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Polyacetylenes from the Roots of Swietenia macrophylla King

Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China
Institute of Tropical Agriculture and Forestry, Hainan University, Haikou 570228, China
Authors to whom correspondence should be addressed.
Academic Editor: Alessandra Guerrini
Molecules 2019, 24(7), 1291;
Received: 22 February 2019 / Revised: 20 March 2019 / Accepted: 22 March 2019 / Published: 2 April 2019
(This article belongs to the Special Issue Biological Activities of Plant Secondary Metabolites)
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A phytochemical investigation of the roots of Swietenia macrophylla led to the isolation of seven polyacetylenes, including five new compounds (15) and two known ones (67). Their structures were elucidated by extensive spectroscopic analysis and detailed comparison with reported data. All the isolates were tested for their cytotoxicity against the human hepatocellular carcinoma cell line BEL-7402, human myeloid leukemia cell line K562, and human gastric carcinoma cell line SGC-7901. Compounds 1 and 6 showed moderate cytotoxicity against the above three human cancer cell lines with IC50 values ranging from 14.3 to 45.4 μM. Compound 4 displayed cytotoxicity against the K562 and SGC-7901 cancer cell lines with IC50 values of 26.2 ± 0.4 and 21.9 ± 0.3 μM, respectively. View Full-Text
Keywords: Swietenia macrophylla; roots; polyacetylene; cytotoxicity Swietenia macrophylla; roots; polyacetylene; cytotoxicity

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Mi, C.-N.; Wang, H.; Chen, H.-Q.; Cai, C.-H.; Li, S.-P.; Mei, W.-L.; Dai, H.-F. Polyacetylenes from the Roots of Swietenia macrophylla King. Molecules 2019, 24, 1291.

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