in Figure 13, in 29, oscillation of the (indenyl)Re(CO) 3 moiety across the mirror plane containing the anthracenyl framework, which equilibrates each of the three pairs of indenyl protons but maintains the inequivalence of the benzo rings of the anthracene, has a barrier too low to be accessed by V-T NMR even at −80 • C. In contrast, a window-wiper type of motion that equilibrates the terminal rings of the anthracene has to surmount a 48 kJ mol −1 barrier that arises because of the build-up of steric interactions as the indenyl and anthracenyl fragments approach coplanarity. Complete 360 • rotation to generate effective time-averaged C 2v symmetry requires that both processes are operative [20].

Organometallic Derivatives of Indenyl Triptycenes
Attempts to coordinate M(CO) 3 tripods, where M = Cr, Mn or Re, to indenyl triptycenes led to a number of different products (Scheme 12). Dealing first with 9-(3-indenyl)triptycene, 8, reaction with Cr(CO) 6 gave only a single isomer, 34, in which the tricarbonylchromium fragment is sited on a benzo ring of the triptycene (Figure 15), rather than on the six-membered ring of the indenyl substituent [10]. An alternative approach, addition of benzyne to 31, in which the Cr(CO) 3 moiety is already in place, was unsuccessful. However, reaction of 8 with Re 2 (CO) 10 gave a low yield of the η 5 -Re(CO) 3 complex, 35 [20]. We note in particular that the indenyl ring in 35 is oriented such that the tricarbonylrhenium tripod is aligned with a valley between two blades ( Figure 15).
A 13 C NMR study on the η 5 -rhenium complex 38 revealed that, at room temperature, the triptycyl resonances are each split into a 2:1 pattern, clearly indicating that paddlewheel rotation was slow on the NMR time-scale. However, upon raising the temperature, the gradual onset of line broadening, together with computer simulation of the spectra, yielded a barrier of 84 ± 2 kJ mol −1 for equilibration of the three benzo blades; the manganese analogue, 39, behaved similarly. In contrast, in the η 6 -chromium complex, 36, peak decoalescence even at low temperatures was never apparent, revealing that paddlewheel rotation continued essentially unhindered.
The crucial experiment whereby deprotonation of 36 to form its η 5 -haptotropomer, 40, once again brought about a 2:1 splitting of the triptycyl blade NMR resonances is depicted in Scheme 13. The space-filling representation (Figure 17) of the η 5 -Mn(CO) 3 complex, 39, which is an ideal structural model for the isoelectronic anion, 40, illustrates unequivocally how the bulky organometallic group obtrudes into a valley between two benzo blades, thus hindering paddlewheel rotation. One can only conclude that shuttling of the Cr(CO) 3 moiety from the six-membered to the five-membered ring of the 2-indenyl component, brought about by deprotonation, represents a pH-dependent organometallic molecular brake [21].
In the present report, we collect together some of our own wo machines and rotors, whereby a defined pair of molecular fragm single C-C bond (Figure 1, part iv) to attain restricted intramol prepare molecular gearing systems, incorporating a paddlewh attached to a molecular shuttle. The dynamic behaviour of the shu rotation or function as a molecular brake, as in Figure 4. The planned approach was to prepare 9-(3-indenyl)anthracen 7. The synthesis of such molecules requires the attachment of the subsequent Diels-Alder addition of benzyne to form the correspon respectively. One could then envisage incorporation of a bulky or undergo a reversible η 6 ⇿ η 5 haptotropic shift across the in pentahapto-complexed system would hinder paddlewheel rotatio procedure appeared to offer the most propitious route to 6 and 7.

