Recent Studies on Cyclic 1,7-Diarylheptanoids: Their Isolation, Structures, Biological Activities, and Chemical Synthesis

Diarylheptanoids are a family of plant secondary metabolites with a 7 carbon skeleton possessing two phenyl rings at the 1- and 7-positions. They can be subdivided into acyclic and cyclic diarylheptanoids where the latter are further divided into meta,meta-bridged biphenyls ([7.0]metacyclophanes) and meta,para-bridged diphenyl ether heptanoids (oxa[7.1]metapara-cyclophanes). Since the isolation of curcumin from the rhizomes of turmeric (Curcuma longa) in 1815 which was named curcumin, a variety of diarylheptanoids have been isolated from a number of plant families such as Aceraceae, Actinidiaceae, Betulaceae, Burseraceae, Casuarinaceae, Juglandaceae, Leguminosae, Myricaceae, and Zingiberaceae. Earlier studies on these diarylheptanoids have been summarized on several occasions, of which the main themes only focus on isolation, structure elucidation, and the biological properties of linear types. Only a few have covered cyclic diarylheptanoids and their chemical synthesis has been covered lastly by Zhu et al. in 2000. The present paper has, therefore, covered recent progress in cyclic diarylheptanoids focusing on the isolation, structural and biological features, and chemical synthesis.


Introduction
Diarylheptanoids are a family of plant secondary metabolites with a seven-carbon skeleton possessing two phenyl rings at positions 1 and 7. They can be subdivided into acyclic diaryheptanoids (type I, linear) and cyclic diarylheptanoids where the latter are further divided into meta,meta-bridged biphenyls (type II, [7.0]metacyclophanes) [1] and meta,para-bridged diphenyl ether heptanoids (type III, oxa [7.1]metaparacyclophanes) [2,3]. Vogel and Pelletier isolated a "yellow coloring-matter" from the rhizomes of turmeric (Curcuma longa) in 1815 and named it curcumin [4], and a century passed before the structure of curcumin by synthesis was defined as the first diarylheptanoid [5]. Since then, a variety of diarylheptanoids have been isolated from a number of plant families including Aceraceae, Actinidiaceae, Betulaceae, Burseraceae, Casuarinaceae, Juglandaceae, Leguminosae, Myricaceae, and Zingiberaceae. The Vogel and Pelletier isolated a "yellow coloring-matter" from the rhizomes of turmeric (Curcuma longa) in 1815 and named it curcumin [4], and a century passed before the structure of curcumin by synthesis was defined as the first diarylheptanoid [5]. Since then, a variety of diarylheptanoids have been isolated from a number of plant families including Aceraceae, Alpinia + − − [31] Curcuma + − − [4] Their unique and characteristic structural features and wide range of biological properties have contributed to their popularity, which has led to continual isolation, evaluation of biological properties, and total synthesis. The earlier studies on diarylheptanoids were summarized by Claeson et al. [32,33], and by Lv and She [34,35], which included all of these three subcategories. Although the two reviews by Claeson et al. covered the general aspects of diarylheptanoids, the reviews by Lv and She focused on their structures, distributions, biological activities and 13 C-nuclear magnetic resonance (NMR) spectral data of over 400 diarylheptanoids. In addition, additional reviews and papers covering linear diarylheptanoids have appeared recently [36][37][38][39], but reviews addressing cyclic diarylheptanoids are very limited. Furthermore, the main themes of the reviews focused on the isolation, structure elucidation, and biological properties while attention to synthesis was somewhat out of scope. Reviews by Keserü and Nógrádi [2] and by Zhu et al. [3] paid attention to the total synthesis of three categories of diarylheptanoids; no additional summaries have been made since then. The present paper has, therefore, covered the recent progress in macrocyclic diarylheptanoids with a focus on their isolation, structural features, biological properties, and synthesis.  [43] a Giffonin A-K, Q, R, and S are diphenyl ether heptanoids (vide infra). b R' = β-D-glucopyranosyl. c Aceroside I-X are cyclic diphenyl ether heptanoids (vide infra). The second series of biphenyl diarylheptanoids, myricanone (11a) and myricanol (12a) were isolated from Myrica nagi (Myricaceae) [68][69][70]. Myricanone has a variety of biological activities, which have been summarized in Table 3, whereas myricanol has an anti-tau activity thus having anti-Alzheimer's disease activity. It has been figure out that the aS,11R enantiomer [(−)-12aa-(aS)(11R), vide infra] is responsible for the majority of tau-lowering activity [71]. The second series of biphenyl diarylheptanoids, myricanone (11a) and myricanol (12a) we lated from Myrica nagi (Myricaceae) [68][69][70]. Myricanone has a variety of biological activitie ich have been summarized in Table 3, whereas myricanol has an anti-tau activity thus having an zheimer's disease activity. It has been figure out that the aS,11R enantiomer [(−)-12aa-(aS)(11R e infra] is responsible for the majority of tau-lowering activity [71]. The absolute configuration at C-11 of myricanol (12aa) was determined by an X-ray cryst ucture on 16-bromomyricanol (13), prepared by brominating myricanol, and found to be aR [69,7 though the absolute configuration of secondary alcohol at C-11 was assigned as S, the authors d t mention about the atropisomerism [72,73] of the molecule developed by biphenyl axis. Howeve configuration of the biphenyl axis of 16-bromomyricanol could be readily assigned to P (mo ely aR) configuration by carefully analyzing X-ray crystal structure. Myricanol has also bee lated from M. gale [74], M. rubra [28], M. esculenta [75], and M. cerifera [44], and Morella salicifo ] as well. Later, an extensive NMR study revised a previous 13 C-assignment and X-ray analys dy of (±)-myricanol that confirmed the structure [44]. In addition, additional derivatives ricanone and myricanol as well as their glycosides isolated so far reported, are summarized bles 3 and 4.
The absolute configuration at C-11 of myricanol (12aa) was determined by an X-ray crystal structure on 16-bromomyricanol (13), prepared by brominating myricanol, and found to be aR [69,70]. Although the absolute configuration of secondary alcohol at C-11 was assigned as S, the authors did not mention about the atropisomerism [72,73] of the molecule developed by biphenyl axis. However, the configuration of the biphenyl axis of 16-bromomyricanol could be readily assigned to P (more likely aR) configuration by carefully analyzing X-ray crystal structure. Myricanol has also been isolated from M. gale [74], M. rubra [28], M. esculenta [75], and M. cerifera [44], and Morella salicifolia [29] as well. Later, an extensive NMR study revised a previous 13 C-assignment and X-ray analysis study of (±)-myricanol that confirmed the structure [44]. In addition, additional derivatives of myricanone and myricanol as well as their glycosides isolated so far reported, are summarized in Tables 3 and 4.    [87], DPPH radical scavenging (IC50 = 6.8 μM) [88], SOD-like activity (IC50 = 90.5 μg/mL) [89] 12m     It should be noted that a series of myricananins A-H (12e, 12f, 11g, 14, 11h, and 12g-i) were also isolated from Myrica nana and showed inhibitory activity (IC 50 = 45-63 µM) on nitric oxide release in LPS-activated peritoneal macrophages [82].

Acerogenins and Acerosides
Nagai et al. reported the first diphenyl ether diarylheptanoid, acerogenin A (23b) [99] and its glycoside (23a) [100] from Acer nickoense and the latter could be enzymatically hydrolyzed to 23b. Later its regioisomer, 24a, was isolated from the same plant and named as acerogenin B (24a) [101]. One of the most impressive characteristics of 23b and 24a is the chemical shift of H 2 , which resonate at δ 5.84 and 5.46, respectively. Such resonances are highly upfield-shifted compared to the normal

