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Review

The War against Tuberculosis: A Review of Natural Compounds and Their Derivatives

1
School of Pharmacy, Lake Erie College of Osteopathic Medicine, Bradenton, FL 34211, USA
2
Lake Erie College of Osteopathic Medicine, Bradenton, FL 34211, USA
3
School of Dental Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, FL 34211, USA
4
Department of Chemistry, Kavayitri Bahinabai Chaudhari North Maharashtra University, Jalgaon 425 001, Maharashtra, India
5
Department of Pharmacognosy, Poona College of Pharmacy, Bharati Vidyapeeth (Deemed to be University), Pune-411 038, Maharashtra, India
*
Authors to whom correspondence should be addressed.
Molecules 2020, 25(13), 3011; https://doi.org/10.3390/molecules25133011
Received: 9 May 2020 / Revised: 25 June 2020 / Accepted: 26 June 2020 / Published: 30 June 2020
(This article belongs to the Collection Herbal Medicine Research)
Tuberculosis (TB), caused by the bacterial organism Mycobacterium tuberculosis, pose a major threat to public health, especially in middle and low-income countries. Worldwide in 2018, approximately 10 million new cases of TB were reported to the World Health Organization (WHO). There are a limited number of medications available to treat TB; additionally, multi-drug resistant TB and extensively-drug resistant TB strains are becoming more prevalent. As a result of various factors, such as increased costs of developing new medications and adverse side effects from current medications, researchers continue to evaluate natural compounds for additional treatment options. These substances have the potential to target bacterial cell structures and may contribute to successful treatment. For example, a study reported that green and black tea, which contains epigallocatechin gallate (a phenolic antioxidant), may decrease the risk of contracting TB in experimental subjects; cumin (a seed from the parsley plant) has been demonstrated to improve the bioavailability of rifampicin, an important anti-TB medication, and propolis (a natural substance produced by honeybees) has been shown to improve the binding affinity of anti-TB medications to bacterial cell structures. In this article, we review the opportunistic pathogen M. tuberculosis, various potential therapeutic targets, available therapies, and natural compounds that may have anti-TB properties. In conclusion, different natural compounds alone as well as in combination with already approved medication regimens should continue to be investigated as treatment options for TB. View Full-Text
Keywords: Tuberculosis; Mycobacterium tuberculosis; multidrug resistance; antibiotics; natural compounds Tuberculosis; Mycobacterium tuberculosis; multidrug resistance; antibiotics; natural compounds
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MDPI and ACS Style

Maiolini, M.; Gause, S.; Taylor, J.; Steakin, T.; Shipp, G.; Lamichhane, P.; Deshmukh, B.; Shinde, V.; Bishayee, A.; Deshmukh, R.R. The War against Tuberculosis: A Review of Natural Compounds and Their Derivatives. Molecules 2020, 25, 3011. https://doi.org/10.3390/molecules25133011

AMA Style

Maiolini M, Gause S, Taylor J, Steakin T, Shipp G, Lamichhane P, Deshmukh B, Shinde V, Bishayee A, Deshmukh RR. The War against Tuberculosis: A Review of Natural Compounds and Their Derivatives. Molecules. 2020; 25(13):3011. https://doi.org/10.3390/molecules25133011

Chicago/Turabian Style

Maiolini, Morgan, Stacey Gause, Jerika Taylor, Tara Steakin, Ginger Shipp, Purushottam Lamichhane, Bhushan Deshmukh, Vaibhav Shinde, Anupam Bishayee, and Rahul R. Deshmukh. 2020. "The War against Tuberculosis: A Review of Natural Compounds and Their Derivatives" Molecules 25, no. 13: 3011. https://doi.org/10.3390/molecules25133011

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