Synthetic Aspects
Our initial target, 9-(3-indenyl)anthracene, 6, was successfully coupling of 9-bromoanthracene and 1-(tributylstannyl)indene cata Interestingly, benzyne addition to 6 occurred not only at the anthracene to give the desired triptycene, 8, but also to the indeny [4 + 2] cyclo-adduct, 10 (Scheme 2). These three structures were va [10,11], and are shown in Figures 5 and 6. These data revealed the the indenyl and the peri-hydrogens at C(1), C(8) and C(13) of the tr η 5 haptotropic shift driven by a deprotonation/protonation sequence prompted us to consider the possibility of using an electrochemically-driven redox approach. To this end, we wished to incorporate archetypal bulky redox-active species, viz. one or more ferrocenyl units. The reported synthesis of 9-ferrocenylanthracene, 41, by Butler, utilising the Negishi-type cross-coupling reaction of chlorozincioferrocene with 9-bromoanthracene using (dppf)PdCl 2 as the catalyst, led to yields of 30-35% [22]. Previous attempts to bring about a Suzuki cross-coupling were unsuccessful unless a large excess of ferrocenylboronic acid was used along with an almost stoichiometric amount of catalyst [23]. However, when tetrabutylammonium hydroxide in 1,4-dioxane was used as the base and (dppf)PdCl 2 as the catalyst, yields up to 90% were achievable (Scheme 14) [24]. As shown in Figure 18, the ferrocenyl substituents in 9-ferrocenylanthracene, 41, and 9,10diferrocenylanthracene, 42, each make dihedral angles of 45 • with the plane of the anthracene; in 42, the ferrocenyls are rotated 89 • from each other, thus engendering C 2 symmetry. However, it is evident from our detailed V-T experiments that 42 can exist in two forms, and at 193 K these atropisomers are indeed detectable by NMR in a 38:62 syn to anti ratio. The dynamic behaviour of 9-ferrocenylanthracene, 41, paralleled that of [η 5 -2-(9anthracenyl)indenyl]tricarbonylrhenium, 29, whereby, entirely analogous to that depicted in Figure 12, the system racemises, via a low-energy process, by oscillation of the ferrocenyl group about the mirror plane containing the anthracene, thereby exhibiting dynamic C s symmetry. The second, higher-energy, process has a barrier of 44 ± 2 kJ mol −1 , and together these allow the ferrocenyl moiety to access both faces of the anthracene and both terminal benzo rings; thus, at room temperature, the molecule exhibits effective C 2v symmetry on the NMR time-scale.
In the structure of 42, depicted in Figure 18, the two ferrocenyl fragments are positioned on the same face of the anthracene, but, because there is a substantial barrier (ca. 45 kJ mol −1 ) towards either of them becoming coplanar with the central anthracene ring, this actually represents an anti-isomer with dynamic C 2h symmetry.