Acerogenins and Acerosides
Nagai et al. reported the first diphenyl ether diarylheptanoid, acerogenin A (23b) [99] and its glycoside (23a) [100] from Acer nickoense and the latter could be enzymatically hydrolyzed to 23b. Later its regioisomer, 24a, was isolated from the same plant and named as acerogenin B (24a) [101]. One of the most impressive characteristics of 23b and 24a is the chemical shift of H 2 , which resonate at δ 5.84 and 5.46, respectively. Such resonances are highly upfield-shifted compared to the normal chemical resonances of protons (δ 7.26) on the benzene ring [102] and neighboring H 4 (δ 6.63 for 23b and 6.65 for 24a) in the molecule. Such a shift of resonances can be explained by the fact that this proton orients towards the shielding region imposed by the ring current of the neighboring phenyl ring [103]. X-ray crystallographic analysis of the related system such as galeon (26c) [104], maximowicziol (24h) [52], and acerogenin B (24a) [105] has revealed that the main planes of the two phenyls are very close to 90 o to each other. chemical resonances of protons (δ 7.26) on the benzene ring [102] and neighboring H 4 (δ 6.63 for 23b and 6.65 for 24a) in the molecule. Such a shift of resonances can be explained by the fact that this proton orients towards the shielding region imposed by the ring current of the neighboring phenyl ring [103]. X-ray crystallographic analysis of the related system such as galeon (26c) [104], maximowicziol (24h) [52], and acerogenin B (24a) [105] has revealed that the main planes of the two phenyls are very close to 90 o to each other.
Continued studies on the same plants led to the isolation of an additional cyclic diaryl ether heptanoid, aceroside IV (25a) as a glycoside. Hydrolysis of glycoside 25a afforded a new diarylheptanoid, acerogenin C (25b) [106], which was additionally isolated from Boswellia ovalifoliolata [19] later. It should be noted that a regioisomer of 25b was also isolated from Acer nikoense and named as acerogenin L (26a) [64].
Additional series of cyclic diaryl ether heptanoids, isolated so far, and their biological properties are summarized in Table 5.
Continued studies on the same plants led to the isolation of an additional cyclic diaryl ether heptanoid, aceroside IV (25a) as a glycoside. Hydrolysis of glycoside 25a afforded a new diarylheptanoid, acerogenin C (25b) [106], which was additionally isolated from Boswellia ovalifoliolata [19] later. It should be noted that a regioisomer of 25b was also isolated from Acer nikoense and named as acerogenin L (26a) [64].
lecules 2018, 23, x FOR PEER REVIEW 11 of emical resonances of protons (δ 7.26) on the benzene ring [102] and neighboring H 4 (δ 6.63 for 2 d 6.65 for 24a) in the molecule. Such a shift of resonances can be explained by the fact that th oton orients towards the shielding region imposed by the ring current of the neighboring phen g [103]. X-ray crystallographic analysis of the related system such as galeon (26c) [10 ximowicziol (24h) [52], and acerogenin B (24a) [105] has revealed that the main planes of the tw enyls are very close to 90 o to each other.
Continued studies on the same plants led to the isolation of an additional cyclic diaryl eth ptanoid, aceroside IV (25a) as a glycoside. Hydrolysis of glycoside 25a afforded a ne arylheptanoid, acerogenin C (25b) [106], which was additionally isolated from Boswel alifoliolata [19] later. It should be noted that a regioisomer of 25b was also isolated from Acer nikoen d named as acerogenin L (26a) [64].
Additional series of cyclic diaryl ether heptanoids, isolated so far, and their biological properti summarized in Table 5.
To determine the geometries of acerogenins, the splitting pattern of the 4 protons (H 2 , H 3 , H 5 and H 6 ) on para-disubstituted phenyl rings of acerogenins A (23b), C (25b), B (24a) and L (26a) in their 1 H NMR spectra may afford important information. Only two resonances were found for these protons appearing as an AB quartet ( 3 J = 8.3 Hz) in the spectra of acerogenins C and L, while four resonances, each being a doublet of doublet, were observed for the those of acerogenin A and B, respectively. These results may indicate that two sets of protons on the para-substituted phenyls in acerogenins A and B, such as H 2 and H 6 , H 3 and H 5 , are not equivalents, and may indicate a possible difference in the rotational energy barrier around the diaryl ether bond, unlike those in acerogenins C and L. The energy barriers in acerogenins C and L are, therefore, somewhat lower than those of acerogenins A and B, respectively. Indeed, the minimized energies of 25b (2.65 Kcal/mole) and 26a (3.85 Kcal/mole) calculated by Chem3D Pro ® are much lower than those of 23b (10.11 Kcal/mole) and 24a (10.15 Kcal/mole). The presence of sp 2 -hybridized carbon (carbonyl) in the heptyl chain of 25b and 26a may reduce both angle strain and H-H steric interactions relative to those of 23b and 24a, respectively. Such a rotational energy barrier in the systems with a substituent such as galeon would be increased sufficiently enough not to rotate, leading to two atropisomers. Indeed, galeon has been isolated on two separate occasions in both levo- [104] and dextrorotatory [112] ones from Myrica gale, respectively. The configuration of planar chirality was determined by X-ray crystallographic analysis of the corresponding 4-bromobenzoate (26d) of (−)-galeon to be M-(−)-galeon (26cb) and thus dextrorotatory one was determined as P-(+)-galeon (26ca). It should be noted that the nature of conformational chirality, the racemization mechanisms, and predictions of these for diaryl ether heptanoids have been recently studied [119]. To determine the geometries of acerogenins, the splitting pattern of the 4 protons (H 2 , H 3 , H 5 and H 6 ) on para-disubstituted phenyl rings of acerogenins A (23b), C (25b), B (24a) and L (26a) in their 1 H NMR spectra may afford important information. Only two resonances were found for these protons appearing as an AB quartet ( 3 J = 8.3 Hz) in the spectra of acerogenins C and L, while four resonances, each being a doublet of doublet, were observed for the those of acerogenin A and B, respectively. These results may indicate that two sets of protons on the para-substituted phenyls in acerogenins A and B, such as H 2 and H 6 , H 3 and H 5 , are not equivalents, and may indicate a possible difference in the rotational energy barrier around the diaryl ether bond, unlike those in acerogenins C and L. The energy barriers in acerogenins C and L are, therefore, somewhat lower than those of acerogenins A and B, respectively. Indeed, the minimized energies of 25b (2.65 Kcal/mole) and 26a (3.85 Kcal/mole) calculated by Chem3D Pro ® are much lower than those of 23b (10.11 Kcal/mole) and 24a (10.15 Kcal/mole). The presence of sp 2 -hybridized carbon (carbonyl) in the heptyl chain of 25b and 26a may reduce both angle strain and H-H steric interactions relative to those of 23b and 24a, respectively. Such a rotational energy barrier in the systems with a substituent such as galeon would be increased sufficiently enough not to rotate, leading to two atropisomers. Indeed, galeon has been isolated on two separate occasions in both levo- [104] and dextrorotatory [112] ones from Myrica gale, respectively. The configuration of planar chirality was determined by X-ray crystallographic analysis of the corresponding 4-bromobenzoate (26d) of (−)-galeon to be M-(−)-galeon (26cb) and thus dextrorotatory one was determined as P-(+)-galeon (26ca). It should be noted that the nature of conformational chirality, the racemization mechanisms, and predictions of these for diaryl ether heptanoids have been recently studied [119].

Garuganins and Garugamblins
A series of cyclic diarylheptanoids with a double bond in a heptyl skeleton were isolated such as 29a (garugamblin-1) and 31 (garugamblin-2) from Garuga gamblei [122,123], garugamblin-3 from After we isolated galeon (26) [22] and its derivatives 27a,b,c [23] from the roots of Juglans mandshirica, and a series of related diaryl ether heptanoids, 27d-f from the stem of Engelhardia roxburghiana [21,120], were additionally isolated. Unfortunately, the plane chirality was not defined in all cases and remained to be clarified. The originally proposed structure 28 [120] as engelhardione was later revised as to 27f [21], which is identical to previously reported pterocarine (26b) [25] and revised structure was confirmed by total synthesis (vide infra). The compound 27c showed strong inhibitory activity (95.7%) on topoisomerase II at 50 µg/mL level [121]. Engelhardiols A (27d) and B (27e) displayed anti-tubercular activity with MIC values of 72.7 and 62.1 µM, respectively [21]. Related engelhardione has MIC of 0.2 µg/mL against Mycobacterium tuberculosis (H37Rv) [120]. To determine the geometries of acerogenins, the splitting pattern of the 4 protons (H 2 , H 3 , H 5 and H 6 ) on para-disubstituted phenyl rings of acerogenins A (23b), C (25b), B (24a) and L (26a) in their 1 H NMR spectra may afford important information. Only two resonances were found for these protons appearing as an AB quartet ( 3 J = 8.3 Hz) in the spectra of acerogenins C and L, while four resonances, each being a doublet of doublet, were observed for the those of acerogenin A and B, respectively. These results may indicate that two sets of protons on the para-substituted phenyls in acerogenins A and B, such as H 2 and H 6 , H 3 and H 5 , are not equivalents, and may indicate a possible difference in the rotational energy barrier around the diaryl ether bond, unlike those in acerogenins C and L. The energy barriers in acerogenins C and L are, therefore, somewhat lower than those of acerogenins A and B, respectively. Indeed, the minimized energies of 25b (2.65 Kcal/mole) and 26a (3.85 Kcal/mole) calculated by Chem3D Pro ® are much lower than those of 23b (10.11 Kcal/mole) and 24a (10.15 Kcal/mole). The presence of sp 2 -hybridized carbon (carbonyl) in the heptyl chain of 25b and 26a may reduce both angle strain and H-H steric interactions relative to those of 23b and 24a, respectively. Such a rotational energy barrier in the systems with a substituent such as galeon would be increased sufficiently enough not to rotate, leading to two atropisomers. Indeed, galeon has been isolated on two separate occasions in both levo- [104] and dextrorotatory [112] ones from Myrica gale, respectively. The configuration of planar chirality was determined by X-ray crystallographic analysis of the corresponding 4-bromobenzoate (26d) of (−)-galeon to be M-(−)-galeon (26cb) and thus dextrorotatory one was determined as P-(+)-galeon (26ca). It should be noted that the nature of conformational chirality, the racemization mechanisms, and predictions of these for diaryl ether heptanoids have been recently studied [119].
It should be noted that recent dynamic NMR studies revealed that garuganin I can undergo conformational enantiomerism, leading to racemization through the rotation of the C 7 -C 8 and C 12 -C 13 sigma bonds [130].
An additional series of diaryl ether heptenoids, giffonins A-K, Q, R, and S, were isolated from the leaves of the hazelnut tree (Corylus avellana) [11,12,132] which are summarized in Table 6. Diaryl ether heptenoids, giffonin D and giffonin H at 10 µM reduced both H 2 O 2 − and H 2 O 2 /Fe 2+ -induced lipid peroxidation by more than 60% and 50%, respectively, being more active than curcumin (19.2%). When hazelnuts were infected by so-called "Cimiciato", the composition of the constituents was changed to produce a new oxa [7.1]metametacyclophane, 40, along with asadanin (1a) and giffonin P (7f) [133]. When hazelnuts were infected by so-called "Cimiciato", the composition of the constituents was changed to produce a new oxa [7.1]metametacyclophane, 40, along with asadanin (1a) and giffonin P (7f) [133]. A unique cyclic diaryl heptadienoid tedarene A (41a) was isolated from the marine sponge Tedania ignis [42] and exhibited a couple of intriguing features. Although two double bonds can impose strain onto the cyclic heptanoid ring in tedarene A, the energy barrier between the two atropisomers is not sufficiently high to prevent interconversion at room temperature showing only one set of 1 H resonances in NMR spectrum without any of protons on para-substituted phenyl ring. Such a phenomenon reflects that the interconversion rate between the two atropisomers is, coincidently, in the coalescence region at room temperature to cause the proton resonances of H 2 and H 6 , as well as H 3 and H 5 , of the para-substituted phenyl ring to be sufficiently broadened to be undetectable. The rotational energy barrier of 41a was calculated by molecular dynamics simulation to be 14.0 Kcal/mol, which is way below the energy barrier (23.3 Kcal/mol) to define atropisomers [134,135]. A diphenyl ether heptatrienoid 42 was also isolated from Ostryopsis nobilis (Betulaceae) and the structure was confirmed by X-ray crystal structure analysis [16]. When hazelnuts were infected by so-called "Cimiciato", the composition of the constituents was changed to produce a new oxa [7.1]metametacyclophane, 40, along with asadanin (1a) and giffonin P (7f) [133]. A unique cyclic diaryl heptadienoid tedarene A (41a) was isolated from the marine sponge Tedania ignis [42] and exhibited a couple of intriguing features. Although two double bonds can impose strain onto the cyclic heptanoid ring in tedarene A, the energy barrier between the two atropisomers is not sufficiently high to prevent interconversion at room temperature showing only one set of 1 H resonances in NMR spectrum without any of protons on para-substituted phenyl ring. Such a phenomenon reflects that the interconversion rate between the two atropisomers is, coincidently, in the coalescence region at room temperature to cause the proton resonances of H 2 and H 6 , as well as H 3 and H 5 , of the para-substituted phenyl ring to be sufficiently broadened to be undetectable. The rotational energy barrier of 41a was calculated by molecular dynamics simulation to be 14.0 Kcal/mol, which is way below the energy barrier (23.3 Kcal/mol) to define atropisomers [134,135]. A diphenyl ether heptatrienoid 42 was also isolated from Ostryopsis nobilis (Betulaceae) and the structure was confirmed by X-ray crystal structure analysis [16].  A unique cyclic diaryl heptadienoid tedarene A (41a) was isolated from the marine sponge Tedania ignis [42] and exhibited a couple of intriguing features. Although two double bonds can impose strain onto the cyclic heptanoid ring in tedarene A, the energy barrier between the two atropisomers is not sufficiently high to prevent interconversion at room temperature showing only one set of 1 H resonances in NMR spectrum without any of protons on para-substituted phenyl ring. Such a phenomenon reflects that the interconversion rate between the two atropisomers is, coincidently, in the coalescence region at room temperature to cause the proton resonances of H 2 and H 6 , as well as H 3 and H 5 , of the para-substituted phenyl ring to be sufficiently broadened to be undetectable. The rotational energy barrier of 41a was calculated by molecular dynamics simulation to be 14.0 Kcal/mol, which is way below the energy barrier (23.3 Kcal/mol) to define atropisomers [134,135]. A diphenyl ether heptatrienoid 42 was also isolated from Ostryopsis nobilis (Betulaceae) and the structure was confirmed by X-ray crystal structure analysis [16].
impose strain onto the cyclic heptanoid ring in tedarene A, the energy barrier between the two atropisomers is not sufficiently high to prevent interconversion at room temperature showing only one set of 1 H resonances in NMR spectrum without any of protons on para-substituted phenyl ring. Such a phenomenon reflects that the interconversion rate between the two atropisomers is, coincidently, in the coalescence region at room temperature to cause the proton resonances of H 2 and H 6 , as well as H 3 and H 5 , of the para-substituted phenyl ring to be sufficiently broadened to be undetectable. The rotational energy barrier of 41a was calculated by molecular dynamics simulation to be 14.0 Kcal/mol, which is way below the energy barrier (23.3 Kcal/mol) to define atropisomers [134,135]. A diphenyl ether heptatrienoid 42 was also isolated from Ostryopsis nobilis (Betulaceae) and the structure was confirmed by X-ray crystal structure analysis [16].

