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Open AccessCommentary

COVID-19, Chloroquine Repurposing, and Cardiac Safety Concern: Chirality Might Help

1
Department of Pharmacy–Pharmaceutical Sciences, University of Bari Aldo Moro, via E. Orabona, 4, I-70126 Bari, Italy
2
Pharmacognosy Research Laboratories & Herbal Analysis Services UK, University of Greenwich, Chatham-Maritime, Kent ME4 4TB, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Diego Muñoz-Torrero
Molecules 2020, 25(8), 1834; https://doi.org/10.3390/molecules25081834
Received: 20 March 2020 / Revised: 14 April 2020 / Accepted: 15 April 2020 / Published: 16 April 2020
The desperate need to find drugs for COVID-19 has indicated repurposing strategies as our quickest way to obtain efficacious medicines. One of the options under investigation is the old antimalarial drug, chloroquine, and its analog, hydroxychloroquine. Developed as synthetic succedanea of cinchona alkaloids, these chiral antimalarials are currently in use as the racemate. Besides the ethical concern related to accelerated large-scale clinical trials of drugs with unproven efficacy, the known potential detrimental cardiac effects of these drugs should also be considered. In principle, the safety profile might be ameliorated by using chloroquine/hydroxychloroquine single enantiomers in place of the racemate. View Full-Text
Keywords: SARS-CoV-2; COVID-19; 2019-nCoV; SARS; chiral switch; MERS; Ebola; repositioning; hydroxychloroquine SARS-CoV-2; COVID-19; 2019-nCoV; SARS; chiral switch; MERS; Ebola; repositioning; hydroxychloroquine
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MDPI and ACS Style

Lentini, G.; Cavalluzzi, M.M.; Habtemariam, S. COVID-19, Chloroquine Repurposing, and Cardiac Safety Concern: Chirality Might Help. Molecules 2020, 25, 1834.

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