Mono-and di-Ferrocenyl Triptycenes
Addition of benzyne to 41 and 42 yields the corresponding ferrocenyl triptycenes, 43 and 44, respectively (Figure 19). On a 500 MHz spectrometer, even at room temperature, the signals of the three benzo blades of 43 are split into a 2:1 pattern, indicating slowed paddlewheel rotation on the NMR time-scale; the barrier was evaluated as 69 ± 2 kJ mol −1 . As with its anthracene precursor, 9,10-diferrocenyltriptycene, 44, exists as two atropisomers, whereby the two sandwich moieties are aligned in the same valley (eclipsed, C 2v , meso) or in different valleys (gauche, C 2 , racemic), and are readily distinguishable by NMR spectroscopy [24]. An Exchange Spectroscopy (EXSY) study of the dynamic behaviour of 9,10-diferrocenyltriptycene revealed a number of interesting features, in particular the nature of the exchange mechanism linking the rotamers of 44. Thus, interconversion of the two mirror forms of the rac isomer proceeds in a stepwise manner via the meso structure; likewise, a 120 • rotation of a single ferrocenyl in the meso isomer generates a rac structure, and these interconversions are readily detectable in the EXSY experiment when the mixing time is short (50 ms). However, with longer mixing times (300 ms), second generation cross-peaks become evident, thereby revealing exchange between sites within the rac or meso isomers. This can only occur via the other rotamer, that is, it must follow the sequence meso → rac → meso or rac → meso → rac [24].
We note that the assignment of 1 H NMR resonances in the vicinity of a ferrocenyl group is greatly facilitated by its extraordinarily large diamagnetic anisotropy [25]. Typically, in ferrocenyl triptycenes, a proton lying directly above a cyclopentadienyl ring is shielded by~1.2 ppm relative to its normal aromatic resonance position. In contrast, protons lying near the horizontal plane containing the iron atom are deshielded by~1.2 ppm, as exemplified by the data for the C 1 -symmetric rotamer of 2,3-dimethyl-9-ferrocenyltriptycene whose structure is shown in Figure 20. This work has been extended to a situation where the triptycene itself is dissymmetric by virtue of the presence of two bulky tert-butyl substituents [26]. Suzuki cross-coupling of 9,10-dibromo-2,6di-tert-butylanthracene with ferrocenylboronic acid catalysed by (dppf)PdCl 2 in dioxane gave 45 ( Figure 21) in 93% yield, and subsequent Diels-Alder addition of benzyne delivered the required 2,6-di-tert-butyl-9,10-diferrocenyltriptycene, 46 (Scheme 14). Since each ferrocenyl unit in the triptycene 46 can adopt one of three different positions, one can envisage nine atropisomers: three eclipsed structures and six gauche conformers. However, symmetry considerations lower this number to six different rotamers, three of which are doubly degenerate.
Stepwise interconversions of these rotamers do not all have identical barriers, since manoeuvring around a bulky tert-butyl substituent is more sterically demanding than the traversal past a C-H linkage. Nevertheless, as noted above, the diamagnetic anisotropy of the ferrocenyl fragments dramatically enhances the separation between aromatic proton resonances such that, at 600 MHz, the problem becomes resolvable, and all six rotamers can be unequivocally identified. Indeed, in Figure 22, are shown the exchange pathways between the six rotamers; in some cases, direct interconversion between rotamers is possible (such as A In the present report, we collect together some of our own work and focus chiefly on molecular machines and rotors, whereby a defined pair of molecular fragments is connected by a rotatable single C-C bond (Figure 1, part iv) to attain restricted intramolecular rotation. Our goal was to prepare molecular gearing systems, incorporating a paddlewheel-shaped triptycene fragment attached to a molecular shuttle. The dynamic behaviour of the shuttle could, in principle, allow free rotation or function as a molecular brake, as in Figure 4.  Figure 4. Schematic of a molecular gearing system in which free rotation of the paddlewheel P is controlled by sliding the "latch" Y of the shuttle S.
The planned approach was to prepare 9-(3-indenyl)anthracene, 6, and 9-(2-indenyl)anthracene, 7. The synthesis of such molecules requires the attachment of the bicyclic unit to anthracene, with subsequent Diels-Alder addition of benzyne to form the corresponding indenyl triptycenes, 8 and 9, respectively. One could then envisage incorporation of a bulky organometallic fragment that could undergo a reversible η 6 ⇿ η 5 haptotropic shift across the indenyl framework, whereby the pentahapto-complexed system would hinder paddlewheel rotation. An appropriate cross-coupling procedure appeared to offer the most propitious route to 6 and 7.

Synthetic Aspects
E), in others a two-step process (e.g., B Molecules 2020, 25, x FOR PEER REVIEW Figure 3. Palladium-catalysed formation of C-C bonds in the tripodal rigid n [7,8], and the rigid ring-in-ring shuttle, 5 [9]. In the present report, we collect together some of our own work and machines and rotors, whereby a defined pair of molecular fragments is single C-C bond (Figure 1, part iv) to attain restricted intramolecular prepare molecular gearing systems, incorporating a paddlewheel-sh attached to a molecular shuttle. The dynamic behaviour of the shuttle cou rotation or function as a molecular brake, as in Figure 4. The planned approach was to prepare 9-(3-indenyl)anthracene, 6, an 7. The synthesis of such molecules requires the attachment of the bicycl subsequent Diels-Alder addition of benzyne to form the corresponding in respectively. One could then envisage incorporation of a bulky organom undergo a reversible η 6 ⇿ η 5 haptotropic shift across the indenyl pentahapto-complexed system would hinder paddlewheel rotation. An a procedure appeared to offer the most propitious route to 6 and 7.