Biosynthetic Pathway
Before the total synthesis of cyclic diarylheptanoids was considered, studies on the biosynthetic pathways are addressed.
Elegant studies on the degradation of acerogenin A and the radioisotope-tracing biosynthetic pathway for 1,7-diaylheptanoids revealed that two cinnamate units coupled to a malonate via acetyl CoA leading to the 1,7-diphenylheptanoid, curcumin [136,137], which was further converted to centrolobol. In addition, Fujita and his coworkers performed two radioisotope experiments [138]: They fed labelled compounds, DL-[3-14 C]phenylalanine and [3-14 C]cinnamic acid to the young shoots of Acer nikoense and found that 95% of the radioactivity of acerogenin remained on the C1/C7, but in the case of L-1-13 C]phenylalanine, only 5% of the radioactivity was incorporated at the positions C1/C7 in acerogenin A. On the other hand, feeding

Biosynthetic Pathway
Before the total synthesis of cyclic diarylheptanoids was considered, studies on the biosynthetic pathways are addressed. Elegant studies on the degradation of acerogenin A and the radioisotopetracing biosynthetic pathway for 1,7-diaylheptanoids revealed that two cinnamate units coupled to a malonate via acetyl CoA leading to the 1,7-diphenylheptanoid, curcumin [136,137], which was further converted to centrolobol. In addition, Fujita and his coworkers performed two radioisotope experiments [138]: They fed labelled compounds, DL-[3-14 C]phenylalanine and [3-14 C]cinnamic acid to the young shoots of Acer nikoense and found that 95% of the radioactivity of acerogenin remained on the C1/C7, but in the case of L-1- 13

Biosynthetic Pathway
Before the total synthesis of cyclic diarylheptanoids was considered, studies on the biosynthetic pathways are addressed. Elegant studies on the degradation of acerogenin A and the radioisotopetracing biosynthetic pathway for 1,7-diaylheptanoids revealed that two cinnamate units coupled to a malonate via acetyl CoA leading to the 1,7-diphenylheptanoid, curcumin [136,137], which was further converted to centrolobol. In addition, Fujita and his coworkers performed two radioisotope experiments [138]: They fed labelled compounds, DL-[3-14 C]phenylalanine and [3-14 C]cinnamic acid to the young shoots of Acer nikoense and found that 95% of the radioactivity of acerogenin remained on the C1/C7, but in the case of L-1- 13  It should be noted that Watanabe et al. isolated alnusonol (5a) along with its suspected precursor platyphyllonol (44) [53], from which one may deduce the presence of dicarbon radical as a possible intermediate in the biosynthetic pathway for the (9S)-alnusonol (5a) via C-C coupling.
Such a premise was proved by the isolation of three cyclized diarylheptanoids such as acerogenin A (23b), (R)-acerogenin B (24a), and acerogenin E (5l), and a linear diarylheptanoid, (−)centrolobol together from the same plants indicates that the former two are biosynthetically related to (−)-centrolobol [107]. In addition, many plants have afforded various combinations of two from the three diarylheptanoids (i.e., linear, biphenyl heptanoids and diphenyl ether heptanoids). One Such a premise was proved by the isolation of three cyclized diarylheptanoids such as acerogenin A (23b), (R)-acerogenin B (24a), and acerogenin E (5l), and a linear diarylheptanoid, (−)-centrolobol together from the same plants indicates that the former two are biosynthetically related to (−)-centrolobol [107]. In addition, many plants have afforded various combinations of two from the three diarylheptanoids (i.e., linear, biphenyl heptanoids and diphenyl ether heptanoids). One possible explanation for these results comes from the intramolecular oxidative coupling of phenolic linear diarylheptanoid via the free diradicals: A phenolic oxidative C-C coupling would lead to meta,meta-bridged biphenyl heptanoids, whereas the corresponding C-O coupling would result in the alternative, meta,para-bridged diphenyl ether heptanoids.

Total Synthesis of Biphenyl Heptanoids
The formation of the aryl-aryl bond has long been of interest in the development of facile synthetic methods, i.e., metal catalyzed coupling reactions, such as Suzuki [139], Stille [140], Negishi [141], Ullmann [142,143], and electro-as well as photochemical methods [144]. Among these, the Suzuki reaction, the Ullmann reaction, and the photochemical process have been applied to biphenyl diarylheptanoids at the final step. The Wittig [145], Thorpe [146], and olefin metathesis [147] reactions have also been employed for the C-C bond formation in the heptane moiety. However, attempts using Thorpe reaction failed to afford the desired cyclic biphenyl heptanoids [148], which would, thus, not be discussed herein.

Aryl-Aryl Bond Formation via Metal Catalyzed Coupling
The Ni(0)-promoted intramolecular coupling of aryl halide developed by Semmelhack [149] was applied to the total synthesis upon biphenyl heptanoid, alnusone (4a) for the first time [150]. The reaction of diiodide 49 in the presence of tetrakis(triphenylphosphine)nickel afforded methylprotected alnusone (50) in 46% yield. The acid-catalyzed deprotection of methyl group produced 4a with 72% yield.
The same strategy has been applied to the synthesis of myricanone and myricanol by Whiting and Wood [151]. The intramolecular ring closure of diiodides 54 provided the corresponding benzylprotected myricanone (55a) and myricanol (55b) in 10% and 7.3% yield, respectively. The low yield was explained by angle strain and van der Waals hydrogen interaction caused by the sp 3 -hybridized

Total Synthesis of Biphenyl Heptanoids
The formation of the aryl-aryl bond has long been of interest in the development of facile synthetic methods, i.e., metal catalyzed coupling reactions, such as Suzuki [139], Stille [140], Negishi [141], Ullmann [142,143], and electro-as well as photochemical methods [144]. Among these, the Suzuki reaction, the Ullmann reaction, and the photochemical process have been applied to biphenyl diarylheptanoids at the final step. The Wittig [145], Thorpe [146], and olefin metathesis [147] reactions have also been employed for the C-C bond formation in the heptane moiety. However, attempts using Thorpe reaction failed to afford the desired cyclic biphenyl heptanoids [148], which would, thus, not be discussed herein.

Aryl-Aryl Bond Formation via Metal Catalyzed Coupling
The Ni(0)-promoted intramolecular coupling of aryl halide developed by Semmelhack [149] was applied to the total synthesis upon biphenyl heptanoid, alnusone (4a) for the first time [150]. The reaction of diiodide 49 in the presence of tetrakis(triphenylphosphine)nickel afforded methyl-protected alnusone (50) in 46% yield. The acid-catalyzed deprotection of methyl group produced 4a with 72% yield.

Total Synthesis of Biphenyl Heptanoids
The formation of the aryl-aryl bond has long been of interest in the development of facile synthetic methods, i.e., metal catalyzed coupling reactions, such as Suzuki [139], Stille [140], Negishi [141], Ullmann [142,143], and electro-as well as photochemical methods [144]. Among these, the Suzuki reaction, the Ullmann reaction, and the photochemical process have been applied to biphenyl diarylheptanoids at the final step. The Wittig [145], Thorpe [146], and olefin metathesis [147] reactions have also been employed for the C-C bond formation in the heptane moiety. However, attempts using Thorpe reaction failed to afford the desired cyclic biphenyl heptanoids [148], which would, thus, not be discussed herein.

