Synthesis, Antimicrobial and Antioxidant Activities of 2-Isoxazoline Derivatives
1
Department of Chemistry, Faculty of Science, University of Ha’il, P.O. Box. 2440, Ha’il 81451, Saudi Arabia
2
Department of Chemistry, Faculty of Science, Yarmouk University, P.O. Box.566, Irbid 21163, Jordan
3
Department of Chemistry, Tafila Technical University, P.O. Box. 179, Tafila 66110, Jordan
*
Author to whom correspondence should be addressed.
Molecules 2020, 25(18), 4271; https://doi.org/10.3390/molecules25184271
Received: 20 August 2020
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Revised: 11 September 2020
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Accepted: 16 September 2020
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Published: 18 September 2020
(This article belongs to the Section Organic Chemistry)
A series of derivatives of trans-3-(2,4,6-trimethoxyphenyl)4,5-dihydroisoxazolo-4,5-bis[carbonyl-(4′phenyl)thiosemicarbazide (9) and of trans-3-(2,4,6-trimethoxyphenyl)-4,5-dihydro isoxazolo-4,5-bis(aroylcarbohydrazide) (10a–c) were synthesized from trans-3-(2,4,6-trimethoxyphenyl)-4,5-dihydro-4,5-bis(hydrazenocarbonyl)isoxazole (8). The structures of the compounds were elucidated by both elemental and spectral (IR, NMR, and MS) analysis. Compound 9 shows activity against some bacterial species. No antibacterial activities were observed for compounds 10a–c. The antioxidant activity of the new compounds has been screened. Compound 9 showed higher antioxidant activity using the DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS (2’-azino–bis(3-ethylbenzoline-6-sulfonic acid) diammonium salt methods.
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Keywords:
isoxazolines; nitrile oxide; 1,3-dipolar cycloaddition; antibacterial activity; antioxidant activity
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MDPI and ACS Style
Alshamari, A.; Al-Qudah, M.; Hamadeh, F.; Al-Momani, L.; Abu-Orabi, S. Synthesis, Antimicrobial and Antioxidant Activities of 2-Isoxazoline Derivatives. Molecules 2020, 25, 4271. https://doi.org/10.3390/molecules25184271
AMA Style
Alshamari A, Al-Qudah M, Hamadeh F, Al-Momani L, Abu-Orabi S. Synthesis, Antimicrobial and Antioxidant Activities of 2-Isoxazoline Derivatives. Molecules. 2020; 25(18):4271. https://doi.org/10.3390/molecules25184271
Chicago/Turabian StyleAlshamari, Asma, Mahmoud Al-Qudah, Fedaa Hamadeh, Lo’ay Al-Momani, and Sultan Abu-Orabi. 2020. "Synthesis, Antimicrobial and Antioxidant Activities of 2-Isoxazoline Derivatives" Molecules 25, no. 18: 4271. https://doi.org/10.3390/molecules25184271
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