Synthetic Aspects
C) is mandatory. Note that the lowest energy route from A to D goes in two steps via E.

Cycloaddition Reactions of Mono-and di-Ferrocenyl Anthracenes
Cycloaddition reactions of anthracenes with a wide range of dienophiles have been intensely studied ever since the original work of Diels and Alder [27], and the relationship between electronic and steric effects is complex. Typically, benzyne adds to 9,10-dimethylanthracene to form exclusively the electronically favoured 9,10-dimethyltriptycene, thus generating three aromatic systems. In contrast, with 9,10-diphenylanthracene, benzyne adds to the 1,4 rather than the 9,10-positions by a factor of 93:7 [28].
Since palladium cross-coupling procedures had provided us with sufficient quantities of monoand di-ferrocenyl anthracenes, 41 and 42, to enable further investigation of their reactivity, we undertook a comprehensive study of their cycloaddition chemistry, in particular their reactions with benzynes, alkynes, maleimides and benzoquinone. As shown in Scheme 15, benzyne, dimethylbenzyne and fluorobenzyne add across C(9) and C(10) to form triptycenes, whereas trifluoromethylbenzyne adds in a 1,4-fashion to give the corresponding tetracene, and tetrafluorobenzyne adds both ways. Likewise, DMAD, N-methyl-and N-phenyl-maleimides and benzophenone all react to yield the appropriate barrelene [29,30]. The more sterically hindered 9,10-diferrocenylanthracene also undergoes 9,10-additions with benzynes bearing small substituents, but trifluoromethylbenzyne, DMAD and the maleimides add predominantly at the C(1) and C(4) positions (Scheme 16).

Cross-Coupling of 2-Phenyl-and 2-Methyl Indenes
The CuCl 2 -mediated reaction of either 2-phenyl or 2-methylindene generates racemic and meso biindenyls (Scheme 17) in almost equal amounts, implying a radical process. Surprisingly perhaps, simply allowing their lithio salts to react slowly with oxygen yields only racemic products; this has been interpreted in terms of a nucleophilic attack by one anion on the peroxide of its partner, but the mechanism remains speculative [31]. The structures of molecules 47 through 50 are shown in Figures 23 and 24 and, in all cases, the indenyl fragments adopt a gauche orientation [19,31]. It is interesting to note that the racemic products always maintain their C 2 symmetry whatever the rotation angle between the two indenyl units. In contrast, meso isomers lose all their symmetry elements unless the central H-C-C-H dihedral angle is 0 • or 180 • , thereby giving rise either to a mirror plane (C s ) or an inversion centre (C i ), respectively. The rotational barriers about the axis linking the indenyls are ca. 85 and 65 kJ mol −1 in the phenyl and methyl cases, respectively [19].

The Curious Case of the 2-Indenyltriptycene Dimer
In a closely related system, the oxidative coupling of 2-indenyltriptycene produces rac-2,2 -di(9triptycyl)-1,1 -biindenyl, 51, whose structure appears as Figure 25. However, the molecule is not strictly C 2 symmetric in the solid state; although the 1,1 -biindenyl core maintains its local C 2 axis, the C s -type orientation of the intermeshed triptycene blades breaks this symmetry, as depicted in the space-fill representation. Remarkably, despite the obvious steric congestion, there is no evidence, even at 193 K, of slowed paddlewheel rotation on the NMR time-scale. Evidently, in solution, it behaves as a molecular gearing system that exhibits dynamic C 2 symmetry implying that the triptycyl units undergo correlated disrotatory motion with concomitant interplanar bending to compensate for the unusually large range of angles (from 103 • to 135 • ) between the paddlewheel blades [31].