Aryl-Aryl Bond Formation via Metal Catalyzed Coupling
The Ni(0)-promoted intramolecular coupling of aryl halide developed by Semmelhack [149] was applied to the total synthesis upon biphenyl heptanoid, alnusone (4a) for the first time [150]. The reaction of diiodide 49 in the presence of tetrakis(triphenylphosphine)nickel afforded methylprotected alnusone (50) in 46% yield. The acid-catalyzed deprotection of methyl group produced 4a with 72% yield.
The same strategy has been applied to the synthesis of myricanone and myricanol by Whiting and Wood [151]. The intramolecular ring closure of diiodides 54 provided the corresponding benzyl-protected myricanone (55a) and myricanol (55b) in 10% and 7.3% yield, respectively. The low yield was explained by angle strain and van der Waals hydrogen interaction caused by the sp 3 -hybridized methylene units compared to those of sp 2 -hybridized E-methine in the former molecule, alnusone. The subsequent hydrogenolysis of 55a afforded 11a while 12a was prepared by hydrogenolysis of 55b followed by hydrolysis. It should be noted that authors did not mention about either the presence of stereoisomers or NMR spectral data for the compound 55b even though 55b has both a chirality center and a chiral axis. The starting 54a,b were prepared by iodination of 53a,c, respectively. The Grignard reagent generated from 51 was reacted with 3-(4-benzyloxyphenyl)propanal (52) to provide 53a in 21% yield. Acetylation of 53a gave 53b and oxidation of 53a with pyridinium chlorochromate (PCC) gave 53c [152].
cules 2018, 23, x FOR PEER REVIEW 18 o hylene units compared to those of sp 2 -hybridized E-methine in the former molecule, alnuso subsequent hydrogenolysis of 55a afforded 11a while 12a was prepared by hydrogenolysis followed by hydrolysis. It should be noted that authors did not mention about either the presen tereoisomers or NMR spectral data for the compound 55b even though 55b has both a chiral ter and a chiral axis. The starting 54a,b were prepared by iodination of 53a,c, respectively. T gnard reagent generated from 51 was reacted with 3-(4-benzyloxyphenyl)propanal (52) to prov in 21% yield. Acetylation of 53a gave 53b and oxidation of 53a with pyridinium chlorochrom C) gave 53c [152].
Ogura and Usuki employed the same strategy to prepare acerogenin E (5l) and K (7h) [153] ch the Ni(0)-catalyzed reaction was modified by a more recent methodology of a domi uence of a Miyaura arylborylation and an intramolecular Suzuki reaction [154] of 59 ethylacerogenin E (60), of which deprotection by BBr3 to yield acerogenin E (5l). The reduction ith NaBH4 was followed by demethylation with BBr3 to provide acerogenin K (7h) in 95% yie starting 59 was prepared from 56 via Claisen-Schmidt condensation, catalytic reduction, a CO2Ag mediated iodination.
Ogura and Usuki employed the same strategy to prepare acerogenin E (5l) and K (7h) [153], in which the Ni(0)-catalyzed reaction was modified by a more recent methodology of a domino sequence of a Miyaura arylborylation and an intramolecular Suzuki reaction [154] of 59 to dimethylacerogenin E (60), of which deprotection by BBr 3 to yield acerogenin E (5l). The reduction of 60 with NaBH 4 was followed by demethylation with BBr 3 to provide acerogenin K (7h) in 95% yield. The starting 59 was prepared from 56 via Claisen-Schmidt condensation, catalytic reduction, and CF 3 CO 2 Ag mediated iodination. sequence of a Miyaura arylborylation and an intramolecular Suzuki reaction [154] of 59 to dimethylacerogenin E (60), of which deprotection by BBr3 to yield acerogenin E (5l). The reduction of 60 with NaBH4 was followed by demethylation with BBr3 to provide acerogenin K (7h) in 95% yield. The starting 59 was prepared from 56 via Claisen-Schmidt condensation, catalytic reduction, and CF3CO2Ag mediated iodination.
The similar oxidative homocoupling of the diboronic ester (62) also gave 60 in 50% yield [155]. The starting 62 was prepared from 58 via glycol protection of ketone, reaction with Cr(CO) 6 , borylation with isopropoxy-4,4-5,5-tetramethyl-1,3,2-dioxoborane, and the deprotection of ketone. It should be noted that neither the reduction of the double bond in 63 to 64 nor the direct cyclization of 63 to 65 under Suzuki-Miyaura coupling was successful [153]; thus, the cyclization of 64 using the above reaction conditions has not been pursued.
Such a method was revisited by Martin et al. for the synthesis of myricanol [71]. The intramolecular cross Suzuki-Miyaura coupling of compound 67, possessing an arylboronic acid pinacol ester and an aryl iodide resulted in a benzyl protected compound 68 as a racemic mixture. Debenzylation by hydrogenolysis, followed by enantioselective reduction of the keto group using Kselectride, led to a racemic mixture of 12aa, which was then resolved by chiral high-performance liquid chromatography (HPLC) to afford (+)-12aa-(aR)(11S) and (−)-12aa′-(aS)(11R), of which the absolute configuration were determined by X-ray analysis. The starting compound 67 was prepared by Claisen-Schmidt reaction of 65 and 66 in 39% yield.
It should be noted that neither the reduction of the double bond in 63 to 64 nor the direct cyclization of 63 to 65 under Suzuki-Miyaura coupling was successful [153]; thus, the cyclization of 64 using the above reaction conditions has not been pursued. It should be noted that neither the reduction of the double bond in 63 to 64 nor the direct cyclization of 63 to 65 under Suzuki-Miyaura coupling was successful [153]; thus, the cyclization of 64 using the above reaction conditions has not been pursued.
Such a method was revisited by Martin et al. for the synthesis of myricanol [71]. The intramolecular cross Suzuki-Miyaura coupling of compound 67, possessing an arylboronic acid pinacol ester and an aryl iodide resulted in a benzyl protected compound 68 as a racemic mixture. Debenzylation by hydrogenolysis, followed by enantioselective reduction of the keto group using Kselectride, led to a racemic mixture of 12aa, which was then resolved by chiral high-performance liquid chromatography (HPLC) to afford (+)-12aa-(aR)(11S) and (−)-12aa′-(aS)(11R), of which the absolute configuration were determined by X-ray analysis. The starting compound 67 was prepared by Claisen-Schmidt reaction of 65 and 66 in 39% yield.
Such a method was revisited by Martin et al. for the synthesis of myricanol [71]. The intramolecular cross Suzuki-Miyaura coupling of compound 67, possessing an arylboronic acid pinacol ester and an aryl iodide resulted in a benzyl protected compound 68 as a racemic mixture. Debenzylation by hydrogenolysis, followed by enantioselective reduction of the keto group using K-selectride, led to a racemic mixture of 12aa, which was then resolved by chiral high-performance liquid chromatography (HPLC) to afford (+)-12aa-(aR)(11S) and (−)-12aa -(aS)(11R), of which the absolute configuration were determined by X-ray analysis. The starting compound 67 was prepared by Claisen-Schmidt reaction of 65 and 66 in 39% yield. pinacol ester and an aryl iodide resulted in a benzyl protected compound 68 as a racemic mixture. Debenzylation by hydrogenolysis, followed by enantioselective reduction of the keto group using Kselectride, led to a racemic mixture of 12aa, which was then resolved by chiral high-performance liquid chromatography (HPLC) to afford (+)-12aa-(aR)(11S) and (−)-12aa′-(aS)(11R), of which the absolute configuration were determined by X-ray analysis. The starting compound 67 was prepared by Claisen-Schmidt reaction of 65 and 66 in 39% yield.
The emerging interest in (−)-aS,11R-myricanol owing to its ability to lower the tau protein level led to a couple of the enantioselective total synthesis: one covers a synthesis of the biaryl macrocycle skeleton via Suzuki-Miyaura cross coupling and ring-closing metathesis reactions [156], and the other includes an enantioselective asymmetric Suzuki cross-coupling, and an indium-mediated The emerging interest in (−)-aS,11R-myricanol owing to its ability to lower the tau protein level led to a couple of the enantioselective total synthesis: one covers a synthesis of the biaryl macrocycle skeleton via Suzuki-Miyaura cross coupling and ring-closing metathesis reactions [156], and the other includes an enantioselective asymmetric Suzuki cross-coupling, and an indium-mediated allylation of an aliphatic aldehyde [157]. Unfortunately, detailed procedures for these methods are currently unavailable. However, the successful enantioselective Suzuki-Miyaura cross coupling for synthesis of subclass linear diarylheptanoid, diospongin B [158], may open a vista to the enantioselective synthesis of biphenyl heptanoids.

Aryl-Aryl Bond Formation via Photochemical Cyclization
Whiting and Wood employed photo-induced radical cyclization for the synthesis of myricanol [27,151]. The irradiation of the bromide 70 in EtOH in the presence of NaOH with a 252 nm wavelength light for 30 min afforded 72 in 10%, which could be readily converted to myricanol. However, an additional heptanoid 73, expected to be formed via C,O-coupling in 71, was not observed. The starting compound 70 were prepared from 52 by the method described for 53a [152]. allylation of an aliphatic aldehyde [157]. Unfortunately, detailed procedures for these methods are currently unavailable. However, the successful enantioselective Suzuki-Miyaura cross coupling for synthesis of subclass linear diarylheptanoid, diospongin B [158], may open a vista to the enantioselective synthesis of biphenyl heptanoids.

Aryl-Aryl Bond Formation via Photochemical Cyclization
Whiting and Wood employed photo-induced radical cyclization for the synthesis of myricanol [27,151]. The irradiation of the bromide 70 in EtOH in the presence of NaOH with a 252 nm wavelength light for 30 min afforded 72 in 10%, which could be readily converted to myricanol. However, an additional heptanoid 73, expected to be formed via C,O-coupling in 71, was not observed. The starting compound 70 were prepared from 52 by the method described for 53a [152].

Total Synthesis of Cyclic Diphenyl Ether Heptanoids
The formation of diphenyl ether has long been challenging especially in the chemistry of polypeptide macrocycles and, therefore, led to the development of a couple of practical methods, such as oxidative coupling of phenols [159], the SNAr reaction [160], the Ullmann reaction [161,162], and others [163,164].

Total Synthesis of Cyclic Diphenyl Ether Heptanoids
The formation of diphenyl ether has long been challenging especially in the chemistry of polypeptide macrocycles and, therefore, led to the development of a couple of practical methods, such as oxidative coupling of phenols [159], the S N Ar reaction [160], the Ullmann reaction [161,162], and others [163,164].

Formation of Macrocycles via Oxidative Coupling
The first attempt for the synthesis of diphenyl ether heptanoid comes from the biomimetic oxidative coupling of diarylheptanoid 76b with Tl(OCOCF 3 ) 3 to yield a trace amount of the corresponding diarylheptanoid 77 [27]. Reactions with K 3 Fe(CN) 6 , Ag 2 O, MnO 2 and VOCl 3 produced only tars and thus no further applications were reported. Under these conditions, only C,O-coupling was proceeded to lead diphenyl ether heptanoid 77 unlike the result previously described above for 72a. The prerequisite 76a was prepared via Grignard reaction of 4-(2-benzyloxy-3,4-dimethoxyphenyl)butyl bromide (51) with 3-(4-benzyloxyphenyl)propanal (74), followed by hydrogenolysis. Recently, Salih and Beaudry examined various oxidative cyclization conditions for acerogenin G (81) [165] and identified the classical phenoxy radical-forming agent PbO2 in HOAc [166] as the oxidant of choice. Oxidative coupling of 81 with PbO2 in HOAc, thus, resulted in cyclization with concomitant oxidative hydroxylation of the diphenyl ether and with esterification of a resident phenol, leading to acetyl pterocarine (82a) and its regioisomer (82b) in a ratio of approximately 3:1. Interestingly, the reaction was completely chemoselective and this no oxidative C-C coupling product (i.e., acerogenin E) was observed. Although the yield was not somewhat low, one promising result is that 40% of the starting acerogenin G (81) was recoverable. The subsequent hydrolysis of 70a afforded pterocarine (26b). The Horner-Wadsworth-Emmons reaction of phosphonate 78 with aldehyde 79 gave diene 80 in 88% yield, which was then subjected to catalytic hydrogenation to lead to starting acerogenin G (81) in 96% yield.

Formation of Macrocycles via SNAr Reaction
The first successful synthesis of acerogenin C (25b) included an intramolecular nucleophilic Recently, Salih and Beaudry examined various oxidative cyclization conditions for acerogenin G (81) [165] and identified the classical phenoxy radical-forming agent PbO 2 in HOAc [166] as the oxidant of choice. Oxidative coupling of 81 with PbO 2 in HOAc, thus, resulted in cyclization with concomitant oxidative hydroxylation of the diphenyl ether and with esterification of a resident phenol, leading to acetyl pterocarine (82a) and its regioisomer (82b) in a ratio of approximately 3:1. Interestingly, the reaction was completely chemoselective and this no oxidative C-C coupling product (i.e., acerogenin E) was observed. Although the yield was not somewhat low, one promising result is that 40% of the starting acerogenin G (81) was recoverable. The subsequent hydrolysis of 70a afforded pterocarine (26b). The Horner-Wadsworth-Emmons reaction of phosphonate 78 with aldehyde 79 gave diene 80 in 88% yield, which was then subjected to catalytic hydrogenation to lead to starting acerogenin G (81) in 96% yield. Recently, Salih and Beaudry examined various oxidative cyclization conditions for acerogenin G (81) [165] and identified the classical phenoxy radical-forming agent PbO2 in HOAc [166] as the oxidant of choice. Oxidative coupling of 81 with PbO2 in HOAc, thus, resulted in cyclization with concomitant oxidative hydroxylation of the diphenyl ether and with esterification of a resident phenol, leading to acetyl pterocarine (82a) and its regioisomer (82b) in a ratio of approximately 3:1. Interestingly, the reaction was completely chemoselective and this no oxidative C-C coupling product (i.e., acerogenin E) was observed. Although the yield was not somewhat low, one promising result is that 40% of the starting acerogenin G (81) was recoverable. The subsequent hydrolysis of 70a afforded pterocarine (26b). The Horner-Wadsworth-Emmons reaction of phosphonate 78 with aldehyde 79 gave diene 80 in 88% yield, which was then subjected to catalytic hydrogenation to lead to starting acerogenin G (81) in 96% yield.

