LARAMED: A Laboratory for Radioisotopes of Medical Interest
Abstract
:1. Introduction
2. The LARAMED Facility
- RILAB radiochemistry labs, designed for R&D (Research and Development) activities on radioisotope production, isolation, purification, and quality control;
- RILAB-Target lab, designed for developing and manufacturing innovative solid target systems for both nuclear physics and medical radioisotopes production; and
- RIFAC labs, for radioisotope/radiopharmaceutical production.
3. Ongoing LARAMED Research Programs
3.1. APOTEMA and TECHN-OSP: 99mTc Cyclotron Production
- radiochemical separation/purification processes’ optimization for extracting 99mTc from the irradiated target [22];
- A hub-lab can produce and deliver stable 100Mo targets;
- hospitals produce and separate 99mTc using their cyclotrons and the automatic module we developed; and
- hospitals send back to the hub-lab the used enriched target material for reprocessing.
3.2. COME: COpper Measurement
3.3. PASTA: Production with Accelerator of Sc-47 for Theranostics Applications
3.4. METRICS: Multimodal pET/mRi Imaging with Cyclotron-Produced 52/51Mn iSotopes
3.5. E-PLATE: Electrostatic Powder pLating for Accelerator TargEts
3.6. TERABIO: innovative technologies for radionuclide ThERApy and BIOimaging
4. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Sample Availability: Samples of the targets are not available from the authors. |
Facility | Target Station/Bunkers | Expected Current |
---|---|---|
RIFAC | RI#1 RI#2 | 500 µA 500 µA |
RILAB | RI#3 A9c | 300 µA 100 nA |
Project | RN | Half-Life | Eγ (keV) | Iγ (%) | Eβ−mean (keV) | I β− (%) | Eβ+mean (keV) | I β+ (%) |
---|---|---|---|---|---|---|---|---|
APOTEMA/TECHN-OSP | 99mTc | 6.0072 h (9) | 140.511 (1) | 89 (4) | ||||
COME | 67Cu | 61.83 h (12) | 184.577 (10) | 48.7 (3) | 141 (13) | 100 (6) | ||
PASTA | 47Sc | 3.3492 days (6) | 159.381 (15) | 68.3 (4) | 162.0 (21) | 100 (8) | ||
METRICS | 52Mn | 5.591 days (3) | 242 (5) | 29.4 (4) | ||||
51Mn | 46.2 m (1) | 962.8 (5) | 97.09 (3) |
Tasks | Main Results |
---|---|
Identification of the optimal irradiation parameters | - Proton beam energies: 15–20 MeV; - Irradiation time: 3–6 h; - Mo-100 enrichment level > 99%. |
Target configuration | - Thick (300 µm) Mo-100 (99.86%) metal target produced by SPS * on a Cu/Au backing; - Thermomechanical stability up to 1.3 kW. |
Target processing | - Dissolution + MEK SE § in an automatic module; - Processing time 60 min; - Recovery yield 93%. |
Mo-100 target recovery in metallic form | - Decomposition of Na2MoO4 to MoO3; - MoO3 reduction to Mo metal (two-steps hydrogen reduction in a dedicated static hydrogen gas overpressure reactor); - Total overall recovery yield > 85%. |
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Share and Cite
Esposito, J.; Bettoni, D.; Boschi, A.; Calderolla, M.; Cisternino, S.; Fiorentini, G.; Keppel, G.; Martini, P.; Maggiore, M.; Mou, L.; et al. LARAMED: A Laboratory for Radioisotopes of Medical Interest. Molecules 2019, 24, 20. https://doi.org/10.3390/molecules24010020
Esposito J, Bettoni D, Boschi A, Calderolla M, Cisternino S, Fiorentini G, Keppel G, Martini P, Maggiore M, Mou L, et al. LARAMED: A Laboratory for Radioisotopes of Medical Interest. Molecules. 2019; 24(1):20. https://doi.org/10.3390/molecules24010020
Chicago/Turabian StyleEsposito, Juan, Diego Bettoni, Alessandra Boschi, Michele Calderolla, Sara Cisternino, Giovanni Fiorentini, Giorgio Keppel, Petra Martini, Mario Maggiore, Liliana Mou, and et al. 2019. "LARAMED: A Laboratory for Radioisotopes of Medical Interest" Molecules 24, no. 1: 20. https://doi.org/10.3390/molecules24010020