Hindered Rotations in Phenyl-Anthracenes
Many ligands widely used in catalytic asymmetric syntheses, such as BINAP, depend for their activity on the phenomenon of non-interconverting atropisomers that give rise to R and S enantiomers because of steric hindrance between bulky aromatic ring systems. We were, therefore, intrigued by the computational prediction that 9-phenylanthracene should adopt an orthogonal orientation of the two ring systems and exhibit a rotational barrier of ca. 84 kJ mol −1 about the axis connecting them [32]. To probe such an assertion experimentally, one must lower the C 2v symmetry of 9-phenylanthracene (or the D 2h symmetry of 9,10-diphenylanthracene), but not introduce any additional steric perturbations.
Once again, a palladium-mediated procedure appeared to be viable. Our initial approach involved the incorporation of meta-fluoro substituents in 9,10-diphenylanthracene, via the Suzuki cross-coupling (in 97% yield) of 9,10-dibromoanthracene with 3-fluorophenylboronic acid, catalysed by (dppf)PdCl 2 in 1,4-dioxane in the presence of tetrabutylammonium hydroxide [33]. The interconversion of the syn and anti rotamers of 9,10-di(3-fluorophenyl)anthracene, 52, was monitored by variable-temperature 13 C-and 19 F-NMR spectroscopy and yielded a barrier of 88 ± 2 kJ × mol −1 , gratifyingly close to the calculated prediction. The structure of anti-52, appears in Figure 26, showing that in the solid state the fluorophenyl groups are orientated at 85 • to the plane of the anthracene. Nevertheless, even this minor perturbation does not really provide an answer for the unsubstituted phenyl group, which requires that the symmetry of the environment of the phenyl be broken rather than the symmetry of the phenyl itself. This was accomplished by the synthesis and structural characterisation of 9-(1-naphthyl)-10-phenylanthracene, 53, by using the same Suzuki procedure to couple 9-iodo-10-phenylanthracene and 1-naththylboronic acid in 55% yield. Since it is known that the rotational barrier in 9-(1-naphthyl)anthracene is~160 kJ mol −1 [32], this provides a rigid mirror-symmetric framework against which the dynamic behaviour of an unsubstituted phenyl ring can be monitored. The structure of 53 is also shown in Figure 26 and reveals that the dihedral angles of the phenyl and naphthyl rings relative to the plane of the anthracene are 80 • and 88 • , respectively. Moreover, even at 303 K, on a 600 MHz spectrometer the ortho proton resonances of the phenyl ring already show non-equivalence, indicating slowed rotation on the NMR time-scale, and a barrier of at least 85 kJ mol −1 [33]. Overall, these observations provide an experimental validation of the computational prediction.

Conclusions
In our studies of sterically hindered molecules, in particular with their relevance to molecular machines, following the examples of our eminent predecessors, we have taken advantage of the versatile palladium cross-coupling approaches of Stille, Heck, Suzuki and Sonogashira to develop convenient, often high-yield, routes to indenyl and ferrocenyl anthracenes and triptycenes. Their structures, reactivity and dynamic behaviour have been elucidated by X-ray crystallography and variable-temperature NMR spectroscopy and have revealed how rotational barriers between molecular fragments can be manipulated by the controlled migration of organometallic moieties.
Moreover, copper-catalysed coupling of substituted 2-indenyl systems to form racemic and meso biindenyls led to an apparently heavily congested molecule, in which, surprisingly, correlated gear rotation of adjacent triptycyl moieties continues unhindered. Finally, the computationally predicted large rotation barrier in 9-phenylanthracene has been experimentally verified by judicious symmetry breaking.