Formation of Macrocycles via SNAr Reaction
The first successful synthesis of acerogenin C (25b) included an intramolecular nucleophilic aromatic substitution (SNAr) macrocyclization of 88a to yield 89 [167]. In order to undertake such an SNAr reaction efficiently, one or more strong electron withdrawing groups, such as a nitro group, are

Formation of Macrocycles via S N Ar Reaction
The first successful synthesis of acerogenin C (25b) included an intramolecular nucleophilic aromatic substitution (S N Ar) macrocyclization of 88a to yield 89 [167]. In order to undertake such an S N Ar reaction efficiently, one or more strong electron withdrawing groups, such as a nitro group, are required at the proper positions [168]. The removal of the nitro group after the cyclization requires a couple of additional steps: the reduction of nitro to amine, followed by Doyle's one-step deamination [169] to provide O-methylacerogenin C (90a). AlCl 3 catalyzed demethylation of 90a afforded acerogenin C (25b). The reaction of acerogenin C (25b) with 2,3,4,6-tetrabenzoylglucopyranosyl bromide in the presence of (n-Bu) 4 NBr provided glycoside 91 with 93% yield, of which subsequent saponification resulted in aceroside IV (25a) in 95% yield. The starting linear heptanoid 88a was prepared by employing methyl acetoacetate ester synthesis. Dicarbanion generated from methyl acetoacetate (83)  Such a strategy was later employed for the synthesis of acerogenins B and L by using 71b as a starting material [170], which was similarly prepared from 92.

Formation of Macrocycles via Intramolecular Ullmann Ether Synthesis
Keserü et al. has reported a synthesis of acerogenin A and C via an intramolecular Ullmann ether Such a strategy was later employed for the synthesis of acerogenins B and L by using 71b as a starting material [170], which was similarly prepared from 92. Such a strategy was later employed for the synthesis of acerogenins B and L by using 71b as a starting material [170], which was similarly prepared from 92.

Formation of Macrocycles via Intramolecular Ullmann Ether Synthesis
Keserü et al. has reported a synthesis of acerogenin A and C via an intramolecular Ullmann ether synthesis [171]. The linear diarylheptanoid 95 was heated at 130 °C in the presence of CuBr-Me2S and

Formation of Macrocycles via Intramolecular Ullmann Ether Synthesis
Keserü et al. has reported a synthesis of acerogenin A and C via an intramolecular Ullmann ether synthesis [171]. The linear diarylheptanoid 95 was heated at 130 • C in the presence of CuBr-Me 2 S and t-BuOK to afford the corresponding O-methylacerogenin C (90a) in 16% yield, which was then converted to acerogenin C (25b) via demethylation by pyridinium chloride. The subsequent reduction of 25b by NaBH 4 led to acerogenin A (23b). The prerequisite starting compound 95 was prepared by Wittig reaction of 93 with 4-iodobenzaldehyde and the subsequent catalytic hydrogenation of the double bond in 94.

Formation of Macrocycles via Intramolecular Ullmann Ether Synthesis
Keserü et al. has reported a synthesis of acerogenin A and C via an intramolecular Ullmann ether synthesis [171]. The linear diarylheptanoid 95 was heated at 130 °C in the presence of CuBr-Me2S and t-BuOK to afford the corresponding O-methylacerogenin C (90a) in 16% yield, which was then converted to acerogenin C (25b) via demethylation by pyridinium chloride. The subsequent reduction of 25b by NaBH4 led to acerogenin A (23b). The prerequisite starting compound 95 was prepared by Wittig reaction of 93 with 4-iodobenzaldehyde and the subsequent catalytic hydrogenation of the double bond in 94.
Jahng and his coworkers [172] employed the same methodology for the synthesis of a series of acerogenins; the linear diarylheptanoids were prepared by employing a series of cross aldol condensations. Retrosynthetic analysis of the methods shown in Scheme 2 revealed that such a method holds the advantage that two types of acerogenins such as acerogenin C and L, can be prepared by the same reaction sequence via starting compounds of 4-halo-3-hydroxybenzaldehydes (96 series) and 3-halo-4-hydroxybenzaldehydes (97 series), respectively.

