Structure-Dependent Activity of Plant-Derived Sweeteners
Department of Pharmaceutical Biology, Kiel University, Gutenbergstraße 76, 24118 Kiel, Germany
Academic Editors: Wolfgang Sippl and Fidele Ntie-Kang
Molecules 2020, 25(8), 1946; https://doi.org/10.3390/molecules25081946
Received: 31 March 2020
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Revised: 19 April 2020
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Accepted: 21 April 2020
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Published: 22 April 2020
(This article belongs to the Special Issue Structure–Activity Relationships (SAR) of Natural Products)
Human sensation for sweet tastes and the thus resulting over-consumption of sugar in recent decades has led to an increasing number of people suffering from caries, diabetes, and obesity. Therefore, a demand for sugar substitutes has arisen, which increasingly has turned towards natural sweeteners over the last 20 years. In the same period, thanks to advances in bioinformatics and structural biology, understanding of the sweet taste receptor and its different binding sites has made significant progress, thus explaining the various chemical structures found for sweet tasting molecules. The present review summarizes the data on natural sweeteners and their most important (semi-synthetic) derivatives until the end of 2019 and discusses their structure–activity relationships, with an emphasis on small-molecule high-intensity sweeteners.
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Keywords:
natural product; plant origin; non-caloric sweeteners; mogrosides; stevia glycosides; phyllodulcin
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Ҫiçek, S.S. Structure-Dependent Activity of Plant-Derived Sweeteners. Molecules 2020, 25, 1946. https://doi.org/10.3390/molecules25081946
AMA Style
Ҫiçek SS. Structure-Dependent Activity of Plant-Derived Sweeteners. Molecules. 2020; 25(8):1946. https://doi.org/10.3390/molecules25081946
Chicago/Turabian StyleҪiçek, Serhat S. 2020. "Structure-Dependent Activity of Plant-Derived Sweeteners" Molecules 25, no. 8: 1946. https://doi.org/10.3390/molecules25081946
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