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Open AccessArticle

Brominated Bisindole Alkaloids from the Celtic Sea Sponge Spongosorites calcicola

1
Marine Biodiscovery Laboratory, School of Chemistry and Ryan Institute, National University of Ireland Galway, University Road, Galway H91 TK33, Ireland
2
National Marine Biodiscovery Laboratory of Ireland, Marine Institute, Renville West, Oranmore H91 R673, Ireland
3
Discipline of Microbiology, School of Natural Sciences, Centre for One Health (Ryan Institute), Infection and Immunity Cluster (NCBES), National University of Ireland Galway, University Road, Galway H91 TK33, Ireland
4
Department of Natural Sciences, National Museums Northern Ireland, 153 Bangor Road, Hollywood BT18 0EU, Ireland
*
Author to whom correspondence should be addressed.
Academic Editors: Artur Silva and Diana Cláudia Pinto
Molecules 2019, 24(21), 3890; https://doi.org/10.3390/molecules24213890
Received: 15 October 2019 / Revised: 23 October 2019 / Accepted: 24 October 2019 / Published: 29 October 2019
As part of an ongoing program to identify new bioactive compounds from Irish marine bioresources, we selected the subtidal sponge Spongosorites calcicola for chemical study, as fractions of this species displayed interesting cytotoxic bioactivities and chemical profiles. The first chemical investigation of this marine species led to the discovery of two new bisindole alkaloids of the topsentin family, together with six other known indole alkaloids. Missing the usual central core featured by the representatives of these marine natural products, the new metabolites may represent key biosynthetic intermediates for other known bisindoles. These compounds were found to exhibit weak cytotoxic activity against HeLa tumour cells, suggesting a specificity towards previously screened carcinoma and leukaemia cells. View Full-Text
Keywords: marine natural products; sponge; cytotoxicity; bisindole alkaloid; Spongosorites marine natural products; sponge; cytotoxicity; bisindole alkaloid; Spongosorites
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MDPI and ACS Style

Jennings, L.K.; Khan, N.M.D.; Kaur, N.; Rodrigues, D.; Morrow, C.; Boyd, A.; Thomas, O.P. Brominated Bisindole Alkaloids from the Celtic Sea Sponge Spongosorites calcicola. Molecules 2019, 24, 3890.

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