Molecules 2018, 23, x FOR PEER REVIEW 23 of 39
Jahng and his coworkers [172] employed the same methodology for the synthesis of a series of acerogenins; the linear diarylheptanoids were prepared by employing a series of cross aldol condensations. Retrosynthetic analysis of the methods shown in Scheme 2 revealed that such a method holds the advantage that two types of acerogenins such as acerogenin C and L, can be prepared by the same reaction sequence via starting compounds of 4-halo-3-hydroxybenzaldehydes (96 series) and 3-halo-4-hydroxybenzaldehydes (97 series), respectively. The Claisen-Schmidt condensation of 98a with 4-benzyloxybenzaldehyde gave diarylheptenoid 99a, which was then subjected to catalytic hydrogenation to yield 96a. In the classical Ullmann reaction condition, CuO-K2CO3 in pyridine was applied to diarylheptanoid 96a to yield Omethylacerogenin C (90a), from which the cleavage of methyl by treating AlCl3 afforded acerogenin C (25b). It is noteworthy that the application of 50 psi H2 to 99b in the presence of 10% Pd/C resulted in the reduction of a double bond, the hydrogenolysis of benzyl ether as well as the Ar-Br bond. However catalytic hydrogenation at 1 atm H2 for 10 h led to the reduction of a double bond and the hydrogenolysis of benzyl ether without cleavage of the Ar-Br bond. The subsequent intramolecular The Claisen-Schmidt condensation of 98a with 4-benzyloxybenzaldehyde gave diarylheptenoid 99a, which was then subjected to catalytic hydrogenation to yield 96a. In the classical Ullmann reaction condition, CuO-K 2 CO 3 in pyridine was applied to diarylheptanoid 96a to yield O-methylacerogenin C (90a), from which the cleavage of methyl by treating AlCl 3 afforded acerogenin C (25b). It is noteworthy that the application of 50 psi H 2 to 99b in the presence of 10% Pd/C resulted in the reduction of a double bond, the hydrogenolysis of benzyl ether as well as the Ar-Br bond. However catalytic hydrogenation at 1 atm H 2 for 10 h led to the reduction of a double bond and the hydrogenolysis of benzyl ether without cleavage of the Ar-Br bond. The subsequent intramolecular Ullmann reaction cyclization reaction followed by demethylation afforded acerogenin L (26a).
The Claisen-Schmidt condensation of 98a with 4-benzyloxybenzaldehyde gave diarylheptenoid 99a, which was then subjected to catalytic hydrogenation to yield 96a. In the classical Ullmann reaction condition, CuO-K2CO3 in pyridine was applied to diarylheptanoid 96a to yield Omethylacerogenin C (90a), from which the cleavage of methyl by treating AlCl3 afforded acerogenin C (25b). It is noteworthy that the application of 50 psi H2 to 99b in the presence of 10% Pd/C resulted in the reduction of a double bond, the hydrogenolysis of benzyl ether as well as the Ar-Br bond. However catalytic hydrogenation at 1 atm H2 for 10 h led to the reduction of a double bond and the hydrogenolysis of benzyl ether without cleavage of the Ar-Br bond. The subsequent intramolecular Ullmann reaction cyclization reaction followed by demethylation afforded acerogenin L (26a).
The same reaction sequence was applied to the synthesis of galeon and pterocarine [173]. The catalytic reduction of the double bond of 99c afforded 97b. The hydrogenation reaction time is critical for keeping the benzyl group: it can be minimized by stopping the reaction in 2.5 h at room temperature. The intramolecular Ullmann reaction of 97b with CuO/K 2 CO 3 in pyridine afforded 90c, from which hydrogenolysis gave galeon (26c) and through subsequent demethylation of 26c afforded pterocarine (26d). The starting 99c was prepared by the same synthetic sequence employed above for 99a,b by Claisen-Schmidt condensation of 6-(4-hydroxy-3-methoxyphenyl)hexan-2-one with 4-benzyloxy-3-bromobenzaldehyde. The same reaction sequence was applied to the synthesis of galeon and pterocarine [173]. The catalytic reduction of the double bond of 99c afforded 97b. The hydrogenation reaction time is critical for keeping the benzyl group: it can be minimized by stopping the reaction in 2.5 h at room temperature. The intramolecular Ullmann reaction of 97b with CuO/K2CO3 in pyridine afforded 90c, from which hydrogenolysis gave galeon (26c) and through subsequent demethylation of 26c afforded pterocarine (26d). The starting 99c was prepared by the same synthetic sequence employed above for 99a,b by Claisen-Schmidt condensation of 6-(4-hydroxy-3-methoxyphenyl)hexan-2-one with 4benzyloxy-3-bromobenzaldehyde.
The same methodology was applied to 100a to afford 101, which gave the corresponding didemethylated product (28) in 42% yield by AlCl3-mediated cleavage of methyl ether moiety [174]. The 1 H NMR spectrum of the product is not identical to that of engelhardione reported previously [120] and but did match that of pterocarine (vide ante). Based on these data, Shen and Sun revised The same methodology was applied to 100a to afford 101, which gave the corresponding didemethylated product (28) in 42% yield by AlCl 3 -mediated cleavage of methyl ether moiety [174]. The 1 H NMR spectrum of the product is not identical to that of engelhardione reported previously [120] and but did match that of pterocarine (vide ante). Based on these data, Shen and Sun revised the structure of engelhardione to be pterocarine [174] (vide ante). The starting 100a was prepared from 6-(3-hydroxy-4-methoxyphenyl)hexan-2-one and 3-bromo-4-methoxybernzaldehyde via Claisen-Schmidt condensation followed by catalytic hydrogenation.
The same methodology was applied to 100a to afford 101, which gave the corresponding didemethylated product (28) in 42% yield by AlCl3-mediated cleavage of methyl ether moiety [174]. The 1 H NMR spectrum of the product is not identical to that of engelhardione reported previously [120] and but did match that of pterocarine (vide ante). Based on these data, Shen and Sun revised the structure of engelhardione to be pterocarine [174] (vide ante). The starting 100a was prepared from 6-(3-hydroxy-4-methoxyphenyl)hexan-2-one and 3-bromo-4-methoxybernzaldehyde via Claisen-Schmidt condensation followed by catalytic hydrogenation.
The catalytic hydrogenation of 104a and 104b, followed by cyclization under Ullmann reaction conditions provided cyclophanes 90d and 90e, respectively. The selective cleavage of the isopropyl ether using BCl3 completed the synthesis of myricatomentogenin (26e) and jugcathanin (26f).
The last part of diphenyl ether-type heptanoids describes the synthesis of garuganins and garugamblins. Beaudry and his coworkers reported an elegant synthesis and conformational dynamics of these series, in which they employed 1,7-diarylhept-3,5-diones as key intermediates [128,129]. To the lithium enolate of 105 was added an aldehyde 106 to produce an aldol product 107. The oxidation of β-hydroxy ketone using IBX gave 1,3-diketone 108, which was subjected to selective debenzylation by BCl3 at -78 °C to give 109. An intramolecular Ullmann reaction using stoichiometric CuO in pyridine at the elevated temperature gave the cyclized product 110 in 38% yield. Methyl ether was achieved by treating CH3OH in presence of p-TsOH. In addition, the treatment of 28b with CH3I afforded garuganin VI (31). Most of garuganins and garugamblins were prepared by using dihydrocinnamaldehyde derivatives 106 with appropriate substituents.
The starting cinnamaldehyde 102 was prepared in 4 steps from the corresponding coumarins via methanolysis, isopropyl ether formation, diisobutylaluminum hydride reduction and Dess-Martin oxidation.
The last part of diphenyl ether-type heptanoids describes the synthesis of garuganins and garugamblins. Beaudry and his coworkers reported an elegant synthesis and conformational dynamics of these series, in which they employed 1,7-diarylhept-3,5-diones as key intermediates [128,129].
To the lithium enolate of 105 was added an aldehyde 106 to produce an aldol product 107.
The oxidation of β-hydroxy ketone using IBX gave 1,3-diketone 108, which was subjected to selective debenzylation by BCl 3 at -78 • C to give 109. An intramolecular Ullmann reaction using stoichiometric CuO in pyridine at the elevated temperature gave the cyclized product 110 in 38% yield. Methyl ether was achieved by treating CH 3 OH in presence of p-TsOH. In addition, the treatment of 28b with CH 3 I afforded garuganin VI (31). Most of garuganins and garugamblins were prepared by using dihydrocinnamaldehyde derivatives 106 with appropriate substituents. [128,129]. To the lithium enolate of 105 was added an aldehyde 106 to produce an aldol product 107.
The oxidation of β-hydroxy ketone using IBX gave 1,3-diketone 108, which was subjected to selective debenzylation by BCl3 at -78 °C to give 109. An intramolecular Ullmann reaction using stoichiometric CuO in pyridine at the elevated temperature gave the cyclized product 110 in 38% yield. Methyl ether was achieved by treating CH3OH in presence of p-TsOH. In addition, the treatment of 28b with CH3I afforded garuganin VI (31). Most of garuganins and garugamblins were prepared by using dihydrocinnamaldehyde derivatives 106 with appropriate substituents.
Finally tedarene A (41a) was prepared by the dehydration of 116, which was prepared 4 steps from 3-(4-methoxyphenyl)propanal (111) and (4-(but-3-yn-1-yl)phenoxy)(t-butyl)dimethylsilane (112) [6] via Ullmann cyclization as a key reaction. An acetylide generated from 112 was reacted with 113 to afford the expected propargyl alcohol 113. The optimized, controlled (6 atm of H2 for 18 h), Finally tedarene A (41a) was prepared by the dehydration of 116, which was prepared 4 steps from 3-(4-methoxyphenyl)propanal (111) and (4-(but-3-yn-1-yl)phenoxy)(t-butyl)dimethylsilane (112) [6] via Ullmann cyclization as a key reaction. An acetylide generated from 112 was reacted with 113 to afford the expected propargyl alcohol 113. The optimized, controlled (6 atm of H 2 for 18 h), and stereospecific hydrogenation of alkyne in 113 produced a Z-alkene (114a), which was then subjected to deprotection of the t-butyldimethylsilyl (TBS) group by tetra-n-butylammonium fluoroborate (TBAF) to give 114b. The intramolecular Ullmann reaction of 114b, followed by demethylation with NaSEt in refluxing DMF, afforded 115. Kozikowski's dehydration method using methanesulfonyl chloride in the presence of NEt 3 in CH 2 Cl 2 from 0 • C to room temperature [176] was applied to 115 to allow the elimination reaction to proceed, along with the unavoidable mesylation of the phenol leading to a mixture of diene E,Zand E,E-isomers 116a and 116b in a 6:4 ratio (as determined by 1 H NMR) in 80% yield. Hydrolysis of the mesylates was finally accomplished by aq. NaOH in an optimized 1:1 CH 3 OH/dioxane mixture at 60 • C, in 67% yield. Preparative HPLC chromatography using a chiral-phase column in direct phase allowed the separation of the two macrocycles, tedarene A (41a) and its isomer 41b in 38.5% and 23% isolated yields, respectively, of which the structures were confirmed by X-ray structure analysis. The starting compound 111 was prepared in 2 steps from 3-(4-benzyloxyphenyl)propanal by regioselective bromination on the aromatic ring by Br 2 in presence of AlCl 3 , and the subsequent IBX oxidation of the resulting alcohol led to the aldehyde. macrocycles, tedarene A (41a) and its isomer 41b in 38.5% and 23% isolated yields, respectively, of which the structures were confirmed by X-ray structure analysis. The starting compound 111 was prepared in 2 steps from 3-(4-benzyloxyphenyl)propanal by regioselective bromination on the aromatic ring by Br2 in presence of AlCl3, and the subsequent IBX oxidation of the resulting alcohol led to the aldehyde. in the presence of t-BuOK afforded the alkene compound 120, which was then converted to the dibromide compound 121 by a three-step reaction sequence. The radical anion induced by intramolecular Wurtz reaction with synchronistical cleavage of isoxazole provided β-enaminoketone 122 in 16% yield, where the intramolecular hydrogen bonding may force to adapt (Z)-alkene. The subsequent hydrolysis followed by methylation of enol with diazomethane led to two regioisomeric (Z)-enol ethers 123a and 123b Compound 123a slowly isomerized to natural garugamblin I (28a) by simply standing in a chloroform solution for 2 weeks. The same isomerization has also been observed for 123b to 124. These observation may imply that (Z)-isomers [(E)-heptenes, 28a and 124] are somewhat more stable than the corresponding (E)-isomers [(Z)-heptenes, 123a and 123b, respectively. subsequent hydrolysis followed by methylation of enol with diazomethane led to two regioisomeric (Z)-enol ethers 123a and 123b Compound 123a slowly isomerized to natural garugamblin I (28a) by simply standing in a chloroform solution for 2 weeks. The same isomerization has also been observed for 123b to 124. These observation may imply that (Z)-isomers [(E)-heptenes, 28a and 124] are somewhat more stable than the corresponding (E)-isomers [(Z)-heptenes, 123a and 123b, respectively.
On the other hand, the same group employed a Wittig reaction for the synthesis of garuganin III (32) [128]. The intramolecular Wittig reaction was pursued by the addition of t-BuOK to a dilute solution of 125 in DMF to produce macrocycle 126. The catalytic hydrogenation over PtO2 doped with Raney nickel saturated the double bond and cleaved isoxazole ring to give the enaminoketone 127. The hydrolysis of 127 quantitatively resulted in the corresponding ketoenol, which was then methylated with diazomethane to yield garuganin III (32) with a mixture of its region-and stereoisomers. Based on the synthesis, the originally proposed structure was revised as shown. The same group employed identical synthetic methodology for the synthesis of garugamblin-2 (31) [178].
On the other hand, the same group employed a Wittig reaction for the synthesis of garuganin III (32) [128]. The intramolecular Wittig reaction was pursued by the addition of t-BuOK to a dilute solution of 125 in DMF to produce macrocycle 126. The catalytic hydrogenation over PtO 2 doped with Raney nickel saturated the double bond and cleaved isoxazole ring to give the enaminoketone 127. The hydrolysis of 127 quantitatively resulted in the corresponding ketoenol, which was then methylated with diazomethane to yield garuganin III (32) with a mixture of its region-and stereoisomers. Based on the synthesis, the originally proposed structure was revised as shown. The same group employed identical synthetic methodology for the synthesis of garugamblin-2 (31) [178]. Ring-closing metathesis has been used as a powerful tool for macrocyclization [147]. The intermolecular Ullmann reaction of 128 and 129 afforded the prerequisite precursor 130, of which the ring closure metathesis with a variety of Grubbs' catalysts for the synthesis of ovalifoliolatin B (35b) [179] did not proceed at all. On the other hand, it is worth noting that an intermolecular ring closure metathesis of 128 and 129 led to an inseparable mixture of stereoisomers of the precursor 131, which was then CuO mediated Ullmann cyclization to provide ovalifoliolatin B (35b) and its cis-isomer 132 in a ratio of 13:1. The catalytic hydrogenation of these two isomers, followed by demethylation by AlCl3 afforded acerogenin C (25b). All attempts for the synthesis of cyclic diarylheptanoids employing ring closing metathesis have, thus far, failed implying the scope of such a reaction for the application towards the synthesis of cyclic diaryl ether heptanoids.

Enantioselective Synthesis of Diaryl Ether Heptanoids
Two types of enantioselective reactions, such as enantioselective Ullmann ether coupling and chiral phase-transfer-catalyzed atropselective diaryl ether formation via SNAr reaction, have been reported.

Via Ring-Closing Metathesis
Ring-closing metathesis has been used as a powerful tool for macrocyclization [147]. The intermolecular Ullmann reaction of 128 and 129 afforded the prerequisite precursor 130, of which the ring closure metathesis with a variety of Grubbs' catalysts for the synthesis of ovalifoliolatin B (35b) [179] did not proceed at all. On the other hand, it is worth noting that an intermolecular ring closure metathesis of 128 and 129 led to an inseparable mixture of stereoisomers of the precursor 131, which was then CuO mediated Ullmann cyclization to provide ovalifoliolatin B (35b) and its cis-isomer 132 in a ratio of 13:1. The catalytic hydrogenation of these two isomers, followed by demethylation by AlCl 3 afforded acerogenin C (25b). All attempts for the synthesis of cyclic diarylheptanoids employing ring closing metathesis have, thus far, failed implying the scope of such a reaction for the application towards the synthesis of cyclic diaryl ether heptanoids. Ring-closing metathesis has been used as a powerful tool for macrocyclization [147]. The intermolecular Ullmann reaction of 128 and 129 afforded the prerequisite precursor 130, of which the ring closure metathesis with a variety of Grubbs' catalysts for the synthesis of ovalifoliolatin B (35b) [179] did not proceed at all. On the other hand, it is worth noting that an intermolecular ring closure metathesis of 128 and 129 led to an inseparable mixture of stereoisomers of the precursor 131, which was then CuO mediated Ullmann cyclization to provide ovalifoliolatin B (35b) and its cis-isomer 132 in a ratio of 13:1. The catalytic hydrogenation of these two isomers, followed by demethylation by AlCl3 afforded acerogenin C (25b). All attempts for the synthesis of cyclic diarylheptanoids employing ring closing metathesis have, thus far, failed implying the scope of such a reaction for the application towards the synthesis of cyclic diaryl ether heptanoids.

Enantioselective Synthesis of Diaryl Ether Heptanoids
Two types of enantioselective reactions, such as enantioselective Ullmann ether coupling and chiral phase-transfer-catalyzed atropselective diaryl ether formation via SNAr reaction, have been reported.

Enantioselective Synthesis of Diaryl Ether Heptanoids
Two types of enantioselective reactions, such as enantioselective Ullmann ether coupling and chiral phase-transfer-catalyzed atropselective diaryl ether formation via S N Ar reaction, have been reported.
Salih and Beaudry reported the first asymmetric syntheses of (−)-myricatomentogenin, (−)-jugcathanin, (+)-galeon, and (+)-pterocarine by enantioselective Ullmann cross-coupling reaction [180]. The intramolecular coupling reaction was evaluated using enantiopure ligands known to accelerate the Ullmann reaction and some other privileged ligand structures. Cu-catalyzed cross coupling of 97c in the presence of BINOL-type ligands would lead enantioselectivity with low chemical yields. Among the 21 tested ligands, N-methyl-L-proline did lead to not only increased chemical yield up to 41% but also enantioselectivity up to 68:32 in the presence of 20 mol% CuI. Variations in the N-alkyl group, the ring size, and the carboxylic acid functionality did not significantly improve the yield or enantioselectivity of the reaction. The survey of a variety of inorganic and organic bases in the Ullmann coupling indicated that use of K 3 PO 4 instead of Cs 2 CO 3 could be the conditions of choice with a higher enantiomeric ration without a significant loss of chemical yield (see Table 7). Thus, enantioselective cross Ullmann coupling of 97c was pursued under the optimized reaction conditions [CuI (20 mol %), N-methyl-L-proline (40 mol %), K 3 PO 4 (2 equiv.) in dioxane] afforded (pR)-90f with 72:28 er. Although they did not find any better system, such enantiomeric ratio can be improved to 92:8 er by recrystallization. The partial and complete demethylation of (pR)-90f afforded (+)-galeon (43%, (92:8 er) and (+)-pterocarine (45%, 92:8), respectively. accelerate the Ullmann reaction and some other privileged ligand structures. Cu-catalyzed cross coupling of 97c in the presence of BINOL-type ligands would lead enantioselectivity with low chemical yields. Among the 21 tested ligands, N-methyl-L-proline did lead to not only increased chemical yield up to 41% but also enantioselectivity up to 68:32 in the presence of 20 mol% CuI. Variations in the N-alkyl group, the ring size, and the carboxylic acid functionality did not significantly improve the yield or enantioselectivity of the reaction. The survey of a variety of inorganic and organic bases in the Ullmann coupling indicated that use of K3PO4 instead of Cs2CO3 could be the conditions of choice with a higher enantiomeric ration without a significant loss of chemical yield (see Table 7). Thus, enantioselective cross Ullmann coupling of 97c was pursued under the optimized reaction conditions [CuI (20 mol %), N-methyl-L-proline (40 mol %), K3PO4 (2 equiv.) in dioxane] afforded (pR)-90f with 72:28 er. Although they did not find any better system, such enantiomeric ratio can be improved to 92:8 er by recrystallization. The partial and complete demethylation of (pR)-90f afforded (+)-galeon (43%, (92:8 er) and (+)-pterocarine (45%, 92:8), respectively.  20% mol) in the presence of K3PO4 (2 equiv) and chiral ligand, N-methyl-L-proline (40 mol%)] afforded 90g in moderate yield and with a degree of enantioselectivity (67:33 er). The enantiomeric ratio of cyclophane 90g was increased up to 82:18 er by additional recrystallization. The treatment of 90g with BCl3 gave a 1:1 mixture of the product with one isopropyl group (90h) and (−)-myricatomentogenin (26e) in nearly quantitative yield without any loss in enantioenrichment. Subsequent methylation followed by the removal of isopropyl group in 90h provided (−)-jugcathanin (26f) without any loss in enantiomeric ratio. accelerate the Ullmann reaction and some other privileged ligand structures. Cu-catalyzed cross coupling of 97c in the presence of BINOL-type ligands would lead enantioselectivity with low chemical yields. Among the 21 tested ligands, N-methyl-L-proline did lead to not only increased chemical yield up to 41% but also enantioselectivity up to 68:32 in the presence of 20 mol% CuI. Variations in the N-alkyl group, the ring size, and the carboxylic acid functionality did not significantly improve the yield or enantioselectivity of the reaction. The survey of a variety of inorganic and organic bases in the Ullmann coupling indicated that use of K3PO4 instead of Cs2CO3 could be the conditions of choice with a higher enantiomeric ration without a significant loss of chemical yield (see Table 7). Thus, enantioselective cross Ullmann coupling of 97c was pursued under the optimized reaction conditions [CuI (20 mol %), N-methyl-L-proline (40 mol %), K3PO4 (2 equiv.) in dioxane] afforded (pR)-90f with 72:28 er. Although they did not find any better system, such enantiomeric ratio can be improved to 92:8 er by recrystallization. The partial and complete demethylation of (pR)-90f afforded (+)-galeon (43%, (92:8 er) and (+)-pterocarine (45%, 92:8), respectively.  ) in the presence of K3PO4 (2 equiv) and chiral ligand, N-methyl-L-proline (40 mol%)] afforded 90g in moderate yield and with a degree of enantioselectivity (67:33 er). The enantiomeric ratio of cyclophane 90g was increased up to 82:18 er by additional recrystallization. The treatment of 90g with BCl3 gave a 1:1 mixture of the product with one isopropyl group (90h) and (−)-myricatomentogenin (26e) in nearly quantitative yield without any loss in enantioenrichment. Subsequent methylation followed by the removal of isopropyl group in 90h provided (−)-jugcathanin (26f) without any loss in enantiomeric ratio. accelerate the Ullmann reaction and some other privileged ligand structures. Cu-catalyzed cross coupling of 97c in the presence of BINOL-type ligands would lead enantioselectivity with low chemical yields. Among the 21 tested ligands, N-methyl-L-proline did lead to not only increased chemical yield up to 41% but also enantioselectivity up to 68:32 in the presence of 20 mol% CuI. Variations in the N-alkyl group, the ring size, and the carboxylic acid functionality did not significantly improve the yield or enantioselectivity of the reaction. The survey of a variety of inorganic and organic bases in the Ullmann coupling indicated that use of K3PO4 instead of Cs2CO3 could be the conditions of choice with a higher enantiomeric ration without a significant loss of chemical yield (see Table 7). Thus, enantioselective cross Ullmann coupling of 97c was pursued under the optimized reaction conditions [CuI (20 mol %), N-methyl-L-proline (40 mol %), K3PO4 (2 equiv.) in dioxane] afforded (pR)-90f with 72:28 er. Although they did not find any better system, such enantiomeric ratio can be improved to 92:8 er by recrystallization. The partial and complete demethylation of (pR)-90f afforded (+)-galeon (43%, (92:8 er) and (+)-pterocarine (45%, 92:8), respectively.  ) in the presence of K3PO4 (2 equiv) and chiral ligand, N-methyl-L-proline (40 mol%)] afforded 90g in moderate yield and with a degree of enantioselectivity (67:33 er). The enantiomeric ratio of cyclophane 90g was increased up to 82:18 er by additional recrystallization. The treatment of 90g with BCl3 gave a 1:1 mixture of the product with one isopropyl group (90h) and (−)-myricatomentogenin (26e) in nearly quantitative yield without any loss in enantioenrichment. Subsequent methylation followed by the removal of isopropyl group in 90h provided (−)-jugcathanin (26f) without any loss in enantiomeric ratio. accelerate the Ullmann reaction and some other privileged ligand structures. Cu-catalyzed cross coupling of 97c in the presence of BINOL-type ligands would lead enantioselectivity with low chemical yields. Among the 21 tested ligands, N-methyl-L-proline did lead to not only increased chemical yield up to 41% but also enantioselectivity up to 68:32 in the presence of 20 mol% CuI. Variations in the N-alkyl group, the ring size, and the carboxylic acid functionality did not significantly improve the yield or enantioselectivity of the reaction. The survey of a variety of inorganic and organic bases in the Ullmann coupling indicated that use of K3PO4 instead of Cs2CO3 could be the conditions of choice with a higher enantiomeric ration without a significant loss of chemical yield (see Table 7). Thus, enantioselective cross Ullmann coupling of 97c was pursued under the optimized reaction conditions [CuI (20 mol %), N-methyl-L-proline (40 mol %), K3PO4 (2 equiv.) in dioxane] afforded (pR)-90f with 72:28 er. Although they did not find any better system, such enantiomeric ratio can be improved to 92:8 er by recrystallization. The partial and complete demethylation of (pR)-90f afforded (+)-galeon (43%, (92:8 er) and (+)-pterocarine (45%, 92:8), respectively.  ) in the presence of K3PO4 (2 equiv) and chiral ligand, N-methyl-L-proline (40 mol%)] afforded 90g in moderate yield and with a degree of enantioselectivity (67:33 er). The enantiomeric ratio of cyclophane 90g was increased up to 82:18 er by additional recrystallization. The treatment of 90g with BCl3 gave a 1:1 mixture of the product with one isopropyl group (90h) and (−)-myricatomentogenin (26e) in nearly quantitative yield without any loss in enantioenrichment. Subsequent methylation followed by the removal of isopropyl group in 90h provided (−)-jugcathanin (26f) without any loss in enantiomeric ratio. accelerate the Ullmann reaction and some other privileged ligand structures. Cu-catalyzed cross coupling of 97c in the presence of BINOL-type ligands would lead enantioselectivity with low chemical yields. Among the 21 tested ligands, N-methyl-L-proline did lead to not only increased chemical yield up to 41% but also enantioselectivity up to 68:32 in the presence of 20 mol% CuI. Variations in the N-alkyl group, the ring size, and the carboxylic acid functionality did not significantly improve the yield or enantioselectivity of the reaction. The survey of a variety of inorganic and organic bases in the Ullmann coupling indicated that use of K3PO4 instead of Cs2CO3 could be the conditions of choice with a higher enantiomeric ration without a significant loss of chemical yield (see Table 7). Thus, enantioselective cross Ullmann coupling of 97c was pursued under the optimized reaction conditions [CuI (20 mol %), N-methyl-L-proline (40 mol %), K3PO4 (2 equiv.) in dioxane] afforded (pR)-90f with 72:28 er. Although they did not find any better system, such enantiomeric ratio can be improved to 92:8 er by recrystallization. The partial and complete demethylation of (pR)-90f afforded (+)-galeon (43%, (92:8 er) and (+)-pterocarine (45%, 92:8), respectively.  ) in the presence of K3PO4 (2 equiv) and chiral ligand, N-methyl-L-proline (40 mol%)] afforded 90g in moderate yield and with a degree of enantioselectivity (67:33 er). The enantiomeric ratio of cyclophane 90g was increased up to 82:18 er by additional recrystallization. The treatment of 90g with BCl3 gave a 1:1 mixture of the product with one isopropyl group (90h) and (−)-myricatomentogenin (26e) in nearly quantitative yield without any loss in enantioenrichment. Subsequent methylation followed by the removal of isopropyl group in 90h provided (−)-jugcathanin (26f) without any loss in enantiomeric ratio. accelerate the Ullmann reaction and some other privileged ligand structures. Cu-catalyzed cross coupling of 97c in the presence of BINOL-type ligands would lead enantioselectivity with low chemical yields. Among the 21 tested ligands, N-methyl-L-proline did lead to not only increased chemical yield up to 41% but also enantioselectivity up to 68:32 in the presence of 20 mol% CuI. Variations in the N-alkyl group, the ring size, and the carboxylic acid functionality did not significantly improve the yield or enantioselectivity of the reaction. The survey of a variety of inorganic and organic bases in the Ullmann coupling indicated that use of K3PO4 instead of Cs2CO3 could be the conditions of choice with a higher enantiomeric ration without a significant loss of chemical yield (see Table 7). Thus, enantioselective cross Ullmann coupling of 97c was pursued under the optimized reaction conditions [CuI (20 mol %), N-methyl-L-proline (40 mol %), K3PO4 (2 equiv.) in dioxane] afforded (pR)-90f with 72:28 er. Although they did not find any better system, such enantiomeric ratio can be improved to 92:8 er by recrystallization. The partial and complete demethylation of (pR)-90f afforded (+)-galeon (43%, (92:8 er) and (+)-pterocarine (45%, 92:8), respectively.  ) in the presence of K3PO4 (2 equiv) and chiral ligand, N-methyl-L-proline (40 mol%)] afforded 90g in moderate yield and with a degree of enantioselectivity (67:33 er). The enantiomeric ratio of cyclophane 90g was increased up to 82:18 er by additional recrystallization. The treatment of 90g with BCl3 gave a 1:1 mixture of the product with one isopropyl group (90h) and (−)-myricatomentogenin (26e) in nearly quantitative yield without any loss in enantioenrichment. Subsequent methylation followed by the removal of isopropyl group in 90h provided (−)-jugcathanin (26f) without any loss in enantiomeric ratio. Subsequent Ullmann cross-coupling of 97d under optimized conditions [CuI (20% mol) in the presence of K 3 PO 4 (2 equiv) and chiral ligand, N-methyl-L-proline (40 mol%)] afforded 90g in moderate yield and with a degree of enantioselectivity (67:33 er). The enantiomeric ratio of cyclophane 90g was increased up to 82:18 er by additional recrystallization. The treatment of 90g with BCl 3 gave a 1:1 mixture of the product with one isopropyl group (90h) and (−)-myricatomentogenin (26e) in nearly quantitative yield without any loss in enantioenrichment. Subsequent methylation followed by the removal of isopropyl group in 90h provided (−)-jugcathanin (26f) without any loss in enantiomeric ratio. Alternatively, Ding et al. used the chiral phase transfer-transfer catalyst to induce an asymmetry during intramolecular SNAr cyclization for the formation of diphenyl ether [181]. They screened the reaction conditions in the presence of various chiral phase-transfer catalysts and found the cinchonine-derived ligand 133 as a phase-transfer catalyst of choice and 20% CsOH in toluene as base and solvent (see Table 8) as a best reaction condition. Therefore, the intramolecular SNAr reaction of 88b was explored on a 1 g scale in the presence of PTC 133 (20 mol%), 20% CsOH (aq) in toluene at room temperature to afford the desired product (pS)-89 in 81% yield with an er of 91:9. This er was improved up to 99:1 by recrystallization, with overall 62% yield. In addition, the hydrogenation of (pS)-89 provided the corresponding amino compound 134, of which the absolute configuration was determined as pS by X-ray crystallography. Compound 134 was further converted to a hydroxyl compound 135 without any measurable loss of enantiopurity by using a previously published method [170]. The demethylation of 135 led to pterocarine, which was determined to be (−)-pterocarine by comparison with previously reported Alternatively, Ding et al. used the chiral phase transfer-transfer catalyst to induce an asymmetry during intramolecular S N Ar cyclization for the formation of diphenyl ether [181]. They screened the reaction conditions in the presence of various chiral phase-transfer catalysts and found the cinchonine-derived ligand 133 as a phase-transfer catalyst of choice and 20% CsOH in toluene as base and solvent (see Table 8) as a best reaction condition. Alternatively, Ding et al. used the chiral phase transfer-transfer catalyst to induce an asymmetry during intramolecular SNAr cyclization for the formation of diphenyl ether [181]. They screened the reaction conditions in the presence of various chiral phase-transfer catalysts and found the cinchonine-derived ligand 133 as a phase-transfer catalyst of choice and 20% CsOH in toluene as base and solvent (see Table 8) as a best reaction condition. Therefore, the intramolecular SNAr reaction of 88b was explored on a 1 g scale in the presence of PTC 133 (20 mol%), 20% CsOH (aq) in toluene at room temperature to afford the desired product (pS)-89 in 81% yield with an er of 91:9. This er was improved up to 99:1 by recrystallization, with overall 62% yield. In addition, the hydrogenation of (pS)-89 provided the corresponding amino compound 134, of which the absolute configuration was determined as pS by X-ray crystallography. Compound 134 was further converted to a hydroxyl compound 135 without any measurable loss of enantiopurity by using a previously published method [170]. The demethylation of 135 led to pterocarine, which was determined to be (−)-pterocarine by comparison with previously reported Therefore, the intramolecular S N Ar reaction of 88b was explored on a 1 g scale in the presence of PTC 133 (20 mol%), 20% CsOH (aq) in toluene at room temperature to afford the desired product (pS)-89 in 81% yield with an er of 91:9. This er was improved up to 99:1 by recrystallization, with overall 62% yield. In addition, the hydrogenation of (pS)-89 provided the corresponding amino compound 134, of which the absolute configuration was determined as pS by X-ray crystallography. Compound 134 was further converted to a hydroxyl compound 135 without any measurable loss of enantiopurity by using a previously published method [170]. The demethylation of 135 led to pterocarine, which was determined to be (−)-pterocarine by comparison with previously reported data for its enantiomer [25]. Similarly, the same reaction sequence starting with counter precursor (88c) of 88a afforded the desired compound 136 in 83% yield, but with only moderate enantioselectivity (69:31 er). However the highly (99:1 er) (−)-enriched 136 could be obtained by simple recrystallization, which then converted to (−)-galeon by a simple transformation procedure reported previously.

Conclusion
Steady progress in the chemistry and biology of cyclic diarylheptanoids has resulted in a diverse range of new structures and new biological activity profiles. Slow but continuous efforts on the synthesis of cyclic diarylheptanoids have led not only to the revision of originally proposed structures, but also to the identification of synthetic methods to establish atropenantiomers. Partial success in the enantioselective synthesis of (−)-myricatomentogenin, (−)-jugcathanin, (+)-galeon, and (+)pterocarine by Ullmann cross coupling in the presence of chiral ligands and enantioselective synthesis of (−)-pterocarine and (−)-galeon by enantioselective SNAr formation in the presence of chiral phase-transfer catalyst may open a door to the development of an enantioselective macrocyclization for diphenyl ether heptanoids. On the other hand, a couple of the enantioselective total syntheses for the biaryl macrocycle skeleton via Suzuki-Miyaura cross-coupling and successful enantioselective Suzuki-Miyaura cross-coupling for the synthesis of subclass linear diarylheptanoid, diospongin B [158] may lead to a practical enantioselective synthesis of biphenyl heptanoids.
However, to the best of our knowledge, the structure-activity relationship (SAR) study of cyclic diarylheptanoids is very limited [80,182,183]; thus, the identification of good drug candidates has not Similarly, the same reaction sequence starting with counter precursor (88c) of 88a afforded the desired compound 136 in 83% yield, but with only moderate enantioselectivity (69:31 er). However the highly (99:1 er) (−)-enriched 136 could be obtained by simple recrystallization, which then converted to (−)-galeon by a simple transformation procedure reported previously. Similarly, the same reaction sequence starting with counter precursor (88c) of 88a afforded the desired compound 136 in 83% yield, but with only moderate enantioselectivity (69:31 er). However the highly (99:1 er) (−)-enriched 136 could be obtained by simple recrystallization, which then converted to (−)-galeon by a simple transformation procedure reported previously.

Conclusion
Steady progress in the chemistry and biology of cyclic diarylheptanoids has resulted in a diverse range of new structures and new biological activity profiles. Slow but continuous efforts on the synthesis of cyclic diarylheptanoids have led not only to the revision of originally proposed structures, but also to the identification of synthetic methods to establish atropenantiomers. Partial success in the enantioselective synthesis of (−)-myricatomentogenin, (−)-jugcathanin, (+)-galeon, and (+)pterocarine by Ullmann cross coupling in the presence of chiral ligands and enantioselective synthesis of (−)-pterocarine and (−)-galeon by enantioselective SNAr formation in the presence of chiral phase-transfer catalyst may open a door to the development of an enantioselective macrocyclization for diphenyl ether heptanoids. On the other hand, a couple of the enantioselective total syntheses for the biaryl macrocycle skeleton via Suzuki-Miyaura cross-coupling and successful enantioselective Suzuki-Miyaura cross-coupling for the synthesis of subclass linear diarylheptanoid, diospongin B [158] may lead to a practical enantioselective synthesis of biphenyl heptanoids.
However, to the best of our knowledge, the structure-activity relationship (SAR) study of cyclic diarylheptanoids is very limited [80,182,183]; thus, the identification of good drug candidates has not

Conclusion
Steady progress in the chemistry and biology of cyclic diarylheptanoids has resulted in a diverse range of new structures and new biological activity profiles. Slow but continuous efforts on the synthesis of cyclic diarylheptanoids have led not only to the revision of originally proposed structures, but also to the identification of synthetic methods to establish atropenantiomers. Partial success in the enantioselective synthesis of (−)-myricatomentogenin, (−)-jugcathanin, (+)-galeon, and (+)-pterocarine by Ullmann cross coupling in the presence of chiral ligands and enantioselective synthesis of (−)-pterocarine and (−)-galeon by enantioselective S N Ar formation in the presence of chiral phase-transfer catalyst may open a door to the development of an enantioselective macrocyclization for diphenyl ether heptanoids. On the other hand, a couple of the enantioselective total syntheses for the biaryl macrocycle skeleton via Suzuki-Miyaura cross-coupling and successful enantioselective Suzuki-Miyaura cross-coupling for the synthesis of subclass linear diarylheptanoid, diospongin B [158] may lead to a practical enantioselective synthesis of biphenyl heptanoids.
However, to the best of our knowledge, the structure-activity relationship (SAR) study of cyclic diarylheptanoids is very limited [80,182,183]; thus, the identification of good drug candidates has not been fruitful yet. Not only development of a facile enantioselective macrocyclization method but also more intense SAR study have become a prerequisite for realizing such a goal.
Author Contributions: J.G.P. organized the first draft, which was reorganized and refined by Y.J.